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骨盆软骨肉瘤导致肺动脉肿瘤栓塞一例报道并文献复习

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实用心脑肺血管病杂志 2024年第3期32卷 128-131页

作者：张译方刘丽宗兆婧遵义医科大学附属医院呼吸与危重症医学科二病区贵州省遵义市563000

肺栓塞是由于各种栓子堵塞肺动脉及其分支引起的肺循环障碍临床综合征。软骨肉瘤是一种起源于结缔组织的恶性肿瘤,起病隐匿、无特异性临床表现,肺栓塞是软骨肉瘤的少见并发症,尤其是肺动脉肿瘤栓塞。肺动脉血栓栓塞和肿瘤栓塞在影像学... 详细信息

肺栓塞是由于各种栓子堵塞肺动脉及其分支引起的肺循环障碍临床综合征。软骨肉瘤是一种起源于结缔组织的恶性肿瘤,起病隐匿、无特异性临床表现,肺栓塞是软骨肉瘤的少见并发症,尤其是肺动脉肿瘤栓塞。肺动脉血栓栓塞和肿瘤栓塞在影像学上难以区分,但临床治疗方案完全不同,且患者预后差异较大。本文报道1例骨盆软骨肉瘤导致肺动脉肿瘤栓塞的发病过程、临床表现、影像学检查、病理检查结果及诊疗过程,以提高临床医生对软骨肉瘤导致肺动脉肿瘤栓塞的认识及其对肺动脉血栓栓塞和肿瘤栓塞的鉴别诊断能力。

关键词：肺栓塞软骨肉瘤肿瘤转移病例报告

Intelligent Breakage Assessment of Composite Insulators on Overhead Transmission Lines by Ellipse Detection Based on IRHT

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1942-1949页

作者： Zhikang Yuan Linxuan He Shaohe Wang Youping Tu zhaojing Li Cong Wang Fan Li College of Electronic and Information Engineering Tongji UniversityShanghai 201804China the State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China State Grid Zhejiang Electric Power Research Institute Hangzhou 310014China State Grid Jiangxi Electric Power Research Institute Nanchang 330000China

With the development of unmanned aerial vehicle(UAV)technology,visible images are playing an important role in the maintenance of power *** achieve the shed breakage evaluation of composite insulators by UAV visible images,an intelligent fault assessment method is ***,the composite insulators in visible light images are identified by *** image preprocessing,the image is enhanced and the noise is ***,a canny operator is used to extract the edge of the *** Improved Randomized Hough Transform(IRHT)is used to detect the ellipses in the edge *** parameters of the detected ellipse,length of major axes and minor axes,center coordinates and deflection angle of major axes,are used to realize the segmentation of the composite ***,the number of pixel points in the ellipse and the distance between the points and the ellipse boundary are used to judge whether there are breakage or cracks on the *** area ratio of the breakage to the whole shed is calculated based on the number of pixel points inside the broken *** method can be realized without a large amount of training dataset of the specific fault type and provides a technical basis for the online fault assessment of a composite insulator on overhead transmission lines.

关键词： Breakage assessment composite insulator ellipse detection Improved Randomized Hough Transform(IRHT)

苏木色素-滤纸指示标签的制备及其对猪肉新鲜度的监测

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包装工程 2024年第19期45卷 190页

作者：赵洪喜周景廉尹兆京余祥英东莞理工学院生命健康技术学院

目的以天然色素苏木色素为pH指示剂，制备一种可视化监测猪肉新鲜度的指示标签，并探究其实际应用效果。方法以苏木色素提取液为指示剂，以定性滤纸为载体制备指示标签。利用比色分析和氨敏感性分析，测试表征标签的指示性能，并进一... 详细信息

