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Journal of Environmental Sciences 2024年第3期137卷 347-357页

作者： Tengda Shi Ruijing Li Jie Fu chao Hou Hui Gao Guanjie Cheng Haibo Zhang Shuaichen Jin liang Kong Guangshui Na College of Marine Technology and Environment Dalian Ocean UniversityDalian 116023China Laboratory for coastal marine eco-environment process and carbon sink of Hainan province/Yazhou Bay Innovation Institute Hainan Tropical Ocean UniversitySanya 572022China National Marine Environmental Monitoring Center Dalian 116023China College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai 201306China NCS Testing Technology Co. Ltd.Beijing 10081China

Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific *** concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in *** halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross *** model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE *** and wet deposition dominated the processes involving OPE transfer to *** OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater *** findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic.

关键词： Organophosphate esters(OPEs) Long-range transport Fugacity model Antarctic Fate

Switching On/Off of Guide RNA by Photoinduced Strand Displacement for Functional Control of CRISPR/Cas9

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CCS Chemistry 2024年第5期6卷 1338-1351页

作者： Yang Wang chao-Qun Wu Qiu-Long Zhang Ming Shao Yan Liu liang-liang Wang Zun-Yun Wang Juan Du liang Xu Central Laboratory Department of the Second Affiliated Hospital School of MedicineThe Chinese University of Hong KongShenzhen&Longgang District People’s Hospital of ShenzhenShenzhen 518172 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060 MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275 School of Pharmacy and Medical Technology Putian UniversityPutian 351100

Functional control of CRISPR/Cas9 is essential for precise gene *** engineering of guide RNA(gRNA)provides diverse approaches for conditional control of CRISPR/Cas9 function with a variety of chemical reactive ***,previous investigations into chemically engineering gRNA only unidirectionally regulated the CRISPR/Cas9 function via stimuli-induced caging/decaging ***,we propose a combinatory strategy to engineer the dynamics of gRNA in which photocontrolled strand-displacement reactions coupled with sequence designs of gRNA can achieve lightinduced switching-on/off control of CRISPR/Cas9 *** analysis and cellular gene regulation indicate this approach is capable of both activating and deactivating CRISPR/Cas9 activities using light ***,photocontrolled multiplex modulations of gene expression for opposite regulatory effects have also been achieved simultaneously under the same cellular *** work establishes an essential principle for construction of stimuli-induced switching-on/off modulations of gRNA that can greatly enrich the versatility of conditional control for a variety of CRISPR/Cas9-based applications.

关键词： modified oligonucleotides gene manipulation optical control CRISPR/Cas9 strand displacement

Supertetragonal BaZrS_(3):A promising perovskite sulphide with giant ferroelectricity and low band gap

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 126-133页

作者： Menglu Li Sa Zhang Chenhan Liu xiaotao Zu liang Qiao Haiyan xiao School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China College of Mathematics and Physics Chengdu University of TechnologyChengdu 610059China Micro-and Nano-scale Thermal Measurement and Thermal Management Laboratory Ministry of Education Key Laboratory of Numerical Simulation of Large-Scale Complex SystemsSchool of Energy and Mechanical EngineeringNanjing Normal UniversityNanjing 210023China

Over the past century,ferroelectricity has offered exciting opportunities for fundamental research and device ***,most of the discovered excellent ferroelectrics are oxide materials with large band gaps,limiting their potential for optoelectronics *** using first-principles calculations we identify a new narrow-gap ferroelectric beyond oxides,i.e.,ferroelectric perovskite sulphide BaZrS_(3).Under large compressive strains,BaZrS_(3)can be stabilized into a unique supertetragonal phase with an extraordinary polarization of 67.16μC/cm^(2),which is even stronger than that of conventional oxide ***,the supertetragonal BaZrS_(3)exhibits a direct narrow band gap of 1.2 eV and excellent electronic *** on the chemical bonding analysis,we attribute the formation of supertetragonal phase to charge re-ordering in which theπbond overlap along the long〈Zr-S〉bond completely vanishes and the antibonding states of theσbond appear below the Fermi *** work provides a conceptual strategy for designing new ferroelectrics for electronic and photovoltaic applications.

