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A Cu/Cinchona P,N-ligand system enabled general asymmetric C(sp^3)–C(sp) coupling

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Science China Chemistry 2020年第6期63卷 751-752页

作者： xianwei li Chao-Jun li Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis McGill University801 Sherbrooke St.W.MontrealQuebec H3A 0B8Canada School of Chemical Engineering and light Industry Guangdong University of TechnologyGuangzhou 510006China

Due to the special structural feature and versatile reactivity towards various types of transformations,alkynes have inspired continuous research interest for their generation,incorporation and application in organic synthesis,chemical biology and material science[1].Notably,since its invention in 1975,the Sonogashira reaction,which efficiently couples aryl halides with aryl or vinyl terminal alkynes via Pd(0)/Cu(I)synergistic catalysis.

关键词： A Cu/Cinchona P,N-ligand system enabled general asymmetric C coupling

依帕司他对放射性肺炎小鼠线粒体氧化应激损伤的保护作用

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中国临床药理学与治疗学 2024年第7期29卷 809-818页

作者：李泽朋顾文强陈晓王银华李先伟皖南医学院药学院药理学教研室安徽芜湖241002 芜湖市第二人民医院肿瘤放疗科安徽芜湖241000

目的:探讨依帕司他(Epa)对放射性肺炎(RP)小鼠线粒体氧化应激损伤的影响及其机制。方法:C57BL/6小鼠随机对照(CON)组、放射(IR)组、IR联合10 mg/kg Epa处理组及IR联合20 mg/kg Epa处理组,每组各16只。采用6MV X线直线加速器全胸单次照射... 详细信息

目的:探讨依帕司他(Epa)对放射性肺炎(RP)小鼠线粒体氧化应激损伤的影响及其机制。方法:C57BL/6小鼠随机对照(CON)组、放射(IR)组、IR联合10 mg/kg Epa处理组及IR联合20 mg/kg Epa处理组,每组各16只。采用6MV X线直线加速器全胸单次照射15 Gy建立放射性肺炎模型。照射后连续灌胃给药6~8周。HE染色观察肺组织病理变化。透射电镜观察肺组织线粒体结构。EliSA检测血浆白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及转化生长因子-β1(TGF-β1)的水平。免疫组化检测肺组织醛糖还原酶(AR)的表达。比色法检测肺组织丙二醛(MDA)及4-羟基壬烯醛(4-HNE)含量。制备肺组织单细胞悬液,使用DCFH-DA探针检测细胞内活性氧(ROS)水平。实时定量PCR检测AR、IL-6、TNF-α和TGF-β1 mRNA的表达。Western blot法检测AR、IL-6、TNF-α、TGF-β1、BAX、Bcl2、Cleaved Caspase-3、8-氧鸟嘌呤DNA糖基化酶1(OGG1)及沉默信号调节因子3(SIRT3)的蛋白水平。结果:与CON组相比,IR组肺泡水肿,肺泡间隔增厚并伴大量炎症细胞浸润;炎症因子IL-6、TNF-α和TGF-β1的水平明显升高(P<0.01);Bcl2的表达明显下调而BAX、Cleaved Caspase-3的表达明显上调(P<0.05,P<0.01)。与IR组相比,Epa连续给药6~8周后,小鼠肺组织炎症损伤明显减轻,炎症因子IL-6、TNF-α和TGF-β1的水平明显降低(P<0.05,P<0.01),细胞凋亡程度明显减轻(Bcl2的表达上调而BAX、Cleaved Caspase-3的表达下调)。与CON组相比,IR组AR的表达明显升高,ROS、MDA及4-HNE的水平明显增加(P<0.01),OGG1和SIRT3的表达明显降低(P<0.01),线粒体损伤明显加剧。而与IR组相比,Epa连续给药6~8周后,IR组AR的表达明显下调(P<0.05,P<0.01),ROS、MDA及4-HNE的水平明显降低,OGG1和SIRT3的表达明显增加,线粒体损伤明显减轻(P<0.05,P<0.01)。结论:Epa对放射性肺炎具有保护作用,其作用可能与其抑制AR的表达,减轻线粒体氧化应激损伤,抑制炎症反应和细胞凋亡有关。

关键词：依帕司他放射性肺炎醛糖还原酶线粒体氧化应激小鼠

埃克替尼抑制肺泡上皮细胞上皮间充质转化进程改善博来霉素诱导的肺纤维化

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中国药学杂志 2024年第12期59卷 1120-1128页

作者：许文奇肖雷徐炜严静静顾文强李先伟安徽医科大学第一附属医院东城院区合肥230000 皖南医学院第二附属医院泌尿外科安徽芜湖241000 皖南医学院药理学教研室安徽芜湖241002

目的探究埃克替尼(icotinib,ICO)的抗肺纤维化(pulmonary fibrosis,PF)作用及其潜在的分子机制。方法C57BL/6小鼠随机分为假手术(Sham)组、PF组、ICO 30 mg·kg^(-1)剂量组及ICO 60 mg·kg^(-1)剂量组,每组n=8。单次气管注射博来霉素(BL... 详细信息

目的探究埃克替尼(icotinib,ICO)的抗肺纤维化(pulmonary fibrosis,PF)作用及其潜在的分子机制。方法C57BL/6小鼠随机分为假手术(Sham)组、PF组、ICO 30 mg·kg^(-1)剂量组及ICO 60 mg·kg^(-1)剂量组,每组n=8。单次气管注射博来霉素(BLM,3 mg·kg^(-1))建立小鼠PF模型。HE及Masson染色观察肺组织病理变化及胶原沉积情况。免疫组化检测肺组织Ⅰ型胶原(collagenⅠ)的表达。体外培养肺泡上皮细胞,实验设对照(control)组、表皮生长因子(epidermal growth factor,EGF)组(100 ng·mL^(-1))及EGF联合ICO(0.1、1、10 mmol·L^(-1))3个剂量组。免疫荧光法检测细胞E-钙黏蛋白(E-cadherin)和α-平滑肌肌动蛋白(α-SMA)的表达及核因子-κB(NF-κB)p65核转移情况。Western blots检测肺组织和(或)细胞collagenⅠ、E-cadherin、α-SMA、Vimentin、磷酸化表皮生长因子受体(phosphorylation epidermal growth factor receptor,p-EGFR)、磷酸化核因子κB抑制物α(p-IκBα)、磷酸化NF-κB p65(p-NF-κB p65)的蛋白水平及NF-κB p65核转移情况。结果动物实验表明,ICO抑制了BLM诱导的胶原沉积,减少了Ⅰ型胶原的表达,减轻了博来霉素诱导的上皮-间充质转化(epithelial-mesenchymal transition,EMT)(E-cadherin表达增加,Vimentin和α-SMA表达减少),降低了EGFR,IκBα和NF-κB p65的磷酸化水平并抑制了NF-κB p65的核转移。细胞实验发现,EGF可激活肺泡上皮细胞EMT和EGFR/NF-κB信号通路,而ICO可逆转这一作用。结论ICO可能通过抑制EGFR/NF-κB信号通路的活化,逆转了EGF诱导的EMT和博来霉素诱导的小鼠肺纤维化。

关键词：埃克替尼肺纤维化上皮-间充质转化表皮生长因子受体/核因子-κB信号通路

Operating condition influences on PCDD/Fs emissions from sinter pot tests with hot flue gas recycling

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Journal of Environmental Sciences 2012年第5期24卷 875-881页

作者： Yongmei Yu Minghui Zheng xianwei li Xiaolei He State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences P.O. Box 2871 Beijing 100085 China Research Institute of Baoshan Iron & Steel Co. Ltd. Shanghai 201900 China

This study was designed to clarify the influence of operating conditions on the formation and emissions of polychlorinated-p-dibenzodioxins and dibenzofurans （PCDD/Fs） from a sintering process with hot flue gas recycling. A pilot scale sinter pot with simulated flue gas recycling was developed, and four key operational parameters, including temperature, oxygen content of the simulated waste flue gas, the coke rate of the sintering mixture, and the quicklime quality, were selected for exploring PCDD/Fs formation. The results showed that the temperature of the recycled flue gas had a major affect on PCDD/Fs formation, and a high temperature could significantly increase their formation during sintering. A clear linear correlation between the temperature of recycling flue gas and PCDD/Fs emission （r = 0.93） was found. PCDD/Fs could be reduced to a certain extent by decreasing the level of oxygen in the recycled flue gas, while sintering quality was unchanged. The coke rate had no significant influence on the formation of PCDD/Fs, but the quality of quicklime used in the sintering mixture could affect not only the amount of PCDD/Fs emissions but also the sintering productivity. Compared with a benchmark sinter pot test, PCDD/Fs emissions markedly decreased with improvements to quicklime quality. However, the reduction in PCDD/Fs emissions realized by using high-quality quicklime was limited by the temperature of the inlet gas. The highest reduction achieved was 51% compared with conventional quicklime when the temperature of the inlet gas was 150°C.

关键词： PCDD/Fs sintering recycling flue gas formation mechanism

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电力一次设备的故障预测及检修措施分析

集成电路应用 2024年第5期41卷 326-328页

作者：李显伟乌仁其其格国网新疆电力有限公司吐鲁番供电公司新疆838000

阐述电力设备一次设备故障的预测检修特点,分析设备故障的原因。介绍电力一次设备故障的预测方法,包括借助监测设备、借助带电和在线监测装置、利用先进的红外技术。针对断路器、变压器、隔离开关、避雷器的故障,提出电力一次设备故障... 详细信息

阐述电力设备一次设备故障的预测检修特点,分析设备故障的原因。介绍电力一次设备故障的预测方法,包括借助监测设备、借助带电和在线监测装置、利用先进的红外技术。针对断路器、变压器、隔离开关、避雷器的故障,提出电力一次设备故障的检修措施。

关键词：在线监测红外技术故障预测故障检修

Further control synthesis for time-delay systems with actuator saturation

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控制理论与应用（英文版） 2013年第1期11卷 128-131页

作者： Mao WANG Yue GU xianwei li Space Control and Inertial Technology Research Center Harbin Institute of Technology Shanghai Aerospace Control Engineering Institute

This paper is concerned with the control synthesis problem for systems with time-varying delay and actuator saturation. A new controller design method is proposed in which auxiliary feedback matrix method is adopted to handle the saturation term in the system. The improvement of the proposed method lies in the application of delay partitioning idea to further enlarge the estimated domain of attraction. All the results are given in terms of linear matrix inequalities. Finally, a numerical example is provided to demonstrate the effectiveness and superiority of our obtained results.

关键词： Time-delay systems Actuator saturation Attraction domain Delay partitioning

An improved method that incorporates the estimated runoff for peak discharge prediction on the Chinese Loess Plateau

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International Soil and Water Conservation Research 2023年第2期11卷 290-300页

作者： Wenhai Shi Miaomiao Wang Donghao li xianwei li Mengying Sun Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region Chang'an UniversityMinistry of EducationChina School of Water and Environment Chang'an UniversityChina

An accurate prediction of peak discharge in watersheds is critical not only for water resource manage-ment,but also for understanding the complex relationships of hydrological *** this study,a modified peak discharge formula based on the Chemicals,Runoff,and Erosion from Agricultural Man-agement Systems(CREAMS)model was developed by introducing rainfall intensity and soil moisture *** reliability of the proposed method was tested with data from 1464 storm events in 41 watersheds and was applied to 256 storm events in five remaining typical watersheds using the opti-mized *** results indicate that the proposed method is highly accurate in terms of model efficiency,as determined by Nash-Sutcliffe efficiencies(NSEs)of 88.60%,74.04%,and 90.12%during the calibration,validation,and application cases,***,it performed better than the original and modified CREAMS ***,using the parameters derived from the initial 41 watersheds and the runoff estimated using the modified Soil Conservation Service curve number(SCS-CN)method,the proposed method was used to predict the peak discharge from the last five typical *** NSE(63.88-80.83%)and low root mean square error(RMSE)values(0.31-35.93 m^(3)s^(-1))were obtained for the five ***,the proposed peak discharge model,combined with the modified SCS-CN method,may accurately predict event-based peak discharge and runoff for general applications under various hydrological and geomorphic conditions in the Loess Plateau region.

关键词： Chemicals,Runoff,and Erosion from agricultural management systems (CREAMS) NRCS-CN Peak discharge Surface runoff Rainfall intensity

基于网络药理学探究北五味子治疗缺血性脑卒中机制

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黑龙江医学 2024年第12期48卷 1433-1436页

作者：李显伟张宇黄鑫大庆龙南医院神经外科黑龙江大庆163000

目的:探究北五味子治疗缺血性脑卒中的有效活性物质和具体机制。方法:通过中药系统药理学技术平台筛选出北五味子的有效活性成分,应用Swiss target prediction数据库获得有效活性物质的作用靶点;通过人类基因数据库和在线人类孟德尔遗... 详细信息

目的:探究北五味子治疗缺血性脑卒中的有效活性物质和具体机制。方法:通过中药系统药理学技术平台筛选出北五味子的有效活性成分,应用Swiss target prediction数据库获得有效活性物质的作用靶点;通过人类基因数据库和在线人类孟德尔遗传数据库获得缺血性脑卒中的作用靶点;通过韦恩图获得共同靶点,借助String数据库进行蛋白质互作网络的建立;通过DAVID数据库进行基因本体(GO)分析获得生物学过程条目、分子功能条目和细胞组成条目;通过基因组百科全书(KEGG)通路富集分析,获得北五味子发挥作用的潜在作用机制;通过Cytoscape 3.8.2软件建立北五味子有效成分-靶点-通路网络。结果:北五味子具有7种治疗缺血性脑卒中的有效成分,18个核心靶点;通过GO分析发现北五味子治疗缺血性脑卒中涉及220个生物学过程条目,27个细胞组成条件,34个分子功能条目;通过KEGG通路富集分析发现北五味子发挥治疗缺血性脑卒中涉及到VEGF信号通路、PI3K-Akt信号通路、脂质与动脉粥样硬化通路和TNF信号通路等;北五味子治疗缺血性脑卒中网络涉及到35个节点、184条边,平均相邻节点数目为10.514,网络中心度为0.309。结论:北五味子有效成分、多靶点、多通路起到防治缺血性脑卒中的作用。本次研究预测的北五味子防治缺血性脑卒中潜在机制可为开展实验研究及临床应用提供依据。

关键词：北五味子网络药理学缺血性脑卒中

A Novel Improved Bat Algorithm in UAV Path Planning

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Computers, Materials & Continua 2019年第7期61卷 323-344页

作者： Na lin Jiacheng Tang xianwei li liang Zhao School of computer science Shenyang Aerospace UniversityShenyang110000China School of Information Engineering Suzhou UniversitySuzhou215000China Global Information and Telecommunication Institute Waseda UniversityTokyo169-0051Japan

Path planning algorithm is the key point to UAV path planning *** traditional path planning methods still suffer from low convergence rate and insufficient *** this paper,three main methods are contributed to solving these ***,the improved artificial potential field(APF)method is adopted to accelerate the convergence process of the bat’s position ***,the optimal success rate strategy is proposed to improve the adaptive inertia weight of bat *** chaos strategy is proposed to avoid falling into a local *** with standard APF and chaos strategy in UAV path planning scenarios,the improved algorithm CPFIBA(The improved artificial potential field method combined with chaotic bat algorithm,CPFIBA)significantly increases the success rate of finding suitable planning path and decrease the convergence *** results show that the proposed algorithm also has great robustness for processing with path planning ***,it overcomes the shortcomings of the traditional meta-heuristic algorithms,as their convergence process is the potential to fall into a local *** the simulation,we can see also obverse that the proposed CPFIBA provides better performance than BA and DEBA in problems of UAV path planning.

关键词： UAV path planning bat algorithm the optimal success rate strategy the APF method chaos strategy