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Magnitude and direction of temperature variability affect hospitalization for myocardial infarction and stroke:population-based evidence from Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 1-11页

作者： Zhou Yang Murui Zheng Ze-lin Yan Hui Liu Xiangyi Liu Jie-qi Jin Jiagang Wu Chun-Quan Ou State Key Laboratory of Organ Failure Research Department of BiostatisticsGuangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Guangzhou Center for Disease Control and Prevention Guangzhou 510440China

Relationships between nonoptimal temperatures and cardiovascular disease(CVD)mortality have been well ***,evidence of the association between temperature variability(TV)and CVD morbidity is *** study aimed to quantify the risk and burden of CVD-related hospitalization associated with the magnitude and direction of *** on meteorology and population-based hospitalizations for myocardial infarction(MI)and stroke were collected in Guangzhou,China,from 2013 to *** temperature variability(HTV)was measured as the standard deviation of hourly temperature records over specific exposure *** direction(upward or downward)of HTV was defined as the average daily mean temperature change relative to that of the previous day during the exposure ***-Poisson regression was applied to assess the impact of HTV after adjusting for the daily mean temperature,and the hospitalization fractions attributable to HTV were calculated.A 1℃-increase in HTV was significantly associated with a 2.24%and 1.72%increase in hospitalizations for MI and hemorrhagic stroke(HS)at lag 0–1 d,respectively,and a 1.55%increase in hospitalizations for ischemic stroke(IS)at lag 0–3 *** the study period,5.99%,4.64%,and 4.53%of MI,HS,and IS hospitalizations,respectively,were attributable to *** upward TV exerts acute effects on CVD hospital admissions,whereas the impact of downward TV generally *** findings highlight the importance of the magnitude and direction of temperature fluctuations,in addition to the mean level,in assessing the adverse health impacts of temperature variations.

关键词： Hourly temperature variability Cardiovascular Hospitalization Direction China

Surface reconstruction and structural transformation of twodimensional Ni-Fe MOFs for oxygen evolution in seawater media

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Nano Research 2024年第4期17卷 2429-2437页

作者： Liyuan xiao Xue Bai Jingyi Han Tianmi Tang Siyu Chen Hui qi Changmin Hou Fuquan Bai Zhenlu Wang Jingqi Guan Institute of Physical Chemistry College of ChemistryJilin UniversityChangchun 130021China The Second Hospital of Jilin University Changchun 130021China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryCollege of ChemistryChangchun 130023China

As a four-electron transfer reaction,oxygen evolution reaction(OER)is limited by large overpotential and slow ***,we in-situ synthesized two-dimensional(2D)Ni-Fe metal-organic framework nanosheets on nickel foam(NixFe-TPA/NF,TPA=terephthalic acid)for oxygen evolution in alkaline and alkaline seawater *** 1 M KOH,Ni3Fe-TPA/NF shows a low overpotential(η10)of 189 mV at 10 mA·cm^(-2) and an ultra-low overpotential of only 260 mV at 500 mA·cm^(-2).In alkaline seawater,Ni3Fe-TPA/NF still provides impressive OER performance,with anη10 of 265 ***-situ Raman characterization results show that the phase transition occurs during the OER,and Ni3FeOOH with more oxygen vacancies is in-situ formed,reducing the OER energy *** functional theory(DFT)reveals that the synergy between Ni and Fe reduces the energy barrier and accelerates the rate-determining *** addition,the ultra-thin 2D sheet structure and the close combination of Ni3FeOOH and highly conductive NF support ensure the high catalytic OER ***,the surface reconstruction and structural modification strategy can be used to design and prepare high-performance OER electrocatalysts for energy-related applications.

