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Engineering biomimetic silk fibroin hydrogel scaffolds with“organic-inorganic assembly”strategy for rapid bone regeneration

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Bioactive Materials 2024年第10期40卷 541-556页

作者： Renjie Liang Rui Li Weidong Mo xianzhu zhang Jinchun Ye Chang Xie Wenyue Li Zhi Peng Yuqing Gu Yuxuan Huang Shufang zhang Xiaozhao Wang Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineHainingChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of Medicine79 Qingchun RdHangzhouChina

Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic properties for large-size and weight-bearing bone defects ***,an“organic-inorganic assembly”strategy is developed to construct silk fibroin(SF)-based bone scaffolds with the aforementioned *** secondary structure reshuffling,the 3.3-fold increment ofβ-sheet structures in SF hydrogel resulted in a 100-fold improvement of mineral-assembly efficacy via influencing the ion adsorption process and providing templates for mineral ***,abundant minerals were deposited within the hydrogel and also on the surface,which indicated entire mineral-assembly,which ensured the biomimetic mechanical properties of the digital light processing 3D printed SF hydrogel scaffolds with haversian-mimicking *** vitro experiments proved that the assembly between the mineral and SF results in rapid adhesion and enhanced osteogenic differentiation of human bone marrow-derived mesenchymal stem *** vivo experiments further proved that the mineral-assembled SF hydrogel scaffold could significantly enhance integration and bone regeneration at the weight-bearing site within one *** SF-based“organic-inorganic assembly”strategy sheds light on constructing cell-free,growth factor-free and natural polymer-derived bone scaffolds with biomimetic 3D structure,mechanical properties and excellent osteogenic properties.

关键词： Silk fibroin Organic-inorganic assembly Mineralization DLP 3D printing Bone regeneration

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Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl(BSN-GelMA)hydrogel

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Bioactive Materials 2023年第1期19卷 88-102页

作者： Hongwei Wu Yuna Shang Wei Sun Xinyi Ouyang Wenyan Zhou Jieji Lu Shuhui Yang Wei Wei Xudong Yao g Xiaozhao Wang xianzhu zhang Yishan Chen Qiulin He Zhimou Yang Hongwei Ouyang Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Sports Medicine Zhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina College of Chemistry Tianjin Normal UniversityTianjin300387PR China Faculty of Science The University of MelbourneParkvilleVIC3010Australia International Institutes of Medicine The 4th Affiliated Hospital of Zhejiang University School of MedicineYiwuZhejiangChina Key Laboratory of Bioactive Materials Ministry of EducationState Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesCollaborative Innovation Center of Chemical Science and Engineeringand National Institute of Functional MaterialsNankai UniversityTianjin300071China

Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical *** integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface,graft necrosis and ***,poor gap integration is a serious concern,which eventually leads to deterioration of joint *** deal with such complications,this study has developed a strategy to effectively enhance integration of the gap region following mosaicplasty by applying injectable bioactive supramolecular nanofiber-enabled gelatin methacryloyl(GelMA)hydrogel(BSN-GelMA).A rabbit osteochondral defect model demonstrated that BSN-GelMA achieved seamless osteochondral healing in the gap region between plugs of osteochondral defects following mosaicplasty,as early as six ***,the International Cartilage Repair Society score,histology score,glycosaminoglycan content,subchondral bone volume,and collagen II expression were observed to be the highest in the gap region of BSN-GelMA treated *** improved outcome was due to bio-interactive materials,which acted as tissue fillers to bridge the gap,prevent cartilage degeneration,and promote graft survival and migration of bone marrow mesenchymal stem cells by releasing bioactive supramolecular nanofibers from the GelMA *** study provides a powerful and applicable approach to improve gap integration after autologous *** is also a promising off-the-shelf bioactive material for cell-free in situ tissue regeneration.

