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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

作者： JIANG xiao-yan ZHANG Ji-long ZOU Wei Chang Zhi-yuan

U/U of the environmental sample can indicate the existence of uranium irradiation,and even can be uesd to estimate the burnup of nuclear spent fuel.A study on the burnup estimation of irradiated uranium which was mixed with natural uranium was carried out by measuring the U/U and U/U in the samples by using MC-ICP-MS. According to the equation(1) and(2),a programme for calculating the burnup of the irradiated

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang yanlin Fu Peiyan Long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan Qi Wei Hong yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Notes on Proper Class of Triangles

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Acta Mathematica Sinica,English Series 2013年第11期29卷 2137-2154页

作者： xiao yan yanG Department of Mathematics Northwest Normal University

Let T be a triangulated category and ζ a proper class of triangles. Some basics properties and diagram lemmas are proved directly from the definition of ζ.

关键词： Proper class of triangles triangulated category

Effects of microplastic polystyrene,simulated acid rain and arbuscular mycorrhizal fungi on Trifolium repens growth and soil microbial community composition

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Pedosphere 2024年第2期34卷 424-437页

作者： Wanlin LI yan xiao College of Agro-grassland Science Nanjing Agricultural UniversityNanjing 210095China

Microplastic pollution is a global and ubiquitous environmental problem in the oceans as well as in the terrestrial *** examined the fate of microplastic polystyrene(MPS)beads in experimental soil in the presence and absence of symbiotic arbuscular mycorrhizal fungi(AMF)and simulated acid rain(SAR)to determine whether the combinations of these three factors altered the growth of white clover Trifolium *** found that MPS,SAR,or AMF added singly to soil did not alter *** growth or *** contrast,MPS and AMF together significantly reduced shoot biomass,while SAR and MPS together significantly reduced soil available phosphorus independent of AMF *** polystyrene,AMF,and SAR together significantly reduced soil NO_(3)^(-)-*** mycorrhizal fungi added singly also enriched the beneficial soil bacteria(genus Solirubrobacter),while MPS combined with AMF significantly enriched the potential plant pathogenic fungus *** mycorrhizal fungi inoculation with MPS increased the abundance of soil hydrocarbon degraders independent of the presence of *** addition,the abundance of soil nitrate reducers was increased by MPS,especially in the presence of AMF and ***,SAR alone increased the abundance of soil pathogens within the fungal community including antibiotic *** findings indicate that the coexistence of MPS,SAR,and AMF may exacerbate the adverse effects of MPS on soil and plant health.

关键词： acid deposition arbuscular mycorrhizal fungi symbiosis hydrocarbon degradation microbial alpha diversity microplastic pollution pathogen

A Reverse Auction Framework for Hybrid Access in Femtocell Network

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Journal of Computer Science & Technology 2017年第6期32卷 1250-1264页

作者： yan-Jiao Chen xiao-yan Yin Jin Zhang State Key Laboratory of Software Engineering School of Computer Wuhan University Wuhan 430072 China School of Information Science and Technology Northwest University Xi'an 710127 China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen 518055 China

In the two-tier macro-femto heterogeneous network, hybrid access is regarded as the most ideal access con- trol approach to mitigating macro-femto cross-tier interference and enhancing overall network performance. However, the implementation of hybrid access is hindered by a lack of incentive market mechanism to motivate private femtocell owners to offer access permissions to macro users. In this paper, we propose a reverse auction framework for access permission transaction between a macrocell operator and multiple femtocell owners to promote hybrid access. Our goal is to maximize social welfare while guaranteeing the truthfulness of the auction. Since the coverage of multiple femtocells may overlap, we partition each cell to adjust the granularity of access permission availability. We first propose a Vickery-Clarke-Grove （VCG）-based mechanism, which costs the least among all auction mechanisms that produce maximum social welfare. As the VCG mechanism is too time-consuming, we propose two alternative truthful mechanisms, namely, generalized second- price and suboptimal mechanism. We further extend the auction framework to the scenario where femtocell owners have heterogeneous valuations for access permissions in different locations.

关键词： femtocell hybrid access reverse auction

A simple image-based method for online moisture content estimation of iron ore green pellets

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Journal of Iron and Steel Research International 2023年第5期30卷 851-863页

作者： Shu-yi Zhou xiao-yan Liu College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362006FujianChina

Moisture content(MC)is an important quality metric of iron ore green pellets in pelletizing process in ironmaking *** image-based methods for MC estimation may result in big errors for gray-scale pellet images captured under various lighting *** proposed a simple image-based method to improve the MC estimation accuracy by illumination correction and linear regression ***,the illumination of the pellet image was transformed into the reference illumination by use of a color checker chart and piecewise linear interpolation,so that the influence of different illuminations could be greatly *** experimental analysis,it was found that MC is approximately adversely proportional to the average intensity of the transformed images.A simple model for MC prediction was then established by linear *** demonstrated that the proposed method has good robustness to different lighting conditions and achieves the best performance in metrics of mean square error,mean absolute error and maximum absolute error in comparison with five state-of-art MC estimating *** on a working disk pelletizer shows that the proposed method can predict well the change of moisture content with time,and its computing efficiency can satisfy the requirement for online MC monitoring during the pelletizing process.