关键词： density functional theory(DFT)calculation Ni3FeOOH oxygen evolution reaction seawater electrolysis surface reconstruction

Age-cumulative Effect of REC8 Reduction on Meiotic Chromosome Segregation Errors in Mice

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Reproductive and Developmental Medicine 2021年第4期5卷 193-198页

作者： Li-Yuan Tian ling Zhang Cheng-qiu Tao xiao-qi lin Feng Zhang Bin Zhang Department of Obstetrics Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Objective:This study aimed to explore the relationship between cohesin subunit REC8 reduction and meiosis chromosome segregation errors in the ***:Rec8^(+/-)mice were generated using CRIPSR/Cas9 gene *** association between age and REC8 expression levels in the ovary was determined by Western *** segregation errors were investigated by immunofluorescence imaging of superovulated ***-type andRec8^(+/-)female mice at 5,8,20,36,and 40 weeks were used to evaluate ovarian reserve by ovarian clearing and ***:Ovary REC8 expression levels gradually decreased with age,while chromosome segregation errors increased with *** errors were more common inRec8^(+/-)mice,suggesting an association with REC8 *** ovarian reserve capacity decreased significantly with *** ovarian reserve inRec8^(+/-)mice was inferior to that of age-matched wild-type mice,indicating important roles of age and REC8 levels in the ovarian ***:REC8 reduction has an age-cumulative effect on meiotic chromosome segregation errors in mouse ***8 haploinsufficiency poses a major challenge in generating normal and reproductive oocytes in aging mice.

关键词： Chromosome Segregation Errors Cohesin Meiosis REC8

Atorvastatin ameliorated myocardial fibrosis by inhibiting oxidative stress and modulating macrophage polarization in diabetic cardiomyopathy

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World Journal of Diabetes 2024年第6期15卷 1070-1073页

作者： xiao-Tian Lei Dan-Lan Pu Geng Shan qi-Nan Wu Department of Endocrinology The First Affiliated Hospital of the Third Military Medical University(Army Medical University)Chongqing 400038China Department of Endocrinology Chongqing Yubei District People's HospitalChongqing 400030China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People's Hospital of DazuChongqing 402360China

In this editorial,we commented on the article published in the recent issue of the World Journal of *** cardiomyopathy(DCM)is characterized by myocardial fibrosis,ventricular hypertrophy and diastolic dysfunction in diabetic patients,which can cause heart failure and threaten the life of *** pathogenesis of DCM has not been fully clarified,and it may involve oxidative stress,inflammatory stimulation,apoptosis,and *** is lack of effective therapies for DCM in the clinical *** have been widely used in the clinical practice for years mainly to reduce cholesterol and stabilize arterial plaques,and exhibit definite cardiovascular protective *** have shown that statins also have anti-inflammatory and antioxidant *** were particularly concerned about the recent findings that atorvastatin alleviated myocardial fibrosis in db/db mice by regulating the antioxidant stress and antiinflammatory effects of macrophage polarization on diabetic myocardium,and thereby improving DCM.

关键词： Diabetic cardiomyopathy Statins Macrophage Oxidative stress

Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents

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International Journal of Mental Health Promotion 2024年第4期26卷 261-269页

作者： Yanjing Cao Chenchen Xu qi Li Shan Lu Jing xiao Beijing Key Laboratory of Learning and Cognition and Department of Psychology Capital Normal UniversityBeijing100048China Center for Child Development Capital Normal UniversityBeijing100048China

Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban *** this need,the longitudinal invariance of these measures over time remains *** research explores the structural components of the Center for Epidemiological Studies Depression Scale(CES-D)and examines its consistency across various living environments and temporal stability in a cohort of Chinese ***:In the initial phase,1,042 adolescents furnished demographic details and undertook the CES-D *** a three-month interval,967 of these participants repeated the CES-D *** study employed Confirmatory factor analysis(CFA)to scrutinize the scale’s structural *** investigated factorial invariance by conducting a twopronged CFA:one comparing urban *** backgrounds,and another contrasting the results from the initial assessment with those from the ***:The CES-D demonstrated adequate reliability in both rural and urban high school student *** preliminary four-factor model applied to the CES-D demonstrated a good fit with the collected *** tests,including multigroup analyses comparing rural and urban samples and longitudinal assessments,confirmed the scale’s ***:The results suggest that the CES-D serves as a reliable instrument for evaluating depressive symptoms among Chinese *** applicability is consistent across different living environments and remains stable over time.

