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Unveiling an ancient whole-genome duplication event in Stentor,the model unicellular eukaryotes

Science China Life Sciences 2025年

作者： weibo Zheng Chao Li Zhaorui Zhou xiao Chen Michael Lynch Ying yan School of Life Sciences Ludong University Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Biodesign Center for Mechanisms of Evolution Arizona State University Marine College Shandong University

Whole-genome duplication(WGD) events are widespread across eukaryotes and have played a significant role in moulding the genetic architectures of diverse organisms. In the present study, the newly sequenced genome of a giant ciliated protist, Stentor roeselii, provides an opportunity for the analysis of the collinearity and retention of reciprocal best-hit genes between two Stentor species. As a main result, we have unveiled a previously undetected ancient WGD event shaping the genome of its congener, Stentor coeruleus, a model protist used in cytological and evolutionary studies. Genomes of two congeners, S. coeruleus and S. roeselii, are compared and analyzed, revealing that:(i)the former exhibits a much higher retention rate of colinear-gene pairs(28%) than does S. roeselii, and in S. coeruleus, 75% of genes that have a RBH hit in S. roeselii, have paralogs with high amino-acid identity, consistent with a WGD event in the lineage leading to S. coeruleus;(ii) the S. roeselii genome possesses extremely short intergenic regions, implying that the lengths of intergenic regions are under strong selection;(iii) the unique characteristics of introns may have been shaped in the common ancestor of heterotrichs;(iv) gene families that play a role in activities of multiple protein kinases and voltage-gated ion channels expanded rapidly in the ancestor of both taxa, possibly relating to the remarkable regenerative ability in Stentor. This study offers new insights into the evolutionary dynamics of ciliate genomes,with implications for understanding of the processes underlying the evolution of genomic complexity.

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慢性间断性低氧诱导大鼠前包钦格复合体磷酸化PKC底物表达增加

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生理学报 2020年第5期72卷 559-565页

作者：亢君君魏晓燕刘莹莹空军军医大学神经生物学教研室西安710032

延髓腹外侧前包钦格复合体(pre-Bötzinger complex,pre-BötC)被认为是呼吸节律产生中枢。间断性低氧可诱导呼吸长时程易化(long-term facilitation,LTF),是呼吸可塑性的电生理特征。本研究组前期研究显示慢性间断性低氧(chronic intermi... 详细信息

延髓腹外侧前包钦格复合体(pre-Bötzinger complex,pre-BötC)被认为是呼吸节律产生中枢。间断性低氧可诱导呼吸长时程易化(long-term facilitation,LTF),是呼吸可塑性的电生理特征。本研究组前期研究显示慢性间断性低氧(chronic intermittent hypoxia,CIH)诱导大鼠pre-BötC磷酸化蛋白激酶Cθ(phospho-protein kinase Cθ,P-PKCθ)表达上调。本研究旨在探讨磷酸化-蛋白激酶C底物(P-PKC substrates,P-PKCsub)在大鼠pre-BötC的超微结构分布以及CIH干预后的表达变化。应用神经激肽1受体(neurokinin-1 receptor,NK1R)免疫反应(immunoreactive,ir)产物作为pre-BötC神经元的标志,并用抗P-PKCsub抗体双标记进行免疫荧光和免疫电镜观察,用Western blot分析延髓腹外侧区(包含pre-BötC)P-PKCsub蛋白的表达变化。结果显示,光镜下,NK1R-ir标记主要沿pre-BötC神经元胞膜分布,清晰勾勒胞体和突起。P-PKCsub-ir标记多呈点状分布在胞体和突起,膜下亦有分布。大部分P-PKCsub-ir神经元共表达NK1R。CIH干预诱导延髓腹外侧区P-PKCsub蛋白表达水平上调。电镜下,NK1R-ir产物主要分布在pre-BötC神经元胞体和树突的胞膜内表面。P-PKCsub-ir金颗粒分布在pre-BötC神经元胞体和树突,在细胞膜下有较多分布,内质网和突触后致密体亦可见。以上结果提示,CIH干预可能通过激活PKCθ,上调P-PKCsub蛋白表达,参与pre-BötC的呼吸可塑性调控。

关键词：前包钦格复合体蛋白激酶C底物慢性间断性低氧呼吸可塑性超微结构

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The Synthesis,Characterization and Antitumor Activity of Derivants of 5-Fiuorouracil Dipeptide

The Synthesis,Characterization and Antitumor Activity of Der...

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第五届全国化学生物学学术会议

作者： Mao-Lin Hu xiao-wei yan Ping Yin College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou 325027,P.R.China

＜正＞5-Fluorouracil is a kind of popular antimetabolic drug used in *** has similar structure which is necessary to the cancer cell,content with uracil in the same enzyme system,blocks the metabolic link,impedes the synthesis of DNA,and prohibits the propagation of the cancer *** a kind of antitumor drug,5-fluorouracil has inhibition effect on many kinds of ***,its

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耐力训练SD大鼠胸主动脉零应力状态的重建

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上海体育学院学报 2007年第3期31卷 77-80页

作者：危小焰龚文辉孙元刚上海体育学院运动科学学院上海200438

将SD大鼠随机分成训练组和对照组,参照Bedford大鼠耐力训练模型对训练组进行电动跑台训练,16周后将SD大鼠断头处死,将胸主动脉取出,使用计算机图像采集及分析系统测量血管环的张开角、壁厚、内径并计算壁厚/内径。结果表明:在零应力状... 详细信息

