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Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARγsignaling pathway

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Journal of Genetics and Genomics 2023年第1期50卷 20-26页

作者： Jie wen Jiangming Deng Ting xiao Yu Liu wen Meng Department of Nephrology Hunan Key Laboratory of Kidney Disease and Blood PurificationThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Metabolic Syndrome Research Center The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China

Dysregulation of microRNAs(miRNAs)in adipocytes plays a critical role in the pathogenesis of obesity.However,the signaling mechanisms regulating miRNAs production in adipose tissue remain largely unclear.Here,we show that adipose tissue-specific knockout of Ras homolog enriched in brain(Rheb),a direct upstream activator of mTOR,increases miR-182-5p level in mouse subcutaneous white adipose tissues.Interestingly,the inhibition of mTOR signaling by rapamycin has no effect on miR-182-5p level in primary subcutaneous white adipocytes,suggesting the presence of a mTOR-independent mechanism regulating Rheb-mediated miR-182-5p expression.Consistent with this view,Rheb-ablation activates the cAMP/PPARγsignaling pathway.In addition,treatment of white adipocytes with pioglitazone,a PPARγagonist,dramatically upregulates miR-182-5p levels.Our study reveals a unique mechanism by which Rheb regulates miR-182-5p in adipocytes.Given that increasing miR-182-5p in adipose tissue promotes beige fat development,our study also suggests a unique mechanism by which Rheb promotes thermogenesis and energy expenditure.

关键词： Rheb miR-182-5p White adipocytes cAMP/PPARγpathway Adipose tissue

Inherent relationship between process parameters,crystallization and mechanical properties of continuous carbon fiber reinforced PEEK composites

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Defence Technology（防务技术） 2023年第6期24卷 269-284页

作者： xiao-long Ma Li-hua wen Shi-yu Wang Jin-you xiao wen-hao Li xiao Hou School of Astronautics Northwestern Polytechnical UniversityXi'an710072China China Aerospace Science and Technology Corporation Beijing100048China

High-performance thermoplastic composites have been developed as significant structural materials for cutting-edge equipment in the aerospace and defence fields.However,the internal mechanism of processing parameters on mechanical properties in the manufacturing process of thermoplastic composite structures is still a serious challenge.The purpose of this study is to investigate the process/crystallization/property relationships for continuous carbon fiber(CF)reinforced polyether-ether-ketone(PEEK)composites.The composite laminates are fabricated according to orthogonal experiments via the thermoforming method.The mechanical performance is investigated in terms of crystallization properties and fracture morphology characterizations.Experimental results show that the mechanical performance and crystallization properties of thermoplastic composites are significantly affected by the coupling of processing parameters.The increased molding temperature,pressure,and holding time improve the degree of fiber/matrix infiltration and affect the crystallinity and crystalline morphology of the matrix,which further influences the mechanical properties of the composites.This is reflected in the test results that crystallinity has an approximately linear effect on mode-I interlaminar fracture toughness and transverse flexural modulus.As well as the higher molding temperature can destroy the pre-existent crystals to improve the toughness of the matrix,and the well-defined crystalline structures can be observed when fabricated at higher temperatures and longer periods of holding time.

关键词： Polymer matrix composites Thermoplastic Processing parameters Mechanical properties Crystallization

陈晓雯基于“络病学说”辨治高尿酸血症经验浅析

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中医药通报 2022年第8期21卷 6-8页

作者：杨琦陈晓雯(指导) 安徽中医药大学第一附属医院安徽合肥230031

陈晓雯教授结合多年临床经验,依据叶天士络病学说,探讨高尿酸血症的发病机制,认为其为本虚标实、虚实夹杂之证。脾肾亏虚,湿热瘀阻络脉为其发病的基础,若络脉日久闭塞不通,则易发为痹证。因此,陈晓雯教授提出清热祛湿、化瘀通络的治法,... 详细信息

陈晓雯教授结合多年临床经验,依据叶天士络病学说,探讨高尿酸血症的发病机制,认为其为本虚标实、虚实夹杂之证。脾肾亏虚,湿热瘀阻络脉为其发病的基础,若络脉日久闭塞不通,则易发为痹证。因此,陈晓雯教授提出清热祛湿、化瘀通络的治法,自拟苓玉清络饮,疗效显著,可为高尿酸血症的中医证治及研究提供新的思路。

关键词：络病高尿酸血症苓玉清络饮名医经验

A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao Wei wen-lin Tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

Adsorbed and free gas occurrence characteristics and controlling factors of deep shales in the southern Sichuan Basin,China

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Petroleum Science 2023年第3期20卷 1301-1311页

作者： Shang-wen Zhou Dong-xiao Zhang Department of Energy and Resources Engineering College of EngineeringPeking UniversityBejing100871China PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhenGuangdong 518055China

Deep shale gas(3500-4500 m)will be the important succeeding field for the growth of shale gas production in China.Under the condition of high temperature and high pressure in deep shale gas reservoirs,its gas occurrence characteristics are markedly different from those of medium and shallow layers.To elucidate the gas occurrence characteristics and controlling factors of deep shales in the Wufeng-Longmaxi Formation,methane adsorption,low-temperature N2,and cO2 adsorption experi-ments were conducted.The results show that in deep shales,the mesopores provide approximately 75%of the total specific surface area(SA)and 90%of the total pore volume(PV).Based on two hypotheses and comparing the theoretical and actual adsorption capacity,it is speculated that methane is adsorbed in deep shale in the form of micropore filling,and free gas is mainly stored in the mesopores.Correlation analysis demonstrated that ToC is the key material constraint for the adsorption capacity of deep shale,and micropore SSA is the key spatial constraint.Other minerals and mesopore parameters have limited effect on the amount of adsorbed gas.Moreover,the free gas content ranges from 2.72 m^(3)/t to 6.20 m^(3)/t,with an average value of 4.60 m^(3)/t,and the free gas content ratio is approximately 58%,suggesting that the deep shale gas reservoirs are dominated by free gas.This ratio may also increase to approximately 70%when considering the formation temperature effect on adsorbed gas.Gas density,porosity,and gas saturation are the main controlling factors of free gas content,resulting in significantly larger free gas content in deep shale than in shallower formations.

关键词： Adsorbedgas Free gas Gas occurrence characteristics Deep shale

Repairing whole facial nerve defects with xenogeneic acellular nerve grafts in rhesus monkeys

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Neural Regeneration Research 2022年第5期17卷 1131-1137页

作者： Guo-Chen Zhu Da-Jiang xiao Bi-wen Zhu Yan xiao Department of Otorhinolaryngology-Head and Neck Surgery Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina Department of Otorhinolaryngology-Head and Neck Surgery Affiliated Wuxi Clinical College of Nantong UniversityWuxiJiangsu ProvinceChina College of Animal Science&Technology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong ProvinceChina Department of Pathology Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina

Acellular nerve allografts conducted via chemical extraction have achieved satisfactory results in bridging whole facial nerve defects clinically,both in terms of branching a single trunk and in connecting multiple branches of an extratemporal segment.However,in the clinical treatment of facial nerve defects,allogeneic donors are limited.In this experiment,we exposed the left trunk and multiple branches of the extratemporal segment in six rhesus monkeys and dissected a gap of 25 mm to construct a monkey model of a whole left nerve defect.Six monkeys were randomly assigned to an autograft group or a xenogeneic acellular nerve graft group.In the autograft group,the 25-mm whole facial nerve defect was immediately bridged using an autogenous ipsilateral great auricular nerve,and in the xenogeneic acellular nerve graft group,this was done using a xenogeneic acellular nerve graft with trunk-branches.Examinations of facial symmetry,nerve-muscle electrophysiology,retrograde transport of labeled neuronal tracers,and morphology of the regenerated nerve and target muscle at 8 months postoperatively showed that the faces of the monkey appeared to be symmetrical in the static state and slightly asymmetrical during facial movement,and that they could actively close their eyelids completely.The degree of recovery from facial paralysis reached House-Brackmann grade II in both groups.Compound muscle action potentials were recorded and orbicularis oris muscles responded to electro-stimuli on the surgical side in each monkey.Fluoro Gold-labeled neurons could be detected in the facial nuclei on the injured side.Immunohistochemical staining showed abundant neurofilament-200-positive axons and soluble protein-100-positive Schwann cells in the regenerated nerves.A large number of mid-graft myelinated axons were observed via methylene blue staining and a transmission electron microscope.Taken together,our data indicate that xenogeneic acellular nerve grafts from minipigs are safe and effective for repairing whole facial nerve defects in

