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Rare Metals 2020年第9期39卷 1063-1071页

作者： Guang-Yin liu Yi-Yang Zhao Yu-Feng Tang xiao-di liu Miao liu Peng-Jiang Wu College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang 473061China

Ti2Nb10O29/C nanoparticles with a carbon content of 13 wt%and a mean size of 50 nm were fabricated through a convenient and effective in situ sol-gel *** small grain size and carbon modification can improve the pseudocapacitive effect of the Ti2Nb10O29/C nanoparticles,leading to excellent rate capacity,especially at high current ***,the discharge capacity of the Ti2Nb10O29/C electrode is 258.3,236.0,216.6,184.5 and161.5 mAh·g-1 at different current densities of 1C,5C,10C,20C and ***,the discharge capacity of the Ti2Nb10O29 electrode is 244.9 mAh·g-1 at 1C,which is rapidly reduced to 89.7 mAh·g-1 at *** addition,the small size and carbon layer of the Ti2Nb10O29/C nanoparticles can supply abundant active sites for Li+storage as well as enhance the electronic conductivity and Li+diffusion,endowing these nanoparticles with a high discharge capacity and excellent cycle performance.

关键词： Nanoparticles Anode materials Sol-gel method Energy storage

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Fast secondary relaxation and plasticity initiation in metallic glasses

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National Science Review 2018年第5期5卷 616-618页

作者： Ji Chao Qiao xiao di liu Qing Wang Chain Tsuan liu Jian Lu Yong Yang School of Mechanics and Civil & Architecture Northwestern Polytechnic University Centre for Advanced Structural Materials Department of Mechanical and Biomedical EngineeringCity University of Hong Kong Laboratory for Structures Institute of MaterialsShanghai University

Metallic glasses (MGs) are a promising engineering material with superb strength. However, their ‘Achilles’ heel’is their poor ductility in ambient conditions, particularly under tension. Unlike their crystalline c... 详细信息

关键词： MG Fast secondary relaxation and plasticity initiation in metallic glasses

Ionic liquid-induced ultrathin and uniform N-doped carbon-wrapped T-Nb_(2)O_(5) microsphere anode for high-performance lithium-ion battery

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Rare Metals 2021年第11期40卷 3205-3214页

作者： Rui-Xue Sun Yang Yue Xin-Feng Cheng Ke Zhang Su-Ying Jin Guang-Yin liu Yu-Xin Fan Yan Bao xiao-di liu College of Chemistry and Pharmaceutical Engineering Engineering Technology Research Center of Henan Province for Solar CatalysisNanyang Normal UniversityNanyang 473061China College of Science Henan Agricultural UniversityZhengzhou 450001China

Orthorhombic-phase Nb_(2)O_(5)(T-Nb_(2)O_(5)) has been widely investigated as an intercalation anode material for Li-ion batteries due to the larger interplanar lattice spacing and high ***,its applications are limited by the intrinsic low electric ***,an ultrathin N-doped carbon-coating layer was constructed on porous T-Nb_(2)O_(5) microspheres uniformly via a convenient thermal treatment method with ionic liquid as a carbon *** synthesized T-Nb_(2)O_(5)@N-C exhibits significantly enhanced rate capability(155.5 mAh·g^(-1) at 20 C) than initial T-Nb_(2)O_(5)(110.2 mAh·g^(-1) at 20C).Besides,T-Nb_(2)O_(5)@N-C shows ultralong cycle life,with only a 0.02% decrease in the capacity per cycle at a high current density of 10 *** corresponding electrochemical tests show that the preferable rate capability of T-Nb_(2)O_(5)@N-C electrode is attributed to the increased electronic conductivity and pseudocapacitance contribution induced by ultrathin surface N-doped carbon *** the other hand,the mesoporous structure of T-Nb_(2)O_(5)@N-C ensures fast Li+ diffusion dynamics and electrolyte ***,T-Nb_(2)O_(5)@N-C also performs well in a LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(4) llT-Nb_(2)O_(5)@N-C full *** work provides a facile method to construct integrated anode materials for potential applications in lithium-ion batteries.

关键词： Ionic liquid Ultrathin N-doped carbon T-Nb_(2)O_(5) Lithium-ion battery Full cell

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Identification and Mapping of Two New Genes Conferring Resistance to Powdery Mildew from Aegilops tauschii （Coss,） Schmal

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Journal of Integrative Plant Biology 2006年第10期48卷 1204-1209页

作者： xiao-Li Sun di liu Hai-Quan Zhang Na-Xin Huo Rong-Hua Zhou Ji-Zeng Jia Key Laboratory of Crop Germplasm and Biotechnology Ministry of Agriculture Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China

Two powdery mildew resistance genes were Identified from Aegilops tauschll accessions Y201 and Y212 and mapped using two different F2 populations derived from the crosses between susceptible accession Y2272 and Y201, and susceptible accession Y2263 and Y212. Genetic analysis of resistance to powdery mildew Indicated that the resistance of Y201 was controlled by a single dominant gene, whereas the resistance of Y212 was controlled by a single recessive gene. We have temporarily designated these genes as PmY201 and PmY212, respectively. By bulk segregation analysis, six mlcrosatelllte markers Including Xgwm174, cfd26, cfd57, cfdl02, Xgwm583 and Xgwm639 were found to be linked to PraY201 with genetic distances of 5.2, 7.7, 9.6, 12.5, 20.2 and 22.1 cM, respectively. Five SSR markers, including cfd57, Xgwm182, cfd7, cfd102, and cfd12, were found to be linked to PmY212 with distances of 5.6, 7.2, 11.5, 14.7, and 18.5 cM, respectively. According to the locations of the linked markers, the two resistance genes were located In the 5DL region. Based on the chromosomal locations and the resistance patterns of the two genes, we propose that PmY201 and PmY212 are two novel powdery mildew resistance genes, and are suitable for marker-assisted selection.

关键词： Aegilops tauschii mapping marker-assisted selection microsatellite markers powdery mildew

Interaction between LCSCs and lung cancer microenvironment and TCM intervention

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Tumor Microenvironment Research 2020年第1期2卷 16-22页

作者： xiao-di liu Shan-Qi Guo Rui-Yu Mou Ming-Xin Wu xiao-Jiang Li First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China

Lung cancer has become a leading cause of cancer-related death because of its high morbidity and *** some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung cancer in the last decade,actually there is no substantial breakthrough for the 5-year survival rate of patients has no significant improvement and is still below 15%.Plenty of evidence suggests that malignant tumors including lung cancer have a unique subgroup of cells featured with self-renewal and multidirectional differentiation *** stem cells(CSCs)are the root of tumor growth and metastasis,and the characteristic changes of malignant phenotype(such as recurrence,invasion and metastasis,and drug resistance)are closely linked with *** paper explored the possible correlated mechanism of the complex interaction between lung cancer stem cells(LCSCs)and lung cancer microenvironment,to provide ideas for the R&D of relevant treatment technologies,the promotion of the progress in traditional medical technology,and the breakthrough of the bottleneck of long-term effect of lung cancer.

关键词： Lung cancer Lung cancer stem cells Lung cancer microenvironment

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锡青铜激光选区熔化工艺及其性能

稀有金属材料与工程 2018年第3期47卷 1007-1012页

作者：白玉超杨永强王迪肖然刘洋华南理工大学广东广州510640

为了研究QSn6.5-0.1锡青铜激光选区熔化(SLM)技术直接成型工艺及其成型性能,设计三因素四水平正交工艺实验,研究激光功率、扫描速度和扫描间距对致密度的影响,采用SEM、OM、Micro-CT以及显微硬度仪研究微观组织与硬度。结果表明:选择合... 详细信息

为了研究QSn6.5-0.1锡青铜激光选区熔化(SLM)技术直接成型工艺及其成型性能,设计三因素四水平正交工艺实验,研究激光功率、扫描速度和扫描间距对致密度的影响,采用SEM、OM、Micro-CT以及显微硬度仪研究微观组织与硬度。结果表明:选择合理的优化工艺参数,锡青铜(SLM)成型致密度最高达到98.71%;微观组织为网络状枝晶结构且分布均匀的(α+δ)相和α相;成型试样显微维氏硬度比传统铸造的软态(700～900 MPa)高45%左右;直接成型的风轮模型致密性高。表明采用激光选区熔化技术可以成型性能较好的QSn6.5-0.1锡青铜合金零件。

关键词：激光选区熔化锡青铜工艺参数微观组织显微维氏硬度

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Androgen receptor mediated resistance in the progression of castration-resistant prostate cancer

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TMR Integrative Medicine 2019年第23期3卷 1-11页

作者： Rui-Yu Mou xiao-Jiang Li Shan-Qi Guo Wen-Jie Li Ming-Xin Wu xiao-di liu Zhang Chang Song Bo Chang Zhang Ying-Jie Jia First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China

The incidence of prostate cancer has increased year by year in the *** improvements in diagnosis,surgical techniques,and drugs,survival rates of prostate cancer have improved little,and most prostate cancer-related deaths are as a result of castration resistant prostate cancer(CRPC),which progresses and metastasizes after surgical or medical *** pathogenesis of CRPC is still *** has been found that the majority of CRPC patients have overexpression of androgen receptors(ARs),and there are many forms of changes in the signaling pathways that intersect with them during he process to *** ribonucleic acid(miRNA)plays an important role in regulating the expression and translation of prostate cancer target genes,and in the life cycle of cell cycle distribution and ***,active changes in miRNA expression are also closely related to ***,the study of AR-related signaling pathways and AR and miRNA-related signaling pathways is of great significance in the treatment of CRPC.

关键词： Castration-resistant prostate cancer Androgen receptor MiRNA Mechanism study

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-Jun liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan xiao liu Mao-Ju Tang Man Luo xiao-Wu Zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin xiao Liang Shu-Peng liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng Shen xiao-Bo Li division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Pditionally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,Pdings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram