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Hybrid Analytical and Data-Driven Model Based Instance-Transfer Method for Power System Online Transient Stability Assessment

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1664-1675页

作者： Feng Li qi Wang Yi tang Yan xu jie Dang School of Electrical Engineering Southeast UniversityNanjing 210000China Center for Power Engineering(CPE) School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore Central China Branch of State Grid Corporation of China Wuhan 430077China

Data-driven methods are widely recognized and generate conducive results for online transient stability ***,the tedious and time-consuming process of sample collection is often *** functioning of power systems involves repetitive sample collection due to the constant variations occurring in the operation mode,thereby highlighting the importance of collection *** a means to achieve high sample collection efficiency following the operation mode change,we propose a novel instance-transfer method based on compression and matching strategy,which facilitates the direct acquisition of useful previous samples,used for creating the new sample ***,we present a hybrid model to ensure rationality in the process of sample similarity comparison and selection,where features of analytical modeling with special significance are introduced into data-driven *** the same time,a data-driven method can also be integrated in the hybrid model to achieve rapid error correction of analytical models,enabling fast and accurate post-disturbance transient stability *** a paradigm,we consider a scheme for online critical clearing time estimation,where integrated extended equal area criterion and extreme learning machine are employed as analytical model part and data-driven error correction model part,*** results validate the credible efficacy of the proposed method.

关键词： Critical clearing time extreme learning machine instance-transfer method transient stability assessment

MODELLING THE POLYALANINE BACKBONE STARTING FROM ALPHA-CARBON GUIDE POSITIONS

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Chinese Chemical Letters 1990年第1期1卷 87-90页

作者： Yu LUO xu Liang JIANG Lu Hua LAI Chun xu QU xiao jie xu you qi tang Institute of Physical Chemistry,Peking University,Beijing 100871

An automatic procedure for building a protein polyalanine backbone from guiding alpha-carbon positions is presented here,which is different from a previously developed'spare parts'approach(Jones and Thirup,1986;Claessens et al.,1989). In our procedure,the geometric restraint of angle N-CA-C is used to generate a list of polypeptide chains,and several filters are used later to select the best *** most important filter is based upon the Ramachandran scatter plot of mainchain dihedral angles PHI and *** for all test cases are satisfactory,with more than 95%of peptide planes correctly reconstructed and the overall root-mean-square deviation less than 0.5 angstrom compared with the refined X-ray coordinates.

关键词： Bank MODELLING THE POLYALANINE BACKBONE STARTING FROM ALPHA-CARBON GUIDE POSITIONS length maps

APPLICATION OF MONTE-CARLO SIMULATED ANNEALING ON CONFORMATIONAL ANALYSIS

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Chinese Chemical Letters 1991年第10期2卷 809-812页

作者： qiao Lin DENG Yu Zhen HAN Lu Hua LAI xiao jie xu you qi tang Institute of Physical Chemistry, Peking University, Beijing 100871 Ming Hong Hao Institute of Molecular Science, Shanxi University, Taiyuan

Monte-Carlo simulated annealing method (SA) was applied to the conformational analysis of flexible molecules such as peptides. The programs SAMM and SAPEP have been developed, using MM2 force field for organic molecul... 详细信息

关键词： Th APPLICATION OF MONTE-CARLO SIMULATED ANNEALING ON CONFORMATIONAL ANALYSIS DE flexible

Effective time, correction speed and termination time of hemiepiphysiodesis in children

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World Journal of Orthopedics 2024年第1期15卷 1-10页

作者： Jian-Fa Zeng Yu-Yin Xie Can Liu Zhen-qi Song Zheng xu Zhong-Wen tang jie Wen Sheng xiao Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University school of MedicineChangsha 410003Hunan ProvinceChina

In children with asymmetric growth on the medial and lateral side of limbs,if there still remains growth potential,the guided growth technique of hemiepiphysiodesis on one side of the epiphysis is recognized as a safe and effective ***,when the hemi-epiphysiodesis start to correct the deformities,how many degrees could hemi-epiphysiodesis bring every month and when to remove the hemi-epiphysiodesis implant without rebound phenomenon are still on *** article reviews the current studies focus on the effective time,correction speed and termination time of hemi-epiphysiodesis.

关键词： Hemi-epiphysiodesis Percutaneous epiphysiodesis Transphyseal screws Eight plate

Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery

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World Journal of Orthopedics 2024年第5期15卷 390-399页

作者： Can Liu Zheng xu Jian-Fa Zeng Zhen-qi Song Yu-Yin Xie Zhong-Wen tang jie Wen Sheng xiao Department of Anatomy Hunan Normal University School of MedicineChangsha 410003Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Combined femoral and acetabular anteversion is the sum of femoral and acetabular anteversion,representing their morphological relationship in the axial *** with the increasing understanding of hip dysplasia in recent years,numerous scholars have confirmed the role of combined femoral and acetabular anteversion in the pathological changes of hip *** present,the reconstructive surgery for hip dysplasia includes total hip replacement and redirectional hip preservation *** an important surgery index,combined femoral and acetabular anteversion have a crucial role in these ***,we discuss the role of combined femoral and acetabular anteversion in pathological changes of hip dysplasia,total hip replacement,and redirectional hip preservation surgery.

关键词： Combined anteversion Femoral anteversion Acetabular anteversion Hip dysplasia Hip preservation surgery Total hip replacement

The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3760-3773页

作者： qien Li Yiqun Dai Xin-Cheng Huang Lanlan Sun Kaixuan Wang xiao Guo Dingqiao xu Digao Wan Latai An Zixuan Wang Huanying tang qi qi Huihui Zeng Minjian qin Jia-Yu xue Yucheng Zhao Tibetan Medicine Research Center of qinghai University Tibetan Medical CollegeQinghai UniversityXining 810016China School of Pharmacy Bengbu Medical UniversityBengbu 233030China Department of Resources Science of Traditional Chinese Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China College of Horticulture Bioinformatics CenterAcademy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi’an 712046China

Coumarins,derived from the phenylpropanoid pathway,represent one of the primary metabolites found in *** alignment of the tetrahydropyran(THP)and tetrahydrofuran(THF)rings with the lactone structure results in the formation of at least four types of complex ***,the mechanisms underlying the structural diversity of coumarin remain poorly ***,we report the chromosome-level genome assembly of Notopterygium incisum,spanning 1.64 Gb,with a contig N50 value of 22.7 Mb and 60,021 annotated protein-coding ***,we identified the key enzymes responsible for shaping the structural diversity of coumarins,including two p-coumaroyl CoA 2′-hydroxylases crucial for simple coumarins basic skeleton architecture,two UbiA prenyltransferases responsible for angular or linear coumarins biosynthesis,and five CYP736 cyclases involved in THP and THF ring ***,two bifunctional enzymes capable of catalyzing both demethylsuberosin and osthenol were identified for the first *** analysis implies that tandem and ectopic duplications of the CYP736 subfamily,specifically arising in the Apiaceae,contributed to the structural diversity of coumarins in ***,this study proposes a parallel evolution scenario for the complex coumarin biosynthetic pathway among different angiosperms and provides essential synthetic biology elements for the heterologous industrial production of coumarins.

关键词： Notopterygium incisum Parallel evolution Biosynthesis Pyranocoumarins Furanocoumarins

Analysis and comparison of retinal vascular parameters under different glucose metabolic status based on deep learning

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1581-1591页

作者： Yan Jiang Di Gong xiao-Hong Chen Lin Yang Jing-Jing xu qi-jie Wei Bin-Bin Chen Yong-Jiang Cai Wen-Qun Xi Zhe Zhang Departments of Laboratory Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina Center of Health Management Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Visionary Intelligence Ltd. Beijing 100080China Ophthalmology Center the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM:To develop a deep learning-based model for automatic retinal vascular segmentation,analyzing and comparing parameters under diverse glucose metabolic status(normal,prediabetes,diabetes)and to assess the potential of artificial intelligence(AI)in image segmentation and retinal vascular parameters for predicting prediabetes and ***:Retinal fundus photos from 200 normal individuals,200 prediabetic patients,and 200 diabetic patients(600 eyes in total)were *** U-Net network served as the foundational architecture for retinal arteryvein *** automatic segmentation and evaluation system for retinal vascular parameters was trained,encompassing 26 ***:Significant differences were found in retinal vascular parameters across normal,prediabetes,and diabetes groups,including artery diameter(P=0.008),fractal dimension(P=0.000),vein curvature(P=0.003),C-zone artery branching vessel count(P=0.049),C-zone vein branching vessel count(P=0.041),artery branching angle(P=0.005),vein branching angle(P=0.001),artery angle asymmetry degree(P=0.003),vessel length density(P=0.000),and vessel area density(P=0.000),totaling 10 ***:The deep learning-based model facilitates retinal vascular parameter identification and quantification,revealing significant *** parameters exhibit potential as biomarkers for prediabetes and diabetes.

关键词： deep learning retinal vascular parameters segmentation model diabetes prediabetes

Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： xiao-Li WANG Ai-qing FENG Xi-Yong HOU qing-Chen CHAO Bai-Yuan SONG Yu-Bin LIU qi-Guang WANG He xu Yu-Xin ZHANG Dong Li Li-jie DONG Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi xu Liang Yu Ting-Mao xue Zhi-jie xiao Pui-Chi Tin Hiu-Ling Fung Hoi-tang Ma Jing-Ping Yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger