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Acta Mathematica Sinica,English Series 2017年第12期33卷 1632-1646页

作者： xiao li guo Yue Yang MEN Department of Mathematics and Information Science Zhengzhou University of Light Industry Zhengzhou 450002 P. R. China Institute of Applied Physics and Computational Mathematics Beijing 100088 P. R. China

In this paper, we investigate the partial regularity of suitable weak solutions to the multi- dimensional stationary Navier-Stokes equations with fractional power of the Laplacian （-△）^α （n/6 ≤α〈1 and a ≠ 1/2）. It is shown that the n ＋ 2 - 6α （3 ≤ n ≤5） dimensional Hausdorff measure of the set of the possible singular points of suitable weak solutions to the system is zero, which extends a recent result of Tang and Yu [19] to four and five dimension. Moreover, the pressure in ε-regularity criteria is an improvement of corresponding results in [1, 13, 18, 20].

关键词： Stationary Navier-Stokes equations suitable weak solutions partial regularity

Dynamic stabilization of Na atom in an intense pulsed laser field

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Chinese Physics B 2018年第4期27卷 281-284页

作者： xiao-li guo Song-Feng Zhao guo-li Wang xiao-Xin Zhou Key Laboratory of Atomic and Molecular Physics ＆ Functional Materials of Gansu Province College of Physics and Electronic Engineering Northwest Normal University Lanzhou 730070 China

We investigate theoretically the ionization properties of the valence electron for the alkali metal atom Na in an intense pulsed laser field by solving numerically the time-dependent Schrodinger equation with an accurate l-dependent model *** calculating the variations of the ionization probabilities with laser peak intensity for wavelengths ranging from 200 nm to 600 nm,our results present a dynamic stabilization trend for the Na atom initially in its ground state（3 s） and the excited states（3 p and 4 s） exposed to an intense pulsed laser *** a clear ＂window＂ of dynamic stabilization at lower laser intensities and longer wavelengths for the initial state 4 s（the second excited state） is *** analyzing the time-dependent population distributions of the valence electron in the bound states with the different values of principal quantum number n and orbital quantum number l,we can attribute the dynamic stabilization to the periodic population in the low-excited states since the valence electron oscillates rapidly between the lowly excited states and the continuum states.

关键词： accurate model potential atomic dynamic stabilization ionization probability

Aldol Reactions Catalyzed by Proline Functionalized Polyacrylonitrile Fiber

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Chemical Research in Chinese Universities 2013年第2期29卷 256-262页

作者： xiao Jia li guo-wei ZHANG Wen-qin Department of Chemistry School of Sciences Tianjin University Tianjin 300072 P. R. China

A proline functionalized fiber catalyst was employed for aldol reactions in water. In the presence of the fiber catalyst, the aldol reactions proceeded smoothly at 40 ℃ and the products were obtained in excellent yields which were higher than those obtained for the reactions catalyzed by L-proline or trans-4-hydroxy-L-proline. This newly developed fiber catalyst is applicable to the reactions of a wide range of aromatic aldehydes and exhibits ex- cellent reusability（up to 6 times） without any additional treatment.

关键词： Polyacrylonitrile fiber(PANF) Proline Aldol reaction Supported catalyst

Molecular Recognition Based on Hydrogen-bonding in the Coliposomes of Phosphatidylcholine and Amphiphiles Using Nucleobases

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Chemical Research in Chinese Universities 2006年第6期22卷 803-807页

作者： SONG li-ming ZHU Tao WANG Qiu-sheng ZHANG xiao li guo-wen Key Lab for Supramolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A functional amphiphile, N^6 -myristoyl-9-[ 8-（ 1-trimethylamino） octyl ] adenine bromide （MTOAB）, was used to form coliposomes of phosphatidyleholine（PC）, PC/thymine, and PC/TOTB using sonication . The morphologies of the coliposomes were characterized using TEM （transmission electron microscopy）. The UV-Vis spectroscopic behavior of PC/MTOAB/thymine （molar ratio = 5： 1： 1 ） and PC/MTOAB/TOTB （molar ratio = 5： 1： 1 ） of coliposomal solutions showed that as a result of base pairing, absorption intensity showed a decrease at 263 nm with increase of time. The decrease of absorption intensity is ascribed to the hypochromic effect, which is because of the formation of hydrogen bonds between adenine and thymine in the coliposomes. The same effect was also observed for the mixture of aqueous PC/MTOAB liposomes and PC/TOTB liposomes after fusion, whereas the nocomplementary coliposomcs formed from PC/MTOAB and PC/TOTB did not show these spectroscopic changes. The molecular recognition through hydrogen interactions between adenine and thymine is very slow because of the possible occurrence of molecular lateral diffusion and exchange of amphiphile before recognition progresses in coliposomes. These results provide useful information for the design of supramolecular devices such as vesicles and liposomes,which can be used to mimic primitive recognition processes observed in biological systems.

