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Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population

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Chinese Medical Journal 2014年第4期127卷 638-644页

作者： Xu RY Ye P Luo LM Sheng L Wu HM xiao WK Zheng J Wang F xiao th Department of Geriatric Cardiology Chinese People&#39 s Liberation Army General Hospital Beijing 100853 China Department of Geriatric Cardiology Navy General Hospital Beijing 100048 China Department of Geriatric Cardiology Chinese People&#39 s Liberation Army General Hospital Beijing 100853 China

Background N-terminal pro-B-type natriuretic peptide （NT-proBNP） and high-sensitivity cardiac troponin T （hs-cTnT） are excellent biomarkers for detecting heart failure and subclinical myocardial ***,it remains unclear whether subclinical myocardial injury is associated with NT-proBNP elevation in a community based *** In a community based study,levels of hs-cTnT and of NT-proBNP were determined in 1 497 participants older than 45 *** lower detection limit of the hs-cTnT assay used in the present study was 0.003 ng/*** association of hs-cTnT levels and NT-proBNP levels was *** When the subjects with undetectable （〈0.003 ng/ml）,intermediate （0.003-0.014 ng/ml）,and elevated （≥0.014 ng/ml） levels of hs-cTnT were compared （r=0.175,P 〈0.001）,a strong association between the hs-cTnT levels and NT-proBNP levels was observed （β=-0.206,P 〈0.001; β=-0.118,P 〈0.001,respectively）.In multivariable analyses,older age and hs-cTnT were positively and independently associated with NT-proBNP levels （β=0.341,P 〈0.001; β=0.143,P 〈0.001,respectively）,and male gender and the levels of eGFR were inversely and independently associated with NT-proBNP *** the subjects with normal or elevated NT-proBNP were analyzed separately,the hs-cTnT level was not an independent predictor for the NT-proBNP level in the normal NT-proBNP group,whereas the hs-cTnT level was the only independent predictor for NT-proBNP level in the elevated NT-proBNP group （β=0.399,P 〈0.01）.Conclusions In this community based population,NT-proBNP elevation was *** addition to female gender and older age,subclinical myocardial injury indicated by the hs-cTnT level was another important factor in NT-proBNP elevation.

关键词： N-terminal pro-brain natriuretic peptide cardiac troponin T myocardial injury

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Triggering highly nonlinear responses in 229 th nuclei with an intense laser

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Nuclear Science and Techniques 2025年第2期36卷 1-4页

作者： xiao-Jun Liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China

In a recent paper published in ***.133,152503(2024),***,***,and *** predicted that modern intense lasers can induce highly nonlinear responses in the 229 th nucleus for the first time,which is an astonishing effect of light-nucleus *** phenomenon is underpinned by two key factors:(1)the presence of a very low-lying nuclear excited state and(2)a nuclear hyperfine mixing effect that significantly enhances light-nucleus *** resulting highly nonlinear responses facilitate efficient nuclear excitation and enable coherent light emission from the nucleus,resulting in high harmonic generation.229 th presents a promising platform for advancements in both laser-nuclear physics and nuclear clock *** pioneering work by Zhang et *** a new frontier in light-matter interactions.

关键词： nonlinear intense frontier

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the Potential of Wacapou (Vouacapoua americana) Extracts to Develop New Biobased Protective Solutions for Low-Durability Wood Species

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Journal of Renewable Materials 2025年第1期13卷 79-100页

作者： Emma Kieny Kévin Candelier Louis Milhe Yannick Estevez Cyrielle Sophie Romain Lehnebach Jérémie Damay Daniela Florez Emeline Houël Marie-France thévenon Julie Bossu CIRAD Ecologie de Forêts de Guyane(EcoFoG)AgroparisTechCNRSINRAEUniversitéde GuyaneKourou97379France CIRAD UPR BioWooEBMontpellierF-34398France BioWooEB Universitéde MontpellierCIRADMontpellierF-34398France CNRS Ecologie de Forêts de Guyane(EcoFoG)AgroparisTechCIRADINRAEUniversitéde GuyaneKourouGuyane Française97379France Sorbonne Université CNRSLaboratoire de Biodiversitéet Biotechnologies MicrobiennesLBBMObservatoire OcéanologiqueBanyuls-sur-Mer66650France

the valorization of Amazonian wood residues into active chemical compounds could be an eco-friendly,cost-effective and valuable way to develop wood preservative formulations to enhance the decay and termite resistance of low-durable wood ***(Vouacapoua americana.,Fabaceae)is a well-known Guianese wood spe-cies commonly used in local wood construction due to its outstanding natural durability,which results from the presence of a large panel of extractives *** addition,its industrial processing generates large amounts of *** residues were extracted by maceration using four different solvents(water/ethanol,ethyl acetate,hexane and dichloromethane/methanol),separately and *** yield of each extractive fraction was determined,and their chemical compositions were analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS).Ethyl acetate led to the highest extraction yield,and the active compounds were identiﬁed in the obtained extractive *** this sense,the fungicidal and termite-repellent properties of these extractives were then tested using a screening laboratory(with temperate and tropical microorganisms),according to the solution concentration(1%,2.5%,5%,8%and 10%).Finally,Virola michelii Heckel wood samples(low durable species)were impregnated with the 8%concentration *** impregnated wood samples were then exposed to a soil bed *** results highlighted that the nature of the solvent used during wood maceration affects the con-tent of the obtained extractive ***-Performance Liquid Chromatography–High-Resolution Mass Spectrometry(UHPLC-HRMS)analyses showed the inﬂuence of extraction parameters on the nature of the extracted *** extracts(from ethyl acetate maceration)showed good anti-fungal and anti-termite ***,the concentration in extractives had an impact on the anti-termite activity level for Reti-culitermesﬂavipes and Cryptotermes *** based on W

