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Differences in and factors controlling organic matter enrichment in the Ziliujing Formation shale in the Sichuan Basin

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Petroleum Science 2024年第1期21卷 77-86页

作者： Peng Li Zhong-Bao Liu He Bi Tao Jiang Rui-Kang Bian Peng-Wei Wang xiao-Yu shang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Efficient Development Beijing102206China Key Laboratory of Shale Oil/Gas Exploration and Production Technology SINOPECBeijing102206China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China Chinese Academy of Geological Sciences Beijing100037China No.4 Oil Production Plant in Daqing Oilfield Co Ltd. Daqing163511HeilongjiangChina

Lacustrine shale oil and gas are important fields for unconventional exploration and development in China,and organic-rich shale deposition lays down the critical foundation for hydrocarbon *** are two sets of shale,the Dongyuemiao and Da’anzhai Members,in the Ziliujing Formation in the Sichuan *** identify the differential enrichment characteristics of organic matter and clarify its controlling factors,geochemical analyses of organic and inorganic geochemical analyses were *** results showed that the total organic carbon content of the Dongyuemiao shale(1.36%)is slightly higher than that of the Da’anzhai shale(0.95%).The enrichment of organic matter in the two shales resulted from the comprehensive controls of paleoproductivity,paleoenvironment,and terrigenous input,but different factors have different *** addition,driven by climate,the change in the sulfate concentration in the bottom water further led to the different intensities of bacterial sulfate reduction in early *** made a great difference regarding organic matter accumulation in the two *** general,climate may have played a dominant role in organic matter enrichment in the two sets of shale.

关键词： Lacustrine shale Ziliujing Formation Sichuan Basin Enrichment mechanism of organic matter

Investigation on the mechanism of Qiangxinhuoli prescription in the treatment of chronic heart failure based on p38-MAPK signaling pathway

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Traditional Medicine Research 2024年第7期9卷 13-24页

作者： Di Guo Qiu-Han Zheng Di Wang Zhi Pan xiao-Ling shang College of Basic Medicine Changchun University of Chinese MedicineChangchun 130117China. Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130117China.

Background:The aim of this study is to investigate the mechanism of action underlying the therapeutic effects of the national patent Chinese medicine compound“Qiangxinhuoli prescription(QXHLF)”on chronic heart failure(CHF).Methods:In vitro,the H_(9)C_(2) cell model was induced by ANGII,and cell proliferation and related protein expression were detected by Cell Counting Kit-8 and Western *** vivo,A rat model of CHF was prepared by ligation of the left anterior descending coronary *** effects of QXHLF on cardiac function in CHF rats were evaluated by cardiac index,hemodynamic changes,enzyme-linked immunosorbent assay,hematoxylin-eosin staining,immunohistochemistry,Western blot and *** expression of pro-apoptotic factors and anti-apoptotic factors,as well as TGFβ1,p-p38,TAK 1 mRNA,and protein,were ***:In vitro,QXHLF has a significant inhibitory effect on the proliferation of H_(9)C_(2) *** can reduce the expression levels of TAK 1,TGFβ1,p-p38,Caspase3 and BAX proteins in H_(9)C_(2) cells,and increase the expression level of BCL_(2) *** vivo,QXHLF has the potential to increase left ventricular systolic pressure,m aximum rate of change in left ventricular pressure while decreasing left ventricular end diastolic pressure,and inhibiting the serum levels of brain natriuretic ***,QXHLF exhibits significant improvements in the pathological alterations of myocardial cells and fibers in CHF rats,leading to enhanced myocardial tissue morphology and notable advantages in combating myocardial *** can reduce the levels of BAX and Caspase3 and up-regulate the expression of BCL_(2),thereby inhibiting cardiomyocyte ***,QXHLF demonstrates inhibitory effects on the mRNA and protein expression levels of TGFβ_(1),TAK_(1),and p-p38 in the heart tissue of the CHF rat ***:These findings indicate that QXHLF has a therapeutic effect on CHF by inhibiting the p38-MAPK signaling pathway,reducing m

关键词： chronic heart failure Qiangxinhuoli prescription p38MAPK pathway H_(9)C_(2) Action mechanism

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袁世凯“逼迫清帝退位”说献疑

史学集刊 2024年第1期 4-25页

作者：尚小明北京大学历史学系北京100871

辛亥鼎革时期的袁世凯并没有在理念上经历从君主立宪到民主共和的转变。出于维系多民族国家统一、社会安定及自身利益考虑,袁氏实际上是想造成虚君共和。他首先坚持以十九信条为宗旨,力图主导国民会议之组织,以防唐绍仪和伍廷芳会谈所... 详细信息

辛亥鼎革时期的袁世凯并没有在理念上经历从君主立宪到民主共和的转变。出于维系多民族国家统一、社会安定及自身利益考虑,袁氏实际上是想造成虚君共和。他首先坚持以十九信条为宗旨,力图主导国民会议之组织,以防唐绍仪和伍廷芳会谈所定国民会议方案造成民主共和结果。接着因南京临时政府建立及国民会议商谈走进死胡同,他又意图由清廷授权其组织临时政府,以取消南京临时政府。为此他采取了模棱两可的策略,一方面劝导清廷“速定大计”,改建共和,使南方以为清帝将要退位,另一方面在预拟的相关诏书中竭力避用“退位”一类字眼,并试图将由其“全权组织临时政府”写入诏书。在遭到满蒙亲贵和革命党两方反对后,袁氏转而依靠段祺瑞等北洋将领联衔电奏,要求“立定共和政体,以巩皇位而定大局”,仍未放弃清帝。在得到与南方协商皇室优待条件的授权以后,袁氏奉旨反复拒绝将“逊位”二字写入诏书,主张改用“辞政”。因南方坚决反对虚君共和,袁氏才不得不于最后时刻经清廷授权,同意南方的提议,以“辞位”替代“逊位”。一系列史实证明,所谓袁氏“逼迫清帝退位”的说法是不能成立的。这种观点实际上放大了袁氏对推翻帝制和建立共和的贡献,而真正要逼迫清帝退位的,其实是革命党人和那些转向民主共和的立宪派人士。

关键词：辛亥南北议和袁世凯虚君共和民主共和段祺瑞清帝退位诏书

Uncovering Chemical Interactions between Danshen and Danggui Using Liquid Chromatography–Mass Spectrometry and Network Pharmacology-Based Research on Stroke

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 230-243页

作者： Han-Qing Pang Jia-Xiu Guo xiao-Yu shang Jian Wang Hui Liu Jing Tian Lu Zhang Jian-Bin Wang Wei Shi Bing-Chun Yan Liang Liu Department of Pharmacy School of MedicineInstitute of Translational MedicineYangzhou UniversityYangzhouChina School of Medicine Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile DiseasesYangzhou UniversityYangzhouChina School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University)GuilingChina Yangzhou Food and Drug Inspection and Testing Center YangzhouChina

Objective: The objective of this study was to decipher chemical interactions between Danshen and Danggui using liquid chromatography–mass spectrometry(LC-MS) and explore the mechanisms of Danshen–Danggui against stroke using network pharmacology and molecular docking. Materials and Methods: First, the chemical compounds of Danshen–Danggui were profiled using ultra-high-performance liquid chromatography(HPLC)-quadrupole time-of-flight MS. Accurately characterized compounds in various proportions of Danshen–Danggui were quantified using HPLC combined with triple quadrupole electrospray tandem MS. Network pharmacology was used to uncover the essential mechanisms of action of Danshen–Danggui against stroke. Discovery Studio Software was used for the molecular docking verification of key active chemicals and stroke-related targets. Results: A total of 53 compounds were characterized, and 22 accurately identified constituents(10 phenolic acids, 8 phthalides, and 4 tanshinones) were quantified in 15 proportions of Danshen–Danggui. The quantification results showed that Danggui significantly increased the dissolution of most phenolic acids(compounds from Danshen), whereas Danshen promoted the dissolution of most phthalides(compounds from Danggui). Overall, the combination of Danshen and Danggui at a 1:1 ratio resulted in the maximum total dissolution rate. Further network pharmacology and molecular docking results indicated that Danshen–Danggui exerted anti-stroke effects mainly by regulating inflammation-related(tumor necrosis factor, hypoxia-inducible factor, and toll-like receptor) signaling pathways, which ranked among the top three pathways based on Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Conclusion: The chemical compounds in Danshen–Danggui could interact with each other to increase the dissolution of the most active compounds, which could provide a solid basis for uncovering the compatibility mechanisms of Danshen–Danggui and Danshen–Danggu

关键词： Chemical interactions Danggui Danshen liquid chromatography–mass spectrometry network pharmacology

葡萄扩展蛋白家族全基因组分析及VvEXPA27功能研究

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农业生物技术学报 2024年第4期32卷 762-774页

作者：张建鹏尚霄丽濮阳职业技术学院

果粒大小是决定葡萄(Vitis vinifera)外观品质与产量的重要因素之一，细胞膨大对于决定葡萄果实最终大小至关重要。扩展蛋白(expansin, EXP)是细胞壁松弛蛋白，通过破坏细胞壁中纤维素微纤维和相关基质多糖之间的非共价键促进细胞膨大... 详细信息