关键词： supertetragonal phase perovskite sulphide ferroelectricity

Research on Quantitative Identification of Three-Dimensional Connectivity of Fractured-Vuggy Reservoirs

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Energy Engineering 2024年第5期121卷 1195-1207页

作者： Xingliang Deng Peng Cao Yintao Zhang Yuhui Zhou xiao Luo liang Wang Exploration and Development Research Institute PetroChina Tarim Oilfield CompanyKorla841000China PetroChina Hangzhou Research Institute of Geology Hangzhou310023China School of Petroleum Engineering Yangtze UniversityWuhan430100China

The fractured-vuggy carbonate oil resources in the western basin of China are extremely *** connectivity of carbonate reservoirs is complex,and there is still a lack of clear understanding of the development and topological structure of the pore space in fractured-vuggy ***,effective prediction of fractured-vuggy reservoirs is *** view of this,this work employs adaptive point cloud technology to reproduce the shape and capture the characteristics of a fractured-vuggy *** identify the complex connectivity among pores,fractures,and vugs,a simplified one-dimensional connectivity model is established by using the meshless connection element method(CEM).Considering that different types of connection units have different flow characteristics,a sequential coupling calculation method that can efficiently calculate reservoir pressure and saturation is *** automatic history matching,the dynamic production data is fitted in real-time,and the characteristic parameters of the connection unit are *** results show that the three-dimensional connectivity model of the fractured-vuggy reservoir built in this work is as close as 90%of the fine grid model,while the dynamic simulation efficiency is much higher with good accuracy.

关键词： Fractured-vuggy reservoir three-dimensional connectivity connection unit dynamic prediction automatic history matching

OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1- p62/SQSTM1 complex

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World Journal of Gastroenterology 2024年第15期30卷 2155-2174页

作者： Nan Wang chao-Yang Li Teng-Fei Yao xiao-Dan Kang Hui-Shu Guo Clinical Laboratory Medicine The First Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina The Institute of Integrative Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina The Institute of Laboratory Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Central Laboratory The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Necroptosis has emerged as a novel molecular pathway that can be targeted by chemotherapy agents in the treatment of ***-1,which is derived from the bulbs of Ornithogalum saundersiae Baker,exerts a wide range of pharmaco-logical *** To explore whether OSW-1 can induce necroptosis in colorectal cancer(CRC)cells,thereby expanding its range of clinical *** We performed a sequence of functional experiments,including Cell Counting Kit-8 assays and flow cytometry analysis,to assess the inhibitory effect of OSW-1 on CRC *** utilized quantitative proteomics,employing tandem mass tag label-ing combined with liquid chromatography-tandem mass spectrometry,to analyze changes in protein *** bioinformatic analysis was conducted to elucidate the biological processes associated with the identified *** electron microscopy(TEM)and immunofluorescence studies were also performed to examine the effects of OSW-1 on ***,western blotting,siRNA experiments,and immunoprecipitation were employed to evaluate protein interactions within CRC *** The results revealed that OSW-1 exerted a strong inhibitory effect on CRC cells,and this effect was accompanied by a necroptosis-like morphology that was observable via ***-1 was shown to trigger necroptosis via activation of the RIPK1/RIPK3/MLKL ***,the accumulation of p62/SQSTM1 was shown to mediate OSW-1-induced necroptosis through its interaction with *** We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway,and that this effect is mediated by the RIPK1-p62/SQSTM1 complex,in CRC *** results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.

关键词： OSW-1 Necroptosis RIPK1 P62/SQSTM1 Colorectal cancer

Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 700-709页

作者： Kai Liu Chun-xiao Wu Hui liang Tao Wang Ji-Yuan Zhang xiao-Tao Wang Department of Radiation and Oncology Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina Department of Gastroenterology Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou 510400Guangdong ProvinceChina Department of Gastrointestinal Surgery Hunan Provincial People’s HospitalChangsha 410002Hunan ProvinceChina Department of Traditional Chinese medicine Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common type of cancer and has the fourth highest death rate among all *** is a lack of studies examining the impact of liver metastases on the effectiveness of immunotherapy in individuals diagnosed with *** To investigate the influence of liver metastases on the effectiveness and safety of immunotherapy in patients with advanced *** This retrospective investigation collected clinical data of patients with advanced stomach cancer who had immunotherapy at our hospital from February 2021 to January *** baseline attributes were compared using either the Chi-square test or the Fisher exact probability *** chi-square test and Kaplan-Meier survival analysis were employed to assess the therapeutic efficacy and survival duration in GC patients with and without liver *** The analysis comprised 48 patients diagnosed with advanced GC,who were categorized into two groups:A liver metastasis cohort(n=20)and a non-liver metastatic cohort(n=28).Patients with liver metastasis exhibited a more deteriorated physical condition compared to those without liver *** objective response rates in the cohort with metastasis and the cohort without metastasis were 15.0%and 35.7%(P>0.05),***,the disease control rates in these two cohorts were 65.0%and 82.1%(P>0.05),*** median progression-free survival was 5.0 months in one group and 11.2 months in the other group,with a hazard ratio of 0.40 and a significance level(P)less than *** median overall survival was 12.0 months in one group and 19.0 months in the other group,with a significance level(P)greater than *** Immunotherapy is less effective in GC patients with liver metastases compared to those without liver metastasis.

关键词： Gastric cancer Spread of cancer to the liver Treatment with immunotherapy Effectiveness of treatment

Effect of short-time low-temperature austenitizing on microstructure and mechanical properties of DT300 ultra-high strength steel fabricated by laser powder bed fusion

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1763-1777页

作者： Chen-yang Jiang xiao-qiang Li Jin-tao Wang Hao Luo Sheng-qing Gao Sheng-guan Qu chao Yang National Engineering Research Centre of Near-Net-Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640GuangdongChina Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

To address the inhomogeneous microstructure and improve the mechanical properties of DT300 ultra-high strength steel specimens fabricated by laser powder bed fusion,different post-heat treatment schedules are *** the increase in austenitizing temperature and time,the migration rate of austenite grain boundaries continuously increases with the dissolution of nano-carbides,and the formation of nano-oxides and twin martensite is also inhibited *** rapid growth in the size of prior austenite grains and martensite laths,as well as the decrease in the content of nano-oxides and twin martensite,led to a rapid decrease in the strength(yield strength and ultimate tensile strength)from HT2 to HTF *** HT1 specimens(austenitizing at 830℃for 30 min,then oil quenching and tempering at 300℃for 120 min and finally air cooling)display excellent mechanical properties of yield strength of 1572 MPa,ultimate tensile strength of 1847 MPa,elongation of 9.84%,and fracture toughness of 106 MPa m^(1/2),which are counterparts to those of conventional DT300 steel forgings after heat treatment.

关键词： DT300 ultra-high strength steel Laser powder bed fusion-Short-time low-temperature austenitizing Microstructure Mechanical property

Ultrahard X-ray multifunctional application beamline at the SSRF

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Nuclear Science and Techniques 2024年第6期35卷 14-25页

作者： Ke Yang Zhao-Hui Dong Chun-Yin Zhou Zi-Long Zhao Dong-Xu liang Sai-chao Cao Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

The ultrahard X-ray multifunctional application beamline(BL12SW)is a phase-II beamline project at the Shanghai Syn-chrotron Radiation *** primary X-ray techniques used at the beamline are high-energy X-ray diffraction and imaging using white and monochromatic *** main scientific objectives of ultrahard X-ray beamlines are focused on two research *** is the study of the structural properties of Earth’s interior and new materials under extreme high-temperature and high-pressure conditions,and the other is the characterization of materials and processes in near-real service *** beamline utilizes a superconducting wiggler as the light source,with two diamond windows and SiC discs to filter out low-energy light(primarily below 30 keV)and a Cu filter assembly to control the thermal load entering the subsequent optical *** beamline is equipped with dual *** first was a meridional bending Laue monochromator cooled by liquid nitrogen,achieving a full-energy coverage of 30-162 *** second was a sagittal bending Laue monochromator installed in an external building,providing a focused beam in the horizontal direction with an energy range of 60-120 *** were four experimental hutches:two large-volume press experimental hutches(LVP1 and LVP2)and two engineering material experimental hutches(ENG1 and ENG2).Each hutch was equipped with various near-real service conditions to satisfy different *** example,LVP1 and LVP2 were equipped with a 200-ton DDIA press and a 2000-ton dual-mode(DDIA and Kawai)press,***1 and ENG2 provide in situ tensile,creep,and fatigue tests as well as high-temperature *** June 2023,the BL12SW has been in trial *** is expected to officially open to users by early 2024.

