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Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin xiao Liang Shu-Peng Liu Rui-Lan Wang Qing-Wei zhang Yu-Feng Shen xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,P<0.001].Additionally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,P<0.001).Multivariate and univariate analyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,P<0.001)were significant risk factors for GPs,while pepsinogen I was identified as a protective *** PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

近视患者光学相干断层成像与多焦视网膜电图的变化

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国际眼科杂志 2017年第6期17卷 1073-1076页

作者：强薇张小娟曹楠珏张帆夏丽坤中国医科大学附属盛京医院眼科中国辽宁省沈阳市110004

近视是生活中最常见的眼科疾病,它严重威胁着人们的眼部健康。目前,很多研究者应用光学相干断层成像(optical coherence tomography,OCT)以测量近视的视网膜结构变化,视网膜结构变化则是由屈光增加引起的眼轴增长导致的。另外,人们利用... 详细信息

近视是生活中最常见的眼科疾病,它严重威胁着人们的眼部健康。目前,很多研究者应用光学相干断层成像(optical coherence tomography,OCT)以测量近视的视网膜结构变化,视网膜结构变化则是由屈光增加引起的眼轴增长导致的。另外,人们利用多焦视网膜电图进行视网膜功能的测量。全局闪光多焦视网膜电图(multifocal electroretinography,mf-ERG)可以同时测量视网膜内层和外层的功能。有些研究者在同一个研究中联合应用OCT和mf-ERG,以便于更好地了解近视引起的结构与功能变化的联系。我们需要更多的研究以了解二者之间的联系。

关键词：近视中间-内层视网膜层外核层光感受器细胞层视网膜神经纤维层多焦视网膜电图全局闪光多焦视网膜电图

Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions

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World Journal of Psychiatry 2025年第1期15卷 26-31页

作者： Bing-Ren zhang xiao Yang Affiliated Hospital(School of Clinical Medicine) Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Mental Health Education and Counseling Center Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina

This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing(MI)in addressing an-xiety and depression among young and middle-aged patients following percuta-neous coronary *** further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease *** aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhan-cing intrinsic *** has demonstrated its effectiveness in posto-perative recovery for oncological surgery,stroke,organ transplants,and gastroin-testinal procedures,as well as in managing chronic conditions such as diabetes,obesity,and periodontal *** approach is patient-centered,adaptable,cost-effective,and easily replicable,though its limitations include reliance on the therapist’s expertise,variability in individual responses,and insufficient long-term follow-up *** research could focus on developing individualized and precise intervention models,exploring applications in digital health management,and confirming long-term outcomes to provide more compre-hensive support for patient rehabilitation.

关键词： Chronic disease management Motivational interviewing Patient-centered Postoperative rehabilitation Treatment adherence

Surface Modification of PVA Membranes by APTEOS for Pervaporation of Ethanol/Water Mixtures（摘要）

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华东理工大学学报（自然科学版） 2011年第1期37卷 44-44页

作者： MENG xiao-juan zhang Qiu-gen LIU Qing-lin Department of Chemical ＆ Biochemical Engineering College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 Fujian China

固定化酶TLIM催化制备富含甘油二酯的大豆油

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食品科技 2017年第9期42卷 177-181页

作者：吴琼刘晓娟张姗姗中国农业科技东北创新中心长春130033 长春大学食品科学与工程学院农产品深加工省重点实验室长春130022

以固定化脂肪酶TL IM为催化剂,采用甘油解法在无溶剂体系中制备富含甘油二酯的大豆油。利用气质联用检测甘油二酯含量。考察底物摩尔比、反应温度、反应时间和加酶量对甘油解反应影响,利用响应面试验设计优化各主要因子,并经回归分析获... 详细信息

以固定化脂肪酶TL IM为催化剂,采用甘油解法在无溶剂体系中制备富含甘油二酯的大豆油。利用气质联用检测甘油二酯含量。考察底物摩尔比、反应温度、反应时间和加酶量对甘油解反应影响,利用响应面试验设计优化各主要因子,并经回归分析获得最优的工艺条件为:加酶量2.0 g,水解温度50℃,水解时间16 h,大豆油与甘油的摩尔比为5:1。在最佳工艺条件下验证,得到大豆油中甘油二酯含量为17.04%。所得回归模型拟合情况良好,达到设计要求。

关键词：大豆油甘油二酯脂肪酶TL IM 制备

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“共享”发展理念的历史发展与实践路径

石河子大学学报（哲学社会科学版） 2016年第6期30卷 9-14页

作者：谢晓娟张妍辽宁大学马克思主义学院辽宁沈阳110036

"共享"发展的凝练和提出经历一个历史发展的过程。从"鼓励和允许一部分人先富起来"到实现"共同富裕",一直到"共享发展",体现了中国共产党对社会主义认识的不断深化,反映了党对改革开放经验教训的总结与思考。"共享"发展理念是要解决我... 详细信息

"共享"发展的凝练和提出经历一个历史发展的过程。从"鼓励和允许一部分人先富起来"到实现"共同富裕",一直到"共享发展",体现了中国共产党对社会主义认识的不断深化,反映了党对改革开放经验教训的总结与思考。"共享"发展理念是要解决我国目前存在的城乡、区域、行业之间等发展不平衡的问题。该文认为要实现"共享发展"归根结底要取决于制度创新,从而实现发展起点的人人参与,发展过程的人人平等和发展结果的人人共享。

关键词：共享共同发展共同富裕

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin zhang Guangyu Yang Lei xiao Zhiyong Kan Jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms