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Towards a Component Framework for Architecture-Based Self-Adaptive Applications

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1227-1232页

作者： ZHOU Yu MA Xiaoxing TAO xianping lu Jian State Key Laboratory for Novel Software Technology Nanjing University Nanjing 210093 Jiangsu China

Self-adaptive software is an efficient way to cope with highly dynamic nature of the environment where it is situated. In this paper, from the perspective of software architecture, we propose a component framework for supporting the architecture-based design and development of self-adaptive applications. It captures some key elements of the research on software architecture and provides more flexible facilities to decouple interacting components. Based on that, a prototype is implemented to demonstrate its feasibility, and at last a case study is presented to illustrate our framework.

关键词： software architecture component framework self-adaptive

Studies on the Distribution and Radioimmunoimaging of ^(99m)Tc-Labeled 5-Fluorouracil Loaded Immunological Nanoparticles in Tissues and Human Gastric Carcinoma Xenografts

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Chinese Journal of Clinical Oncology 2007年第5期4卷 307-312页

作者： Kaihong Huang Jianhua Liu Zhaohua Zhu Xuexian Li xianping lu Institute of Gastroenterology Departmentof Nuclear Medicine the 2nd Affiliated Hospital of Sun Yat-sen University Guangzhou510120 China.

OBJECTIVE To explore the method of preparation of 99m↑Tc labeled AntiVEGF McAb 5-FU loaded polylactic acid nanoparticles （99m↑TC-5-FU-Ab-NPs）, and investigate the biological distribution of the nanoparticles in human gastric carcinoma xenografts. METHODS Anti-VEGF monoclonal antibodyes （MCAB）in 5-FU-Ab-NPs were labeled with 99m↑Tc using a modified Schwarz method. After isolation of the 99m↑TC-5-FU-Ab-NPs using a Sephadex G-250 column, the labeling percentage and radiochemical purity were determined using paper chromatography. The immunocempetence of the 99m↑TC-5-FU-Ab-NPs as tumor markers was determined using ELISA and immunohistochemistry. 99m↑TC-5-FU-Ab-NPs （experimental group）, 99m↑Tc-labelled murine multiclonal IgG loaded polylactic acid and nanoparticles （control group） were injected via the tail vein into SCID mice bearing human gastric carcinoma. A radio-immunity ECT image was developed at 2 and 6 h after the injection. Following the ECT imaging, the mice were sacrificed, their tissue and tumor radioactivity distribution determined, and percentage of the injected-dose per gram （%ID/g） and tumor/ nontumor （T/NT） ratio calculated. High performance liquid chromatography （HPLC） was used to determine the 5-FU concentration in the tumor tissue and blood in the mice of both groups. RESULTS The percentage of 99m↑TC-5-FU-Ab-NPs labeling was 90%-95%. There was no obvious decrease in the antibody activity before and after labeling. The radio-immuno-imaging （RII） showed that the tumor image had developed 2 h after injection of the 99m↑TC-5-FU-Ab-NPs, and with time it was clearer at the 6th hour following the injection. The %lD/g of the tumor tissue at both 2 h and 6 h after the injection was significantly higher compared to the control group. The tumor %lD/g and the tumor to blood activity ratio （TB） of the experimental group at 6 h following the injection increased compared to that at 2 h, and at the same time, 5-FU concentration in the tumor of the experimental gro

关键词： radionuclide imaging gastric carcinoma monoclonal antibody nanoparticles

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建立跨专业领域药物警戒体系的思考

中国药物警戒 2020年第3期17卷 154-156,164页

作者：王欣昊鲁先平深圳微芯生物科技股份有限公司广东深圳518057

近年来,我国通过药品审评审批制度改革,加快临床急需、罕见病治疗和创新药物上市审评审批,大大满足了我国患者对于创新治疗药物可及性的需求,同时也给我国的药品安全风险监测工作带来了巨大挑战。2018年66号公告对于药品上市许可持有人... 详细信息

近年来,我国通过药品审评审批制度改革,加快临床急需、罕见病治疗和创新药物上市审评审批,大大满足了我国患者对于创新治疗药物可及性的需求,同时也给我国的药品安全风险监测工作带来了巨大挑战。2018年66号公告对于药品上市许可持有人(持有人)的药品不良反应报告和监测工作提出了明确和具体的要求。持有人的药物警戒工作面临着由过去仅注重对个例报告收集与分析,到对药品进行全面系统安全性评价和风险管理的转变。药物警戒科学是一门跨专业学科,因此需要持有人有效地整合公司内部和外部的资源,构建密切合作、多方参与的药物警戒工作网络,以更好地进行药品安全风险监测和评估,履行持有人的法律责任,保障患者用药安全。

