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Hepatic senescence, the good and the bad

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World Journal of Gastroenterology 2019年第34期25卷 5069-5081页

作者： Nazmul Huda Gang Liu Honghai Hong Shengmin Yan Bilon Khambu xiao-ming yin Department of Pathology and Laboratory Medicine Indiana University School of MedicineIndianapolis

Gradual alterations of cell’s physiology and functions due to age or exposure to various stresses lead to the conversion of normal cells to senescent *** becoming senescent,the cell stops dividing permanently but remains metabolically *** senescence does not have a single marker but is characterized mainly by a combination of multiple markers,such as,morphological changes,expression of cell cycle inhibitors,senescence associatedβ-galactosidase activity,and changes in nuclear *** cells in an organ become senescent,the entire organism can be *** may occur through the senescence-associated secretory phenotype(SASP).SASP may exert beneficial or harmful effects on the microenvironment of *** on senescence has become a very exciting field in cell biology since the link between age-related diseases,including cancer,and senescence has been *** loss of regenerative and homeostatic capacity of the liver over the age is somehow connected to cellular *** major contributors of senescence properties in the liver are hepatocytes and *** cells in the liver have been implicated in the etiology of chronic liver diseases including cirrhosis and hepatocellular carcinoma and in the interference of liver *** review summarizes recently reported findings in the understanding of the molecular mechanisms of senescence and its relationship with liver diseases.

关键词： Senescence Senescence associated secretory phenotype Hepatocyte Cholangiocyte Hepatic stellate cell Cell cycle arrest DNA damage

Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

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Liver Research 2018年第3期2卷 112-119页

作者： Bilon Khambu Shengmin Yan Nazmul Huda Gang Liu xiao-ming yin Department of Pathology and Laboratory Medicine Indiana University School of MedicineIndianapolisINUSA

Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver *** evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver *** autophagy prevents the clearance of excessive lipid droplets(LDs),damaged mitochondria,and toxic protein aggregates,which can be generated during the progression of various liver diseases,thus contributing to the development of steatosis,injury,steatohepatitis,fibrosis,and *** this review,we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver *** also examine the mechanisms of defects in autophagy,and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease(NAFLD)and alcoholic liver disease(ALD),focusing mainly on steatosis and liver ***,we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases.

关键词： Autophagy Non-alcoholic fatty liver disease(NAFLD) Alcoholic liver disease(ALD) Liver injury Steatosis

Towards disentangling the classification of freshwater fish trypanosomes

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Marine Life Science & Technology 2023年第4期5卷 551-563页

作者： Peng Zhang Jie Liu xiao‑ming yin Jun‑Yu Zhou Julius Lukeš Zhao‑Rong Lun De-Hua Lai Guangdong Provincial Key Laboratory of Aquatic Economic Animals State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China BGI Genomics BGI-ShenzhenShenzhen 518083China Institute of Parasitology Biology CentreCzech Academy of SciencesČeskéBudějovice(Budweis)37005Czech Republic Biomedical Research Centre School of ScienceEngineering and EnvironmentUniversity of SalfordSalford M54WTUK

Currently,new species of freshwater fish trypanosomes,which are economically important parasites,are being described based on subjectively selected features,i.e.,their cell morphology and the host *** have performed detailed phylogenetic and haplotype diversity analyses of all 18S rRNA genes available for freshwater fish trypanosomes,including the newly obtained sequences of Trypanosoma carassii and Trypanosoma *** on a sequence similarity of 99.5%,we divide these trypanosomes into 15 operational taxonomic units,and propose three nominal scenarios for distinguishing *** and other aquatic *** find evidences for the existence of a low number of freshwater fish trypanosomes,with *** having the widest geographic and host *** analyses support the existence of an umbrella complex composed of *** and two sister species.

关键词： Freshwaterﬁsh trypanosomes 18S rRNA Morphology Phylogeny

Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography

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World Journal of Gastroenterology 2009年第28期15卷 3532-3537页

作者： Mai-Lin Chen Qing-Yu Zeng Jian-Wei Huo xiao-ming yin Bao-Ping Li Jian-Xin Liu Department of Radiology ChinaMeitan General Hospital No. 29 Xibahe Nanli ChaoyangDistrict Beijing 100028 China

AIM： TO assess the hepatic microvascular parameters in patients with liver cirrhosis by perfusion computed tomography （CT）. METHODS： Perfusion CT was performed in 29 patients without liver disease （control subjects） and 39 patients with liver cirrhosis, including 22 patients with compensated cirrhosis and 17 patients with decompensated cirrhosis, proved by clinical and laboratory parameters. CT cine-scans were obtained over 50 s beginning with the injection of 50 mL of contrast agent. Hepatic microvascular parameters, mean transit time （MTT） and permeability surface area product （PS） were obtained with the Perfusion 3 software （General Electric, ADW 4.2）. RESULTS： The overall differences of MTT and PS between control subjects, patients with compensated cirrhosis and those with decompensated cirrhosis were statistically significant （P = 0.010 and P = 0.002, respectively）. MTT values were 15.613 ± 4.1746 s, 12.592 ± 4.7518 s, and 11.721 ± 4.5681 s for the three groups, respectively, while PS were 18.945 ± 7.2347 mL/min per 100 mL, 22.767 ± 8.3936 mL/min per 100 mL, and 28.735 ± 13.0654 mL/min per 100 mL. MTT in decompensated cirrhotic patients were significantly decreased compared to controls （P = 0.017）, whereas PS values were remarkably increased （P = 0.001）.CONCLUSION： The hepatic microvascular changes in patients with liver cirrhosis can be quantitatively assessed by perfusion CT. Hepatic microvascular parameters （MTr and PS）, as measured by perfusion CT, were significantly altered in decompensated cirrhosis.

关键词： Tomography X-ray computed Hepaticmicrocirculation Cirrhosis

Dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： Xuan Liu Zi-Xia Lin yin-Biao Shi xiao-Yan Wang ming-Ye Ding xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,leading to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** findings might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion Downshifting Anti-counterfeiting Luminescent thermometry

Autophagy in liver diseases: A matter of what to remove and whether to keep

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Liver Research 2018年第3期2卷 109-111页

作者： xiao-ming yin Department of Pathology and Laboratory Medicine Indiana University School of MedicineIndianapolisINUSA

*** There are three types of autophagy,macroautophagy,microautophagy and chaperon-mediated *** is the largest in terms of the scale,and often briefly referred to as autophagy as *** recent years,researches in the field of autophagy have become such a strong trend that many new findings have been made that advance not only the understanding of the biology of autophagy.

关键词： diseases remove liver

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG Yu-xia ZHAO Yan-na YU xiao-ling yin Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

Mass spectrometry profiling analysis enables the identification of new modifications in ribosomal RNA

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Chinese Chemical Letters 2023年第3期34卷 157-161页

作者： xiao-Meng Tang Tian-Tian Ye Xue-Jiao You xiao-ming yin Jiang-Hui Ding Wen-Xuan Shao Meng-Yuan Chen Bi-Feng Yuan Yu-Qi Feng Sauvage Center for Molecular Sciences Department of ChemistryWuhan UniversityWuhan 430072China School of Public Health Wuhan UniversityWuhan 430071China

Ribosomal RNAs(rRNAs) provide the structural framework of ribosomes and play critical roles in protein *** ribosome biogenesis,rRNAs acquire various modifications that can influence the structure and catalytic activity of ***,rRNA modifications in plants have yet to be fully ***,we proposed a method to purify rRNAs by a successive isolation with different strategies,including poly A-based m RNA depletion and agarose gel electrophoresis-based purification,with which highly pure rRNAs could be *** addition,we developed a liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS) method to systematically profile and characterize modifications from the isolated highly pure plant 18S rRNA and 25S ***-ESI-MS/MS analysis showed that 10 and 12 kinds of modifications were present in plant 18S rRNA and 25S rRNA,***,among these identified modifications,2 kinds of modifications of N^(2),N^(2)-dimethylguanosine(m^(2,2)G)and N^(6),N^(6)-dimethyladenosine(m^(6,6)A) in 18S rRNA,and 4 kinds of modifications of m^(2,2)G,m^(6,6)A,N7-methylguanosine(m^(7)G) and 3-methyluridin(m^(3)U) in 25S rRNA,were first reported to be present in ***,exposure of Arabidopsis thaliana to cadmium(Cd) led to significant changes of modifications in both 18S rRNA and 25S rRNA of plants,indicating that rRNA modifications play important roles in response to environmental *** discovery of new modifications in plant rRNAs improves the spectra of plant rRNA modifications and may promote the investigation of the functional roles of plant ribosomes in regulating gene expression.

关键词： Ribosomal RNA RNA modification Plant Arabidopsis thaliana Profiling Mass spectrometry

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-ming yin Li-Li Wu Shu-Sheng Li xiao-Na Pan xiao-Li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release