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Targeting the resolution pathway of inflammation using Ac2–26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis

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Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 483-493页

作者： xianyan qin Liming He Donghao Fan Wenlang Liang qin Wang Jiyu Fang Key Laboratory of Advanced Technologies of Materials Ministry of Education and School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Advanced Materials Processing and Analysis Center and Department of Materials Science and Engineering University of Central FloridaFlorida 32816United State

Rheumatoid arthritis(RA)is a common autoimmune disease characterized by joint inflammation and immune dysfunction.Although various therapeutic approaches have been utilized for the treatment of RA in clinical applications,the low responsiveness of RA patients and undesired systemic toxicity are still unresolved problems.Targeting the resolution pathway of inflammation with pro-resolving mediators would evoke the protective actions of patient for combating the inflammation.Ac2–26,a 25-amino acid peptide derived from Annexin A(a pro-resolving mediator),has shown good efficacy in the treatment of inflammatory disorders.However,the low bioavailability of Ac2–26 peptides hinders their efficacy in vivo.In this paper,we formed PEGylated lipid nanoparticles(LDNPs)by the co-assembly of l-ascorbyl palmitate(L-AP)and N-(carbonyl methoxypolyethylene glycol-2000)-1,2-distearoyl-sn–glycero-3-phosphoethanolamine(DSPE-PEG 2 k)to encapsulate and deliver Ac2–26 peptides to the arthritic rats.They showed good stability and biocompatibility.After being intravenously administrated,Ac2–26 peptide-loaded PEGylated lipid nanoparticles(ADNPs)showed the prolonged in vivo circulation time and enhanced accumulation in inflamed sites.In vivo therapeutic evaluations revealed that ADNPs could attenuate synovial inflammation and improve joint pathology.Therefore,the pro-resolving therapeutic strategy using ADNPs is effective in RA treatment.

关键词： Pegylated lipid nanoparticles Drug delivery Pro-resolving therapy Ac2–26 peptide Rheumatoid arthritis

An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis

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Acta Pharmaceutica Sinica B 2021年第3期11卷 835-847页

作者： xianyan qin Yingying Xu Xu Zhou Tao Gong Zhi-Rong Zhang Yao Fu Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Key Laboratory of Advanced Technologies of Materials Ministry of Education and School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Sichuan Provincial Orthopedic Hospital Chengdu 610041China

Localized delivery,comparing to systemic drug administration,offers a unique alternative to enhance efficacy,lower dosage,and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests.Herein,a localized drug delivery platform ("plum?pudding"structure) with controlled release and long-acting features is developed through an injectable hydrogel ("pudding") crosslinked via self-assembled triblock polymeric micelles ("plum") to help reduce renal interstitial fibrosis.This strategy achieves controlled and prolonged release of model therapeutics in the kidney for up to three weeks in mice.Following a single injection,local treatments containing either anti-inflammatory small molecule celastrol or anti-TGFb antibody effectively minimize inflammation while alleviating fibrosis via inhibiting NF-k B signaling pathway or neutralizing TGF-b1 locally.Importantly,the micelle-hydrogel hybrid based localized therapy shows enhanced efficacy without local or systemic toxicity,which may represent a clinically relevant delivery platform in the management of renal interstitial fibrosis.

关键词： Hydrogel "Plum-pudding"structure Localized therapy Controlled release Renal fibrosis Inflammation Celastrol Anti-TGFβantibody

从马王堆汉墓出土编织物看湖湘地区秦汉时期编织技艺

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浙江纺织服装职业技术学院学报 2024年第1期23卷 27-33页

作者：董鲜艳湖南省博物馆湖南长沙410005

1972~1974年长沙马王堆汉墓出土了大量纺织服饰文物,在出土的纺织服饰文物中除了有织造的纱、绢、纹绮、四经绞罗、经锦和锦面有大小绒圈并附有立体效果辅助的绒圈锦,另外还有一大类编织物。这类编织物作为纺织服饰的一部分,涵盖的内容... 详细信息

1972~1974年长沙马王堆汉墓出土了大量纺织服饰文物,在出土的纺织服饰文物中除了有织造的纱、绢、纹绮、四经绞罗、经锦和锦面有大小绒圈并附有立体效果辅助的绒圈锦,另外还有一大类编织物。这类编织物作为纺织服饰的一部分,涵盖的内容比较广泛,编织技法也比较复杂。通过对马王堆汉墓出土编织物的整理研究,根据编织方法和编织类型的不同,结合文献资料记载将这些编织物分为三大类,在此基础上将马王堆汉墓出土的编织物和先秦时期湖湘地区楚墓出土编织物进行对比研究。通过对比结果可推测:在湖湘地区先秦时期的编织种类比汉代编织种类丰富,是因为随着编织技术的发展,斜编结构结合双层、重平、表里换层等方式,衍生出丰富且种类多样的编织技法,满足各种用途;斜绞复合结构沿袭了先秦时期的编织技术,广泛使用在服饰和生活应用中,斜绞复合结构在汉代大量使用的基础上,用于纱冠时对其进行髹漆,保证纱冠透气的同时又满足了形状的要求;绞编结构由于特有的功用在秦汉时期大量使用于鞋履的编织。

关键词：马王堆汉墓编织物湖湘地区编织技艺

面向神经重症患者护理的脑电双频谱指数监测仪优化设计

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自动化与仪器仪表 2024年第1期 243-246,251页

作者：庄先艳郑小琴秦丹丹王秀华遂宁市中心医院四川遂宁629000

为了实现当前脑电双频谱指数(Bispectral index, BIS)监测仪对神经重症患者的动态化监测,研究对其内部麻醉监测架构进行改进,提出了优化的BIS监测仪,并对其有效性进行了验证。结果表明,研究提出的框架在麻醉监测上相对于使用LSTM网络模... 详细信息

为了实现当前脑电双频谱指数(Bispectral index, BIS)监测仪对神经重症患者的动态化监测,研究对其内部麻醉监测架构进行改进,提出了优化的BIS监测仪,并对其有效性进行了验证。结果表明,研究提出的框架在麻醉监测上相对于使用LSTM网络模型的框架提升最高达到15%左右,预测准确性最高。而在实际应用中,麻醉前后动脉血压的差距为6%~14%,而体温变化维持在0.9℃~1.6℃之间,术后心率的变化同样维持在1.3~4.4次/分、血氧饱和度差距仅在0.4%~0.5%,BIS指数分数差距为5~12分之间。同时其在麻醉诱导、维持以及苏醒上的精确性分别为58.1%、96.0%以及56.6%,整体上准确率达到了90.1%,综合性能最好。综合来看,研究提出的改进的BIS监测仪在麻醉深度监测上具备较高的有效性,对神经重症患者护理具有重要意义。

关键词：神经重症患者 BIS监测仪编码器 EEG

Failure Mechanisms and Structural Optimization of Shredder Hammer for Metal Scraps

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Chinese Journal of Mechanical Engineering 2016年第4期29卷 792-801页

作者： ZHOU xianyan HU Zhili TAO Yijun qin Xunpeng HUA Lin Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of Technology Wuhan 430070 China Hubei Lidi Machine Tool Company Limited Yichang 443000 China

Recycling retired cars can relieve the environmental pollution and resource waste efficiently.However,a few publications can be found on the failure mechanisms and optimization method of recycling equipment,shredders.Thus,the failure mechanisms and structural optimization of shredder hammers for retired cars are studied aiming improving shredding efficiency and reducing cost.Failure types of shredder hammer are studied theoretically,and it is found that wear failure and fatigue failure are the two main failure types of shredder hammer.The shredding process of metal scraps is analyzed by finite element method,and it can be divided into four stages based on the stress states：initial stage,collision stage,grinding stage and separation stage.It is proved that the shredding efficiency can be improved by increasing cutouts on the hammer head.Finally,it is determined that the hammer with two cutouts is the optimal structure for metal scraps,which can improve the shredding efficiency by 20% and lengthen the hammer life by 15%.This study provides scientific basis for the industry application and theoretical foundation for further research.

关键词： Metal scraps recycling impacts grinding structural optimization

三维编织玻璃纤维/环氧树脂复合材料薄壁管轴向压缩性能的温度效应

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复合材料学报 2023年第10期40卷 5588-5600页

作者：李紫伦杨安坤覃小红武鲜艳易洪雷东华大学纺织学院上海201620 嘉兴学院材料与纺织工程学院嘉兴314001 浙江大学机械工程学院杭州310027

通过三维编织成型技术与树脂传递模塑工艺(RTM)制备了15°、25°、35°3种编织角三维编织玻璃纤维/环氧树脂复合材料薄壁管,分别在低温(-100℃、-50℃)、室温(20℃)和高温(80℃、110℃、140℃、170℃)环境下对三维编织复合材料薄壁管进... 详细信息

通过三维编织成型技术与树脂传递模塑工艺(RTM)制备了15°、25°、35°3种编织角三维编织玻璃纤维/环氧树脂复合材料薄壁管,分别在低温(-100℃、-50℃)、室温(20℃)和高温(80℃、110℃、140℃、170℃)环境下对三维编织复合材料薄壁管进行轴向准静态压缩性能测试,基于X射线微计算机显微断层扫描技术(显微CT)研究了温度和编织角对三维编织玻璃纤维/环氧树脂复合材料薄壁管轴向压缩性能和损伤形态的影响。结果表明:三维编织玻璃纤维/环氧树脂复合材料薄壁管准静态压缩性能具有显著的温度效应。温度越高,增强体与基体的结合越弱,编织复合材料薄壁管的压缩强度、压缩模量与比吸收能越低。随着温度的升高,编织复合材料薄壁管的破坏模式发生从局部剪切失效到纤维束-基体界面大面积脱粘的改变。编织角对三维编织复合材料薄壁管的压缩强度、压缩模量及比能量吸收均有不同程度影响,小编织角编织复合材料薄壁管沿编织纱线方向的取向更高,能承受更大的轴向载荷,因此抗压缩性能更好。