果粒大小是决定葡萄(Vitis vinifera)外观品质与产量的重要因素之一，细胞膨大对于决定葡萄果实最终大小至关重要。扩展蛋白(expansin, EXP)是细胞壁松弛蛋白，通过破坏细胞壁中纤维素微纤维和相关基质多糖之间的非共价键促进细胞膨大。本研究以’黑比诺PN40024’基因组为参考，基于Pfam数据库采用HMMER对葡萄扩展蛋白家族成员进行全基因组鉴定，剔除冗余序列后，共筛到31个成员。通过生物信息学分析筛选到两个候选基因VvEXPA06和VvEXPA27。RT-qPCR结果显示，VvEXPA06仅在花后20 d上调表达，VvEXPA27在花后20和48 d均上调表达。将VvEXPA27进行拟南芥(Arabidopsis thaliana)异源表达，并对其转基因植株进行功能验证。结果表明，与对照组相比，过表达VvEXPA27的T3代纯合转基因拟南芥的第3片叶的细胞面积、果荚长度和莲座叶直径均明显增加，表明VvEXPA27在细胞膨大过程中起到积极的作用。本研究为解析葡萄果实细胞膨大的分子机制提供理论参考，为其分子育种提供基因资源。

关键词：葡萄果实膨大生物信息学扩展蛋白

Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min Liu Hai-Lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-xiao shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao xiao-Yan Dong Dao-Jiong Lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen Li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

Dielectric anisotropy in liquid crystal mixtures with nematic and smectic phases

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Chinese Physics B 2024年第8期33卷 519-524页

作者：汤星舟叶家耀王子烨姜皓译尚小虎杨朝雁李炳祥 Nanjing University of Posts and Telecommunications College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology)Nanjing 210023China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

The modulation of dielectric anisotropy(△ε)is pivotal for elucidating molecular interactions and directing the alignment of liquid *** this study,we combine liquid crystals with opposing dielectric anisotropies to explore the impact of varying concentrations on their *** report the sign-reversal of△εin both the nematic and smectic A phases of these mixed liquid crystals,alongside a dual-frequency behaviour across a broad temperature *** research further quantifies the influence of mixture ratios under various temperatures and electric field *** exploration may pave the way for the discovery of new physical phenomena.

关键词： mixed liquid crystal dielectric anisotropy tunable nematic smectic

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基于网络文本的昆明市城市公园感知研究

科技和产业 2024年第3期24卷 119-125页

作者：肖上区智西南林业大学园林园艺学院昆明650224

以昆明市的27个城市公园为例,采集社交网络平台中的使用后评价文本,基于内容分析法,结合ROST Content Mining和Excel软件对评价文本数据进行高频词统计、语义网络分析、情感倾向和统计分析,定性与定量结合地对昆明市城市公园游憩感知因... 详细信息

以昆明市的27个城市公园为例,采集社交网络平台中的使用后评价文本,基于内容分析法,结合ROST Content Mining和Excel软件对评价文本数据进行高频词统计、语义网络分析、情感倾向和统计分析,定性与定量结合地对昆明市城市公园游憩感知因子进行总结归类。结果显示,公园出行主要集中在气候适宜的节假日,不同功能类型的公园构成要素的关注度各有差异,其中自然环境因素和服务管理水平的关注度最高,社会环境因素的整体感知度较低,消极倾向评论中对服务管理设施有较高提及率。最后根据游客的真实感受从环境规划设计、人文景观营造和服务设施水平3个方面提出提升建议。

关键词：城市公园公园感知网络文本

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艾叶的提取工艺及其在动物生产的应用

饲料研究 2024年第8期47卷 182-185页

作者：尚泽正尚晓丹张瑞李淑怡白莹河北工程大学生命科学与食品工程学院河北邯郸056038

艾叶是一种多年生菊科草本植物,具有安胎止血、散寒排湿等作用。艾叶中含有蛋白质、脂肪、维生素、矿物质元素等营养成分,具有抗菌、抗炎、抗氧化等多种功效。艾叶作为饲料添加剂可提升动物的生长性能和免疫功能,改善动物产品的品质,因... 详细信息

艾叶是一种多年生菊科草本植物,具有安胎止血、散寒排湿等作用。艾叶中含有蛋白质、脂肪、维生素、矿物质元素等营养成分,具有抗菌、抗炎、抗氧化等多种功效。艾叶作为饲料添加剂可提升动物的生长性能和免疫功能,改善动物产品的品质,因此艾叶及其活性成分发挥相关功能的分子机制值得深入研究。文章综述了艾叶活性成分的提取工艺、在动物生产中的应用及其作用机制,为艾叶合理地应用于动物生产提供参考。

关键词：艾叶活性成分提取工艺动物养殖分子机制

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