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基于SPH-FEM耦合方法的开挖面稳定性多尺度分析

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公路 2024年第1期69卷 392-399页

作者：华振肖健华黄明峰熊昊中交一公局厦门工程有限公司厦门市361000 深圳大学土木与交通工程学院深圳市518600 深圳大学滨海城市韧性基础设施教育部重点实验室深圳市518060 深圳大学深圳市地铁地下车站绿色高效智能建造重点实验室深圳市518060

运用光滑粒子流体力学(SPH)模拟土体在开挖扰动下的大变形破坏过程,通过有限元(FEM)模拟非大变形土体与隧道结构,运用多尺度方法来探究开挖面稳定性问题。两种方法所建立的土体区域皆运用相同的三维摩尔-库伦本构模型进行高斯积分点上... 详细信息

运用光滑粒子流体力学(SPH)模拟土体在开挖扰动下的大变形破坏过程,通过有限元(FEM)模拟非大变形土体与隧道结构,运用多尺度方法来探究开挖面稳定性问题。两种方法所建立的土体区域皆运用相同的三维摩尔-库伦本构模型进行高斯积分点上的求解,以确保一致性。通过与开挖面稳定性模型试验的标定,验证了该方法的可行性。以此为基础,运用控制变量法进行一系列参数分析,探究了土体受到开挖扰动时的竖向位移、竖向应力的变化规律及对应位移场、应力场和等效塑性应变场的变化规律。最后,研究了等沉降面的发展情况,证明了这种多尺度方法的可信度。对于开挖面稳定性方面的研究,这种耦合方法可以较好地反映土体的变形规律和破坏机制,为研究开挖面稳定性提供了一种有效的计算工具。

关键词：隧道工程开挖面稳定分析 FEM-SPH耦合算法多尺度方法大变形计算开挖面稳定性

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互联网搭售行为违法性认定的困局及纾解

竞争政策研究 2024年第1期 5-15页

作者：吴太轩肖健华西南政法大学经济法学院

互联网搭售行为可谓屡见不鲜。但是,互联网经济具有的免费模式、双边市场、网络效应及跨界竞争等特征致使互联网搭售行为形式多样、表征复杂,行为违法性认定也陷入困境。实践考察发现,当前认定互联网搭售行为违法性尚存产品独立性认定... 详细信息

互联网搭售行为可谓屡见不鲜。但是,互联网经济具有的免费模式、双边市场、网络效应及跨界竞争等特征致使互联网搭售行为形式多样、表征复杂,行为违法性认定也陷入困境。实践考察发现,当前认定互联网搭售行为违法性尚存产品独立性认定标准不明、行为强制性难以判定、竞争效果评估存在障碍等困局。鉴于此,提出以下建议:其一,产品独立性认定应摈弃传统单一标准的认定模式,构建以消费者需求标准为核心的复合标准认定模式;其二,行为强制效果判定应弱化对主观心理的考量,侧重对客观事实进行判断;其三,竞争效果评估应当从法益保护视角出发,对行为产生的正负效果进行多维度的结构化衡量。

关键词：互联网搭售违法性认定反垄断

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中国海洋经济高质量发展区域差异与收敛性

五邑大学学报（自然科学版） 2024年第1期38卷 70-78页

作者：肖健华胡琪琴肖昊玥五邑大学经济管理学院广东江门5529020 暨南大学暨南大学伯明翰大学联合学院广东广州510000

为了探索我国海洋经济高质量发展的时空异质性与收敛性,本文基于五大新发展理念,构建包含“经济发展、科技创新、生态环境、社会民生、对外开放”五大领域的海洋经济高质量发展评价指标体系,并运用突变级数法测度2007—2019年我国沿海1... 详细信息

为了探索我国海洋经济高质量发展的时空异质性与收敛性,本文基于五大新发展理念,构建包含“经济发展、科技创新、生态环境、社会民生、对外开放”五大领域的海洋经济高质量发展评价指标体系,并运用突变级数法测度2007—2019年我国沿海11省市海洋经济高质量发展水平,采用泰尔指数及收敛模型分别考察海洋经济高质量发展水平的动态分布、差异来源和收敛趋势.研究结果表明,全国及三大海洋经济圈海洋经济高质量发展综合指数呈先上升后下降趋势,各地区海洋经济发展水平具有显著差异性,表明我国海洋经济发展的非均衡性有所加剧,而区域内差异是导致总体差异变化的主要因素.东部海洋经济圈存在σ收敛,而全国及北部、南部海洋经济圈不存在σ收敛.全国及三大海洋经济圈存在绝对β收敛,并且条件β收敛也显著.

关键词：海洋经济高质量发展突变级数法泰尔指数收敛性分析

Dynamic Observation of Cartilage Damage and Serum IL-1β, TNF-α, IL-6 and IL-17 in Post-traumatic Rat Osteoarthritis Model

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Journal of Northeast Agricultural University(English Edition) 2022年第3期29卷 59-65页

作者： Lv Liang-yu Ma Tian-wen Yu Yue Jia Li-na Xu Xin-yu Zhao Ming-chao Chen Hong Sheng Xuan-bo Li Ting xiao jian-hua Gao Li College of Veterinary Medicine Northeast Agricultural UniversityHeilongjiang Key Laboratory Animals and Comparative MedicineHarbin 150030China

The pathogenesis of animal osteoarthritis(OA)is not clear.The aim of this study was to investigate the dynamic changes of cartilage lesions and serum IL-1β,TNF-α,IL-6 and IL-17 inflammatory factors in a post-traumatic osteoarthritis model in rats,and to explore their values in monitoring the progression of osteoarthritis.Forty male SD rats were randomly divided into the control group(n=20)and the model group(n=20).The OA model was established by anterior cruciate ligament transection combined with partial medial meniscus resection(ACLT+PMMx)in the model group,and sham operation was performed in the control group.On the 0th,10th,20th and 30th days after modeling,the degree of joint swelling and the number of white blood cells in the peripheral blood were evaluated,and tibia samples were taken for macroscopic observation score and pathological observation.The serum levels ofIL-1β,TNF-α,IL-6 and IL-17 concentration were detected by enzyme-linked immunosorbent assay(ELISA).The results showed that the cartilage damage in the tibial surface and pathological observations of rats in the model group gradually increased with time,the eye scores increased and increased significantly on the 20th and 30th days(P<0.01),and the joints of the rats were swollen.And the swelling was extremely significant on the 30th day(P<0.01).Compared with the control group,the number of white blood cells in the peripheral blood of the model group gradually increased,and the increase was extremely significant on the 20th and 30th days(P<0.01).The serum IL-17 concentration in the model group tended to increase,and the increase was significant on the 20th day(P<0.05)and extremely significant on the 30th day(P<0.01);the serum TNF-αand IL-1βconcentrations in the model group showed an increasing trend,and the increase was extremely significant on the 10th,20th and 30th days(P<0.01);IL-6 concentration in the serum of the model group showed an increasing trend,and it increased significantly on the 30th day(P<0.05).The results showed that in the rat mod

关键词： osteoarthritis inflammatory factor cartilage injury rat

Design and Implementation of Stud-farm Daily Management System Based on C/S Structure

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Journal of Northeast Agricultural University(English Edition) 2014年第3期21卷 50-59页

作者： Luan Hong-liang Wang Hong-bin Qin Hong-yu Wang Chao Zhai Zhi-nan xiao jian-hua College of Veterinary Medicine Northeast Agricultural University

In order to achieve the computerization and digitization of the daily system of stud-farm, the immunization system technology, racecourse health monitoring technologies and the stud-farm prevention technologies were combined to built the studfarm daily management system. By using Visual Studio 2008 and Microsoft Office Access 2003, an immunization information system was developed based on Client/Server structure and combined with the key immunization link of horses. The system included studfarm immune management and racecourse health monitoring system. The immune management contained immunization information input, the inquiry of immunization information, immunization statistics, immunization-reminding and system management. The racecourse health monitoring system included stud-farm monitoring, horses monitoring and inquiry and statistics of health monitoring. The software realized the analysis and tips of the daily information in stud-farm. The software could record the appropriate data and carry on the statistics. The stud-farm daily management system greatly improved the efficiency of the expanded program about immunization and horses＇ healthy rearing technique.

关键词： immunization management,health monitoring,system design,stud-farm

Experimental investigation on using CO_(2)/H_(2)O emulsion with high water cut in enhanced oil recovery

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Petroleum Science 2024年第2期21卷 974-986页

作者： Xi-Dao Wu Peng xiao Bei Liu Guang-Jin Chen jian-hua Pang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Ocean Intelligence Technology Center Shenzhen Institute of Guangdong Ocean UniversityShenzhen518120GuangdongChina

CO_(2) emulsions used for EOR have received a lot of interest because of its good performance on CO_(2)mobility reduction.However,most of them have been focusing on the high quality CO_(2) emulsion(high CO_(2) fraction),while CO_(2) emulsion with high water cut has been rarely researched.In this paper,we carried out a comprehensive experimental study of using high water cut CO_(2)/H_(2)O emulsion for enhancing oil recovery.Firstly,a nonionic surfactant,alkyl glycosides(APG),was selected to stabilize CO_(2)/H_(2)O emulsion,and the corresponding morphology and stability were evaluated with a transparent PVT cell.Subsequently,plugging capacity and apparent viscosity of CO_(2)/H_(2)O emulsion were measured systematically by a sand pack displacement apparatus connected with a 1.95-m long capillary tube.Furthermore,a high water cut(40 vol%) CO_(2)/H_(2)O emulsion was selected for flooding experiments in a long sand pack and a core sample,and the oil recovery,the rate of oil recovery,and the pressure gradients were analyzed.The results indicated that APG had a good performance on emulsifying and stabilizing CO_(2) emulsion.An inversion from H_(2)O/CO_(2) emulsion to CO_(2)/H_(2)O emulsion with the increase in water cut was confirmed.CO_(2)/H_(2)O emulsions with lower water cuts presented higher apparent viscosity,while the optimal plugging capacity of CO_(2)/H_(2)O emulsion occurred at a certain water cut.Eventually,the displacement using CO_(2)/H_(2)O emulsion provided 18.98% and 13.36% additional oil recovery than that using pure CO_(2) in long sand pack and core tests,respectively.This work may provide guidelines for EOR using CO_(2) emulsions with high water cut.

关键词： CO_(2)/H_(2)O emulsion High water cut CO_(2) mobility control Enhanced oil recovery

Neuronomodulation of Excitable Neurons

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Neuroscience Bulletin 2024年第1期40卷 103-112页

作者： Yizhang Chen Lin xiao jian Qiu Institute of Neuroscience Second Military Medical UniversityShanghai 200433China Institute for Brain Research and Rehabilitation Key Laboratory of BrainCognition and Education Sciences of Ministry of EducationSouth China Normal UniversityGuangzhou 510631China Department of Chemical Physiology and Biochemistry Oregon Health and Science UniversityPortlandOR 97239USA

Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the blood.Neuronomodulation can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,i.***.the ion channel,or through an intermediate step on different molecules.The major players in direct neurono-modulation are ligand-gated or voltage-gated ion channels.The key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various ligands.Indirect neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these actions.Elucidating neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关键词： Neuron Membrane potential Excitability Chemoactivation Neuronomodulation

Thiazoloisoindigo-based Polymer Semiconductors: Synthesis,Structure-Property Relationship, Charge Carrier Polarity, and Field-Effect Transistor Performance

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Chinese Journal of Polymer Science 2024年第1期42卷 24-31,I0006页

作者： Bo-Wen Li Miao Xiong Mei-hua Liu Zhi-Gao Li Long Sang Zi-Han Xiong Biao xiao jian Pei xiao-Bo Wan Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationSchoolofOptoelectronic Materials&TechnologyJianghan UniversityWuhan430056China Bejing National Laboratoryfor Molecular Sciences the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Developing new polymeric semiconductors with excellent device performance is essential for organic electronics. Herein, we synthesized two new thiazoloisoindigo(Tz II)-based polymers, namely, P(Tz II-d Th-d Th) and P(Tz II-d Th-d Tz), by copolymerizing thiophene-flanked Tz II with bithiophene and bithiazole, respectively. Owing to the more electron-deficient nature of bithiazole than bithiophene, P(Tz II-d Th-d Tz)possesses deeper LUMO/HOMO levels of-3.45/-5.47 e V than P(Tz II-d Th-d Th)(-3.34/-5.32 e V). The organic field-effect transistor(OFET) devices based on P(Tz II-d Th-d Th) exhibited p-type behaviors with an average hole mobility value as high as 1.43 cm^(2)·V^(-1)·s^(-1), while P(Tz II-d Th-d Tz)showed typical ambipolar characteristics with average hole and electron mobilities of 0.38 and 0.56 cm^(2)·V^(-1)·s^(-1). In addition, we compared the performances of both polymers with other Tz II-based polymers reported in our previous work, and showed that the charge carrier polarity can be manipulated by adjusting the number of the thiophene units between the acceptor unit. As the increase of the number of thiophene rings,charge carrier polarity shifts from electron-dominated ambipolar transport to hole-dominated ambipolar transport and then to unipolar hole transport in OFETs, which provides an effective molecular design strategy for further optimization of polymer OFET performance.

关键词： Field-effect transistor Charge carrier polarity Thiazoloisoindigo

Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao Feng hua Zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and pharmaceuticals.However,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in humans.This study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide poisoning.Methods:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July 2022.The entire course of the incidents was described in detail.Blood 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass spectrometer.Hema-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic mitophagy.Results:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective measures.The typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical evolution.Rash and fever may be the important premonitory symptoms for further organ injuries.The chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and micro-circulation.Three patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive treatments.One patient survived by liver transplantation.The postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual hepatocytes.Conclusions:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning.The chemical enter

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury