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Zhao Xuemin:A Celebrated Doctor of Folk Medicine

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World Journal of Integrated Traditional and Western Medicine 2016年第4期2卷 1-4页

作者： Fang Hui Zhang Chun xiao dangsheng The First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310000China Academe of Southeast Health Science ＆ Technology Zhejiang provinceHangzhou 310000China Institute ofZhao Xuemin Traditional Chinese Medicine Academe of Southeast Health Science ＆ TechnologyZhejiang provinceHangzhou 310000China

Traditional Chinese Medicine originated from the application of herbs and other natural materials. Since Tang Dynasty, there are two mainstreams during the development of TCM: folk TCM and classic TCM. Without any support from the government, folk TCM got fade away. However, during Qing Dynasty, Zhao Xuemin collected a large amount of folk prescriptions which were called zoufang and edited into Chuanya Neibian and Chuanya Waibian. Zhou Xuemin was respected as a celebrated medical scientist of Qing Dynasty due to his great contribution.

关键词： Traditional Chinese Medicine herbal medicine folk medicine

Wuxing Theory is an Ideal Mode for Discovering the Interrelationships Between the Energy Metabolism and Stem Cell Proliferation & Differentiation in Our Body

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World Journal of Integrated Traditional and Western Medicine 2018年第3期4卷 56-61页

作者： xiao dangsheng Yang Jiezuan Fang Hui VIP Ward First Affiliated Hospital College of Medicine Zhejiang University First Affiliated Hospital College of Medicine Zhejiang University State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Department of Internal Medicine First Affiliated HospitalCollege of Medicine Zhejiang University

Yinyang theory and Wuxing theory are the core part in Traditional Chinese Medicine. On the principles of these theories, we definite the energy metabolism and stem cell proliferation & differentiation(SCPD) as yang and yin respectively. There are five factors which can influence the energy metabolism and SCPD: nutrition, oxygen, energy, end metabolic products and stem cell. These five factors have their metabolic pathways in our body. On the principle of wuxing theory, supply of nutrition should be regarded as earth^(TCM), supply of oxygen as metal^(TCM), releasing and utilization of energy as fire^(TCM), releasing of end metabolic products as water^(TCM), and SCPD as wood^(TCM). The interrelationship between the five pathways can be described on the principle of wuxing theory. In all, both yinyang theory and wuxing theory are the just model to discover the mysteries of life.

关键词： Yinyang Wuxing TCM Energy metabolism Stem cell

The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4＋CD25＋ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment

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Cellular & Molecular Immunology 2016年第5期13卷 678-687页

作者： Jiezuan Yang Guoping Sheng dangsheng xiao Haiyan Shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province PR China

The frequency and T-cell receptor beta-chain variable （TCRBV） patterns of peripheral CD4＋CD25＋ regulatory T-cells （Tregs） are ambiguously altered in chronic hepatitis B （CHB） patients following tenofovir disoproxil fumarate （TDF） treatment. Moreover, the clinical significance of these parameters in relation to hepatitis B e antigen （HBeAg） seroconversion （SC） is largely unknown. In this study, the circulation of Tregs in HBeAg-positive CHB patients was determined by flow cytometry, and the molecular profiles of frequent TCRBV patterns of Tregs were analyzed using a gene melting spectral pattern. The parameters, such as Treg frequency, the number of skewed TCRBV patterns, hepatitis B virus （HBV） DNA levels, and alanine aminotransferase （ALT） levels, were analyzed by comparing their associations in seroconverting and non-seroconverting patients following TDF treatment. The Treg frequency was significantly correlated with the ALT level in seroconverting but not in non-seroconverting patients. Similarly, skewed TCRBV patterns were remarkably associated with HBV DNA levels in the SC group. Six TCRBV families （BV3, BV11, BV12, BV14, BV20, and BV24） were more prevalent than other TCRBV members in seroconverting patients pretreated with TDF, while BV12, BV15, and BV22 were predominant in non-seroconverting patients during TDF treatment. Taken together, the preferential TCRBV patterns may be associated with immune responses related to SC. The dynamic frequency and skewed TCRBV patterns of peripheral Tregs could contribute to predicting SC in CHB patients. Moreover, the conserved TCRBV complementarity-determining region （CDR3） motif may be targeted to develop personalized immunotherapy for CHB patients.

关键词： chronic hepatitis B individual treatment gene melting spectral pattern regulatory T-cells T-cell receptorbeta-chain variable

A novel understanding about oxidization of glucose in term of Wuxing TCM theory

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World Journal of Integrated Traditional and Western Medicine 2016年第1期2卷 31-36页

作者： Fang Hui Li Shengjie Zhu Qiuhong Pan Huiyun xiao dangsheng The First Affiliated Hospital Zhejiang universityHangzhou 310000China

Yin-yang theory and Wuxing theory are the core parts of Traditional Chinese Medicine（TCM）. Most of researches on Wuxing theory are based on the paradigm of TCM or Traditional Chinese Culture. It is an evitable challenge to interpret Wuxing theory in the term of biomolecular, biochemistry, stem cell and so on. The oxidation of glucose is the important pathway in cell and there are five basic factors which will be responsible for the undergoing of this reaction. The relationships among these factors are similar to Wuxing theory just like inter-promotion and inter-restraint. So, this understanding on Wuxing theory maybe take some advancement for the modernization of TCM.

关键词： Wuxing theory Oxidation Metabolism Inter-promotion Inter-restraint System biology.

Energy has the same characteristics of Qi in traditional Chinese medicine

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World Journal of Integrated Traditional and Western Medicine 2016年第2期2卷 14-18页

作者： xiao dangsheng Li Shengjie Zhu Qiuhong Fang Hui Pan Huiyun VIP Ward The first Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000China Department of Internal Medicine College of MedicineZhejiang UniversityHangzhou 310000China Depamnent of Nuiology The first Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000China Department of Gerontology College of MedicineZhejiang UniversityHangzhou 310000China

Giving the accurate definition of the core part of Traditional Chinese Medicine(TCM) is another way for the modernization of TCM. Many researchers had launched their original researches on this way and realized that qi got some characteristics of energy. In this paper, energy is also thought as having the same characteristics as qi for energy is invisible and filled with cell in different patterns. The movement of qi in cell can be understood as the transformations of the chemical energy. So, cell should be regarded as a device which is organized by biomelocules for the transformation from chemical energy to heat energy.

关键词： Metabolism Energy System Biology Qi Oxidation

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生命本质和新型生物模式图的构建探讨

医学争鸣 2020年第6期11卷 29-34页

作者：肖党生方辉杨介钻浙江大学医学院附属第一医院干部科浙江杭州310003 浙江大学医学院附属第一医院急诊科浙江杭州310003 浙江大学医学院附属第一医院传染病诊治国家重点实验室浙江杭州310003

生命定义是生物医学内的核心问题。现今西医学领域内生命定义都没能指导临床实践。中医以阴阳气血的概念认识生命现象。借助中医学的思维方式,可以将生命定义为:在细胞中,生命本质是遗传信息指导下的能量代谢过程;在多细胞生命体内,生... 详细信息

生命定义是生物医学内的核心问题。现今西医学领域内生命定义都没能指导临床实践。中医以阴阳气血的概念认识生命现象。借助中医学的思维方式,可以将生命定义为:在细胞中,生命本质是遗传信息指导下的能量代谢过程;在多细胞生命体内,生命本质是伴随干细胞分裂分化过程的能量代谢过程。能量物质是生命体内所有的代谢过程的初始底物。获取能量物质是生命体内代谢过程的第一步,而能量物质进入细胞后依次形成四个代谢通路。热能推动代谢终产物排泄过程是生命体内代谢的最后一步,也是推动生命现象演化的原动力。在人体中,这一过程则由低到高形成四个排泄平面。总体而言,生命体内的代谢过程可以总结为能量物质的氧化过程,这一过程生命体中受到能量物质、氧、催化剂、能量及代谢终产物等五个因素的影响。这五个因素在生命体内都形成相应的代谢通路,并维持能量物质氧化过程顺利进行。

关键词：能量代谢基因蛋白质干细胞氧化代谢

论能量物质在人体内代谢过程是少阳病的生理基础

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中医临床研究 2020年第33期12卷 132-135页

作者：肖党生方辉杨介钻浙江大学医学院附属第一医院浙江杭州310003 浙江大学医学院附属第一医院传染病诊治国家重点实验室浙江杭州310003

以生命认识为核心,探讨《伤寒论》各种证候的现代生理、病理基础是中医现代化的方向之一。在人体内,能量代谢过程和干细胞分裂分化过程是人体内各种代谢的核心所在。能量物质的代谢过程可以分为能量物质的摄入,能量物质转化和氧化以及... 详细信息

