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Effects of Photodynamic Therapy on Nav1.7 Expression in Spinal Dorsal Root Ganglion Neurons

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Current Medical Science 2022年第6期42卷 1267-1272页

作者： Dong-xu ZOU xiao-zhen li Hong CAI Medical School of Chinese PLA Beijing100853China Department of Dermatology Air Force Medical CenterPLABeijing100142China

Objective The aim of this study was to examine the effects of photodynamic therapy(PDT)on the expression of Nav1.7 in spinal dorsal root ganglion(DRG)*** The primary DRG neurons from newborn SD rats were *** cells were identified by neuron-specific enolase immunofluorescence *** neurons were divided into four groups:control group,photosensitizer group,laser group,and PDT *** cell viability was detected by a cell counting kit-8(CCK8)***-PCR and Western blotting were used to determine the mRNA and protein expression levels of Nav1.7 in DRG *** The purity of the cultured primary DRG neurons was greater than 90%.Compared with the control group,no significant change was found in the cell viability of the photosensitizer group,while the viability in the laser group and the PDT group was significantly *** mRNA and protein expression levels of Nav1.7 were significantly greater in the laser group and the PDT group than in the control *** the same time,the mRNA and protein expression levels of Nav1.7 were greater in the laser group than in the PDT *** Both laser and PDT could upregulate the expression of Nav1.7 in DRG neurons,and the promoting effect might be related to the pain induced by clinical *** study provides a research basis for the use of laser and PDT to treat pain.A better understanding of the relationship between Nav1.7 and PDT can help clinicians better manage PDT-related pain.

关键词： photodynamic therapy pain dorsal root ganglion Nav1.7 laser

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配合饲料混合均匀度3种测定方法的比较分析

饲料研究 2024年第7期47卷 110-115页

作者：唐连英李晓珍吴志艳郑永凤王迪李琦华鲁琼芬云南农业大学动物科学技术学院云南昆明650201 云南西南农牧集团股份有限公司云南昆明650224 云南省动物营养与饲料重点实验室云南昆明650201

试验旨在对3种(甲基紫法、摩尔法、氯离子选择电极法)测定饲料混合均匀度的方法进行分析比较,为饲料企业选择测定方法提供参考。试验选用仔猪前期配合饲料、乳猪浓缩饲料、中猪配合饲料、肉鸡前期料、肉鸡中期料和肉鸡后期料6种饲料,每... 详细信息

试验旨在对3种(甲基紫法、摩尔法、氯离子选择电极法)测定饲料混合均匀度的方法进行分析比较,为饲料企业选择测定方法提供参考。试验选用仔猪前期配合饲料、乳猪浓缩饲料、中猪配合饲料、肉鸡前期料、肉鸡中期料和肉鸡后期料6种饲料,每种饲料采集两个批次,共计120个样本,采用甲基紫法、摩尔法、氯离子选择电极法测定饲料的混合均匀度。结果显示:氯离子选择电极法测定的6种饲料混合均匀度变异系数(CV)均在国家标准允许范围10.00%以下,甲基紫法测定结果除中猪配合饲料以外,其余5种饲料均小于10.00%;摩尔法测定的3种猪饲料的混合均匀度均小于10.00%,3种鸡饲料混合均匀度均大于10.00%。用甲基紫法测定的中猪配合饲料的混合均匀度变异系数显著大于氯离子选择电极法(P<0.05);用摩尔法测定的肉鸡前期料和中期料混合均匀度的变异系数均显著大于甲基紫法和氯离子选择电极法(P<0.05);用摩尔法测定肉鸡后期料混合均匀度的变异系数显著大于甲基紫法和氯离子选择电极法(P<0.05),甲基紫法测定肉鸡后期料混合均匀度显著大于氯离子选择电极法(P<0.05)。研究表明,使用氯离子选择电极法测定6种饲料混合均匀度的效果较好。

关键词：饲料混合均匀度甲基紫法摩尔法氯离子选择电极法

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Optimal indicator for changing the filter during the continuous renal replacement therapy in intensive care unit patients with acute kidney injury:A crossover randomized trial

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World Journal of Emergency Medicine 2022年第3期13卷 196-201页

作者： Cheng Hang li-jun liu Zhao-yun Huang Jian-liang Zhu Bao-chun Zhou xiao-zhen li Intensive Care Unit Kunshan Hospital of TCMSuzhou 215300China Intensive Care Unit the Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

