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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai Chen Dan Liu qian xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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Potential Distribution on Random Electrical Networks

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 549-559页

作者： Da-qian qian xiao-dong Zhang Department of Mathematics Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China

Let N = （G, c） be a random electrical network obtained by assigning a certain resistance for each edge in a random graph G ∈ G（n, p） and the potentials on the boundary vertices. In this paper, we prove that with ... 详细信息

关键词： Electrical network potential distribution random graphs

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Three-dimensional coordinates test method with uncertain projectile proximity explosion position based on dynamic seven photoelectric detection screen

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Defence Technology（防务技术） 2022年第9期18卷 1643-1652页

作者： Han-shan Li xiao-qian Zhang School of Electronic and Information Engineering Xi'an Technological UniversityXi'an710021China

To objectively obtain the three-dimensional coordinates of the projectile fuze proximity explosion when projectile intersects the head of missile target, we propose a dynamic seven photoelectric detection screen test method, which is made up of six plane detection screens and a flash photoelectric dynamic detection screen. The three-dimensional coordinates calculation model of the projectile proximity explosion position based on seven plane detection screens with dynamic characteristics is *** to the relation of the dynamic seven photoelectric detection screen planes and the time values,the analytical function of the projectile proximity explosion position parameters under non-linear motion is derived. The projectile signal filtering method based on discrete wavelet transform is explored in this work. Additionally, the projectile signal recognition algorithm using an improved particle swarm is proposed. Based on the characteristics of the time duration and the signal peak error for the projectile passing through the detection screen, the signals attribution of the same projectile passing through six detection screens are analyzed for obtaining precise time values of the same projectile passing through the detection screens. On the basis of the projectile fuze proximity explosion test, the linear motion model and the proposed non-linear motion model are used to calculate and compare the same group of projectiles proximity explosion position parameters. The comparison of test results verifies that the proposed test method and calculation model in this work accurately obtain the actual projectile proximity explosion position parameters.

关键词： Dynamic multi-screen array plane Flash photoelectric detection target Projectile signal processing Particle swarm Proximity explosion fuze Three-dimensional coordinate

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Flight parameter calculation method of multi-projectiles using temporal and spatial information constraint

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Defence Technology（防务技术） 2023年第1期19卷 63-75页

作者： Han-shan Li xiao-qian Zhang School of Electronic and Information Engineering Xi'an Technological UniversityXi'an710021China

The dynamic parameters of multiple projectiles that are fired using multi-barrel weapons in highfrequency continuous firing modes are important indicators to measure the performance of these *** characteristics of multiple projectiles are high randomness and large numbers launched in a short period of time,making it very difficult to obtain the real dispersion parameters of the projectiles due to the occlusion or coincidence of multiple *** six intersecting-screen testing system,in this paper,we propose an association recognition and matching algorithm of multiple projectiles using a temporal and spatial information constraint *** extract the output signal from each detection screen and then use the wavelet transform to process the output *** present a method to identify and extract the time values on which the projectiles pass through the detection screens using the wavelet transform modulus maximum *** then use the correlation of the output signals of three parallel detection screens to establish a correlation coefficient recognition constraint function for the multiple *** on the premise of linear projectile motion,we establish a temporal and spatial constraint matching model using the projectile’s position coordinates in each detection screen and the projectile’s time constraints within the multiple intersecting-screen *** then determine the time values of the multiple projectiles in each detection screen using an iterative search cycle registration,and finally obtain the flight parameters for the multiple projectiles in the presence of *** proposed method and algorithm were verified experimentally and can solve the problem of uncertainty in projectiles flight parameter under different multiple projectile firing states.

关键词： Six detection screen array Multi-projectile Recognition and matching Temporal and spatial information constraint Wavelet transform

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Multi-area detection sensitivity calculation model and detection blind areas influence analysis of photoelectric detection target

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Defence Technology（防务技术） 2022年第4期18卷 547-556页

作者： Han-shan Li xiao-qian Zhang Hui Guan School of Electronic and Information Engineering Xi’an Technological UniversityXi’an710021China

Multi-element array photoelectric detector is the core devices to form a photoelectric detection target with a large field of *** photoelectric detection target brings about the problem of uneven detection sensitivity distribution in the detection *** improve the uneven detection sensitivity of this photoelectric detection target,this paper analyzes the distribution law of the uneven detection sensitivity of the photoelectric detection target using the multi-element array photoelectric detector,dissects the main factors affecting the detection sensitivity according to the photoelectric detection principle,establishes the calculation model of detection sensitivity of the photoelectric detection target in the different detection areas and proposes a method to improve the detection sensitivity by compensating the gain of each unit photoelectric *** analysis of simulation and experimental results show that the proposed method of photoelectric detection target can effectively improve the output signal amplitude of the projectile under the certain detection distance,in particular,the output signal amplitude of the projectile is significantly increased when the projectile passes through the detection blind *** experimental results are consistent with the simulation results,which verify the effectiveness of the proposed improvement method.

