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Chemical Research in Chinese Universities 2012年第4期28卷 743-746页

作者： xiao Li-bai xing xiao-ling ZHAO Feng-qi XU Kang-zheng YAO Er-gang TAN Yi HAO Hai-xia Science and Technology on Combustion and Explosion Laboratory Xi'an Modern Chemistry Research InstituteXi'an 710065P.R.China School of Chemical Engineering Northwest UniversityXi'an 710065P.R.China

The molar enthalpies of dissolution for 2-（dinitromethylene）-5-methyl-1,3-diazacyclopentane（DNMDZ） in dimethyl sulfoxide（DMSO） and N-methyl pyrrolidone（NMP） were measured using an RD496-2000 Calvet microcalorimeter at 298.15 K under atmospheric *** formulae for the calculation of the molar enthalpies of dissolution（Δ diss H） were obtained from the experimental data of the dissolution processes of DNMDZ in DMSO or *** relationships between the rate constant（k） and the molality（b） and between the reaction order（n） and the molality（b） were *** corresponding kinetic equations describing the two dissolution processes were dα/dt=10^-2.16（1-α） ^1.01 for the dissolution of DNMDZ in DMSO,and dα/dt=10^-2.02（1-α）^ 0.85 for the dissolution of DNMDZ in NMP,respectively.

关键词： 2-(Dinitromethylene)-5-methyl-1 3-diazacyclopentane Dissolution Kinetics Dimethylsulfoxide N-Methyl pyrrolidone

Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

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World Journal of Clinical Cases 2024年第6期12卷 1111-1119页

作者： xiao-Yu xing Wei Zhang Li-Ya Liu Li-Ping Han Department of Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND Neuroendocrine neoplasms of the female genital tract are *** To enhance our clinical understanding of neuroendocrine carcinoma(NEC)of the *** A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary,analyzing clinicopathological characteristics,treatment modalities,and survival *** The median age at diagnosis was 34.5 years(range:20 to 62 years).Among the 12 cases,9 were small cell carcinoma of the ovary and 3 were large cell *** cases were stage I tumors,one case was stage IV,and six cases were stage *** patients underwent surgery as part of their *** patients received adjuvant *** the 12 patients,one patient received radiotherapy,and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after *** median progression-free survival was 13 months,and the median overall survival was 19.5 *** cases remained disease-free,while eight cases experienced tumor recurrence,including three cases that resulted in death due to disease *** NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical *** resection remains the mainstay of treatment,with some patients benefiting from adjuvant chemoradiation therapy.

关键词： Neuroendocrine carcinoma Ovary Pathology Treatment

International Workshop on Cavitation was held in Wuxi

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Journal of Hydrodynamics 1989年第3期1卷 101-102页

作者： Pan Sen-sen Peng xiao-xing

There was warm weather, sunshine with no rain," International Workshop onCavitation" was held in Hubin Motel of Wuxi city, April 11-12, 1989. The workshop is jointly sponsored and supported by the Material and EngineeringDivision, the mathematics and Physics Division and the International CooperationBureau of the National Natural Science Foundation of China (NNSFC). China Ship

关键词： mathematics jointly weather sunshine workshop Dalian Nanjing Wuhan Bubble Erosion

The Akt/glycogen synthase kinase-3β pathway participates in the neuroprotective effect of interleukin-4 against cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2020年第9期15卷 1716-1723页

作者： Mei Li Wen-Wei Gao Lian Liu Yue Gao Ya-Feng Wang Bo Zhao xiao-xing Xiong Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Personnel Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Interleukin-4(IL-4) has a protective effect against cerebral ischemia/reperfusion injury. Animal experiments have shown that IL-4 improves the short-and long-term prognosis of neurological function. The Akt(also called protein kinase B, PKB)/glycogen synthase kinase-3β(Akt/GSK-3β) signaling pathway is involved in oxidative stress, the inflammatory response, apoptosis, and autophagy. However, it is not yet clear whether the Akt/GSK-3β pathway participates in the neuroprotective effect of IL-4 against cerebral ischemia/reperfusion injury. In the present study, we established a cerebral ischemia/reperfusion mouse model by middle cerebral artery occlusion for 60 minutes followed by a 24-hour reperfusion. An IL-4/anti-IL-4 complex(10 μg) was intraperitoneally administered 30 minutes before surgery. We found that administration of IL-4 significantly alleviated the neurological deficits, oxidative stress, cell apoptosis, and autophagy and reduced infarct volume of the mice with cerebral ischemia/reperfusion injury 24 hours after reperfusion. Simultaneously, IL-4 activated Akt/GSK-3β signaling pathway. However, an Akt inhibitor LY294002, which was injected at 15 nmol/kg via the tail vein, attenuated the protective effects of IL-4. These findings indicate that IL-4 has a protective effect on cerebral ischemia/reperfusion injury by mitigating oxidative stress, reducing apoptosis, and inhibiting excessive autophagy, and that this mechanism may be related to activation of the Akt/GSK-3β pathway. This animal study was approved by the Animal Ethics Committee of Renmin Hospital of Wuhan University, China(approval No. WDRY2017-K037) on March 9, 2017.

关键词： Akt/glycogen synthase kinase-3βpathway apoptosis autophagy cerebral ischemia/reperfusion injury infarct volume interleukin-4 neuroprotection oxidative stress

Microwave-assisted one-pot synthesis of 3-substituted-3,4-dihydrocoumarins via tendem Konevenagel and Hantzsch reactions

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Chinese Chemical Letters 2009年第1期20卷 25-28页

作者： Jing Li Qiang Liu Rui Guang xing xiao Xia Shen Zhen Gang Liu Bo Zhou State Key Laboratory of Applied Organic Chemistry. College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 PR China

A convenient route for the synthesis of 3,4-dihydrocoumarin derivates from salicylaldehyde derivates and 1,3-dicarbonyl compounds under solvent-free microwave irradiation conditions was described. In this way, a range... 详细信息

关键词： 3,4-Dihydrocoumarin Salicylaldehyde Hantzsch ester Microwave irradiation One-pot reaction

Isothermal detection of RNA transcription levels using graphene oxide-based SYBR Green I fluorescence platform

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Chinese Chemical Letters 2014年第3期25卷 482-484页

作者： Wen-Ge Ma Su-Qin Lu De-Bin Zhu xiao-Bo xing Bi-Hua Su Guangzhou Nansha Center for Disease Control & Prevention Department of Medical Ultrasonics The Third Affiliated HospitalSun Yat-Sen University MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science College of BiophotonicsSouth China Normal University Guangzhou Baiyun District Center for Disease Control & Prevention

An isothermal graphene oxide （GO）-based SYBR Green I fluorescence platform for sensitive detection of RNA transcription levels is proposed. Briefly, a synthesized T7 DNA template was transcribed by T7 RNA polymerase, to produce many copies of single-stranded （ss） RNA transcripts. The ssRNA transcripts were then hybridized with a label-free ssDNA probe which alone will be adsorbed on the GO surface. The resultant double-stranded （ds） RNA：DNA hybrids were incubated with GO and SYBR Green 1. Then the hybrid binding with SYBR Green I emits enhanced fluorescence for detection. Experimental results show that the detection limit of the method is 0.5 pmol]L of T7 DNA template. A calibration curve with a linearity range of 0.5 pmol[L to 5 nmol/L is established, thus, making quantitative analysis feasible. The method may become a powerful tool for RNA transcription detection due to its sensitivity, rapidity and convenience.

关键词： Isothermal detectionRNA transcription leveGraphene oxideSYBR Green 1Fluorescence

Effects of Heat Treatment on Dimension Stability of Larch Pallet Decks

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Journal of Harbin Institute of Technology(New Series) 2013年第3期20卷 75-80页

作者： Xue-Chun Yang Bing Wang Jin-Zhuo Wu xiao-Qi xing Shi-Jun Yang College of Engineering and Technology Northeast Forestry University

The useful life of wooden pallets is lower because of the defects in lumbers. The quality of lumber can be significantly enhanced by heat treatment. In this paper,the larch pallet decks samples were heat-treated under the conditions of different time and temperatures. The quantity of water uptake has reduced 16. 8% under the condition of 250 ℃ for 150 min. The resistance of water absorption efficiency increases 165. 34% under the condition of 175 ℃ for 90 min. The anti-shrink efficiency increases 72. 08% under the condition of 250 ℃ for 90min. The results showed that the dimension stability of larch panels can be improved by heat treatment. The condition of 250 ℃ for 180 min is the best heat treating condition to improve the dimension stability.

关键词： larch pallet heat treatment resistance of water absorption efficiency anti-shrink efficiency dimension stability

Solid Solute Regularity of La Atom inα-Fe Supercell by First-principles

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Journal of Iron and Steel Research International 2016年第11期23卷 1213-1218页

作者： Cai-xia WANG Jian YANG Sha LIU xiao-lei xing Ji-bo WANG Xue-jun REN Qing-xiang YANG State Key Laboratory of Metastable Materials Science and Technology Yanshan University School of Materials Science and Engineering University of Science and Technology Beijing School of Engineering Liverpool John Moores University

The structure stability, elastic property and electronic structure of a-Fe supercell with La atom were inves- tigated by first-principles, in which, generalized gradient approximation （GGA） with the Perdew Burke Ernzerhof （PBE） was used as exchange-correlation functional, a-Fe supercells with La atom include a-Fe supercell with La atom in octahedral interstitial solid solute （La-OISS）, that with La atom in tetrahedral interstitial solid solute （La-TISS） and that with La atom in substitutional solid solute （La-SSS）. The results show that the La-SSS a-Fe supercell is more stable than La-OISS one. The resistance to volume change, reversible deformation and stiffness of La-OISS a-Fe supercell are stronger than those of La-SSS one. Moreover, the degrees of anisotropy and ionization in La-SSS a-Fe supercell are both stronger than those in La-OISS one. The bonding strength between La atom and Fe atom in La-SSS a-Fe supercell is larger than that in La-OISS one.

关键词： La atom a-Fe supercell solid solution first-principles bonding strength

Identification of a Novel Gene SRG4 Expressed at Specific Stages of Mouse Spermatogenesis

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Acta Biochimica et Biophysica Sinica 2004年第5期36卷 351-359页

作者： xiao-Wei xing, Lu-Yun LI, Gang LIU, Jun-Jiang FU, xiao-Jun TAN, and Guang-Xiu LU* Human Reproduction and Stem Cell Engineering Institute, Central South University, Changsha 410078, China Human Reproduction and Stem Cell Engineering Institute Central South University

Spermatogenesis is a complex process. Two spermatocytes expression sequence tags (ESTs) BG101130 and BG100990 were found. Their putative amino acid sequences have high homology with rat Spag4 (sperm antigen 4). By electrical hybridization, a novel cDNA encoding polypeptide of 348 amino acid residues was identified from a mouse testis cDNA library. The new gene was designated as SRG4 (Spermatogenesis related gene 4) (GenBank accession No. AY307077). Results of Northern blot and RT- PCR revealed that SRG4 expressed specifically in mouse testis. Changes of SRG4 expression in mouse dif- ferent development stages were observed by RT-PCR. The SRG4 mRNA was hardly detected in 2 weeks postpartum, and expressed abundantly from 3 weeks later, reaching top lever at 4–5 weeks, while slightly down in aging mouse testis. Results of in situ hybridization showed that SRG4 gene expressed abundantly in spermatocytes, round spermatids. This indicated SRG4 gene may play an important role in mouse meiotic divisions of spermatocytes.

关键词： gene cloning testis tissues expression pattern in situ hybridization spermatogenesis

Quantum Beat Spectroscopy of SO_(2)in the 235-224nm Range

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Chinese Physics Letters 1999年第9期16卷 641-642页

作者： CHEN Yang PEI Lin-sen JIN Jin CHEN Cong-xiang MA xing-xiao Department of Chemical Physics University of Science and Technology of ChinaHefei 230026 Open Laboratory of Bond Selective Chemistry Chinese Academy of SciencesHefei 230026

Using time-resolved laser-induced fluorescence(LIF)spectroscopy,the fluorescence quantum beat decay was observed in C(1B_(2))←X(1A_(1))transition of SO_(2)*** experimental results show that only the v_(3) mode and its combination band v_(1)+v_(2)+v_(3) excitation exist the beat *** the result,we attribute the quantum beat states to the coupling of the v3 vibration mode of C state with the high vibrational levels of the electronic ground state.

关键词： molecule. state. decay