关键词： Green pellet Moisture content Image processing Pelletizing process

Phase behavior of undecane–tetradecane mixtures confned in SBA-15

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Chinese Chemical Letters 2013年第10期24卷 885-888页

作者： xiao yan xiao-Zheng Lan College of Chemistry and Materials Science Shandong Agriculture University

Phase behavior of undecane-tetradecane （n-C11H24-C14H3o, C11-C14） mixtures in bulk and confined in SBA-15 have been studied using differential scanning calorimetry. The bulk C11-C14 system shows multiple phase regions due to rotator phase. Confined in the pores of SBA-15 （pore diameters 3.8- 7.8 rim）, the mixtures only show a melting boundary of a straight line and a curve, respectively. In SBA- 15 （ 17.2 nm）, phase behavior of the mixtures has some similarity to that of the bulk. Under confinement, the phase diagrams of the mixtures vary with the pore size, temperature, and compositions.

关键词： Confinement Undecane-tetradecanemixtures Size effect Phase diagram

Empirical Likelihood for Partially Linear Errors-in-variables Models with Longitudinal Data

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 664-683页

作者： Li yan xiao-yan TAN Xia CHEN School of Mathematics and Statistics Shaanxi Normal UniversityXi’an 710119China

Empirical likelihood inference for partially linear errors-in-variables models with longitudinal data is *** regularity conditions,it is shown that the empirical log-likelihood ratio at the true parameters converges to the standard Chi-squared ***,we consider some estimates of the unknown parameter and the resulting estimators are shown to be asymptotically *** simulations and a real data analysis are given to illustrate the performance of the proposed method.

关键词： empirical likelihood measurement error confidence regions coverage probability longitudinal data

Effects of boundary slippage on thin-film lubricationbetween two nonparallel plane plates

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Acta Mechanica Sinica 2012年第3期28卷 625-630页

作者： Shu-Hao Ban xiao-yan Li College of Mechanical and Energy Engineering Changzhou University

Hydrodynamic lubrications between two plane plates with an intersection angle θ have been investigated us- ing the boundary slippage theory, and relations are obtained between dimensionless pressures and coordinate x, between bearing capacity, friction force, friction coefficient and di- mensionless slipping size factor. The results show that bear- ing capacity of two plane plates without boundary slippage significantly increases with increasing intersection angle θ when 0 〈 θ 〈 1°, whereas decreases with increasing in- tersection angle 0 when θ 〉 1°. The results also show that negative pressure occurs in fluid entrance region and bearing capacity decreases, and friction force and friction coefficient increase with the increase of dimensionless slipping size fac- tor.

关键词： Bearing capacity Boundary slippage Dimen-sionless slipping size factor Friction coefficient Hydrody-namic lubrication Negative pressure

Macular Perfusion Changes and Ganglion Cell Complex Loss in Patients with Silicone Oil-related Visual Loss

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Biomedical and Environmental Sciences 2020年第3期33卷 151-157页

作者： MA Ya ZHU xiao Qing PENG xiao yan Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective The aim of this study was to investigate macular perfusion changes and ganglion cell complex(GCC)loss in patients with unexplained visual loss following vitrectomy and silicone oil(SO)tamponade,and to evaluate the correlation between retinal blood flow and GCC loss using optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT).Methods This retrospective study included seven eyes(seven patients)with unexpected visual loss after vitrectomy and SO *** was used to evaluate the alterations in retinal vessel density(VD)in the superficial capillary plexus(SCP),deep capillary plexus(DCP),and radial peripapillary capillary plexus(RPCP).OCT was used to measure the thickness of GCC and retinal nerve fiber layer(RNFL).Medical records of patients were *** Quantitative analysis of OCTA images revealed a significant reduction in SCP VD in the affected eyes compared with the controls(all sections P<0.05).No difference was found in GCC thickness,but FLV(focal loss volume)and GLV(global loss volume)were significantly higher in the affected eyes(both P<0.001).SCP VD was inversely correlated with FLV and *** Silicone oil-related severe visual loss was associated with superficial retinal microvasculature damage and ganglion cell apoptosis.

关键词： Silicone oil Visual loss Optical coherence tomography angiography Ganglion cell complex