以生命认识为核心,探讨《伤寒论》各种证候的现代生理、病理基础是中医现代化的方向之一。在人体内,能量代谢过程和干细胞分裂分化过程是人体内各种代谢的核心所在。能量物质的代谢过程可以分为能量物质的摄入,能量物质转化和氧化以及代谢终产物的释放等三个步骤。其中能量物质的转化和氧化过程是承接能量物质摄入和代谢终产物排泄中间过程,这一过程包括物质转换,即各种中间产物的形成;能量转换,即化学能转换成热能、机械能等。这些生理过程都应归属少阳经的生理学基础。当少阳经功能出现异常时就会出现以口苦、咽干、目眩等为主要表现的少阳病。当然,进入机体的能量物质还可以激活并参与干细胞的分裂分化过程,这一过程可能是少阳经血分证的生理学基础。

关键词：少阳经阴阳气机能量代谢干细胞

论能量物质在人体内存储异常为太阴病的病理基础

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中医临床研究 2020年第21期12卷 13-15页

作者：肖党生方辉杨介钻浙江大学医学院附属第一医院干部科浙江杭州310003 浙江大学附属第一医院急诊科浙江杭州310003 浙江大学附属第一医院传染病诊治国家重点实验室浙江杭州310003

在中医学领域内,阴阳平衡和气机运行是人体生理病理基础.结合现代医学,人体内的阴阳可以分别定义为人体内的能量代谢过程和干细胞分裂分化过程,二者间的相互作用推动人体内能量转化,即人体内的气机运行.人体内的干细胞分裂分化过程是人... 详细信息

在中医学领域内,阴阳平衡和气机运行是人体生理病理基础.结合现代医学,人体内的阴阳可以分别定义为人体内的能量代谢过程和干细胞分裂分化过程,二者间的相互作用推动人体内能量转化,即人体内的气机运行.人体内的干细胞分裂分化过程是人体阴分形成的生理基础,这一过程需要能量物质作为物质基础,即能量物质进入人体后以脂肪、多糖、蛋白质等形式进行储备,为干细胞分裂分化过程提供物质基础,推动干细胞通过分裂分化生成体细胞,实现组织器管内细胞更新,维持组织器官结构稳定.能量物质被人体吸收后在人体内存储的生理过程就是太阴经的生理学基础.这一过程出现异常后就形成太阴病,并成为太阴病提纲证的病理生理基础.太阴病的主要治疗原则在于行气化湿,芳香温化.

关键词：能量代谢干细胞阴阳太阴经气机

探讨新型冠状病毒肺炎重症患者的中医治疗原则和方剂

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中医临床研究 2020年第6期12卷 71-73页

作者：肖党生方辉杨介钻浙江大学医学院附属第一医院老年科浙江杭州310003 浙江大学附属第一医院急诊科浙江杭州310003 浙江大学附属第一医院传染病诊治国家重点实验室浙江杭州310003

人体生命本质是伴随干细胞分裂分化过程的能量代谢过程。干细胞分裂分化过程是人体内抗损伤修复的核心过程。在新型冠状病毒感染的早期,病毒侵犯和炎性反应导致肺上皮细胞死亡增加,适度增强干细胞分裂分化过程就可以修复组织损伤,阻止... 详细信息

人体生命本质是伴随干细胞分裂分化过程的能量代谢过程。干细胞分裂分化过程是人体内抗损伤修复的核心过程。在新型冠状病毒感染的早期,病毒侵犯和炎性反应导致肺上皮细胞死亡增加,适度增强干细胞分裂分化过程就可以修复组织损伤,阻止炎性反应进展。但是,随着患者病情恶化,机体内干细胞分裂分化过程中会出现热化和寒化表现,即免疫细胞生成方向会强化(热化),成为炎症风暴形成的细胞基础;肺部上皮细胞生成受阻(寒化)。重症患者出现严重肺部炎性病变。患者康复过程也是肺部炎症消退的过程,治疗原则包括温肾阳,补脾气,化痰湿,祛血瘀、血热;同时注意温解太阳经上的寒气。避免过度劳作和不良作息也是治疗康复过程中需要注意的问题。

关键词：新型冠状病毒肺炎干细胞炎症风暴少阴病厥阴病