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Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients:Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1407-1419页

作者： Yu Li Wei-ke xiao xiao-Jun Li Hui-Yuan Dong Department of General Surgery No.942 Hospital of PLAYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Acute cholecystitis(AC)is a common disease in general surgery.Laparoscopic cholecystectomy(LC)is widely recognized as the"gold standard"surgical procedure for treating AC.For low-risk patients without complications,LC is the recommended treatment plan,but there is still controversy regarding the treatment strategy for moderate AC patients,which relies more on the surgeon's experience and the medical platform of the visiting unit.Percutaneous transhepatic gallbladder puncture drainage(PTGBD)can effectively alleviate gallbladder inflammation,reduce gallbladder wall edema and adhesion around the gallbladder,and create a"time window"for elective surgery.AIM To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients,providing a theoretical basis for choosing reasonable surgical methods for AC patients.METHODS In this study,we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with AC.We performed searches in the following databases:PubMed,Web of Science,EMBASE,Cochrane Library,China National Knowledge Infrastructure,and Wanfang Database.The search encompassed literature published from the inception of these databases to the present.Subsequently,relevant data were extracted,and a meta-analysis was conducted using RevMan 5.3 software.RESULTS A comprehensive analysis was conducted,encompassing 24 studies involving a total of 2564 patients.These patients were categorized into two groups:1371 in the LC group and 1193 in the PTGBD+LC group.The outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD+LC group and the LC group in multiple dimensions:(1)Operative time:Mean difference(MD)=17.51,95%CI:9.53-25.49,P<0.01;(2)Conversion to open surgery rate:Odds ratio(OR)=2.95,95%CI:1.90-4.58,P<0.01;(3)Intraoperative bleeding loss:MD=32.27,95%CI:23.03-41.50,P<0.01;(4)Postoperative hospital stay:MD=1.44,95%CI:0.14-2.73,P=0.03;(5)Overall postoperative compli-cation rate:OR=1.88,95%CI:1.45-2

关键词： Acute cholecystitis Laparoscopic cholecystectomy Percutaneous transhepatic gallbladder drainage Metaanalysis Efficacy

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Exponential Stability of Impulsive Neutral Stochastic Functional Differential Equations with Markovian Switching

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系统科学与复杂性学报:英文版 2023年第4期36卷 1560-1582页

作者： xiao ke LI Shuyong School of Mathematics and Statistics Sichuan University of Science&EngineeringZigong 643002China Department of Mathematics Sichuan UniversityChengdu 610065China School of Mathematics and Physics Mianyang Teachers’CollegeMianyang 621000China

The aim of this paper is to the discussion of the exponential stability of a class of impulsive neutral stochastic functional differential equations with Markovian switching.Under the influence of impulsive disturbance,the solution for the system is discontinuous.By using the Razumikhin technique and stochastic analysis approaches,as well as combining the idea of mathematical induction and classification discussion,some sufficient conditions for the pth moment exponential stability and almost exponential stability of the systems are obtained.The stability conclusion is full time-delay.The results show that impulse,the point distance of impulse and Markovain switching affect the stability for the system.Finally,two examples are provided to illustrate the effectiveness of the results proposed.

关键词： Delay,exponential stability,impulsive Markovian switching,neutral Razumikhin technique,stochastic functional differential equations

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A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo TE Li-ger HUANG Xin ZUO Xin HAN xiao-ke WANG Shu-song Hebei key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang(050024)China Xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying mechanisms.Methods A reproductive damage model was established in rats by feeding of TGs.Twenty-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)group.Rats in M,DS and LC groups received 40 mg/kg TGs orally.Starting from the 5th week,after administration of TGs for 4 h every day,rats in DS and LC groups were administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 weeks.Rats in Group C continued to receive the control treatment.Hematoxylin-eosin staining was used for histopathological analysis of rat testicular tissues.Enzyme-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)concentrations.Chemiluminescence assay was used to determine the serum testosterone content.Quantitative real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant pathway.Results Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(Pke protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TGs exposure(P<0.05).All of these phenotypes were

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

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Scene text recognition via dual character counting-aware visual and semantic modeling network

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Science China(Information Sciences) 2024年第3期67卷 313-314页

作者： ke xiao Anna ZHU Brian kenji IWANA Cheng-Lin LIU School of Computer Science and Artificial Intelligence Wuhan University of Technology Human Interface Laboratory Kyushu University State key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences School of Artificial Intelligence University of Chinese Academy of Sciences

Scene text recognition(STR) is drawing increasing attention nowadays due to its wide application in real life. Character counting information, as auxiliary information, has been shown to be effective in boosting text ... 详细信息

关键词： Decoding

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Constructing inter-diffusive PtCuNi/WO_(3)interface to enhance the catalytic activity and stability in oxygen reduction

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Tungsten 2024年第2期6卷 293-303页

作者： Hao-Zhe Xu Dong Li Ying Chen Pin Fang xiao-Xing ke Olga Demidenko Yu-Jing Li Beijing key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Scientifi c-Practical Materials Research Centre National Academy of Sciences of Belarus220072 MinskBelarus

Platinum-group-metal-based alloy nanocrystals have been considered as the most effi cient catalysts for oxygen reduction reaction(ORR).However,the poor stability issues limit their further deployment in industrialization.Tungsten oxide(WO_(3))has received attention due to its intrinsic electrochemical stability and proton absorption/desorption capability.In this work,we prepared PtCuNi/WO_(3)/C hybrid catalyst with inter-diff usive alloy/WO_(3)interface on carbon.The catalyst exhibits enhanced activity and stability associated with the WO_(3)content.The characterization results suggest that the increased activity originates from the complementary proton supply of non-stoichiometric H_(x)WO_(3).Moreover,WO_(3)prevents the particle from dissolution and detachment under vigorous electrochemical polarizations.The enhanced stability originates from the electronic interaction established between Pt and W.This work provides new strategies to design high-performance ORR catalysts by taking the merits of WO_(3)。

关键词： Tungsten oxide PtCuNi Interface Electronic interaction

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T2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 819-832页

作者： Hui-Da Zheng Qiao-Yi Huang Qi-Ming Huang xiao-Ting ke Kai Ye Shu Lin Jian-Hua Xu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Computed Tomography/Magnetic Resonance Imaging The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Group of Neuroendocrinology Garvan Institute of Medical ResearchSydneyNSW 2010Australia

BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported yet.Developing a non-invasive model to predict the differentiation grade of CRC is of great value.AIM To develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on T2-weighted images(T2WI).METHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July 2023.Patients were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 ratio.Lesions were delineated layer by layer on high-resolution T2WI.Least absolute shrinkage and selection operator regression was applied to screen for radiomic features.Radiomics and clinical models were constructed using the multilayer perceptron(MLP)algorithm.These radiomic features and clinically relevant variables(selected based on a significance level of P<0.05 in the training set)were used to construct radiomics-clinical models.The performance of the three models(clinical,radiomic,and radiomic-clinical model)were evaluated using the area under the curve(AUC),calibration curve and decision curve analysis(DCA).RESULTS After feature selection,eight radiomic features were retained from the initial 1781 features to construct the radiomic model.Eight different classifiers,including logistic regression,support vector machine,k-nearest neighbours,random forest,extreme trees,extreme gradient boosting,light gradient boosting machine,and MLP,were used to construct the model,with MLP demonstrating the best diagnostic performance.The AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation cohort.The AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation cohort.The clinical model achieved an AUC of 0.751(95%CI:0.661-0.842)in the training cohort and

关键词： Radiomics Colorectal cancer Differentiation grade Machine learning T2-weighted imaging

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A Post-Quantum Cross-Domain Authentication Scheme Based on Multi-Chain Architecture

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Computers, Materials & Continua 2024年第2期78卷 2813-2827页

作者： Yi-Bo Cao Xiu-Bo Chen Yun-Feng He Lu-Xi Liu Yin-Mei Che xiao Wang ke xiao Gang Xu Si-Yi Chen Information Security Center State Key Laboratory ofNetworking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Information Center of China North Industries Group Corporation Beijing100089China School of Information Science and Technology North China University of TechnologyBeijing100144China

Due to the rapid advancements in network technology,blockchain is being employed for distributed data storage.In the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in different trust domains,which has resulted in the extensive development of cross-domain authentication techniques.However,the emergence of many attackers equipped with quantum computers has the potential to launch quantum computing attacks against cross-domain authentication schemes based on traditional cryptography,posing a significant security threat.In response to the aforementioned challenges,our paper demonstrates a post-quantum cross-domain identity authentication scheme to negotiate the session key used in the cross-chain asset exchange process.Firstly,our paper designs the hiding and recovery process of user identity index based on lattice cryptography and introduces the identity-based signature from lattice to construct a post-quantum cross-domain authentication scheme.Secondly,our paper utilizes the hashed time-locked contract to achieves the cross-chain asset exchange of blockchain nodes in different trust domains.Furthermore,the security analysis reduces the security of the identity index and signature to Learning With Errors(LWE)and Short Integer Solution(SIS)assumption,respectively,indicating that our scheme has post-quantum security.Last but not least,through comparison analysis,we display that our scheme is efficient compared with the cross-domain authentication scheme based on traditional cryptography.

关键词： Cross-domain identity authentication lattice-based cryptography blockchain hashed time-locked contract

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Metastatic clear cell sarcoma of the pancreas:From diagnosis to treatment

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World Journal of Clinical Cases 2024年第17期12卷 2925-2927页

作者： Chen Wang ke-xiao Yu Yu Chen Department of Orthopedics Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China

This article presents a comprehensive case report on an uncommon instance of metastatic clear cell sarcoma(CCS)originating from the pancreas.The high mortality rate of pancreatic carcinoma underscores the importance of precise diagnosis and early detection.The authors report a novel case of CCS with pancreatic metastasis,detailing successful surgical intervention through distal pancreatectomy and splenectomy,resulting in favourable outcomes.This study highlights the standard role of surgery in treating advanced CCS and emphasizes preoperative imaging and thorough patient history assessment.This article also underscores the necessity for long-term surveillance due to the potential for recurrence or metastasis.Despite the favourable recovery postsurgery,the absence of subsequent follow-up evaluation prompts consideration of the need for extended monitoring.This article raises questions about the nature of the pancreatic lesion and suggests the possibility of a primary lesion.Further evidence is crucial to establish the correlation between the features related to the development of the patient's primary and metastatic tumours.In conclusion,this study offers valuable insights into metastatic CCS of the pancreas,highlighting the importance of regular postoperative follow-up for improved outcomes through early detection and intervention.

关键词： Editorial Clear cell sarcoma Case report Metastasis Pancreatic cancers

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A case of herpesviral corneal endotheliitis presenting with corneal endothelial defect

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1375-1378页

作者： Yan-Xia Chen Han Deng xiao-Yun ke Min Fu Department of Ophthalmology Women and Children’s HospitalSchool of MedicineXiamen UniversityXiamen 361003Fujian ProvinceChina Department of Ophthamology Zhujiang HosptialSouthern Medical UniversityGuangzhou 510280Guangdong ProvinceChina

Dear Editor,Corneal endotheliitis,first reported in 1982 as an autoimmune disorder by Khodadoust and Attarzadeh[1],is now recognized to be frequently induced by viral infections,including varicella zoster virus(VZV),cytomegalovirus(CMV)and herpes simplex virus(HSV),that can cause inflammatory and immune-related injuries or direct damages to corneal endothelial cells[2-3].In cases with this type of endotheliitis of viral origin,manifestations may include conjunctival ciliary congestion or mixed congestion,corneal subepithelial bulla,localized corneal edema,keratic precipitates(KP)characteristic to the edema area,puckered posterior elastic lamina,mild anterior chamber reaction,intraocular pressure(IOP)elevation in presence of inflammation in trabecular meshwork,and endothelial decompensation[3-4].Accurate diagnosis of viral corneal endotheliitis is challenging due to its complex presentation,leading to a high misdiagnosis rate.To the best of our knowledge,there was no previous report of viral corneal endotheliitis presenting with corneal endothelial defects in the English literature.

关键词： corneal injuries herpes

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miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice

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Neuroscience Bulletin 2023年第2期39卷 194-212页

作者： xiao ke Manfei Deng Zhuoze Wu Hongyan Yu Dian Yu Hao Li Youming Lu Kai Shu Lei Pei Department of Neurobiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China The Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan 430030China Department of Pathophysiology Basic Medical SchoolNorth Sichuan Medical CollegeNanchong 637100China Department of Physiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Post-stroke depression(PSD)is a serious and common complication of stroke,which seriously afects the rehabilitation of stroke patients.To date,the pathogenesis of PSD is unclear and efective treatments remain unavailable.Here,we established a mouse model of PSD through photothrombosis-induced focal ischemia.By using a combination of brain imaging,transcriptome sequencing,and bioinformatics analysis,we found that the hippocampus of PSD mice had a signifcantly lower metabolic level than other brain regions.RNA sequencing revealed a signifcant reduction of miR34b-3p,which was expressed in hippocampal neurons and inhibited the translation of eukaryotic translation initiation factor 4E(eIF4E).Furthermore,silencing eIF4E inactivated microglia,inhibited neuroinfammation,and abolished the depression-like behaviors in PSD mice.Together,our data demonstrated that insufcient miR34b-3p after stroke cannot inhibit eIF4E translation,which causes PSD by the activation of microglia in the hippocampus.Therefore,miR34b-3p and eIF4E may serve as potential therapeutic targets for the treatment of PSD.

关键词： Post-stroke depression Hippocampus miRNA Microglia Neuroinfammation

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