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An Approach to Modelling and Analysing Reliability of Breeze/ADL-based Software Architecture

International Journal of Automation and computing 2017年第3期14卷 275-284页

作者： Chen Li Hong-Ji Yang hua-xiao liu Centre for Creative Computing Bath Spa University UK College of Computer Science and Technology Jilin University Changchun 130012 China

Breeze/architecture description language（ADL）, is an eX tensible markup language（XML） based architecture description language which is used to model software systems at the architecture level. Though Breeze/ADL provides an appropriate basis for architecture modelling, it can neither analyse nor evaluate the architecture reliability. In this paper, we propose a Breeze/ADL based strategy which, by combining generalized stochastic Petri net（GSPN） and tools for reliability analysis, supports architecture reliability modelling and evaluation. This work expands the idea in three directions： Firstly, we give a Breeze/ADL reliability model in which we add error attributes to Breeze/ADL error model for capturing architecture error information, and at the same time perform the system error state transition through the Breeze/ADL production. Secondly, we present how to map a Breeze/ADL reliability model to a GSPN model, which in turn can be used for reliability analysis. The other task is to develop a Breeze/ADL reliability analysis modelling tool–EXGSPN（Breeze/ADL reliability analysis modelling tool）, and combine it with platform independent petri net editor 2（PIPE2） to carry out a reliability ***： Breeze/architecture description language （ADL）, is an eXtensible markup language （XML） based architecture description language which is used to model software systems at the architecture level. Though Breeze/ADL provides an appropriate basis for architecture modelling, it can neither analyse nor evaluate the architecture reliability. In this paper, we propose a Breeze/ADL based strategy which, by combining generalized stochastic Petri net （GSPN） and tools for reliability analysis, supports architecture reliability modelling and evaluation. This work expands the idea in three directions： Firstly, we give a Breeze/ADL reliability model in which we add error attributes to Breeze/ADL error model for capturing architecture error information, and at the same time perform

关键词： Software architecture reliability Breeze/architecture description language(ADL) generalized stochastic Petri net(GSPN) Breeze graph grammar

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FlexPDA:A Flexible Programming Framework for Deep Learning Accelerators

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Journal of Computer Science & Technology 2022年第5期37卷 1200-1220页

作者： Lei liu Xiu Ma hua-xiao liu Guang-li Li Lei liu College of Computer Science and Technology Jilin UniversityChangchunChina Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchunChina State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina

There are a wide variety of intelligence accelerators with promising performance and energy efficiency,deployed in a broad range of applications such as computer vision and speech ***,programming productivity hinders the deployment of deep learning *** low-level library invoked in the high-level deep learning framework which supports the end-to-end execution with a given model,is designed to reduce the programming burden on the intelligence ***,it is inflexible for developers to build a network model for every deep learning application,which probably brings unnecessary repetitive *** this paper,a flexible and efficient programming framework for deep learning accelerators,FlexPDA,is proposed,which provides more optimization opportunities than the low-level library and realizes quick transplantation of applications to intelligence accelerators for fast *** evaluate FlexPDA by using 10 representative operators selected from deep learning algorithms and an end-to-end *** experimental results validate the effectiveness of FlexPDA,which achieves an end-to-end performance improvement of 1.620x over the low-level library.

关键词： deep learning accelerator programming framework domain-specific language

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Effect of NF-κB p65 antisense oligodeoxynucleotide on transdifferentiation of normal human lens epithelial cells induced by transforming growth factor-β2

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 29-32页

作者： Chao liu Xao-Li Wu Xin-Yi Wu Zhen-hua Zhang xiao-hua liu Department of Ophthalmology Qilu Hospital Shandong University Jinan 250012 Shandong Province China Department of Ophthalmology Central Hospital of QingdaoQingdao 266042 Shandong Province China Department of Ophthalmology Rongjun Hospital of Shandong Jinan 250013 Shandong Province China Department of Stomatology Central Hospital of QingdaoQingdao 266042 Shandong Province China

AIM：To study the inhibition of nuclear factor kappa-B p65（NF-κB p65）antisense oligodeoxynucleotide（ASODN）on transdifferentiation of normal human lens epithelial cells induced by transforming growth factor-β2（TGF-β2）.·M ETHODS：NF-κBp65ASODNand NF-κBp65missense oligodeoxynucleotide（MSODN）were designed and *** lens epithelial cell line（HLE B-3）cells were prepared for study and divided into 7 *** group was HLE B-3 cells cultured in dulbecco’s modified eagle medium（DMEM）.T1,T2,and T3 group were HLE B-3 cells cultured in DMEM with 10 ng/m L TGF-β2 for 6h,12h,24h respectively.A＋T group was HLE B-3 cells cultured with 10 ng/m L TGF-β2for 24h after transfected by NF-κB p65 ASODN for 24h.M＋T group was HLE B-3 cells cultured with 10 ng/m L TGF-β2 for 24h after transfected by NF-κB p65 MSODN for *** negative control group was HLE B-3 cells cultured with 10 ng/m L TGF-β2 for 24h after cultured with transfer agent（Hi Per Fect）for *** morphology was observed at different time points using an inverted *** expression of NF-κB p65 m RNA was detected with reverse transcription-polymerase chain reaction（RT-PCR）,and the expression ofα-smooth muscle actin（α-SMA）protein was assayed with ELISA.·RESULTS：With the TGF-β2 stimulation prolongation,the expression of NF-κB p65 m RNA and a-SMA protein increased in T1,T2,T3 groups compared with the control group,and the difference was statistically significant（〈0.05）.NF-κB p65 ASODN lowered the expression of NF-κB p65 m RNA andα-SMA protein induced by TGF-β***-κB p65 MSODN and Hi Per Fect did not lower the expression of NF-κB p65 m RNA andα-SMA protein induced by TGF-β*** difference between control group and A＋T group was not statistically significant（〉0.05）,but the difference among A＋T group and other groups was statistically significant（〈0.05）.·CONCLUSION：NF-κB p65 ASODN could lower the expression of NF-κB p65 m RNA andα-SMA protein induced by TGF-β2,and antagonized TGF-β2-induced transdifferentiati

关键词： nuclear factor kappa-B p65 antisenseoligodeoxynucleotide transforming growth factor-β2 α-smooth muscle actin lens epithelial cells

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A simple method for determining water content in organic solvents based on cobalt(Ⅱ) complexes

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Chinese Chemical Letters 2011年第2期22卷 189-192页

作者： Lin Zhou xiao hua liu Hai Xin Bai Hong Juan Wang College of Plant Protection Henan Agricultural UniversityZhengzhou 450002China College of Sciences Henan Agricultural UniversityZhengzhou 450002China

A method to determine water content in organic solvents was developed based on the color change of cobalt（Ⅱ） nitrate in different *** color-change mechanism and optimal conditions for determining the water content were *** results showed that there was a good linear relationships between the absorbance of cobalt（Ⅱ） complexes in organic solvents and water contents withγin 0.9989～*** method has the advantages of low cost,good reproducibility,good sensitivity,simple in operation,fast in detection,friendly to the environment and no limitation on linear range for determining water *** was used to determine water in samples with a satisfactory recovery in 97.81%～101.24%.

关键词： Determination Water content Cobalt(Ⅱ) nitrate Organic solvent

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Skeletal phenotypes and molecular mechanisms in aging mice

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Zoological Research 2024年第4期45卷 724-746页

作者： Qiao Guan Yuan Zhang Zhi-Kun Wang xiao-hua liu Jun Zou Ling-Li Zhang School of Exercise and Health Shanghai University of SportShanghai 200438China College of Athletic Performance Shanghai University of SportShanghai 200438China

Aging is an inevitable physiological process,often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health *** on skeletal diseases caused by aging in humans is challenging due to lengthy study durations,difficulties in sampling,regional variability,and substantial ***,mice are preferred for such studies due to their similar motor system structure and function to humans,ease of handling and care,low cost,and short generation *** this review,we present a comprehensive overview of the characteristics,limitations,applicability,bone phenotypes,and treatment methods in naturally aging mice and prematurely aging mouse models(including SAMP6,POLG mutant,LMNA,SIRT6,ZMPSTE24,TFAM,ERCC1,WERNER,and KL/KL-deficient mice).We also summarize the molecular mechanisms of these aging mouse models,including cellular DNA damage response,senescence-related secretory phenotype,telomere shortening,oxidative stress,bone marrow mesenchymal stem cell(BMSC)abnormalities,and mitochondrial ***,this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.

关键词： Aging Premature aging Mice Bone Gene knockout

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Influence of Heat Treatment Temperature on Microstructure and Property of 00Cr13Ni5Mo2 Supermartensitic Stainless Steel

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Journal of Iron and Steel Research International 2014年第3期21卷 364-368页

作者： De-ning ZOU xiao-hua liu Ying HAN Wei ZHANG Jiao LI Kun WU School of Metallurgy and Engineering Xi'an University of Architecture and Technology Key Laboratory of Advanced Structural Materials of Ministry of Education Changchun University of Technology State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

The microstructural evolution and mechanical property of 00Crl3NiSMo2 supermartensitic stainless steel （SMSS） subjected to different heat treatments were investigated. Room tensile tests, hardness tests, scanning elec- tron microscopy, transmission electron microscopy and X ray diffraction were conducted on the heat-treated steels. It is found that the microstructure of the heat-treated steel is composed of tempered lath martensite, retained austenite and ^-ferrite. The austenitizing temperature and tempering temperature have a significant effect on the microstrtlctur al changes, which leads to the complex variations of mechanical properties. The fine tempered lath martensite and more dispersed reversed austenite in the microstructure facilitate improving the comprehensive mechanical properties of the studied steel. The optimal heat treatment process of 00Crl3Ni5Mo2 SMSS is obtained by austenitizing at 1000 ℃ for 0.5 h＋air cooling followed by tempering at 630 ℃ for 2 h＋air cooling, where the excellent combination of ten- sile strength, elongation and hardness can be achieved.

关键词： supermartensitic stainless steel heat treatment microstructure mechanical property reversed austenite

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Fabrication and thermoelectric properties of Yb-doped ZrNiSn half-Heusler alloys

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International Journal of Smart and Nano Materials 2012年第1期3卷 64-71页

作者： xiao-hua liu Jian He Han-Hui Xie Xin-Bing Zhao Tie-Jun Zhu State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering Zhejiang UniversityHangzhou 310027P.R.China Department of Physics and Astronomy Clemson UniversitySouth Carolina 29634-0978USA

Half-Heusler(HH)alloys constitute an important class of materials that exhibit promising potential in high-temperature thermoelectric(TE)power *** this work,we synthesized Zr_(1−x)Yb_(x)NiSn(x=0,0.01,0.02,0.04,0.06 and 0.10)HH alloys using a time-efficient levitation melting and spark plasma sintering procedure.X-ray diffraction showed that the samples were predominantly single phased,and that the lattice constant increased systematically with increasing Yb doping *** doping effects of Yb on the thermoelectric properties were *** was found that Yb doping consistently decreased the electrical and thermal *** the other hand,the effects of Yb doping on the Seebeck coefficient were found to be *** magnitude of the Seebeck coefficient(n-type)was increased upon Yb doping up to x=0.02,above which Yb doping introduced notable p-type *** a result,the room-temperature Seebeck coefficient of the x=0.10 sample became positive although the magnitude was not *** thermoelectric figure of merit,ZT,reached a maximum of∼0.38 at 900 K for the x=0.01 *** doping on the Ni and Sn sites are necessary to further optimize the TE performance of Zr_(1−x)Yb_(x)NiSn alloys.

关键词： half-Heusler alloy thermoelectric power levitation melting spark plasma sintering Yb doping

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Attachment of tyrosinase on mixed self-assembled monolayers for the construction of electrochemical biosensor

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Chinese Chemical Letters 2010年第10期21卷 1239-1242页

作者： Xue Ping Ji Xian Rui Li Na Wang Rui Xing Ni xiao Hong liu hua Ai Xiong Department of Medical Chemistry Hebei Medical University Shijiazhuang 050017 China

A mixed self-assembled monolayers （SAMs） of thioctic acid （T-COOH） and thioctic acid amide （T-NH2） were used to immobilize tyrosinase for fabricating biosensor. The results showed that the mixed SAMs prepared from solution at the ratio of 1：4 provided an excellent microenvironment for enzymatic reaction between tyrosinase and substrate. The biosensor exhibited a fast response and high sensitivity for sensing substrate.

关键词： Biosensor Tyrosinase Catechol Self-assembled monolayers Gold electrode

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Changes in brain-derived neurotrophic factor expression after transplanting microencapsulated sciatic nerve cells of rabbits into injured spinal cord of rats

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Neural Regeneration Research 2007年第10期2卷 582-586页

作者： Wen xue Fu xiao hua liu xiao lin huang Yao fang Yang Xiang xin Che Wei nie Xiang Hui yong Jiang De ming liu Department of Anatomy Medical CollegeJiujiang UniversityJiujiang332000JiangxiProvinceChina Department of Internal Medicine Affiliated HospitalJiujiang UniversityJiujiang332000Jiangxi ProvinceChina Department of Anatomy Medical College of Nanchang UniversityNanchang 330006JiangxiProvinceChina

Changes of brain-derived neurotrophic factor （BDNF） expression reflect function of nerve cells; meanwhile, they play a significant role in researching interventions on plerosis of nerve injury. OBJECTIVE： To observe and compare the effects on changes of BDNF expression in rats with spinal cord injury between microencapsulated sciatic nerve cells of rabbits and only transplanting sciatic nerve cells of rabbits. DESIGN： Randomized controlled animal study. SETTING： Medical School of Jiujiang College. MATERIALS： The experiment was carried out in the Medical Science Researching Center, Jiujiang College from May 2004 to May 2006. A total of 90 healthy adult SD rats, weighing 250 - 300 g, of either gender; and 10 rabbits, weighing 2.0 - 2.5 kg, of either gender, were provided by Jiangxi Experimental Animal Center. METHODS： Sciatic nerve tissue of rabbits was separated to make cell suspension, After centrifugation, suspension was mixed with 15 g/L alginate saline solution and ejaculated to 20 mmol/L barium chloride saline solution by double-cavity ejaculator. The obtained cell microcapsules were suspended in saline. Rats were randomly divided into microencapsulated group, only suspension group, and only injured group with 30 animals in each group. After anesthesia, T10 spinous process and vertebra lamina of rats in the former two groups were exposed. Spinal cord tissue in 2-mm length was removed from rats by spinal cord right hemi-section. The gelatin sponges with the size of 2 mm × 2 mm × 2 mm were grafted as filing cage, and absorbed 10 μL microencapsulated sciatic nerve cells of rabbit in the microencapsulated group and 10 μL sciatic nerve cells of rabbits in the only suspension group; respectively. No graft was placed in the only injured group. MAIN OUTCOME MEASURES： On the 1^st, 3^rd, 7^th, 14^th and 28^th days after operation, immunohistochemistry （SABC technique） was used to detect distribution and amount of positive-reactive neurons in BDNF of spinal cord samples wh

关键词： spinal cord injuries transplantation, heterologous nerve growth factors

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Quasi-Min-Max Model Predictive Control for Discrete-Time Singular Systems with Input-to-State Stability

Quasi-Min-Max Model Predictive Control for Discrete-Time Sin...

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2015年中国智能自动化学术会议

作者： Chan Gao xiao-hua liu School of Mathematics and Statistics Science

The paper concerns robust quasi-min-max model predictive control for a class of discrete-time singular systems with input constrains and persistent *** deal with the persistent disturbance, we introduce the notion of input-to-state stability of discrete-time singular system for the first time. The optimal control can be obtained by solving a quasi-min-max optimal problem of a finite horizon cost *** the basis of the proposed dual-mode MPC approach, it can be proved that the closedloop discrete-time singular system is input-to-state stability. Finally, a numerical simulation shows the feasibility and the effectiveness of the proposed method.

关键词： Model predictive control(MPC) Discrete-time singular systems Input-to-state stability(ISS) Persistent disturbance Dual-mode approach

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