关键词：三维编织复合材料薄壁管编织角准静态压缩性能温度效应破坏模式 X射线显微CT

Analysis of phosphorus forms in sediment cores from ephemeral ponds on Ardley Island, West Antarctica

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Advances in Polar Science 2015年第1期26卷 47-54页

作者： YANG Lianjiao qin xianyan SUN Liguang HUANG Tao WANG Yuhong Institute of Polar Environment School of Earth and Space Sciences University of Science and Technology of China Geological Survey of Anhui Province

The guano of penguins, other seabirds, and pinnipeds is an important source of phosphorus in the ecosystems of Antarctica. To study the vertical distribution of phosphorus in sediments influenced by penguins, we measured phosphorus forms in two sediment cores （（31 and Q2） from ephemeral ponds on Ardley Island. We also investigated the correlations between these phosphorus forms and physicochemical characteristics. Inorganic phosphorus was the main form of phosphorus in both cores. The vertical distribution patterns of phosphorus forms in G1 and Q2 differed, indicating different sedimentary sources. The GI sediment profile was more influenced by penguin guano than the Q2 profile, and as a result sediments in the G1 core had higher total phosphorus, non-apatite inorganic phosphorus, and apatite phosphorus content. The findings from two ephemeral ponds on Ardley Island indicate that the contribution of penguin guano to organic matter in G1 core has increased in recent times, while Q2 showed a relatively larger contribution from mosses in ancient times, evident from the lithology and the vertical trend in organic matter.

关键词： sediment phosphorus forms penguins

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宜昌湿地群高影响天气特征及影响度分析

水利水电技术（中英文） 2022年第S1期53卷 17-25页

作者：成勤王清龙罗剑琴肖湛臻张丽陈鲜艳湖北省宜昌市气象局湖北宜昌443000 中国气象局国家气候中心北京100081

湿地系统对高影响天气敏感,分析宜昌湿地群暴雨、大风、高温和雷电特征及影响度,得出以下结论:(1)宜昌暴雨呈增多趋势,影响度小于0.5。隔河岩库区、熊渡库区、南河和泗洋河湿地自然保护区位于暴雨影响度相对大值区。(2)宜昌大风日数增多... 详细信息

湿地系统对高影响天气敏感,分析宜昌湿地群暴雨、大风、高温和雷电特征及影响度,得出以下结论:(1)宜昌暴雨呈增多趋势,影响度小于0.5。隔河岩库区、熊渡库区、南河和泗洋河湿地自然保护区位于暴雨影响度相对大值区。(2)宜昌大风日数增多,均值为7.4 d,影响度小于0.4,大值区主要在沿江峡谷、高海拔地区和东部冷空气通道上。三峡库区、隔河岩库区、香溪河、湾潭河和漳河湿地自然保护区位于大风影响度大值区。(3)宜昌高温增多,均值为23.4 d。河谷、低山、东部平原以及城市化影响明显的地区高温影响度较高。香溪河、三峡库区、泗洋河、沮河、大溪库区、高坝洲库区和熊渡库区湿地自然保护区位于高温影响度大值区。(4)宜昌雷暴天数和时长均呈减少趋势,主要活动时间为6—8月,雷电流强度主要集中在10~50 kA,雷电影响度小于0.5。沮河、漳河、三峡库区、南河和熊渡库区湿地自然保护区位于雷电影响度相对大值区。

关键词：湿地群高影响天气暴雨大风高温雷电

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巢湖北部土壤重金属污染特征及生态风险评价

中国科学技术大学学报 2017年第5期47卷 426-434页

作者：秦先燕彭苗枝胡波吴剑雄孙跃安徽省地质调查院安徽合肥230001

以巢湖北部为研究对象,分析了165个表层土壤样品中As,Cd,Cr,Cu,Hg,Ni,Pb和Zn含量及污染特征,并与其他地区土壤重金属元素含量进行了对比.利用污染指数法和潜在生态风险指数法对土壤重金属污染和潜在生态风险进行了评价.结果表明,8种重... 详细信息

以巢湖北部为研究对象,分析了165个表层土壤样品中As,Cd,Cr,Cu,Hg,Ni,Pb和Zn含量及污染特征,并与其他地区土壤重金属元素含量进行了对比.利用污染指数法和潜在生态风险指数法对土壤重金属污染和潜在生态风险进行了评价.结果表明,8种重金属平均含量顺序依次为:Cr>Zn>Ni>Pb>Cu>As>Cd>Hg,Cd和Hg变异系数较大,且对深层土壤元素有较明显的富集作用.单因子污染指数评价结果显示土壤各重金属均为清洁水平,污染程度依次为:Pb>Cr>As=Ni>Cu>Cd>Zn>Hg;综合污染指数表明土壤总体为清洁水平.在8种重金属中,Cd和Hg是研究区土壤重金属处于强生态风险的主要因子,贡献率分别为19.40%和72.87%.

关键词：巢湖表层土壤重金属内梅罗生态风险评价