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Pharmacokinetic Study of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats

Chinese Medical Sciences Journal 2010年第1期25卷 13-19页

作者： xiao-xiao liu Yong-ping Jiang Biopharmaceutical R＆D Center Chinese Academy of Medical Sciences ＆ Peking Union Medical College Suzhou 215126 China Biopharmagen Corp. Suzhou 215126 China

Objective To study the pharmacokinetics of a novel recombinant human granulocyte colonystimulating factor (rhG-CSFa) in rats and to determine the proteolytic rates of rhG-CSFa in the whole blood and serum of rats in vitro. Methods The pharmacokinetics of rhG-CSFa and conventional (wild type,WT) granulocyte colonystimulating factor (G-CSF) were investigated in Sprague-Dawley rats which received either intravenous or subcutaneous injection of rhG-CSFa or WT G-CSF at three different doses (20,50,or 100 μg/kg). The blood samples of rats were collected at multiple time points (from 0.08 to 12 h) and the concentrations of rhG-CSFa and WT G-CSF in serum were determined with a sandwich enzyme-linked immunosorbent assay (ELISA). For the study of proteolytic rates in vitro,the concentrations of rhG-CSFa or WT G-CSF were determined at 3-minute intervals after addition of the respective drug to rat’s whole blood or serum. Results Pharmacokinetic analysis of serum rhG-CSFa or WT G-CSF levels indicated that,at each dose tested,for either route of drug administration,the area under concentration-time curve values and the maximum serum concentration of rhG-CSFa were higher than those of WT G-CSF,and the serum half life of rhG-CSFa was longer than that of WT G-CSF. Subsequent in vitro whole blood and serum stability study showed that the rates of drug degradation in WT G-CSF were 1.8 folds and 1.5 folds higher than those in rhG-CSFa,respectively. Conclusion rhG-CSFa has better serum and whole blood stability in vitro and higher bioavailability in vivo as compared to WT G-CSF.

关键词： recombinant human granulocyte colony-stimulating factor pharmacokinetics half life bioavailability proteolytic rate

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A new spirostanol saponin from the rhizomes of Paris mairei

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Chinese Chemical Letters 2009年第7期20卷 820-822页

作者： xiao xiao liu Lei Wang Ting Ting Zhang Qiang Wang Department of Chinese Materia Medica Analysis China Pharmaceutical University Nanjing 210038 China Department of Phytochemistry China Pharmaceutical University Nanjing 210038. China

A new spirostanol steroidal saponin, named maireioside A （1）, together with three known steroidal saponins, hypoglaucin G （2）, parisaponin I （3）, and diosgenin-3-O-α-L-rhamnopyranosyl （1→4）-[α-L-rhamnopyranosyl （1→2）]-β-D-glucopyranoside （4）, were isolated from the rhizomes of Paris mairei. The structure elucidation was accomplished by 1D and 2D NMR methods, HR-ESI-MS, and hydrolysis. C 2009 Qiang Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Spirostanol saponin Paris mairei Maireioside A

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Embedment of red phosphorus in anthracite matrix for stable battery anode

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Rare Metals 2022年第8期41卷 2819-2825页

作者： Yu-Chen Tan Wei-Wei liu Wen-Yu Wang xiao-xiao liu Jun-Mou Du Yong-Ming Sun Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China

Red phosphorus(red P)is a promising anode material for lithium-ion batteries(LIBs)due to its high theoretical capacity of 2596 mAh·g^(-1),abundant resource and low ***,the application of P-based anode suffers from several crucial issues,including limited electronic conductivity and drastic volume variation during its electrochemical lithiation/delithiation ***,we reported a red P/anthracite composite featuring red P embedded into micrometer-sc ale porous anthracite framework fabricated through a one-pot ball milling synthesis process.

关键词： battery anode lithium

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Enhanced strength and toughness in 40CrNiMo steels by austempering below martensite start temperature

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Journal of Iron and Steel Research International 2022年第5期29卷 810-818页

作者： xiao-xiao liu Zheng Zhang Jie Zhang Ran Yang Cheng-shuang Yu Jun-wei Qiao Li-na Han College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Zhejiang Laifual Drive Co. Ltd.Shaoxing312462ZhejiangChina

The austempering above and below martensite transition temperature(M_(s))was employed in a medium-carbon low-alloy 40CrNiMo steel,and the bainite and martensite multiphase microstructures with different volume fractions were ***,the effect of pre-existing martensite on subsequent transformation of bainite microstructure and mechanical properties is focused and *** microstructure with a volume fraction of pre-existing martensite(V_(PM)),bainite(V_(B)),and martensite/austenite(V_(M/A))constituents of approximately 28%,46%,and 26%,respectively could be obtained by austenitizing below M_(s)(280℃)for 1 h,and an optimum combination of strength,ductility,and impact toughness(yield strength of 1420 MPa,ultimate tensile strength of 1795 MPa,total elongation of 7.9%,and V-notch impact value of 37 J)was *** considerable enhancement of mechanical properties in the sample austenitized below M_(s)is mainly ascribed to the formation of the pre-existing martensite,resulting in an effective reduction in the size of the bainite plates and martensite/austenite constituents.

关键词： Austempering Pre-existing martensite Bainite plate Multiphase microstructure Mechanical property

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Heterometallic zinc uranium oxyfluorides incorporating imidazole ligands

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Chinese Chemical Letters 2015年第6期26卷 641-645页

作者： xiao-xiao liu Yuan Wang Wan-Guo Tian Weiting Yang Zhong-Ming Sun Changchun University of Science & Technology School of Chemistry and Environmental Engineering State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences

Two heterometallic uranium oxyfluorides with hybrid networks were hydrothermally synthesized by incorporating two imidazoles, 1-（biphenyl-4-yl）-lH-imidazole （bpi） and 1,4-di（1H-imidazol-l-yl）ben- zene （dib）, formulated as Zn（bpi）2（UO2）2（H2O）F6 （1） and Zn（dib）（UO2）F4-0.5H20 （2）. Compound 1 consists of chains of edge-sharing UO2F5 and UO2F4（H20） pentagonal bipyramids, which are linked by Zn（bpi）2 moieties to form the sheet structure with decorated bpi. While in compound 2, sheets of edge- sharing dimers of UO2F5 pentagonal bipyramids and ZnF3N2 polyhedra are linked by dib, creating a pillared three-dimensional framework. The two compounds represent the few examples of heterometallic uranium oxyfluorides incorporating organic ligands. The syntheses, structure as well as the IR spectra, UV-vis spectra and luminescent properties of the bimetallic uranium oxyfluorides are studied.

关键词： Uranium Imidazole Crystal structure Luminescence

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Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi Huang xiao-xiao liu Lan-Wei Li Guang-Ming Huang Zhao-Xia Huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

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The roles of cysteines in the heme domain of human soluble guanylate cyclase

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Chinese Chemical Letters 2012年第8期23卷 973-976页

作者： Fang Fang Zhong xiao xiao liu Jie Pan Zhong Xian Huang Xiang Shi Tan Department of Chemistry Fudan UniversityShanghai 200433China Institutes of Biomedical Sciences Fudan UniversityShanghai 200433China

Soluble guanylate cyclase（sGC） is a critical heme-containing enzyme involved in NO *** dimerization of sGC subunits is necessary for its bioactivity and its mechanism is a striking and an indistinct *** roles of heme domain cysteines of the sGC on the dimerization and heme binding were investigated *** site-directed mutations of three conserved cysteines（C78A,C122A and C174S） were studied systematically and the three mutants were characterized by gel filtration analysis,UV-vis spectroscopy and heme transfer ***78 was involved in heme binding but not referred to the dimerization,while Cys174 was demonstrated to be involved in the *** results provide new insights into the cysteine-related dimerization regulation of sGC.

关键词： Human soluble guanylate cyclase sGC Heine domain Cysteine Dimerization

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Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

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Journal of Pharmaceutical Analysis 2023年第11期13卷 1309-1325页

作者： Hui-Nan Zhang Meng Zhang Wen Tian Wei Quan Fan Song Shao-Yuan liu xiao-xiao liu Dan Mo Yang Sun Yuan-Yuan Gao Wen Ye Ying-Da Feng Chang-Yang Xing Chen Ye Lei Zhou Jing-Ru Meng Wei Cao xiao-Qiang Li Department of Health Management Second Affiliated HospitalFourth Military Medical UniversityXi'an710038China Department of Pharmacology School of PharmacyFourth Military Medical UniversityXi'an710032China Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine School of PharmacyFourth Military Medical UniversityXi'an710032China Shaanxi Key Laboratory of“Qin Medicine”Research and Development Shaanxi Administration of Traditional Chinese MedicineXi'an710032China Institute of Materia Medica School of PharmacyFourth Military Medical UniversityXi'an710032China Department of Ultrasound Diagnostics Second Affiliated HospitalFourth Military Medical UniversityXi'an710038China Department of Pharmacy School of Chemistry&PharmacyNorthwest A&F UniversityYanglingShaanxi712100China