关键词： Depression factor structure measurement invariance Chinese adolescent longitudinal invariance

PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts

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Journal of Genetics and Genomics 2024年第2期51卷 243-251页

作者： Xinran Dong Yulan Lu Lanting Guo Chuan Li qi Ni Bingbing Wu Huijun Wang lin Yang Songyang Wu qi Sun Hao Zheng Wenhao Zhou Shuang Wang Center for Molecular Medicine Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China Department of Bioinformatics Hangzhou Nuowei Information Technology Co.LtdHangzhouZhejiang 310000China The Third Research Institute of the Ministry of Public Security Shanghai 200031China Xiamen Campus of Children's Hospital of Fudan University XiamenFujian 361006China Institutes for Systems Genetics West China HospitalChengduSichuan 610041China Shanghai Putuo People's Hospital Tongji UniversityShanghai 200060China

The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://***:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.

关键词： Privacy protecti on Rare diseases in children Genetic testing Web system Trusted executi on envir onment

A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

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Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： Sai-Nan Liu Jia-Hui Meng Li-Yun Cui Hua Chen lin-qi Shi Ru-Jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein *** combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer ***,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different ***,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)*** PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release *** the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their *** cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two *** cytoplasm,the high level of GSH removed the modification of 2-APBA on *** restored RNase A and DOX show a synergistic and enhanced antic-cancer *** system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond

Amorphous NiMo_(3)S_(13)/nickel foam integrated anode for lithium-ion batteries

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Tungsten 2024年第2期6卷 438-446页

作者： Ming-Xin Shi Min Wu Shan-Shan xiao Shan-Ping Liu Rui-qi Yao Ying-qi Li Yong-Hui Wang Yang-Guang Li Hua-qiao Tan Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Institute Charles Gerhardt Montpellier Universite de MontpellierCentre National de la Recherche Scientifi quePlace E.Bataillon34095 Montpellier Cedex 05France

Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer,their structures are easily disrupted during long-term cycling due to the continuous embedding/de-embedding of lithium *** contrast,the amorphous materials have abundant defects and lithium ion storage sites,refl ecting a superior reaction kinetics and long-term cycling ***,we synthesize an integrated hybrid anode by in-situ loading amorphous NiMo_(3)S_(13)nanosheets on nickel foam *** ting from the introduction of Ni^(2+)that amorphizes the molybdenumsulfur clusters,the assembled lithium ion battery based on the integrated NiMo_(3)S_(13)/nickel foam anode delivers a specifi c capacity up to 1659 mA·h·g^(−1)at a current density of 0.6 A·g^(−1)and exhibits superior rate/cycling performance.

关键词： Molybdenum-sulfur clusters Amorphous Integrated anode Crystalline Lithium-ion batteries

Theoretical calculations of proton emission half-lives based on a deformed Gamow-like model

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Chinese Physics C 2024年第4期48卷 107-114页

作者：张冬萌胡笑源亓林静刘宏铭李明李小华 School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of Modern Physics Fudan UniversityShanghai 200433China National Exemplary Base for International Sci&Tech.Collaboration of Nuclear Energy and Nuclear Safety University of South ChinaHengyang 421001China Cooperative Innovation Center for Nuclear Fuel Cycle Technology&Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

In this study,proton emission half-lives were investigated for deformed proton emitters with 53≤Z≤83based on the presented deformed Gamow-like model,where the deformation effect was included in the Coulomb *** experimental half-lives of proton emitters can be reproduced within a factor of *** comparison,the results from the universal decay law and the new Geiger-Nuttall law are also ***,the relevance of the half-lives to the angular momentum l for ^(117)La,^(121)Pr,^(135)Tb,and ^(141)Ho were analyzed,and the corresponding possible values of l were proposed:l=3,3,4,4.

关键词： proton emission half-lives deformed nuclei Gamow-like model