目的以天然色素苏木色素为pH指示剂，制备一种可视化监测猪肉新鲜度的指示标签，并探究其实际应用效果。方法以苏木色素提取液为指示剂，以定性滤纸为载体制备指示标签。利用比色分析和氨敏感性分析，测试表征标签的指示性能，并进一步将指示标签应用于猪肉的新鲜度监测。结果比色分析结果显示标签在pH 4～12范围内会随着pH的增大逐渐由黄色变为暗红色，颜色变化明显；氨敏感性分析结果表明，氨水浓度越高，则标签变色越显著，且变色速度越快。猪肉新鲜度监测实验结果表明，随着猪肉腐败程度的加深，指示标签的颜色由黄色变为暗红色，颜色变化明显，且标签的ΔE与猪肉的pH、挥发性盐基氮（TVB-N）含量呈良好的线性关系（R2分别为0.9897、0.9163），可用于猪肉新鲜度的监测。结论以天然色素苏木色素为pH指示剂、以定性滤纸为载体可构建一种基于色差变化或色差变化时间来监测肉制品新鲜度的指示标签，研究结果可为构建新型天然色素类食品新鲜度指示标签提供参考。

关键词：苏木色素滤纸指示标签比色分析氨敏感性分析猪肉新鲜度

Large-scale screening of disease model through ENU mutagenesis in mice

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Chinese Science Bulletin 2003年第24期48卷 2665-2671页

作者： HEFang WANGZixing zhaojing BAOJie DINGJun RUANHaibin XIEQing ZHANGZuoming GAOXiang ModelAnimalResearchCenter NanjingUniversityNanjing210093China StateKeyLaboratoryofPharmaceuticalBiotechnology NanjingUniversityNanjing210093China DepartmentofAviationMedicine FourthPLAMedicineUniversityXi'an710032China

Manipulation of mouse genome has merged as one of the most important approaches for studying genefunction and establishing the disease model because of the high homology between human genome and mouse genome. In this study, the chemical mutagen ethylnitrosourea (ENU) was employed for inducing germ cell mutations in maleC57BL/6J mice. The first generation (G1) of the backcrossof these mutated mice, totally 3172, was screened for abnor-mal phenotypes on gross morphology, behavior, learning and memory, auditory brainstem response (ABR), electrocardio-gram (ECG), electroretinogram (ERG), flash-visual evoked potential (F-VEP), bone mineral density, and blood sugarlevel. 595 mice have been identified with specific dominantabnormalities. Fur color changes, eye defects and hearing loss occurred at the highest frequency. Abnormalities related to metabolism alteration are least frequent. Interestingly, eye defects displayed significant left-right asymmetry and sexpreference. Sex preference is also observed in mice with ab-normal bone mineral density. Among 104 G1 generation mutant mice examined for inheritability, 14 of them have been confirmed for passing abnormal phenotypes to their progenies. However, we did not observe behavior abnormali-ties of G1 mice to be inheritable, suggesting multi-gene con-trol for these complicated functions in mice. In conclusion, the generation of these mutants paves the way for under-standing molecular and cellular mechanisms of these ab-normal phenotypes, and accelerates the cloning of disease-related genes.

关键词： ENU 基因突变染色体形态学心电图

胸肋间筋膜阻滞对心脏瓣膜置换术后早期恢复质量的影响

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临床麻醉学杂志 2024年第3期40卷 243-247页

作者：方兆晶张勇王晓亮史宏伟鲍红光赵倩南京医科大学附属南京医院、南京市第一医院麻醉疼痛与围术期医学科 210006

目的探讨胸肋间筋膜阻滞(PIFB)对心脏瓣膜置换术后早期恢复质量的影响。方法选择择期行正中切口心脏瓣膜置换术患者80例,男45例,女35例,年龄44~75岁,BMI 18~30 kg/m 2,ASAⅡ或Ⅲ级,随机分为两组:全麻联合PIFB组(P组)和全麻组(C组),每组4... 详细信息

