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Ultrasound features of congenital cytomegalovirus infection in the first trimester:A case report

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World Journal of Clinical Cases 2025年第5期13卷 30-35页

作者： xiao-Li chen Li-Qiang Zhang Li-Li Bai Department of Ultrasound Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental *** majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening *** SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal *** ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV *** karyotyping and microarray analysis of the fetus yielded no significant *** compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her *** ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female *** five months of age,the infant presented with epilepsy and significant growth and developmental *** Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal *** research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.

关键词： Prenatal diagnosis Congenital infection Cytomegalovirus Fetal ultrasound Case report

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： xiao-Man chen Shuo Zhang Shi-Qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu xiao-Yu chen Jie Zhao Pin Li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

Recirculation of Parallel-Connected Planetary Gear Trains

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Chinese Journal of Mechanical Engineering 2022年第2期35卷 100-110页

作者： Hong chen xiao-An chen School of Mechanical Engineering Xihua UniversityChengdu 610039SichuanChina The State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

Recirculation is expected to be identified for its possibility to dramatically decrease the efficiency of planetary gear trains(PGTs).However,it exhibits an unexplained connection with the structure,making it challenging to identify without tedious computation through tooth and speed ratios,thus complicating the design *** study employs a generic model utilizing the mechanical balance principle and reveals the fundamental laws of the previously unexplained connection for parallel-connected ring-sun-type *** necessary and sufficient conditions,torque and structure,were proven for multi-stage and two-stage PGTs without recirculation,*** shows that the structure,specifically whether the links are central gears or carriers,and the connections between them directly impact the recirculation of these PGTs.A geometric model representing the structure and kinematics was developed to visualize the power ***,the recirculation of parallel-connected ring-sun-type PGTs can be predicted without *** results provide the underlying insights to understanding recirculation from the structural connection viewpoint,thereby contributing to the conceptual design phase where the task is to select the kinematic structure and the gear size is unknown.

关键词： Power flow Generic three-terminal Torque direction Multistage PGTs

On a geometric realization of C^＊-algebras

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Frontiers of Mathematics in China 2014年第2期9卷 261-274页

作者： xiao chen Chern Institute of Mathematics Nankai University Tianjin 300071 China

Further to the functional representations of C^＊-algebras proposed by R. Cirelli and A. Manik, we consider the uniform Kahler bundle （UKB） description of some C^＊-algebraic subjects. In particular, we obtain a one-to- one correspondence between closed ideals of a C^＊-algebra A and full uniform Kahler subbundles over open subsets of the base space of the UKB associated with A. In addition, we present a geometric description of the pure state space of hereditary C^＊-subalgebras and show that if B is a hereditary C^＊-subalgebra of A, the UKB of B is a kind of Kahler subbundle of the UKB of A. As a simple example, we consider hereditary C^＊-subalgebras of the C^＊-algebra of compact operators on a Hilbert space. Finally, we remark that each hereditary C^＊- subalgebra of A also can be naturally characterized as a uniform holomorphic Hilbert bundle.

关键词： C^*-algebra uniform isomorphism uniform holomorphic Kahler bundle (UKB) uniform Kahler Hilbert bundle

Regression Analysis for the Additive Hazards Model with General Biased Survival Data

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Acta Mathematicae Applicatae Sinica 2020年第3期36卷 545-556页

作者： xiao-lin chen School of Statistics Qufu Normal UniversityQufu 273165China

In survival analysis,data are frequently collected by some complex sampling schemes,e.g.,length biased sampling,case-cohort sampling and so *** this paper,we consider the additive hazards model for the general biased survival data.A simple and unified estimating equation method is developed to estimate the regression parameters and baseline hazard *** asymptotic properties of the resulting estimators are also ***,to check the adequacy of the fitted model with general biased survival data,we present a test statistic based on the cumulative sum of the martingale-type *** studies are conducted to evaluate the performance of proposed methods,and applications to the shrub and Welsh Nickel Refiners datasets are given to illustrate the methodology.

关键词： additive hazards model estimating equation general biased sampling model checking survival data

Analysis of the stress wave and rarefaction wave produced by hypervelocity impact of sphere onto thin plate

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Defence Technology（防务技术） 2020年第5期16卷 969-979页

作者： Ken Wen xiao-wei chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute of Systems Engineering China Academy of Engineering PhysicsMianyangSichuan621999China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

Shock wave is emitted into the plate and sphere when a sphere hypervelocity impacts onto a thin *** fragmentation and phase change of the material caused by the propagation and unloading of shock wave could result in the formation of debris cloud *** models are deduced based on one-dimensional shock wave theory and the geometry of sphere,which uses elliptic equations(corresponding to ellipsoid equations in physical space)to describe the propagation of shock wave and the rarefaction ***“Effective thickness”is defined as the critical plate thickness that ensures the rarefaction wave overtake the shock wave at the back of the ***“Effective thickness”is directly related to the form of the debris *** relation of the“Effective thickness”and the“Optimum thickness”is also *** impacts of Al spheres onto Al plates are simulated within SPH to verify the propagation models and associated *** results show that the wave fronts predicted by the propagation models are closer to the simulation result at higher impact *** curvatures of the wave fronts decrease with the increase of impact *** predicted“Effective thickness”is consistent with the simulation *** analysis about the shock wave propagation and unloading in this paper can provide a new sight and inspiration for the quantitative study of hypervelocity impact and space debris protection.

关键词： Hypervelocity impact Debris cloud Shock wave Rarefaction wave Effective thickness of plate

Hygrothermal effect on high-velocity impact resistance of woven composites

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Defence Technology（防务技术） 2022年第5期18卷 823-833页

作者： xiao-chen Yang Nan Jia School of Urban Construction Eastern Liaoning UniversityWenhua 325Dandong118003China College of Safety Science and Engineering Liaoning Technical UniversityFuxin123000China China Coal Technology&Engineering Group Shenyang Research Institute Fushun113122China State Key Laboratory of Coal Mine Safety Technology Fushun113122China

The woven glass fiber reinforced composites(GFRP)subjected to high-speed impact is investigated to identify the hygrothermal aging effect on the impact *** the hygrothermal aged and unaged glass/epoxy laminates are subjected to different impact velocities,which is confirmed as a sensitive factor for the failure modes and *** results show the hygrothermal aging effect decreases the ballistic limit by 14.9%,but the influence on ballistic performance is limited within the impact velocity closed to the ballistic *** failure modes and energy dissipation mechanisms are confirmed to be slightly influenced by the hygrothermal aging *** hygrothermal aging effect induced localization of structural deformation and degradation of mechanical properties are the main reasons for the composite undergoing the same failure modes at smaller impact *** on the energy absorption mechanisms,analytical expressions predict the ballistic limit and energy absorption to reasonable accuracy,the underestimated total energy absorption results in a relatively poor agreement between the measured and predicted energy absorption efficiency.

关键词： Hygrothermal aging effect Woven glass/epoxy composite Impact resistance Dynamic failure Energy absorption

Partially Time-varying Coefficient Linear Rate Model for the Recurrent Event Data

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Acta Mathematicae Applicatae Sinica 2014年第3期30卷 681-698页

作者： xiao-lin chen College of Science China University of Petroleum

In [13], Schaubel et al. proposed a semiparametric partially linear rate model for the statistical analysis of recurrent event data. But they only considered the model with time-independent covariate effects. In this paper, rate function of the recurrent event is modeled by a semipaxametric partially linear function which can include the time-varying effects. We propose the method of generalized estimating equations to make inferences about both the time-varying effects and time-independent effects. The large sample properties are established, while extensive simulation studies are carried out to examine the proposed procedures. At last, we apply the procedures to the well-known bladder cancer study.

关键词： partially linear rate model empirical process recurrent event time-varying effects.