关键词： acellular nerve compound muscle action potentials facial nerve defect facial symmetry monkey nerve graft nerve regeneration retrograde labeling test synaptophysin xenogeneic

Generalized Stepping Stone Model with Ξ-resampling Mechanism

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Acta Mathematica Sinica,English Series 2022年第11期38卷 1998-2018页

作者： Hui Li LIU Xiao Wen ZHOU School of Mathematical Sciences Hebei Normal UniversityShijiazhuang 050024P.R.China Department of Mathematics and Statistics Concordia UniversityMontreal H3G1M8Canada

A generalized stepping stone model withΞ-resampling mechanism is a two dimensional probability-measure-valued stochastic process whose moment dual is similar to that of the classical stepping stone model except that Kingman’s coalescent is replaced byΞ-coalescent.We prove the existence of such a process by specifying its moments using the dual function-valuedΞ-coalescent process with geographical labels and migration,and then verifying a multidimensional Hausdorff moment problem.We also characterize the stationary distribution of the generalized stepping stone model and show that it is not reversible if the mutation operator is of uniform jump-type.

关键词： Generalized stepping stone model (Ξ,A,u1,u2-CPGM multidimensional Hausdorff moment problem stationary distribution reversibility

3D trajectory inversion of an adjacent well using scattered P-wave

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Petroleum Science 2023年第2期20卷 857-865页

作者： Lu Cheng xiao-Hua Che wen-xiao Qiao Teng Zhao State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Key Laboratory of Earth Prospecting and Information Technology Beijing102249China

In oil and gas exploitation,cluster well technology can significantly reduce costs and improve efficiency.An effective adjacent well detection method can greatly reduce the risk of collision between adjacent wells.This study proposes a method to invert the 3D trajectory of an adjacent well using a scattered P-wave obtained by borehole azimuthal acoustic reflection imaging.After obtaining the scattered P-wave from the raw data of the target well using the wave field separation technology,the waveform data in an imaging profile can be obtained by the downhole acoustic directional reception technology.Migration imaging technology is then used to obtain the image of the formation in the imaging profile.Subsequently,by analyzing the images of the formation in the imaging profile of the different azimuths,the well spacing and azimuth of the target well can be determined.Finally,the 3D trajectory of the target well can be obtained by solving the inversion equation.This method was validated by processing the field data from a deviated well in a deep formation.The comparison of the inversion and actual trajectories of the target well demonstrated that the maximum deviation of the inversion trajectory is 0.9 m in the north-south direction,0.78 m in the east-west direction,1.45 m in the well spacing,and 2.48°in the azimuth.The field data inversion result demonstrated that the method can effectively use the azimuth reflection acoustic data to invert the 3D trajectory of an adjacent well,which indicates that the borehole azimuthal acoustic reflection imaging technology has great potential within the context of adjacent well detection.

关键词： Acoustic imaging Acoustic reflection logging Directional reception Adjacent well

CO as a therapeutic agent: discovery and delivery forms

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Chinese Journal of Natural Medicines 2020年第4期18卷 284-295页

作者： YANG xiao-xiao KE Bo-wen LU wen WANG Bing-He Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlanta GA 30303USA Department of Anesthesiology West China HospitalChengdu 610000China

Carbon monoxide(CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we discussed CO’s evolution from a well-recognized toxic gas to a signaling molecule, and the effort to develop different approaches to deliver it for therapeutic application. We also summarize recently reported chemistry towards different CO delivery forms.

关键词： Carbon monoxide Gasotransmitter CO delivery CO-RMs Organic CO prodrug