The canonical transient receptor potential channel(TRPC)proteins form Ca^(2+)-permeable cation channels that are involved in various heart ***,the roles of specific TRPC proteins in myocardial ischemia/reperfusion(I/R)injury remain poorly *** observed that TRPC1 and TRPC6 were highly expressed in the area at risk(AAR)in a coronary artery ligation induced I/R ***1/mice exhibited improved cardiac function,lower serum Troponin T and serum creatine kinase level,smaller infarct volume,less fibrotic scars,and fewer apoptotic cells after myocardial-I/R than wild-type or Trpc6/***-specific knockdown of Trpc1 using adeno-associated virus 9 mitigated myocardial I/R ***,Trpc1 deficiency protected adult mouse ventricular myocytes(AMVMs)and HL-1 cells from death during hypoxia/reoxygenation(H/R)***-sequencing-based transcriptome analysis revealed differential expression of genes related to reactive oxygen species(ROS)generation in Trpc1/*** these genes,oxoglutarate dehydrogenase-like(Ogdhl)was markedly ***,Trpc1 deficiency impaired the calcineurin(CaN)/nuclear factorkappa B(NF-kB)signaling pathway in *** of this pathway inhibited Ogdhl upregulation and ROS generation in HL-1 cells under H/R *** immunoprecipitation assays confirmed NF-kB binding to the Ogdhl *** cardioprotective effect of Trpc1 deficiency was canceled out by overexpression of NF-kB and Ogdhl in *** conclusion,our findings reveal that TRPC1 is upregulated in the AAR following myocardial I/R,leading to increased Ca^(2+) influx into associated ***,this upregulates Ogdhl expression through the CaN/NF-kB signaling pathway,ultimately exacerbating ROS production and aggravating myocardial I/R injury.

关键词： TRPC1 Myocardial ischemia/reperfusion Reactive oxygen species OGDHL

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Loupe-assisted versus microscopic varicocelectomy： s there an intraoperative anatomic difference？

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Asian Journal of Andrology 2014年第1期16卷 112-114页

作者： Hao Zhang xiao-Peng liu xiao-Jian Yang Wen-Tao Huang Xing-Xing Ruan Heng-Jun xiao Liao-Yuan Li Xin Gao Yan Zhang Department of Urology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China

The aim of this study was to compare the intraoperative difference in anatomic details between Ioupe-assisted and microscopic varicocelectomy within the same spermatic cord. Between April 2011 and August 2011, 26 men with 33 sides containing grade 2-3 varicocele were enrolled in this study. First, one surgeon performed the open inguinal varicocelectomy under x 3.5 Ioupe magnification. The presumed vascular channels and lymphatics were isolated and marked without ligation. Another surgeon then microsurgically dissected and checked the same spermatic cord using an operating microscope to judge the results in terms of the ligation of the internal spermatic veins and the preservation of the arteries and lymphatics. There were significant differences in the average number of internal spermatic arteries （1.51 vs 0.97）, internal spermatic veins （5.70 vs 4.39） and lymphatics （3.52 vs 1.61） between the microscope and Ioupe-assisted procedures （P 〈 0.001, P 〈 0.001, P 〈 0.001, respectively）. Meanwhile, in varicocele repair with Ioupe magnification, an average of 1.30 β± 1.07 （43/33） internal spermatic veins per side were missed, among the overlooked veins, 1.12 ± 0.93 （37/33） were adhered to the preserved testicular artery, as well as 0.55 ± 0.79 lymphatics and 0.36 ± 0.55 arteries that were to be ligated. In conclusion, microscopic varicocelectomy could preserve more internal spermatic arteries and lymphatics and could ligate more veins than the Ioupe-assisted procedure. To some degree, Ioupe magnification is inadequate for the reliable identification and dissection of the tiny vessels of the spermatic cord, as most of the overlooked veins were adhered to the preserved testicular artery.

关键词： intraoperative difference Ioupe-assisted microscopic varicocelectomy

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu Jing Zhang Jing Yang Jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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