BACKGROUND:The study aims to investigate an optimal indicator for changing the filter during the continuous renal replacement therapy(CRRT)in intensive care unit(ICU)patients with acute kidney injury(AKI).METHODS:Patients with AKI requiring CRRT in an ICU were randomly divided into two groups for crossover trial,i.e.,groups A and *** in the group A were firstly treated with continuous veno-venous hemofiltration(CVVH),followed by continuous veno-venous hemodiafiltration(CVVHDF).Patients in the group B were firstly treated with CVVHDF followed by *** doses of solutes with different molecular weights at the indicated time points between groups were compared.A correlation analysis between the delivered dose and pre-filter pressure(P_(PRE))and transmembrane pressure(P_(TM))was *** operating characteristic(ROC)curves were constructed to evaluate the accuracy of P_(TM) as an indicator for filter ***:A total of 50 cases were analyzed,27 in the group A and 23 in the group *** doses of different molecular-weight solutes significantly decreased before changing the filter in both modalities,compared with those at the initiation of treatment(all Plivered dose of medium-molecular-weight solute in both *** threshold for predicting the rebound of serum concentration of medium-molecularweight solute by P_(TM) was 146.5 mm Hg(1 mm Hg=0.133 k Pa).CONCLUSIONS:The filter can be used as long as possible within the manufacturer’s safe use time limits to remove small-molecular-weight solutes.P_(TM) of 146.5 mm Hg may be an optimal indicator for changing the filter in CRRT therapies to remove medium-molecular-weight solutes.

关键词： Acute kidney injury Continuous renal replacement therapy Solute removal efficiency Delivered dose

一种基于低温共烧陶瓷技术的一分二功率分配器设计方法

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化工自动化及仪表 2024年第2期51卷 192-198,364页

作者：胡雨婷侯明李小珍徐开心张杨昆明理工大学信息工程与自动化学院昆明学院信息工程学院

从小型化的要求出发,提出一种一分二等分功率分配器设计方法。以Wilkinson功率分配器结构为基础,将传统功率分配器中的直线型传输线改为螺旋线型传输线。采用低温共烧陶瓷(LTCC)技术进行小型化功率分配器设计,建模时利用立体叠层结构对... 详细信息

从小型化的要求出发,提出一种一分二等分功率分配器设计方法。以Wilkinson功率分配器结构为基础,将传统功率分配器中的直线型传输线改为螺旋线型传输线。采用低温共烧陶瓷(LTCC)技术进行小型化功率分配器设计,建模时利用立体叠层结构对功率分配器内部的传输线进行布局,内部不同金属层之间使用垂直通孔连接,使得该功率分配器尺寸与传统平面结构功率分配器相比大幅减小。在HFSS软件中完成三维模型建立与电磁仿真,并对设计完成的功率分配器进行加工测试,最终得到该功率分配器回波损耗优于19 dB,插入损耗优于3.5 dB,中心频率2.8 GHz处隔离度优于35 dB,具有较好的隔离度,满足一分二等分功率分配器的性能要求,并且LTCC功率分配器尺寸仅3.18 mm×1.58 mm×0.911 mm。

关键词：一分二等分功率分配器 LTCC 螺旋线结构回波损耗插入损耗中心频率隔离度

A Denoiser for Correlated Noise Channel Decoding: Gated-Neural Network

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China Communications 2024年第2期21卷 122-128页

作者： xiao li ling Zhao zhen Dai Yonggang Lei School of Electronic and Information Engineering Beihang UniversityBeijing 100191China Beijing Institute of Tracking and Telecommunications Technology BITTT

This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).

关键词： belief propagation channel decoding correlated noise neural network

A Novel Gymnosperm Wood from the Lopingian(Late Permian)in Zhangzi,Shanxi,North China and Its Paleoecological and Paleogeographic Implications

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Journal of Earth Science 2024年第1期35卷 167-176页

作者： xiao Shi Jianxin Yu Yuewu Sun zhen Xu Hui li College of Earth Sciences Jilin UniversityChangchun 130061China International Center of Future Science Dinosaur Evolution Research CenterJilin UniversityChangchun 130012China State Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of GeosciencesWuhan 430074China Research Center of Palaeontology and Stratigraphy Jilin UniversityChangchun 130026China Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang 330013China

The Permian-Triassic transition saw extreme climatic changes that severely impacted the terrestrial *** plants,particularly fossil woods,are sensitive to climatic changes,and they,therefore,are unique materials revealing extreme environmental and climatic changes on land at that *** conifer woods were discovered in the Lopingian(Late Permian)strata of the Sunjiagou Formation in Shanxi Province,North *** newly finding permineralized woods record the unique landscape of Lopingian North *** represent a new conifer genus and species:Shanxiopitys zhangziensis *** *** of growth pattern and anatomical characteristics of the fossil woods indicate these trees grew under optimal growing conditions,and without seasonal growth ***,climate signals from leaf fossils,vertebrate fossils and sedimentary evidences indicate a strongly seasonal climate in North China during the ***,it is speculated that these trees likely lived in the gallery forests,which were distributed along the paleo-rivers within a seasonal landscape in the central North China block during the Lopingian.

关键词： Shanxiopitys zhangziensis gen.et sp.nov. wood ecology geography gallery forest Lopingian North China

Large-inductance superconducting microstrip photon detector enabling 10 photon-number resolution

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Advanced Photonics 2024年第1期6卷 96-105页

作者： ling-Dong Kong Tian-Zhu Zhang xiao-Yu liu Hao li zhen Wang xiao-Ming Xie li-Xing You Chinese Academy of Sciences(CAS) Shanghai Institute of Microsystem and Information TechnologyNational Key Laboratory of Materials for Integrated CircuitsShanghaiChina CAS Center for Excellence in Superconducting Electronics ShanghaiChina University of Chinese Academy of Sciences Center of Materials Science and Optoelectronics EngineeringBeijingChina

Efficient and precise photon-number-resolving detectors are essential for optical quantum information *** this,very few detectors have been able to distinguish photon numbers with both high fidelity and a large dynamic range,all while maintaining high speed and high timing *** nanostrip-based detectors excel at counting single photons efficiently and rapidly,but face challenges in balancing dynamic range and ***,we have pioneered the demonstration of 10 true photon-number resolution using a superconducting microstrip detector,with readout fidelity reaching an impressive 98%and 90%for 4-photon and 6-photon events,***,our proposed dual-channel timing setup drastically reduces the amount of data acquisition by 3 orders of magnitude,allowing for real-time photon-number *** then demonstrate the utility of our scheme by implementing a quantum random-number generator based on sampling the parity of a coherent state,which guarantees inherent unbiasedness,robustness against experimental imperfections and environmental noise,as well as invulnerability to *** solution boasts high fidelity,a large dynamic range,and real-time characterization for photon-number resolution and simplicity with respect to device structure,fabrication,and readout,which may provide a promising avenue towards optical quantum information science.

关键词： superconducting microstrips single-photon detector photon-number resolution quantum random number

Effect of Y_(2)O_(3) on microstructure and properties of CoCrFeNiTiNb high entropy alloy coating on Ti-6Al-4V surface by laser cladding

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Journal of Rare Earths 2024年第3期42卷 586-599,I0006页

作者： zhen li Wei Zhao Kedong Yu Ning Guo Guangchun xiao Zhiming Wang Hui Zhang College of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China Shandong Institute of Mechanical Design and Research Jinan250031China

The effects of Y_(2)O_(3) on the microstructure, microhardness, wear resistance, high-temperature oxidation resistance, hot corrosion resistance, and electrochemical corrosion behaviour of CoCrFeNiTiNb high entropy alloy coatings formed on Ti-6Al-4V alloy surfaces were studied. The results show that the addition of Y_(2)O_(3) changes the proportion of the phase but does not change its type. The average grain size is only 1/4.7 of that of the high entropy alloy(HEA) coating, and the fine-grained strengthening leads to increases in the microhardness and wear resistance of 21.8% and 26.9%, respectively. The addition of Y_(2)O_(3) enhances the denseness and bonding properties of the oxide and corrosion product layers, reducing the oxidation and hot corrosion rates by 60.3% and 40.3%, respectively. The addition of Y_(2)O_(3) doubles the corrosion resistance which is attributed to the refinement of the grains, the increased proportion of HCP and TiN, and the weakening of galvanic coupling corrosion.

关键词： Laser cladding High entropy alloy coatings Rare earths Wear properties High temperature properties Electrochemical corrosion

Improving flangeability of multiphase steel by increasing microstructural homogeneity

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1736-1745页

作者： xiao-yu Yang Yong-gang Yang Xing Fang Han-long Zhang zhen-li Mi Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Engineering TechnologyUniversity of Science and Technology BeijingBeijing 100083China Shanghai Baosteel Group Corp.Technology Center Shanghai 201900China

Multiphase microstructure significantly increases the strength,usually at the expense of flangeability because of lacking microstructure *** further improve the strength-flangeability of multiphase steel,the microstructural homogeneity was advanced by adjusting the hard martensite/austenite(M/A)*** strength-flangeability was measured via uniaxial tensile tests and hole expansion *** microstructures were characterized using a scanning electron microscope equipped with an electron backscatter diffraction detector and a transmission electron *** tests were supplementally used to quantitatively reveal the microstructural homogeneity of the *** show that the adjusted multiphase steel achieves an excellent ultimate tensile strength(~800 MPa)and flangeability(~135%hole expansion ratio).A promising homogeneous multiphase microstructure was obtained by controlling undercooled austenite transformed at about 600℃.This microstructure consists of soft polygonal ferrite,blocky bainitic ferrite,and hard M/A *** volume fraction of M/A islands is around 5%,and the average size is less than l *** nanoindentation analysis indicated that the participation of M/A islands impressively influenced the microstructural *** strain partition and better mechanical compatibility were present in the adjusted multiphase steel since the plasticity initiation started late,which resulted in a positive ***,avoiding M/A islands distributed in the chain along the rolling direction on the matrix hindered the possibility of voids coalescing into cracks and stabilized the flanging performance.

关键词： Multiphase steel Flangeability Martensite/austenite island-Microstructural homogeneity-Microstructure Compact strip production process