目的探讨胸肋间筋膜阻滞(PIFB)对心脏瓣膜置换术后早期恢复质量的影响。方法选择择期行正中切口心脏瓣膜置换术患者80例,男45例,女35例,年龄44~75岁,BMI 18~30 kg/m 2,ASAⅡ或Ⅲ级,随机分为两组:全麻联合PIFB组(P组)和全麻组(C组),每组40例。P组麻醉诱导后行双侧胸肋间筋膜平面阻滞,C组不行神经阻滞,术后均使用舒芬太尼静脉自控镇痛。采用15项恢复质量评分量表(QoR-15)评价术前24 h、术后24、72 h恢复情况,记录诱导前、切皮时、锯胸骨时、关胸时、出手术室时的HR和MAP,拔管后4、8、12 h静息和活动(咳嗽)时VAS疼痛评分。记录术中和术后48 h内舒芬太尼用量、拔管时间、重症监护病房(ICU)停留时间、术后首次肛门排气时间、术后住院时间,术后恶心呕吐、低血压、呼吸抑制等不良反应的发生情况和住院期间死亡情况。结果与C组比较,P组术后24、72 h QoR-15评分明显升高(P<0.05),拔管后4、8、12 h静息和活动时VAS疼痛评分明显降低(P<0.05),术中和术后48 h内舒芬太尼用量明显减少(P<0.05),拔管时间、术后首次肛门排气时间、ICU停留时间明显缩短(P<0.05),术后恶心呕吐发生率明显降低(P<0.05)。两组不同时点HR和MAP、术后住院时间、住院期间死亡率差异无统计学意义。P组未发生神经阻滞相关并发症。结论PIFB可以降低正中切口心脏瓣膜置换手术患者术后疼痛,提高术后恢复质量,促进术后康复。

关键词：胸肋间筋膜阻滞心脏瓣膜置换术正中胸骨切口术后恢复质量

Specific targeted killing of ErbB2 positive breast cancer by retrovirus-mediated Immunocaspase-3 secreting T cells

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Chinese Science Bulletin 2004年第13期49卷 1380-1385页

作者： ZHANGLihong JIALintao zhaojing XUYanming WENWeihong BAOWei CAOYunxin SUChenazhi WANGChengji YANGAn-gang DepartmentofImmunology FourthMilitaryMedicalUniversityXi'an710032China DepartmentofBiochemistryandMolecularBiology FourthMilitaryMedicalUniversityXi'an710032China DepartmentofImmunology FourthMilitaryMedicalUniversityXi'an710032China//DepartmentofBiochemistryandMolecularBiologyFourthMilitaryMedicalUniversityXi'an710032China

In this study, lmmunocaspase-3 gene was transfected into Jurkat T lymphocytes and the targeted proapoptotic protein Immunocaspase-3 was stably *** entry to ErbB2 positive SKBr3 breast carcinoma cell line was observed by indirect immunofluorescence *** of SKBr3 cells was significantly inhibited when they were cultured with medium containing ***, lmmunocaspase-3 gene was cloned into retrovirus vector pLNCX, which was then transfected into PA317 cells to package. Packaged cells producing high titer pseudoviruses were acquired and the pseudoviruses were harvested to infect PBMCs, which had been stimulated to division. The latter were selected and administered to nude mice bearing SKBr3 tumors through tail vein. The results showed that the treatment contributed to an inhibition of tumor growth and prolonged the lifetime of nude mice bearing SKBr3 *** efficiency of inhibition of tumor reached 73.25%, and the average lifetime of treated nude mice was 80.95% longerthan that of control group. Immunohistochemical examination revealed the exclusive distribution of Immunocaspase-3 proteins only in the tumor tissue samples; and TUNEL assay confirmed the occurrence of apoptosis in tumor calls. Thepresent study suggests that Immunocaspase-3 secreted by T lymphocytes can selectively bind and enter into ErbB2 positive breast cancer cells, where it exhibits a proapoptotic activity and causes tumor suppression in an in vivo tumor model.

