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Schizandrin prevents dexamethasone-induced cognitive deficits

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Neuroscience Bulletin 2012年第5期28卷 532-540页

作者： xiao Xu Xing zhou xiao-wen zhou Zheng Zhang Min-Jing Liao Qi Gao Huan-Min Luo Department of Pharmacology School of Medicine Jinan University Guangzhou 510632 China Department of Physiology School of Medicine Henan University Kaifeng 475000 China The Joint Laboratory of Brain Function and Health Jinan University and the University of Hong Kong Jinan University Guangzhou 510632 China

Objective To model glucocorticoid-induced cognitive impairment and evaluate the neuroprotection by schi-zandrin （Sch） against dexamethasone （Dex）-induced neurotoxicity in vivo and in vitro. Methods Cerebral cortical cells from neonatal Sprague-Dawley rats （within 24 hours after birth） were cultured for 9 days, and then treated with Dex （10 -4 , 10 -5 , 10 -6 or 10 -7 mol/L） for 24 h or pretreated with 10 -4 mol/L Dex for 24 h followed by 10, 20, 40, or 80 μmol/L Schfor 48 h. Cell viability was assessed using the MTT assay. Immunofluorescence and real-time PCR for MAP2 were performed to confirm the effects of Dex on neurite outgrowth. In vivo, kunming mice were randomly divided into six groups： control [（intragastric （i.g.） vehicle for 42 days]; Dex group I （5 mg/kg·d -1 Dex i.g. treatment for 28 days followed by i.g. vehicle for 14 days）; Dex group II （Dex i.g. for 42 days）; Dex ＋ Sch （Dex i.g. for 28 days followed by 5, 15, or 45 mg/kg·d -1 Sch i.g. for 14 days）. Learning and memory were assessed by Morris water maze test. Histological examination was used to assess pathology and apoptosis in neurons. Results Compared to the Dex groups, Sch increased cell viability in a dose-dependent manner, improved performance in the Morris water maze and ameliorated the morphological changes. Conclusion Sch has neuroprotective effects against insults induced by glucocorticoid.

关键词： neuron glucocorticoid cognitive impairment

AtCLH2, a Typical but Possibly Distinctive Chlorophyllase Gene in Arabidopsis

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Journal of Integrative Plant Biology 2007年第4期49卷 531-539页

作者： Yang Liao Kun An xiao zhou wen-Jun Chen Ben-Ke Kuai State Key Laboratory of Genetic Engineering Department of Biochemistry School of Life Sciences Fudan University Shanghai 200433 China

Chlorophyllase （EC 3.***.1.14） is involved in the first step of chlorophyll degradation. Isolation of chlorophyllase genes greatly facilitates characterization of chlorophyllase properties and elucidation of molecular regulation of their in vivo activities. There are two chlorophyllase genes, AtCLH1 and AtCLH2, in Arabidopsis thaliana. The in vivo roles of AtCLH1 have been reported previously. However, few studies have been carried out on AtCLH2. Here, we show that purified recombinant Chlase2, encoded by AtCLH2, exhibits in vitro chlorophyllase activity. Interestingly, ＂activation＂ of in vitro activity of the recombinant Chlase2 required higher concentrations of a detergent or a polar solvent. To determine its activity in vivo, the expression of AtCLH2 was inhibited by RNA interference. RNAi plants showed decreased contents of chlorophyllide without a substantial change in the total amount of the extractable chlorophyll and consequently presented lower chlorophyllide to chlorophyll ratios in their leaves. In addition, the two AtCLHs exhibited differential expression patterns. Our results suggest that AtCLH2 might play a distinctive role in chlorophyll catabolism in vivo.

关键词： Arabidopsis AtCLH1 AtCLH2 chlorophyllase chlorophyll degradation RNA interference.

A Joint Laplace Transform for Pre-exit Diffusion of Occupation Times

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Acta Mathematica Sinica,English Series 2017年第4期33卷 509-525页

作者： Ye CHEN Xiang Qun YANG Ying Qiu LI xiao wen zhou College of Mathematics and Computer Science Hu'nan Normal University College of Mathematics and Computational Science Hu’nan University of Arts and Science College of Mathematics and Statistics Changsha University of Science and Technology Department of Mathematics and Statistics Concordia University

For a < r < b, the approach of Li and zhou(2014) is adopted to find joint Laplace transforms of occupation times over intervals(a, r) and(r, b) for a time homogeneous diffusion process before it first exits from eithe... 详细信息

For a zhou(2014) is adopted to find joint Laplace transforms of occupation times over intervals(a, r) and(r, b) for a time homogeneous diffusion process before it first exits from either a or b. The results are expressed in terms of solutions to the differential equations associated with the diffusions generator. Applying these results, we obtain more explicit expressions on the joint Laplace transforms of occupation times for Brownian motion with drift, Brownian motion with alternating drift and skew Brownian motion, respectively.

关键词： Laplace transform occupation time time-homogeneous diffusion exit time Brownian motion with alternating drift skew Brownian motion

Low temperature fabrication of flexible carbon counter electrode on ITO-PEN for dye-sensitized solar cells

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Chinese Chemical Letters 2010年第9期21卷 1137-1140页

作者： Li Li Chen Jia Liu Jing Bo Zhang xiao wen zhou xiao Ling Zhang Yuan Lin Department of Chemistry School of Science Beijing Institute of Technology Beijing 100081 China Beijing National Laboratory for Molecular Sciences Key Laboratory. of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

A novel low temperature method was used to prepare the mesoporous carbon（MC） counter electrode（CE） on indium-doped tin oxide coated polyethylene naphthalate（ITO-PEN） for flexible dye-sensitized solar cells（DSSCs）.The obtained flexible MC CEs with carbon loading of 280μg cm^（-2） were characterized by SEM,XRD and electrochemical *** light-to-electricity conversion efficiency of the DSSC fabricated with the prepared flexible MC CE was 86%of that of DSSC based on the decomposited Pt CE.

关键词： Mesoporous carbon Flexible counter electrode Dye-sensitized solar cells

Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer's disease

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Neuroscience Bulletin 2013年第1期29卷 111-120页

作者： Lian-Feng Lin Min-Jing Liao xiao-Yan Xue Wei Zhang Li Yan Liang Cai xiao-wen zhou Xing zhou Huan-Min Luo Department of Pharmacology School of Medicine Jinan University Department of Laboratory Medicine Medical College of Hunan Normal University Ganzhou People's Hospital Department of Pharmacology School of Medicine Jinan University Institute of Brain Sciences School of Medicine Jinan University The Joint Laboratory of Brain Function and Health Jinan University and The University of Hong Kong Jinan University

There is no effective drug to treat Alzheimer＇s disease （AD）, a neurodegenerative disease affecting an estimated 30 million people around the world. Strongly supported by preclinical and clinical studies, amyloid-beta （Aβ） may be a target for developing drugs against AD. Meanwhile, the fact that localized neuronal death/loss and synaptic impairment occur in AD should also be considered. Neuronal regeneration, which does not occur normally in the mammalian central nervous system, can be promoted by neurotrophic factors （NTFs）. Evidence from clinical trials has shown that both Aβ clearance and NTFs are potentially effective in treating AD, thus a new approach combining Aβ clearance and administration of NTFs may be an effective therapeutic strategy.

关键词： Alzheimer’s disease amyloid-beta neurotrophic factors treatment

Electrochemical impedance analysis of nanoporous TiO_2 electrode at low bias potential

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Chinese Chemical Letters 2010年第8期21卷 959-962页

作者： Sheng Jun Li Yuan Lin Zeng Chen Jing Bo Zhang xiao wen zhou College of Physics and Electrics He'nan University Kaifeng 475004 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

TiO2 colloid was prepared by the sol-gel method and was bladed on transparent conduction glass to made nanoporous electrode. The impedance performance of TiO2 electrode was studied at various bias potential.A simplified equivalent circuit was proposed to investigate the charge transport impedance of TiO2 film and good fitting results were obtained.