关键词： Projectile Photoelectric detection target Multi-element array photoelectric detector Detection sensitivity Detection screen

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Squeezing Transformation of Three-Mode Entangled State

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Communications in Theoretical Physics 2005年第5X期44卷 911-916页

作者： qian xiao-Qing SONG Tong-qiang Department of Physics Ningbo University Ningbo 315211 China

We introduce the three-mode entangled state and set up an experiment to generate it. Then we discuss the three-mode squeezing operator squeezed ｜p, X2, X3〉→μ^-3/2｜p/μ, X2/μ, X3/μ） and the optical implement to realize such a squeezed state. We also reveal that c-number .asymmetric shrink transform in the three-mode entangled state, i.e. ｜p, X2,X3）→μ^-1/2｜p/μ, X2,X3）, maps onto a kind of one-sided three-mode squeezing operator {iλ （∑i^3=1 Pi）（∑i^3=1 Qi） -λ/2}. Using the technique of integration within an ordered product （IWOP） of operators, we derive their normally ordered forms and construct the corresponding squeezed states.

关键词： three-mode entangled state c-number asymmetric shrink transform one-sided three-mode squeezing operator

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Hyposmia: a possible biomarker of Parkinson's disease

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Neuroscience Bulletin 2014年第1期30卷 134-140页

作者： qian xiao Sheng Chen Weidong Le Institute of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Institutes of Translational Medicine 1st Affiliated Hospital of Dalian Medical Universtiy

Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson＇s disease （PD） that antedates the typical motor symptoms by several years. It occurs in -90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.

关键词： hyposmia Parkinson's disease olfaction biomarker

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General Regular Variation of n-th Order and the 2nd Order Edgeworth Expansion of the Extreme Value Distribution (Ⅰ)

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Acta Mathematica Sinica,English Series 2005年第5期21卷 1121-1130页

作者： xiao qian WANG Shi Hong CHENG School of Mathematical and Computer Science Nanjing Normal University Nanjing 210097 P. R. China School of Mathematical Sciences Peking University Beijing 100871 P. R. China

In Part Ⅰ the concept of the general regular variation of n-th order is proposed and its construction is discussed. The uniqueness of the standard expression and the higher order regularity of the auxiliary functions... 详细信息

关键词： General regular variation Extreme value distribution Edgeworth expansion

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Bounding the sum of powers of the Laplacian eigenvaluesof graphs

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Applied Mathematics(A Journal of Chinese Universities) 2011年第2期26卷 142-150页

作者： CHEN xiao-dan qian Jian-guo School of Mathematical Sciences Xiamen University Xiamen 361005 Fujian P.R. China

For a non-zero real number α, let sα（G） denote the sum of the αth power of thenon-zero Laplacian eigenvalues of a graph G. In this paper, we establish a connection betweensα（G） and the first Zagreb index in which the H¨older’s inequality plays a key role. By usingthis result, we present a lot of bounds of sα（G） for a connected （molecular） graph G in terms ofits number of vertices （atoms） and edges （bonds）. We also present other two bounds for sα（G）in terms of connectivity and chromatic number respectively, which generalize those results ofZhou and Trinajsti′c for the Kirchho？ index [B Zhou, N Trinajsti′c. A note on Kirchho？ index,Chem. Phys. Lett., 2008, 455： 120-123].

关键词： Laplacian eigenvalues the first Zagreb index Kirchhoff index connectivity chromatic number.

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Experimental and numerical investigation of the impacts of rotor tip-rake on excitation forces of pump-jet propulsors

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Journal of Hydrodynamics 2024年第1期36卷 142-157页

作者： Xue-qin Ji xiao-song Zhang Chen-jun Yang xiao-qian Dong State Key Laboratory of Ocean Engineering Marine Numerical Experiment CentreSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China CSSC Shanghai Marine Energy Saving Technology Co. Ltd.Shanghai200011China China Ship Scientific Research Center Shanghai Branch Shanghai200011China

The tip-clearance flow in a pump-jet propulsor exerts great impacts on the fluctuating pressures and resultant unsteady forces,which are important sources of structural vibrations and radiated noise *** blade geometry close to the tip is an important factor determining the vortex strength in the tip-clearance *** the open-water condition,the effects of raking the rotor tips on the duct-surface fluctuating pressures and the resultant unsteady forces acting on different components of the propulsor are investigated via physical model experiments and the numerical solution of Reynolds-averaged Navier-Stokes(RANS)equations coupled with the SST k-ωturbulence *** measured and simulated results of hydrodynamic pressures are consistent to each other,and the simulated flows help better understand why the fluctuating pressures change with the tip *** strong fluctuations of duct-surface pressures are caused by intensive tip separation *** duct-surface pressure fluctuations are effectively reduced by using the rake distribution near the tip towards blade back side and,for the combination of the five-bladed rotor and the seven-bladed stator,the resultant unsteady horizontal(and vertical)forces acting on the duct and stator are also reduced;while increasing rake leads to negative effect on pressure fluctuations and unsteady horizontal(and vertical)forces acting on all the components of the propulsor.

关键词： Pump-jet tip-clearance tip-rake fluctuating pressures excitation forces

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