关键词： Anti-fungal and anti-termite activities conferred durability extractives French Guiana impregnation guianese species wood by-products

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Single-atom“surgery”on chiral all-dialkynyl-protected superatomic silver nanoclusters

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Science Bulletin 2025年第3期70卷 365-372页

作者： Chengkai Zhang Wei-Dan Si Wei-Dong Tian Wan-Jun xiao Zhi-Yong Gao Zhi Wang Chen-Ho Tung Di Sun School of Chemistry and Chemical Engineering State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

the manipulation of single atom within the metallic kernel of nanoclusters has attracted considerable attention due to its potentials to elucidate kernel-based structure-property relationships at the single-atom ***,new-designed chiral bialkynyl ligands,have been chosen as protective agents to isolate two pairs of 8-electron superatomic silver nanoclusters,R/S-Ag39 and R/S-Ag40.X-ray diffraction analysis reveals that Ag39 and Ag40 with the same number of chiral ligands,possess a closely analogous silver skeleton but a single-atomic *** incorporation of an extra Ag40th atom into Ag40 evokes two significant changes of structure and property compared to Ag39:(i)a reduction in the symmetry of the entire nanocluster,resulting in an enhancement of kernel-related asymmetry g-factor;(ii)a regulation of the transitions(1P→1D and Ligand(π)→1D)of excited state,leading to a second near-infrared(NIR-II,1000-1700 nm)phosphorescent emission red-shift from 1088 to 1150 *** work not only provides vital insights into the relationship between structures and ground/excited states chiroptical activities at the single-atom level,but also presents bialkynyl as a promising stabilizing agent for building superatomic metal nanoclusters.

关键词： Single atom manipulation Chiral bialkynyl ligands Superatomic silver nanoclusters NIR-Il phosphorescence

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区域综合防空C^3I仿真系统的设计及实现

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系统仿真学报 2003年第2期15卷 208-211页

作者：毛少杰李玉萍居真奇乔晓中国电子科技集团公司第二十八所南京210007

防空C3I系统是构成区域防空作战体系的核心,是综合发挥各种防空作战武器效能和确保制空权的关键。因此,有关防空C3I系统的仿真一直是军用仿真领域的研究热点。本文根据系统体系结构设计思想,从功能结构、物理结构和操作结构三个方面对防... 详细信息

防空C3I系统是构成区域防空作战体系的核心,是综合发挥各种防空作战武器效能和确保制空权的关键。因此,有关防空C3I系统的仿真一直是军用仿真领域的研究热点。本文根据系统体系结构设计思想,从功能结构、物理结构和操作结构三个方面对防空C3I仿真系统进行设计,仿真的功能包括预警探测、通信、电子战、航空兵作战指挥与控制、地面防空作战指挥与控制、武器交战等主要功能环节,体现了现代防空作战一体化的特点。仿真模型采用了结构化仿真和半实物仿真相结合的建模方法,并对其中的一些关键模型及算法进行了介绍。

关键词：区域综合防空C^3I仿真系统设计结构化仿真建模防空武器系统

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Investigating Biological Relationships in Burkina Faso Using DNA Testing

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American Journal of Molecular Biology 2025年第1期15卷 97-109页

作者： Bapio Valérie Elvira Jean Télesphore Bazie Moussa Ouattara Serge théophile Soubeiga Abdou Azaque Zoure Prosper Bado Abel Sorgho Touwendpoulimdé Isabelle Kiendrebeogo Lassina Traore Soumaïla Sawadogo Luc Zongo théodora M. Zohoncon Florencia W. Djigma théophane Albert T. Yonli Mahamoudou Sanou Jacques Simpore Centre de Recherche Biomolculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Universit Joseph KI-ZERBO Unit de Formation en Sciences de la Vie et de la Terre Laboratoire de Biologie Molculaire et de Gntique (LABIOGENE) Ouagadougou Burkina Faso Centre National de la Recherche Scientifique et Technologique (CNRST) Institut de Recherche en Sciences de la Sant (IRSS) Ouagadougou Burkina Faso Faculty of Health Sciences University Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso Centre Hospitalier Universitaire Pdiatrie Charles De Gaulle Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso

DNA testing for biological relationships is becoming increasingly common in Burkina Faso. STR analysis remains the most reliable technique for resolving disputes or claims in court regarding biological relationships. this study aimed to establish the links of biological relationships between subjects by analyzing 21 STR loci. the participants were 14 individuals referred to CERBA by the Justice in 2022. Oral or blood samples were taken for each subject. DNA was extracted, and the analysis of DNA polymorphism by PowerPlex® 21 Kit (Part No. DC8902) was performed by capillary electrophoresis on the ABI PRISM 3130 sequencer. DNA profiles were compiled using the GeneMapper IDX software version 1.2. Of the fourteen subjects examined, twelve of these samples had complete genetic profiles, while the other two had partial and absent profiles. the results confirmed the inclusion of three cases of Paternity, one case of maternity, one case of a relationship of brotherhood, and the exclusion of one case of maternity and one case of a relationship of brotherhood. DNA tests improve the resolution of filiations, but they require ethical and cultural awareness and a strengthened legal framework to prevent and protect society.

关键词： DNA STR Identification Genetic Fingerprint Burkina Faso

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Evaluation of Diagnostic Performance of a Multiplex RT-qPCR Method for Detecting DENV Serotypes and CHIKV in Clinical Samples, Ouagadougou, Burkina Faso

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Journal of Biosciences and Medicines 2025年第1期13卷 13-20页

作者： Michel Kiréopori Gomgnimbou Louis Robert W. Belem Boukandou Passi L. Mongo Shoukrat O. T. Bello Armel Moumouni Sanou Albert théophane Yonli théodora Mahoukèdè Zohoncon Jacques Simpore Equipe Biologie Molculaire et Biotechnologies Laboratoire de Recherche Centre MURAZ Institut National de Sant Publique Bobo-Dioulasso Burkina Faso Centre dExcellence Africain en Innovations Biotechnologiques pour lElimination des Maladies Transmission Vectorielle (CEA/ITECH-MTV) Universit Nazi BONI Bobo-Dioulasso Burkina Faso Institut Suprieur des Sciences de la Sant (IN.S.SA) Universit Nazi BONI Bobo-Dioulasso Burkina Faso Centre de Recherche Biomolculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Recherche sur les Maladies Infectieuses et Parasitaire (LR-MIP) Institut de Recherche en Science de la Sante Bobo-Dioulasso Burkina Faso Laboratoire de Biologie Molculaire et de Gntique (LABIOGENE) UFR/SVT Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso Facult de Mdecine Universit Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso

Introduction: Arbovirus diseases such as dengue and chikungunya threaten public health worldwide. Early and rapid diagnosis and surveillance of dengue virus (DENV) and chikungunya virus (CHIKV) infections are essential to the control of these diseases. In this study, we evaluate the diagnostic performance of our new in-house multiplex RT-qPCR method for detecting DENV serotypes and CHIKV in an external laboratory. Methodology: the evaluation study was conducted on 200 clinical samples of suspected patients for arbovirus disease infection, collected in Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso. Our new multiplex RT-qPCR was compared to the commercial kit, the Zika, Dengue, and Chikungunya (ZDC) Real-Time PCR Assays kit (Bio-Rad, California, USA). Results and Conclusions: Among 200 samples, 21.5% (43/200) were DENV-positive by multiplex RT-qPCR, and 21.5% (43/200) were also DENV-positive by reference real-time RT-PCR. 157 (78.5%) samples tested negative for DENV by both tests (new mRT-qPCR and reference test). the sensitivity and specificity of mRT-qPCR were 100%. the DENV serotypes detected were DENV-1 60.5% (26/43) and DENV-3 39.5% (17/43). CHIKV was not detected in this study. Our new mRT-qPCR is sensitive, cost-effective, simple, and can be used in developing country laboratories.

关键词： Evaluation Multiplex RT-qPCR Dengue Virus Chikungunya Burkina Faso

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Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang xiao-Hui Yu Shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo xiao-Mei Zhang Yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** this multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.the majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

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Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing Jiang Lu Wu xiao Yang Yu Pu Bing-Jie Ning Na Peng xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).this drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

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Reconstructing fossil insect communities and palaeoclimates for the Middle Jurassic Yanliao Biota in the Daohugou area of China

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Science Bulletin 2025年第2期70卷 176-179页

作者： Liang Chen Lifang xiao Shilong Guo Nan Yang Conrad C.Labandeira Chungkun Shih Chaofan Shi Dong Ren College of Life Sciences Capital Normal UniversityBeijing 100048China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou 510260China Department of Paleobiology National Museum of Natural HistorySmithsonian InstitutionWashingtonDC 20013USA Department of Entomology University of MarylandCollege ParkMD 20742USA School of Earth Sciences and Engineering Guangdong Provincial Key Lab of Geological Processes and Mineral ResourcesSun Yat-sen UniversityGuangzhou 510275China

Palaeoecological research is essential to understanding the interaction between organisms and their environment during the evolutionary ***,the study of fossil insect communities is challenging because of a limited fossil record and the unavailability of data,which makes it difficult to assess the associations of insects with their environment,especially the role of local climate.

关键词： Jurassic Middle process.

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