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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modified scaffold as potent antifungal agents

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Chinese Chemical Letters 2017年第8期28卷 1731-1736页

作者： xiao-xiao Zhang hong Jin Yuan-Jie deng Xu-Heng Gao Yong Li Yong-Tian Zhao Ke Tao Tai-Ping Hou Key Laboratory of Bio-Resource and Eco-environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610064China College of Chemistry Sichuan UniversityChengdu 610064China

Twenty-seven novel pyrazole carboxamides with diarylamine-modified scaffold were designed,synthesized and characterized in detail via1 H NMR,^（13） C NMR, IR and ESI-HRMS. Preliminary bioassays showed that some of the target compounds exhibited good antifungal activity against Rhizoctonia solani,Rhizoctonia cerealis and Sclerotinia sclerotiorum. Among them, compound 9c-7 exhibited the highest antifungal activities against R. solani, R. cerealis and S. sclerotiorum in vitro with IC_（50） values of 0.013, 1.608 and 1.874 mg/m L, respectively. Notably, compound 9c-7 still presented the highest fungicidal activities against R. solani in vivo with an IC_（50） value of 22.21 mg/m L. Molecular docking simulation results reveal that compound 9c-7 binds well to the hydrophobic pockets of the receptor protein succinate dehydrogenase. This study suggests that compound 9c-7 could act as a potential fungicide to be used for further optimization.

关键词： Pyrazole carboxamide Synthesis Antifungal activities Diarylamine

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Involvement of phosphatidate phosphatase in the biosynthesis of triacylglycerols in Chlamydomonas reinhardtii

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第12期14卷 1121-1131页

作者： xiao-dong deng Jia-jia CAI xiao-wen FEI Key Laboratory of Tropical Crop Biotechnology Ministry of Agriculture Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences School of Science Hainan Medical College

Lipid biosynthesis is essential for eukaryotic cells, but the mechanisms of the process in microalgae remain poorly understood. Phosphatidic acid phosphohydrolase or 3-sn-phosphatidate phosphohydrolase(PAP) catalyzes the dephosphorylation of phosphatidic acid to form diacylglycerols and inorganic orthophosphates. This reaction is integral in the synthesis of triacylglycerols. In this study, the mRNA level of the PAP isoform CrPAP2 in a species of Chlamydomonas was found to increase in nitrogen-free conditions. Silencing of the CrPAP2 gene using RNA interference resulted in the decline of lipid content by 2.4%–17.4%. By contrast, over-expression of the CrPAP2 gene resulted in an increase in lipid content by 7.5%–21.8%. These observations indicate that regulation of the CrPAP2 gene can control the lipid content of the algal cells. In vitro CrPAP2 enzyme activity assay indicated that the cloned CrPAP2 gene exhibited biological activities.

关键词： Phosphatidate phosphohydrolase 2 Triacylglycerol biosynthesis RNAi Chlamydomonas reinhardtii Nitrogen deprivation Over-expression

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Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 27-39页

作者： hong deng Jie Xie Jingquan Zhao Beijing National Laboratory for Molecular Sciences(BNLMS)Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences P.O.Box 101No.21st North Street ZhongguancunBeijing 100190P.R.China

Photodynamic therapy(PDT)has been a routine treatment of tumors and some microvascular diseases,but clinically available photosensitizers are still *** all kinds of photo-sensitizers,hypocellins possess the most characteristics of ideal photosensitizers,such as,high photo-activity but low dark toxicity,fast clearance from *** review is focused on two main topics,drug-delivery problem of hypocrellins and how the environment-sensitive fluorescence of bypecrellins was used for recognition of various ***-delivery of hypocrellins was mainly achieved in two strategies一preparing the drugdelivery vehicles and finding quantitatively amphiphilic *** fAuorescence originated from the intramolecular proton transfer is very distinct from other kinds of ***,it was proved that quan-titative hypocrellin ftuorescence could not only reoognize various biomolecules,including proteins,polysaocharides and lipids,but also distinguish the specific binding from nonspedifie binding with some kind of ***,hypocrellin fluorescence was pH *** is known that tumor cells or tses have the features of a large amount of lipid,neonatal collagen,over expression of polysaccharides,and lower pH values compared to normal *** to the relative but not absolute specifcity,further studies on quantitative recognition of various biomolecules at a cellular level,may find a new clue to treat tumors by joint usage of photodynamic diagnosis(PDD)and PDT.

关键词： Hypocrellins photodynamie therapy drug delivery biomolecular recognition

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Local Invariants for a Class of Tripartite Quantum Mixed States

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Communications in Theoretical Physics 2006年第2期45卷 262-266页

作者： WANG xiao-hong Department of Mathematics Capital Normal University Beijing 100037 China

We study the equivalence of tripartite mixed states under local unitary transformations. The nonlocal properties for a class of tripartite quantum states in C^K× CM ^M×C^N composite systems are investigated and a complete set of invariants under local unitary transformations for these states is presented. It is shown that two of these states are locally equivalent if and only if all these invariants have the same values.

关键词： tripartite quantum states local unitary transformations entanglement invariants

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Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status and future directions

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Frontiers of Medicine 2020年第3期14卷 251-261页

作者： Li Jiang deng Ning xiao-ping Chen Department of Biliary and Pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Postoperative pancreatic fistula (POPF) is the most common and critical complication after pancreatic body and tail *** to effectively reduce the occurrence of pancreatic fistula and conduct timely treatment thereafter is an urgent clinical issue to be *** research standardized the definition of pancreatic fistula and stressed the correlation between POPF classification and patient *** to the literature,identification of the risk factors for pancreatic fistula contributed to lowering the rate of the *** management of the pancreatic stump and perioperative treatment are of great significance to reduce the rate of POPF in clinical *** the occurrence of POPF,the treatment of choice should be determined according to the classification of the pancreatic ***,despite the progress and promising treatment approaches,POPF remains to be a clinical issue that warrants further studies in the future.

关键词： pancreatic fistula pancreatic body and tail resection distal pancreatectomy

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A Silver Cluster-Assembled Material Showing Luminescent Mechanochromism and Thermochromism

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Chinese Journal of Chemistry 2019年第12期37卷 1287-1288页

作者： xiao-hong Ma College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhouHenan 450001China

Silver chalcogenolate clusters(SCCs)[1]are a new category of materials with attractive photophysical ***,the notorious instability and the low emission quantum yield of SCCs hindered the profound investigation.

关键词： properties. Silver attractive

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A new characterization of Willmore submanifolds

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Applied Mathematics(A Journal of Chinese Universities) 2011年第4期26卷 453-463页

作者： XU hong-wei YANG deng-yun Center of Mathematical Sciences Zhejiang University Hangzhou 310027 China.

Let M^n be a compact Willmore submanifold in the unit sphere Sn＋p. In this note, we investigate the first eigenvalue of the SchrSdinger operator L = -△ - q on M, where q is some potential function on M, and present... 详细信息

关键词： Willmore submanifolds Schrodinger operator eigenvalue fiat normal bundle Willmore torus.

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Completeness of the system {z^(λ_n)}in L^2[B,α_0]

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Acta Mathematica Sinica,English Series 2008年第12期24卷 2101-2110页

作者： Ju hong NING Guan Tie deng Department of Mathematics Jiangxi Normal University Nanchang 330022 P. R. China School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

Let B be an unbounded domain located outside an angle domain with vertex at the origin, A ={λn}（n = 1,2,...） be a sequence of complex numbers satisfying sup ｜ arg（λn）｜〈 α 〈 π/2 and denote by M（∧） = {z^λ, λ ∈ ∧} the corresponding system of functions z^λ（λ∈∧）. Let α0（z） be a weight function defined on B. We obtain a completeness theorem for the system M（∧） in the Hilbert space L^2 [B, α0].

关键词： completeness unbounded domain Hilbert space

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Limitations of Lattice Boltzmann Modeling of Micro-Flows in Complex Nanopores

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1808-1822页

作者： ZUO hong deng Shouchun LI Haibo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100094China

The multiscale transport mechanism of methane in unconventional reservoirs is dominated by slip and transition flows resulting from the ultra-low permeability of micro/nano-scale pores,which requires consideration of the microscale and rarefaction *** continuum-based computational fluid dynamics(CFD)becomes problematic when modeling micro-gaseous flow in these multiscale pore networks because of its disadvantages in the treatment of cases with a complicated *** an alternative,the lattice Boltzmann method(LBM),a special discrete form of the Boltzmann equation,has been widely applied to model the multi-scale and multi-mechanism flows in unconventional reservoirs,considering its mesoscopic nature and advantages in simulating gas flows in complex porous ***,numerous LBM models and slip boundary schemes have been proposed and reported in the *** study investigates the predominately reported LBM models and kinetic boundary *** results of these LBM models systematically compare to existing experimental results,analytical solutions of Navier-Stokes,solutions of the Boltzmann equation,direct simulation of Monte Carlo(DSMC)and information-preservation DSMC(IP_DSMC)results,as well as the numerical results of the linearized Boltzmann equation by the discrete velocity method(DVM).The results point out the challenges and limitations of existing multiple-relaxation-times LBM models in predicting micro-gaseous flow in unconventional reservoirs.

关键词： LBM DVM micro-gaseous flow slip boundary schemes effective viscosity flow regimes

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