关键词： Coliposomes Nueleobase Molecular recognition Amphiphile

Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis

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Journal of Integrative Plant Biology 2006年第10期48卷 1244-1249页

作者： li-Wen Jing Shi-Hua Chen xiao-li guo Hui Zhang Yan-Xiu Zhao Key Laboratory of Plant Stress Research College of Life Sciences Shandong Normal University Jinan 250014 China

Ablotlc stress, such as salt, drought and extreme temperature, can result in enhanced production of reactive oxygen species （ROS）. Plants have developed both enzymatic ROS-scavenging and non-enzymatic ROS-scavenging systems. The major ROS-scavenging enzymes of plants include superoxide dismutase （SOD）, ascorbate peroxldaae （APX）, catalaae （CAT）, glutathione peroxldaae （GPX） and peroxiredoxina （Prxa）. In the present work, we identified a gene encoding chloroplast-located peroxiredoxin Q, SsPrxQ, from Suaeda salsa L. located at chloroplast. Overexpression of SsPrxQ In Arabidopsis leads to an increase In salt and low-temperature tolerance.

关键词： overexpression peroxiredoxin Q salt and low-temperature tolerance suaeda salsa subcellular localization

Synthesis and Herbicidal Activity of Novel 5-Substituted Benzenesulfonylureas

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Chemical Research in Chinese Universities 2007年第6期23卷 674-678页

作者： WANG Mei-yi MU xiao-li guo Wan-cheng li Yong-hong li Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry Nankai University Tianfin 300071 P. R. China

Sulfonylurea herbicides have been widely used because of their low application rates, good crop sdeetivities and low mammalian toxicities. However, some sulfonylureas might persist unfavourably in the environment with residual problems. In order to look for ecologically safer and environmentally benign sulfonylureas, and on keeping the pyrimidine ring being monosubstitated, 15 novd C5-monosubstituted benzenesulfonylurea compounds were synthesized. The structures of all the compounds synthesized were confirmed by demental analysis and ^1H NMR. Preliminary herbicidal activities of these new sulfonylurea compounds were determined by ALS screening （ in vitro） and pot bioassay experiments（ in vivo）. The herbicidal results show that some novel sulfonylureas are comparable to commercial Foramsulfuron and Monosulfuron.

关键词： Sulfonylurea 5-Substituted phenyl ring Herbicidal activity

KAI1 is a potential target for anti-metastasis in pancreatic cancer cells

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World Journal of Gastroenterology 2008年第7期14卷 1126-1132页

作者： Jian-Hua Xu xiao-Zhong guo li-Nan Ren li-Chun Shao Min-Pei liu Department of Gastroenterology The General Hospital of Shenyang Military Command Shenyang 110016 Liaoning Province China

AIM: To investigate whether KAI1, as a metastasis suppressor gene, is associated with invasive and metastatic ability of pancreatic cancer ***: KAI1 gene was transfected into pancreatic cancer cell line MiaPaCa Ⅱ by liposomes selected with G418. Expression of transfected cells was measured by Western blotting, immunofluorescence and immunocytochemistry. Tumor cell invasion and metastatic ability were detected through gelatinase activity and reconstituted basement membrane (Matrigel) assay. pCMV-KAI1 was directly injected into the heterotopic human pancreatic adenocarcinoma successfully established in the groin of BALB/C nude mice, by subcutaneous injection of MiaPaCa Ⅱ pancreatic cancer cells. The statistical analysis between groups was determined by Student's two tailed t ***: By Western blotting, MiaPaCa Ⅱ cells transfected by KAI1 gene indicated KAI1 expression at approximately 29.1 kDa. Cytoplasm staining was positive and uniformly spread in transfected cancer cells, using immunohistochemistry and immunofluorescence. The most obvious difference was present after 30 h (MiaPaca Ⅱ 43.6 ± 9.42, pCMV-MiaPaca Ⅱ 44.8 ± 8.56, pCMV-KAI1-MiaPaca Ⅱ 22.0 ± 4.69, P lipofectamine 1.22 ± 0.31 in A group were lower than control 4.61 ± 1.98 and pCMV-KAI 11.67 ± 0.81. Analyses of metastases with and without KAI1 transfection in mice were different in liver and lung between controls 1.62 ± 0.39, 0.45 ± 0.09, pCMV-KAI 1.01 ± 0.27, 0.33 ± 0.09 and KAI1-lipofectamine 0.99 ± 0.21, 0.30 ± 0.09 respectively (P lity. KAI1 gene plays an important role in inhibiting metastasis of

关键词： KAI1 Pancreatic cancer cell line Transfection Immunocytochemistry Western blotting Immunofluorescence Gelatinolysis

Optimization of cerebral organoids:a more qualified model for Alzheimer’s disease research

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Translational Neurodegeneration 2021年第3期10卷 346-358页

作者： Feng-Chen Bi Xin-He Yang xiao-Yu Cheng Wen-Bin Deng xiao-li guo Hui Yang Yin Wang Juan li Yao Yao School of Basic Medical Sciences Ningxia Medical UniversityYinchuan 750004China Key Laboratory of Traditional Chinese Medicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004China School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Affiliated HospitalSoochow UniversitySuzhou 215004China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityGuangzhou 510275China Research Center of Medical Science and Technology Ningxia Medical UniversityYinchuan 750004China

Alzheimer’s disease(AD)is a neurodegenerative disease that currently cannot be cured by any drug or intervention,due to its complicated *** animal and cellular models of AD are unable to meet research needs for ***,recent three-dimensional(3D)cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of *** this review,we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models,and propose possible solutions,in order to improve their application in AD *** concerns associated with human cerebral organoids are also *** also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.

关键词： Cerebral organoids Alzheimer’s disease Pluripotent stem cells

Genomic Distribution of Quantitative Trait Loci for Yield and Yield-related Traits in Common Wheat

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Journal of Integrative Plant Biology 2010年第11期52卷 996-1007页

作者： li-Yi Zhang Dong-Cheng liu xiao-li guo Wen-Long Yang Jia-Zhu Sun Dao-Wen Wang Aimin Zhang The State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China Biological College China Agricultural UniversityBeijing 100193China

A major objective of quantitative trait locus （QTL） studies is to find genes/markers that can be used in breeding programs via marker assisted selection （MAS）.We surveyed the QTLs for yield and yieldrelated traits and their genomic distributions in common wheat （Triticum aestivum L.） in the available published *** then carried out a meta-QTL （MQTL） analysis to identify the major and consistent QTLs for these *** total,55 MQTLs were identified,of which 12 significant MQTLs were located on wheat chromosomes 1A,1B,2A,2D,3B,4A,4B,4D and *** study showed that the genetic control of yield and its components in common wheat involved the important genes such as Rht and ***,several significant MQTLs were found in the chromosomal regions corresponding to several rice genomic locations containing important QTLs for yield related *** results demonstrate that meta-QTL analysis is a powerful tool for confirming the major and stable QTLs and refining their chromosomal positions in common wheat,which may be useful for improving the MAS efficiency of yield related traits.

关键词： Uses Quantitative trait loci Yields Breeds (animals) Genes Soft wheat Imports Chromosomes Genomes Wheats

LH Plays a Role to Enhance the Nuclear and Cytoplasm Synchronization During In vitro Maturation of Ovine Oocytes

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Agricultural Sciences in China 2011年第1期10卷 136-141页

作者： li Kai NI He-min liU Yun-hai ZHAO Yan-wei QU Yang-yan li xiao-yan guo Yong Department of Animal Science ＆ Technology Beijing University o[ Agriculture Beijing 102206 P.R.China

This study is aimed to investigate the effect of luteinizing hormone （LH） on maturation and fertilization in vitro of ovine oocytes. The ovine oocytes were cultured in vitro in medium with or without LH, and then checked by confocal laser scanning microscope to observe the distribution of cortical granules stained with FITC-LCA during different maturation periods. Similarly, some in vitro matured oocytes were also fertilized in vitro for analysis of their developmental potentiality further. After being cultured in vitro for 4 h, there were significant differences about the rate of germinal vesicle break down （GVBD） between the treatment （with LH） and the control groups （without any hormones）（36.76% vs 18%, P〈0.05）. Further, there were also significant differences of the cleavage and blastocyst rates between these two groups （67.15% vs 42.37%, 21.9% vs 12.71%, P〈0.05, respectively）. The distribution of cortical granules appeared to spread from the edges to the central site of sheep oocytes following their delaying durations of maturation in vitro. It can be concluded that LH may play a role to delay the occurence of GVBD, prolong the maturation duration of cytoplasm, and enhance the nuclear and cytoplasm synchronization of ovine oocytes matured in vitro and finally improve their in vitro developmental potentiality.

关键词： ovine oocyte luteinizing hormone in vitro maturation in vitro fertilization distribution of cortical granules