关键词：药品上市许可持有人药物警戒体系

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基于SWOT框架的中药企业专利战略分析

科技管理研究 2009年第1期29卷 210-211页

作者：汪启航廖凤霞卢晓萍重庆电子工程职业学院重庆401331 重庆太极集团有限公司重庆401147

阐述我国中药企业实施专利战略的意义,运用SWOT分析方法,分析中国中药企业专利战略的优势、劣势、机会和威胁,提出我国中药企业专利战略的实施措施。

关键词：专利战略中药企业 SWOT

“五位一体”育人体系联合教学改革创新性分析

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家长 2020年第24期 118-118页

作者：卢先平甘肃省武威第一中学

"五位一体"协同育人的教学模式,在当下教育环境中有着不可忽视的作用。除了课件体系的合理设置以及教师的督导外,家长的配合、从学生角度出发、突出理解与互动,都是形成优秀育人体系教学改革的良好尝试。

关键词：五位一体教学改革创新

强制制冷对镁等离子体中类氦离子能级上粒子数反转的影响

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吉林大学自然科学学报 1989年第3期 42-46页

作者：冯贤平卢仁祥中国科学院上海光机所

采用高Z冷等离子体强制冷却热蕊镁等离子体的方法,获得了镁的类氦离子在软射线区域的粒子数反转证据。并提出了一种简单、方便又能避开涉及绝对标定的数据处理方法,定量地给出了各种等离子体参数和软X射线激光的增益参数。

关键词：制冷等离子体镁激光 X射线

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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益肾安合剂治疗慢性肾衰竭的临床研究

河北中医 2008年第10期30卷 1023-1024,1093页

作者：席淑清路现平河北省遵化市医保中心河北遵化064200 河北省沙河市医院内科河北沙河054001

观察益肾安合剂治疗慢性肾衰竭(CRF)的临床疗效。方法60例CRF患者随机分为2组。治疗组30例采用益肾安合剂,对照组30例采用醛氧淀粉。观察治疗前后血肌酐(Cr)、血尿素氮(BUN)、内生肌酐清除率(Ccr)、血浆白蛋白(ALb)变化及中医证候积分... 详细信息

观察益肾安合剂治疗慢性肾衰竭(CRF)的临床疗效。方法60例CRF患者随机分为2组。治疗组30例采用益肾安合剂,对照组30例采用醛氧淀粉。观察治疗前后血肌酐(Cr)、血尿素氮(BUN)、内生肌酐清除率(Ccr)、血浆白蛋白(ALb)变化及中医证候积分。结果治疗后CRF患者血Cr、BUN、血浆白蛋白(ALb)及中医证候积分较治疗前有明显下降(P均<0.01);临床总有效率治疗组为80.3%,对照组为66.6%,2组比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。结论益肾安合剂能明显改善CRF患者肾功能,调节细胞因子,降低中医证候积分,提高生活质量,延缓慢性肾衰竭的进程。

关键词：健脾,补肾肾功能衰竭,慢性中医药疗法

Towards a programming framework for activity-oriented context-aware applications

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Frontiers of Computer Science 2017年第6期11卷 987-1006页

作者： Xuansong LI xianping TAO Jian lu State Key Laboratory for Novel Software Technology Department of Computer Science and Technology Nanjing University Nanjing 210000 China

Context-aware system is an emerging research area in recent years. Context plays an important role in these systems. In most existing work, context is treated as all rel- ative elements in the environment of an application, and the scope of context is predefined by the developers during the development. However, it is difficult to analyze, specify, and organize everything in the environment accurately and com- pletely; and even when it is possible, the developed applica- tions are difficult to extend or modify as the requests for en- vironment may change over time. In this paper, we focus on activity-oriented context-aware （AOCA） applications where the requests for environment are highly dependent on user activities, and propose a programming framework for devel- oping AOCA applications. In particular, we first present a concept model for describing the notions of activity-oriented context. Next, based on the concept model, we describe the details of the programming framework as well as a develop- ment tool. Moreover, we provide a platform to support the runtime of AOCA applications, and demonstrate the advan- tages of our programming framework through experimental evaluations.

关键词： pervasive computing context-awareness,context-aware programming framework activity-orientedcontext