关键词： ErbB2 乳癌逆转录酶病毒免疫酶 T细胞 caspase-3 细胞凋亡基因治疗

纳米γ-Al_(2)O_(3)负载Ag催化剂催化对硝基酚加氢合成对氨基酚

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精细石油化工 2024年第4期41卷 37-43页

作者：赵倩宇郑召京王爱丽殷恒波江苏大学化学化工学院江苏镇江212013

采用湿化学还原法制备了纳米γ-Al_(2)O_(3)负载纳米Ag(Ag/γ-Al_(2)O_(3))催化剂。X射线衍射(XRD)、X射线光电子能谱(XPS)和透射电子显微镜(TEM)表征表明,纳米Ag颗粒很好的分散在载体γ-Al_(2)O_(3)上,纳米金属Ag颗粒平均粒径介于0.8~1... 详细信息

采用湿化学还原法制备了纳米γ-Al_(2)O_(3)负载纳米Ag(Ag/γ-Al_(2)O_(3))催化剂。X射线衍射(XRD)、X射线光电子能谱(XPS)和透射电子显微镜(TEM)表征表明,纳米Ag颗粒很好的分散在载体γ-Al_(2)O_(3)上,纳米金属Ag颗粒平均粒径介于0.8~1.6 nm之间。在氢气压力1.0 MPa、反应温度150℃反应条件下,5.0%Ag/γ-Al_(2)O_(3)催化对硝基酚加氢完全转化时,对氨基酚选择性为100%。以5.0%Ag/γ-Al_(2)O_(3)催化剂为模型催化剂,采用经验幂函数型反应动力学方程拟合的活化能为26.87 kJ/mol, Ag/γ-Al_(2)O_(3)纳米催化剂具有良好的催化对硝基酚加氢制备对氨基酚活性。

关键词： Ag/γ-Al_(2)O_(3)纳米催化剂对硝基酚加氢对氨基酚

Expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27^(kip1) in hepatocellular carcinoma

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World Journal of Gastroenterology 2004年第10期10卷 1425-1430页

作者： Ke-JunNan zhaojing LingGong DepartmentofInfectiousDiseases FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofMedicalOncologyFirstHospitalofXi'anJiaotongUniversityXi'an71006lShaanxiProvinceChina

AIM: To investigate p27 expression in hepatocellular carcinoma (HCC), adjacent nontumoral and normal liver tissues, and to verify whether the subcellular localization of p27 was altered in ***: The level of p27 in tumoral, nontumoral, and normal liver tissues were assessed by immunohistochemical (IHC) analysis. Parallel immunostaining was done for proliferating cell nuclear antigen (PCNA) to evaluate cell ***: The labeling index (LI) of p27 in tumoral lesions was significantly lower than that in adjacent nontumoral lesions (t=2.444, P=0.017) and normal controls (t=-2.268,P=0.029). The LI of p27 significantly decreased in patients with massive type (t=-2.227, P=0.037) and infiltration (t=2.197, P=0.036). The prognosis of patients with higher p27 LI was longer than that of patients with lower p27 LI (P=0.0247, log-rank test). The LI of PCNA was significantly higher in HCC than that in adjacent nontumoral lesions (t=2.092, P=0.041) and normal controls (t=-3.533, P=0.002).There was no significant correlation between p27 expression and cell proliferation in tumor samples. The level of p27 in the cytoplasmic fraction was higher in tumoral and nontumoral liver tissues, and was associated with clinical stage (t=-2.520, P=0.029) and the degree of invasion (t=2.640, P=0.019). Survival analysis showed that p27 was an independent prognosis marker for HCC ***: These results suggest that p27 underexpressing in patients with HCC is closely associated with infiltration, metastasis, and prognosis. Alterations in the subcellular localization of p27 protein may occur early during hepatocarcinogenesis.

关键词：肝细胞癌细胞周期依赖蛋白激酶肿瘤生成肿瘤病理学 p27^Kip1基因

THE DESIGN OF INTELLIGENT NETWORK MONITORING SYSTEM BASED ON ARM

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THE DESIGN OF INTELLIGENT NETWORK MONITORING SYSTEM BASED ON...