将SD大鼠随机分成训练组和对照组,参照Bedford大鼠耐力训练模型对训练组进行电动跑台训练,16周后将SD大鼠断头处死,将胸主动脉取出,使用计算机图像采集及分析系统测量血管环的张开角、壁厚、内径并计算壁厚/内径。结果表明:在零应力状态下测定张开角发现,训练组的张开角比对照组减小,而血管的壁厚却无明显差异;在血管的管径方面,训练组较对照组明显增大。表明耐力运动可以造成SD大鼠胸主动脉零应力状态及几何形态学的重建。

关键词：耐力训练血管重建 SD大鼠胸主动脉零应力张开角剪切应

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MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang wei Ming Longfu Chen Tianliang Song Moxi Yele Hao Zhang Long yang Gegen Sarula Benliang Liang Luting yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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挤压态AZ80镁合金的塑性变形行为

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粉末冶金材料科学与工程 2014年第1期19卷 31-38页

作者：李慧中卫晓燕梁霄鹏姜俊欧阳杰李轶中南大学材料科学与工程学院长沙410083 中南大学粉末冶金国家重点实验室长沙410083 中南大学有色金属材料科学与工程教育部重点实验室长沙410083

采用Gleeble-1500热模拟实验机，对挤压态AZ80镁合金在变形温度为250～450℃和应变速率为0.001～10 s-1条件下进行热压缩塑性变形。将实验得到的流变应力经过温度修正后，分析该合金的应变速率敏感指数，构建其本构方程，并研究其发生... 详细信息

采用Gleeble-1500热模拟实验机，对挤压态AZ80镁合金在变形温度为250～450℃和应变速率为0.001～10 s-1条件下进行热压缩塑性变形。将实验得到的流变应力经过温度修正后，分析该合金的应变速率敏感指数，构建其本构方程，并研究其发生动态再结晶的临界点。结果表明：低温低应变速率下变形时，AZ80镁合金的应变速率敏感指数较高；低温高应变速率下变形时，应变速率敏感指数较低；应变速率提高和温度降低都会导致发生动态再结晶的临界应变增大。

关键词： AZ80镁合金热压缩本构方程塑性变形再结晶

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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology research 2025年第1期33卷 225-234页

作者： wei Zhang weicheng Wang Rui Wang xiao Han Lijun Zhu Wenjie Guo yanhong Gu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China. Department of Oncology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou 225300 China. State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China.

Background:As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC.Methods and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax's efficacy against tumors. Then we employed various techniques to evaluate different aspects of the experimental outcomes. Immunohistochemistry was used to detect cell proliferation and angiogenesis in tumor tissues. Western blot analysis was utilized to examine the occurrence of cell apoptosis, and flow cytometry to quantitate immune cells within the tumor tissues. Moreover, immunofluorescence was employed to measure cytokine levels.Results:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax, as opposed to individual drug use. Venetoclax was found to amplify the impact of fruquintinib, leading to decreased cancer cell proliferation, increased cancer cell apoptosis, lowered angiogenesis, better vascular structure normalization, and improved immune cell infiltration.Conclusion:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune microenvironment. Our study presents the justification for utilizing the fruquintinib and venetoclax combination in treating CRC. Venetoclax holds promise in being assimilated into anticancer medications for CRC.

关键词： Anti-angiogenesis B-cell lymphoma protein 2 (BCL2) Colorectal cancer (CRC) Fruquintinib Immunotherapy Vascular endothelial growth factor receptor (VEGFR) Venetoclax

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie wei Hongyu Chen Guoqiang Ma Wensheng yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第01期 257-263页

作者： Jiapian Huang Chenxin Wang Xu Wang xiaoyu Zhou wei xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

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铕及其掺杂稀土噻吩乙酸、邻菲啰啉配合物的合成、表征及荧光性能

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发光学报 2008年第5期29卷 827-832页

作者：张梅赵永亮赵艳芳王艳李海燕魏晓燕刘润花内蒙古大学化学化工学院内蒙古呼和浩特010021

合成了十种以2-噻吩乙酸(TPAC)、邻菲啰啉(Phen)为配体,单一稀土Eu3+配合物、Eu3+掺杂La3+、Gd3+、Y3+、Er3+以及不同比例的Eu3+掺杂La3+异核配合物。进行了元素分析、摩尔电导、热谱、红外光谱、核磁共振及荧光性能研究。配合物的组成... 详细信息

合成了十种以2-噻吩乙酸(TPAC)、邻菲啰啉(Phen)为配体,单一稀土Eu3+配合物、Eu3+掺杂La3+、Gd3+、Y3+、Er3+以及不同比例的Eu3+掺杂La3+异核配合物。进行了元素分析、摩尔电导、热谱、红外光谱、核磁共振及荧光性能研究。配合物的组成分别为EuL3L′,Eu0.5Y0.5L3L′,Eu0.5La0.5L3L′,Eu0.5Gd0.5L3L′,Eu0.5Er0.5L3L′和EuxLa1-xL3L′(其中L=TPAC,L′=Phen)。羧酸的氧原子和邻菲啰啉的氮原子与稀土离子配位,配合物为非电解质。荧光光谱的测试表明荧光惰性离子La3+、Gd3+、Y3+对Eu3+的荧光有增强作用,顺序为La3+>Gd3+>Y3+;Er3+对Eu3+的荧光有猝灭作用。不同比例Eu3+掺杂La3+异核配合物中,当Eu3+:La3+=0.50:0.50时敏化作用最强,荧光强度值最大。

关键词： 2-噻吩乙酸邻菲哕啉铕配合物荧光

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