关键词： Shanghai Synchrotron Radiation Facility Ultrahard X-ray High energy diffraction High energy imaging Engineering materials Earth science

Experimental study of the effects of a multistage pore-throat structure on the seepage characteristics of sandstones in the Beibuwan Basin:Insights into the flooding mode

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Petroleum Science 2024年第2期21卷 1044-1061页

作者： Lei Wang xiao Lei Qiao-liang Zhang Guang-Qing Yao Bo Sui xiao-Jun Chen Ming-Wei Wang Zhen-Yu Zhou Pan-Rong Wang xiao-Dong Peng Zhanjiang Branch China National Offshore Oil Corporation(CNOOC)LimitedZhanjiang524057GuangdongChina Faculty of Earth Resources China University of Geosciences(Wuhan)Wuhan430074HubeiChina School of Resources and Safety Engineering Chongqing UniversityChongqing400044China School of Engineering University of ManchesterManchester M139WJUK Hainan Branch China National Offshore Oil Corporation(CNOOC)LimitedHaikou570311HainanChina

To investigate the relationship between grain sizes, seepage capacity, and oil-displacement efficiency in the Liushagang Formation of the Beibuwan Basin, this study identifies the multistage pore-throat structure as a crucial factor through a comparison of oil displacement in microscopic pore-throat experiments. The two-phase flow evaluation method based on the Li-Horne model is utilized to effectively characterize and quantify the seepage characteristics of different reservoirs, closely relating them to the distribution of microscopic pores and throats. It is observed that conglomerate sandstones at different stages exhibit significant heterogeneity and noticeable differences in seepage capacity, highlighting the crucial role played by certain large pore throats in determining seepage capacity and oil displacement efficiency. Furthermore, it was found that the displacement effects of conglomeratic sandstones with strong heterogeneity were inferior to those of conventional homogeneous sandstone, as evidenced by multiple displacement experiments conducted on core samples with varying granularities and flooding systems. Subsequently, core-based experiments on associated gas flooding after water flooding were conducted to address the challenge of achieving satisfactory results in a single displacement mode for reservoirs with significant heterogeneity. The results indicate that the oil recovery rates for associated gas flooding after water flooding increased by 7.3%-16.4% compared with water flooding alone at a gas-oil ratio of approximately 7000 m^(3)/m^(3). Therefore, considering the advantages of gas flooding in terms of seepage capacity, oil exchange ratio, and the potential for two-phase production, gas flooding is recommended as an energy supplement mode for homogeneous reservoirs in the presence of sufficient gas source and appropriate tectonic angle. On the other hand, associated gas flooding after water flooding is suggested to achieve a more favorable develop

关键词： Beibuwan Basin Multistage pore-throat structure Multistage seepage characteristics Microscopic visualization Heterogeneity Gas/water flooding Flooding mode

Tortuosity regulation of two-dimensional nanofluidic films for water evaporation-induced electricity generation

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Nano Research 2024年第7期17卷 6192-6202页

作者： Zhihang Liu chao Liu Anqi Ni Kunpeng Mao Long Chen liang Xue Jingwen Sun Xin Wang Pan Xiong Junwu Zhu Key Laboratory for Soft Chemistry and Functional Materials of Ministry Education School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China

Water evaporation-induced electricity generation is a promising technology for renewable energy ***,the output power of some reported two-dimensional(2D)nanofluidic films is still restricted by the relatively weak water–solid interactions within the tortuous *** further enhance the comprehension and utilization of water–solid interactions,it is of utmost importance to conduct an in-depth investigation and propose a regulatory concept encompassing ion ***,we propose tortuosity regulation of 2D nanofluidic titanium oxide(Ti_(0.8)7O_(2))films to optimize the ion transport within the interlayer nanochannel for enhanced efficiency in water evaporation-induced electricity generation for the first *** significance of tortuosity in ion transport is elucidated by designing three 2D nanofluidic films with different *** analysis and in situ Raman measurement demonstrate that low tortuosity can facilitate the formation of efficient pathways for hydrated proton transport and promote water–solid ***,devices fabricated with the optimized 2D nanofluidic films exhibited a significantly enhanced output power density of approximately 204.01μW·cm^(−2),far exceeding those prepared by the high-tortuosity 2D nanofluidic *** work highlights the significance of the construction of low tortuosity channels for 2D nanofluidic films with excellent performance.

关键词： water evaporation-induced electricity generation tortuosity ion transport two-dimensional nanofluidic films