关键词： Dye-sensitized solar cell Electrochemical impedance spectroscopy Equivalent circuit Charge transport impedance

Development of high-performance dry-pressed anisotropic permanent ferrite for La-Ca-Sr-Co system

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Rare Metals 2020年第1期39卷 89-94页

作者： Dai-Man Zhu Zhao-wen Geng Rong-Ming Liu xiao-wen zhou Li-Ying Jia Guo-Hui Hu Qian Wang Bing-Shan Li National Engineering Technology Research Center for Magnetic Materials BGRIMMBeijing102600China BGRIMM Magnetic Materials and Technology(Fuyang)Co. Ltd.Fuyang236000China

In this work,the BMS-12 pre-sintered material was used as the basic material,and the optimal secondary additive addition amount was found by the wet pressing ***,the anisotropic ferrite material was prepared by dry-pres sing method,and the effects of camphor adhesives,calcium stearate lubricant and powder particle size on the magnetic properties were *** experimental results show that the appropriate addition amount of camphor adhesive and calcium stearate lubricant is 0.6 wt%and 0.8 wt%,*** remanence and coercivity can be obtained for particle size of 0.85-1.00μ*** dry-pressed magnet ferrite was prepared with typical properties of magnetic induction intensity of Br=421 mT,induction coercivity of Hcb=296 kA·m-1,intrinsic coercivity of Hcj=369 kA·m-1 and maximum energy product of(BH)max=33.3 kJ·m-3,which have reached the level of TDK corporation product of FB5 *** shows that the dry-pressed magnet of La-Ca-Sr-Co system has higher remanence and intrinsic coercivity than the traditional wetpressed Sr-ferrite.

关键词： Dry-press molding Permanent magnetic ferrite La-Ca-Sr-Co system Magnetic properties

Preparation and performance of dye-sensitized solar cells based on ZnO-modified TiO_2 electrodes

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International Journal of Minerals,Metallurgy and Materials 2010年第1期17卷 92-97页

作者： Sheng-jun Li Yuan Lin Wei-wei Tan Jing-bo Zhang xiao-wen zhou Jin-mao Chen Zeng Chen College of Physics and Electrics He＇nan University Kaifeng 475004 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The ZnO-modified TiO2 electrode was prepared by adding Zn（CH3COO）2·2H2O to the TiO2 colloid during the sol-gel production process, and was used in dye-sensitized solar cells （DSCs）. The open circuit voltage （Voc） and fill factor （if） of the cells were improved sig- nificantly. The performances of the ZnO-modified TiO2 electrode such as dark current, transient photocurrent, impedance, absorption spectra, and fiat band potential （Vfb） were investigated. It is found that the interface charge recombination impedance increases and Vfb shifts about 200 mV toward the cathodic potential. The effect mechanism of ZnO modification on the performance of DSCs may be that ZnO occupies the surface states of the TiO2 film.

关键词： dye-sensitized solar cells TiO2 electrode modification photoelectrochemical properties

Design of Tough, yet Strong, Heat-resistant PLA/PBAT Blends with Reconfigurable Shape Memory Behavior by Engineering Exchangeable Covalent Crosslinks

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Chinese Journal of Polymer Science 2023年第12期41卷 1868-1878,I0007页

作者： xiao-wen zhou Jing Huang Xu-Hui Zhang Ting Li Yang Wang Shi-Bo Wang Bi-Hua Xia Wei-Fu Dong The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China

Polylactide(PLA)has often been blended with biodegradable poly(butylene adipate-co-terephthalate)(PBAT)to improve its ***,the strength and heat resistance of PLA are always ***,exchangeable hydroxyl-ester crosslinks are constructed in PLA/PBAT blends by successively introducing a tertiary amine-containing polyol,bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane(BTM)and 4,4’-diphenylmethane diisocyanate(MDI)via reactive *** can react with both PLA and PBAT by transesterification,generating PLA or PBAT chains with terminal or pendant hydroxyl groups,which can then react with MDI to form *** internal catalysis of tertiary amine moiety in BTM,transesterification between the residual hydroxyl groups and ester bonds can occur at high temperatures,endowing the PLA/PBAT network with vitrimeric *** to the transesterification and chain extension reactions with MDI between PLA and PBAT,the interfacial adhesion is greatly *** a result of the excellent interfacial adhesion and the network structure,the prepared PLA/PBAT blends show greatly enhanced heat resistance and toughness(more than 40 times that of PLA)while maintaining high stiffness comparable to ***,the prepared PLA/PBAT blends exhibit promising reconfigurable shape memory *** present work provides a new and facile way to achieve high-performance and functional biodegradable polymeric materials.

关键词： Polylactide Dynamic covalent bonds Strengthening and toughening Heat resistance Shape memory