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Fructooligosaccharides enhance the therapeutic effect of xiao-zhi-fang on non-alcoholic fatty liver disease via regulating intestinal flora

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Liver Research 2021年第4期5卷 217-223页

作者： Jiongshan Zhang Yue Li Gemin xiao Yongwei Li Heping Xie Yan Chen Department of Traditional Chinese Medicine The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background:Non-alcoholic fatty liver disease(NAFLD)is a frequently occurring clinical disease,which could be treated by traditional Chinese ***,the effects and mechanisms of xiao-zhi-fang(XZF)alone or in combination with fructooligosaccharides(FOS)on NAFLD remains ***:This study established the NAFLD mouse model by feeding with a high-fat diet and by administering with XZF and/or ***,the fat content in the liver tissues was evaluated by oil red O and hematoxylin and eosin staining,and the liver function indices were examined using a biochemical *** in the intestinal flora were monitored using 16S rRNA gene *** results of the current study showed that the alanine aminotransferase,aspartate aminotransferase,total triglyc-eride,total cholesterol levels,and the amount of lipid accumulation were markedly elevated in NAFLD ***:XZF alone or in combination with FOS significantly reduced lipid accumulation in the liver and blood lipid levels in NAFLD ***,XZF alone or in combination with FOS notably altered the intestinal flora structure in NAFLD ***,17 operational taxonomic units were decreased and nine were increased in the XZF and/or FOS ***:FOS may accelerate the intestinal microecological balance in NAFLD mice after treatment with XZF by promoting intestinal flora growth,thereby enhancing the therapeutic effect of XZF on NAFLD.

关键词： Fructooligosaccharides(FOS) High-fat diet(HFD) Intestinal flora Non-alcoholic fatty liver disease(NAFLD) xiao-zhi-fang(XZF)

Development of a MWDC prototype of the CSR external-target experiment

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-14页

作者： He, Zhou-Bo Qin, zhi Ma, Peng Yang, He-Run Wei, Xiang-Lun Lu, Chen-Gui Wen, Xiang-Jie Zhang, Xiu-Ling Chen, Tao Li, zhi-Jie Yang, Yuan-Sheng Zhan, Mei-Qiang Liu, Can-Wen Li, Meng Qiu, Tian-Li Gong, Yi-Wei Huang, Xin-Jie Yin, xiao-Hao He, zhi-Xuan Zhang, Jun-Wei Zou, Hai-Chuan Fu, Sheng-Wei Guo, Dong Yan, Jun-Wei Cao, Zhe Deng, zhi Kong, Jie xiao, zhi-Gang Hu, Rong-Jiang Duan, Li-Min Chinese Acad Sci Inst Modern Phys Lanzhou 730000 Peoples R China Univ Chinese Acad Sci Sch Nucl Sci & Technol Beijing 100049 Peoples R China Tsinghua Univ Dept Phys Beijing 100084 Peoples R China Univ Sci & Technol China Hefei 230026 Peoples R China Sichuan Univ Inst Nucl Sci & Technol Key Lab Radiat Phys & Technol Minist Educ Chengdu 610064 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China North China Univ Water Resources & Elect Power Zhengzhou 450000 Peoples R China

The cooling storage ring (CSR) external-target experiment (CEE) is a spectrometer used in construction to study the properties of nuclear matter in high-baryon density regions at the Heavy-Ion Research Facility in Lanzhou (HIRFL). This study presents the design, simulation, manufacturing, and testing of a half-size prototype of a multi-wire drift chamber (MWDC) for the CEE. First, the performance of the MWDC connected to homemade electronics was simulated. The results demonstrated that an energy resolution of 18.5% % for 5.9-keV X-rays and a position resolution of 194 mu m for protons can be achieved by the current design. Because the size of the largest MWDC reached 176 cm x 314 cm, a set of 98 cm x 98 cm prototypes was built using the new techniques. The positioning accuracy of the anode wires in this prototype is better than 20 mu m. After optimization, using commercially available electronics, the prototype can achieved an energy resolution of 19.7% % for a Fe-55 X-ray source. The CEE-MWDC detector and electronics were simultaneously tested. An energy resolution of 22% % was achieved for the Fe-55 source; the track residuals were approximately 330 mu m for the cosmic rays. The results demonstrate that the current design and techniques meet the requirements of the CEE-MWDC array.

关键词： CEE MWDC Garfield plus plus Fe-55 source Position resolution DRIFT CHAMBER HIRFL-CSR

A seven-crystal spectrometer for high-energy resolution X-ray spectroscopy at Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2024年第9期35卷 82-91页

作者： Bing-Bao Mei Liang-Xin Wang Song-Qi Gu xiao-zhi Su Shuo Zhang Yao Wei Jing-Yuan Ma Zheng Jiang Fei Song Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

A Johann-type X-ray spectrometer was successfully developed at the hard X-ray branch(in-vacuum undulator with a 24-mm periodic length)of the energy material beamline(E-line)at the Shanghai Synchrotron Radiation Facility(SSRF).This spectrometer was utilized to implement X-ray emission spectroscopy(XES),high-energy resolution fluorescence-detected X-ray absorption spectroscopy(HERFD-XAS),and resonant inelastic X-ray *** spherically bent crystals were positioned on the respective vertical 500-mm-diameter Rowland circles,adopting an area detector to increase the solid angle to 1.75%of 4πsr,facilitating the study of low-concentrate systems under complex reaction *** under the atmosphere pressure,the spectrometer covers the energy region from 3.5 to 18 keV,with the Bragg angle ranging from 73°to 86°during vertical *** offers a promised energy resolution of sub-eV(XES)and super-eV(HERFD-XAS).Generally,these comprehensive core-level spectroscopy methods based on hard X-rays at the E-line with an extremely high photon flux can meet the crucial requirements of a green energy ***,they provide substantial support for scientific advances in fundamental research.

关键词： X-ray emission spectroscopy High-energy-resolution X-ray spectrometer Johann geometry Energy materials SSRF

Combining prognostic value of serum carbohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 798-809页

作者： Dong-Qin Xia Yong Zhou Shuang Yang Fang-Fei Li Li-Ya Tian Yan-Hua Li Hai-Yan Xu Cai-zhi xiao Wei Wang Oncology Treatment Center of Traditional Chinese Medicine Chongqing University Cancer HospitalChongqing 400030China Department of Oncology Chongqing Weisiteng Biotech Translational Research InstituteChongqing 430039China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 430065China

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social *** To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer *** study specifically assessed CA19-9 levels and tumor size before and after *** A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this *** average age was 65.4±10.6 years and 72(46.2%)patients were *** survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR0.5 and*** regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR0.5 and*** on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)***-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(P<0.05).CR and TR after NAT were associated with increased odds of achieving a complete or near-complete pathologic ***,CR(hazard ratio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with *** This study demonstrated that post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.

关键词： Pancreatic ductal adenocarcinoma Carbohydrate antigen 19-9 Tumor size Pathologic response Biomarkers

Exceptional points and quantum dynamics in a non-Hermitian two-qubit system

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Chinese Physics B 2024年第6期33卷 212-218页

作者：张益玺张振涛杨震山魏晓志梁宝龙 School of Physics Science and Information Technology Shandong Key Laboratory of Optical Communication Science and TechnologyLiaocheng UniversityLiaocheng 252059China

We study the exceptional-point(EP) structure and the associated quantum dynamics in a system consisting of a non-Hermitian qubit and a Hermitian qubit. We find that the system possesses two sets of EPs, which divide the systemparameter space into PT-symmetry unbroken, partially broken and fully broken regimes, each with distinct quantumdynamics characteristics. Particularly, in the partially broken regime, while the PT-symmetry is generally broken in the whole four-dimensional Hilbert space, it is preserved in a two-dimensional subspace such that the quantum dynamics in the subspace are similar to those in the PT-symmetry unbroken regime. In addition, we reveal that the competition between the inter-qubit coupling and the intra-qubit driving gives rise to a complex pattern in the EP variation with system parameters.

关键词： non-Hermitian system exceptional point PT-symmetry

农村金融理论新范式:基本原理、实践模式与政策意蕴

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经济学家 2024年第9期 119-128页

作者：陈小知米运生广东金融学院华南创新金融研究院华南农业大学经济管理学院

农村金融领域不完全竞争范式已经脱离了发展中国家之现实。地缘、业缘、亲缘的巨大变化,既带来了农户信用信息的丰富性、空间与行业分布的分散性,也增添了信用评估的技术复杂性。在信息收集与评估方面,以银行为代表的正规金融机构已在... 详细信息

农村金融领域不完全竞争范式已经脱离了发展中国家之现实。地缘、业缘、亲缘的巨大变化,既带来了农户信用信息的丰富性、空间与行业分布的分散性,也增添了信用评估的技术复杂性。在信息收集与评估方面,以银行为代表的正规金融机构已在总体上居优,但“大国小农”的国情农情使得民间中介在还款意愿信息方面将在长期内拥有比较优势。本文将这种新的范式概念化为信息比较优势,并以中国为案例,系统讨论信息比较优势的基本原理、实践模式与政策意蕴。信息比较优势范式的提出,既是对传统范式的迭代,也标志着农村金融领域中国学派的形成。在新的理论范式指引下,中国特色农村金融现代化发展道路也将行稳致远。

关键词：农村金融理论范式信息比较优势实践模式政策取向

Improvement of ionic conductivity of solid polymer electrolyte based on Cu-Al bimetallic metal-organic framework fabricated through molecular grafting

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2943-2958页

作者： Liu-bin SONG Tian-yuan LONG Min-zhi xiao Min LIU Ting-ting ZHAO Yin-jie KUANG Lin JIANG Zhong-liang xiao College of Chemistry and Chemical Engineering Changsha University of Science and TechnologyChangsha 410114China Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation Changsha University of Science and TechnologyChangsha 410114China College of New Energy Ningbo University of TechnologyNingbo 315336China

A composite solid electrolyte comprising a Cu-Al bimetallic metal-organic framework(CAB),lithium salt(LiTFSI)and polyethylene oxide(PEO)was fabricated through molecular grafting to enhance the ionic conductivity of the PEO-based *** and molecular dynamics simulation results indicated that the electrolyte with 10 wt.%CAB(PL-CAB-10%)exhibits high ionic conductivity(8.42×10~(-4)S/cm at 60℃),high Li+transference number(0.46),wide electrochemical window(4.91 V),good thermal stability,and outstanding mechanical ***,PL-CAB-10%exhibits excellent cycle stability in both Li-Li symmetric battery and Li/PL-CAB-10%/LiFePO4 asymmetric battery *** enhanced performances are primarily attributable to the introduction of the versatile *** abundant metal sites in CAB can react with TFSI~-and PEO through Lewis acid-base interactions,promoting LiTFSI dissociation and improving ionic ***,regular pores in CAB provide uniformly distributed sites for cation plating during cycling.

关键词： polyethylene oxide Cu−Al bimetallic metal-organic framework solid lithium metal battery molecular grafting ionic conductivity

Properties of radiation defects and threshold energy of displacement in zirconium hydride obtained by new deep-learning potential

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Chinese Physics B 2024年第7期33卷 456-465页

作者：王玺唐孟蒋明璇陈阳春刘智骁邓辉球 School of Physics and Electronics Hunan UniversityChangsha 410082China College of Materials Science and Engineering Hunan UniversityChangsha 410082China

Zirconium hydride(ZrH_(2)) is an ideal neutron moderator material. However, radiation effect significantly changes its properties, which affect its behavior and the lifespan of the reactor. The threshold energy of displacement is an important quantity of the number of radiation defects produced, which helps us to predict the evolution of radiation defects in ZrH_(2).Molecular dynamics(MD) and ab initio molecular dynamics(AIMD) are two main methods of calculating the threshold energy of displacement. The MD simulations with empirical potentials often cannot accurately depict the transitional states that lattice atoms must surpass to reach an interstitial state. Additionally, the AIMD method is unable to perform largescale calculation, which poses a computational challenge beyond the simulation range of density functional theory. Machine learning potentials are renowned for their high accuracy and efficiency, making them an increasingly preferred choice for molecular dynamics simulations. In this work, we develop an accurate potential energy model for the ZrH_(2) system by using the deep-potential(DP) method. The DP model has a high degree of agreement with first-principles calculations for the typical defect energy and mechanical properties of the ZrH_(2) system, including the basic bulk properties, formation energy of point defects, as well as diffusion behavior of hydrogen and zirconium. By integrating the DP model with Ziegler–Biersack–Littmark(ZBL) potential, we can predict the threshold energy of displacement of zirconium and hydrogen in ε-ZrH_(2).

关键词： zirconium hydride deep learning potential radiation defects molecular dynamics threshold energy of displacement

春节节日文化氛围延续的地方性表现:安顺屯堡“抬汪公”民俗文化活动的考究

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贵州民族研究 2024年第3期45卷 94-98页

作者：肖远平肖志鹏贵州师范大学贵州贵阳550025 华中师范大学国家文化产业研究中心湖北武汉430079 贵阳人文科技学院贵州贵阳550025

贵州安顺屯堡的“抬汪公”传统节日活动是屯堡文化不可或缺的组成部分,每年在正月十八前后举行。虽已经过了元宵节,但该活动仍然受到来自五湖四海的人们的关注,体现贵州屯堡文化的地方质性,即历史演变、文化传承、对祖先的历史贡献之认... 详细信息

贵州安顺屯堡的“抬汪公”传统节日活动是屯堡文化不可或缺的组成部分,每年在正月十八前后举行。虽已经过了元宵节,但该活动仍然受到来自五湖四海的人们的关注,体现贵州屯堡文化的地方质性,即历史演变、文化传承、对祖先的历史贡献之认可以及传承祖先精神的必要性。这一国家级非物质文化遗产活动在推动地方文化发展、促进国家文化软实力提升方面具有较好的作用,因而应充分发挥它的非物质文化遗产价值。

关键词：民俗文化地方性屯堡抬汪公