关键词： Mosaicplasty Osteochondral integration Bioactive supramolecular nanofiber GelMA hydrogel Tissue engineering

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Solution for Output Coordination Equations of Several Typical Parallel Six-Dimensional Acceleration Sensing Mechanisms

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第S1期41卷 96-102页

作者： zhang xianzhu YOU Jingjing zhang Yuanwei College of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing 210037P.R.China

Aiming at the problem that it is difficult to generate the dynamic decoupling equation of the parallel six-dimensional acceleration sensing mechanism,two typical parallel six-dimensional acceleration sensing mechanisms are taken as *** analyzing the scale constraint relationship between the hinge points on the mass block and the hinge points on the base of the sensing mechanism,a new method for establishing the dynamic equation of the sensing mechanism is ***,based on the scale constraint relationship between the hinge points on the mass block and the hinge points on the base of the sensing mechanism,the expression of the branch rod length is *** inherent constraint relationship between the branches is excavated and the branch coordination closed chain of the“12-6”configuration is *** output coordination equation of the sensing mechanism is successfully ***,the dynamic equations of“12-4”and“12-6”configurations are constructed by the Newton-Euler method,and the forward decoupling equations of the two configurations are solved by combining the dynamic equations and the output coordination ***,the virtual prototype experiment is carried out,and the maximum reference errors of the forward decoupling equations of the two configuration sensing mechanisms are 4.23%and 6.53%,*** results show that the proposed method is effective and feasible,and meets the real-time requirements.

关键词： six-dimensional acceleration sensor parallel mechanism topological configuration coordination equation dynamics

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A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi Yi Hui zhang Fangyuan Bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen Jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li Zihao Hu Weiliang Shen Jiaqi Xu xianzhu zhang Youzhi Cai Mengjie Wu Hua Liu Jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

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并联式六维加速度感知机构的操作性能研究进展

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光学精密工程 2023年第19期31卷 2867-2883页

作者：尤晶晶史浩飞张显南京林业大学机械电子工程学院江苏南京210037

六维加速度感知在机器人、航空航天、超精密加工等领域均具有迫切的应用需求,已成为高端装备向“超精尖”发展的一项核心技术。并联式六维加速度传感器具有结构紧凑、动力学解耦精度高等突出优势,其测量性能与感知机构的操作性能有关。... 详细信息

六维加速度感知在机器人、航空航天、超精密加工等领域均具有迫切的应用需求,已成为高端装备向“超精尖”发展的一项核心技术。并联式六维加速度传感器具有结构紧凑、动力学解耦精度高等突出优势,其测量性能与感知机构的操作性能有关。从工作机理的角度,阐述了并联式六维加速度感知机构与并联机器人、并联式六维力感知机构之间的差异。从数学和力学的角度,系统阐释了并联式六维加速度感知机构的静刚度、奇异性、基频共振和故障修复四项操作性能的表征和优化方法,并剖析了现有方法尚不具备自适应性的原因。接着,阐明六维加速度标定平台的必要性和基本要求,并分析了四种原理方案的优缺点。最后,指出挖掘感知机构“性能-结构-激励”三者之间的内在联系,并突破几何/拓扑结构的重构、标定平台的设计和优化这些关键问题,有助于充分发挥并联式六维加速度感知机构的性能优势。

关键词：六维加速度传感器并联机构静刚度奇异性基频共振故障修复

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600MW机组锅炉水压试验研究

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贵州电力技术 2009年第9期12卷 26-28页

作者：张先竹贵州电力建设第二工程公司 550002

1前言盘南电厂是西南地区首次建设单机容量600MW的大型电厂，工程一期规划4×600MW、一次建成。1号、2号锅炉和3号、4号锅炉分别采用东方锅炉厂前后墙对冲自然循环汽包锅炉和上海锅炉厂四角切向燃烧控制循环汽包锅炉。

关键词：汽包锅炉 600MW机组水压试验四角切向燃烧大型电厂上海锅炉厂东方锅炉厂单机容量

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对发热儿童施行健康教育与心理干预的疗效观察

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当代医药论丛 2014年第3X期12卷 195-196页

作者：张先竹云南省丽江市人民医院云南丽江674100

目的:探讨对发热儿童采取健康教育与心理干预对其临床疗效的影响。方法:选取320例发热患儿作为研究对象,采用数字表法将其随机分为观察组(160例)和对照组(160例),为对照组患儿进行儿科常规护理干预,为观察组患儿在进行常规护理的基础上... 详细信息

目的:探讨对发热儿童采取健康教育与心理干预对其临床疗效的影响。方法:选取320例发热患儿作为研究对象,采用数字表法将其随机分为观察组(160例)和对照组(160例),为对照组患儿进行儿科常规护理干预,为观察组患儿在进行常规护理的基础上实施健康教育与心理干预,观察两组患儿的体温变化及临床疗效。结果:观察组患儿治疗的有效率(91.25%)明显高于对照组患儿,其发热持续的时间(8.57±1.33 h)、不思饮食的时间(2.05±0.34 d)、发生惊厥的几率(1.25%)均明显低于对照组患儿(P<0.05)。结论:为发热儿童施行健康教育与心理干预能迅速缓解其临床症状,提高其临床疗效,值得在临床上推广使用。

关键词：小儿发热健康教育心理干预治疗效果

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亚临界600MW机组锅炉吊装研究

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贵州电力技术 2009年第10期12卷 12-14页

作者：张先竹贵州电力建设第二工程公司 550002

1前言在盘南工程锅炉吊装的施工实践中，一批新工艺、新技术在我省、我公司得到首次应用，如汽包倾斜吊装、省煤器出口烟道采用大型加固、竖井受热面采用电动行走葫芦吊装就位、折烟角围墙框架刚性梁大组合、分隔屏过热器的集箱组合吊... 详细信息

1前言在盘南工程锅炉吊装的施工实践中，一批新工艺、新技术在我省、我公司得到首次应用，如汽包倾斜吊装、省煤器出口烟道采用大型加固、竖井受热面采用电动行走葫芦吊装就位、折烟角围墙框架刚性梁大组合、分隔屏过热器的集箱组合吊装等，其中个别工艺属于创新，如受热面高顶板半组合预就位提升穿装；

关键词：组合吊装 600MW机组锅炉亚临界施工实践受热面省煤器刚性梁

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完全各向同性的Stewart型六维加速度感知机构构型综合

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南京航空航天大学学报 2024年第4期56卷 723-730页

作者：张显尤晶晶姜杰凤张缘为李成刚南京林业大学机械电子工程学院南京210037 重庆大学高端装备机械传动全国重点实验室重庆400044 杭州师范大学工学院杭州310036 南京航空航天大学机电学院南京210016

各向同性是六维加速度感知机构的重要性能指标之一,决定了传感器的测量精度。为获得感知机构的完全各向同性,提出了一种新的构型综合方法。首先,运用Newton⁃Euler法并基于支链之间固有的尺度约束关系,构建了Stewart型六维加速度感知机... 详细信息

各向同性是六维加速度感知机构的重要性能指标之一,决定了传感器的测量精度。为获得感知机构的完全各向同性,提出了一种新的构型综合方法。首先,运用Newton⁃Euler法并基于支链之间固有的尺度约束关系,构建了Stewart型六维加速度感知机构的正向解耦方程。其次,剖析了感知机构的各向同性与正向解耦方程中输入矩阵条件数的关联,以及支链位姿与输入矩阵的映射关系。创建了完全各向同性感知机构的构型综合步骤。最后,遵循该步骤,综合出“12⁃6”式Stewart型六维加速度感知机构,并开展了虚拟实验。将添加0.100%随机扰动和零扰动这两种情况相比较,结果显示,六维加速度的最大引用误差为0.169%,也即输入、输出误差的放大倍数仅为1.69。这表明,新构型具有优异的各向同性性能。

关键词：六维加速度传感器并联机构构型综合解耦各向同性

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一起中速磨煤机机座地脚螺栓断裂事件的分析及处理

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贵州电力技术 2009年第6期12卷 69-70页

作者：张先竹黄华贵州电力建设第二工程公司 550002

贵州盘南电厂4×600MW新建工程2号机组在试运过程中出现ZGM113K型中速辊式磨煤机机座地脚螺栓断裂事件，本文回顾了该事件处理情况并作分析和总结，以避免同类事件发生，确保设备的可靠运行。

关键词：中速辊式磨煤机地脚螺栓断裂分析处理

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