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Cellular metabolism: A key player in cancer ferroptosis

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Cancer Communications 2024年第2期44卷 185-204页

作者： xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Public Service Platform of Tumor Organoids Technology ChangshaHunanP.R.China Department of Head and Neck Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Hengyang Medical School University of South ChinaHengyangHunanP.R.China

Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

关键词： cancer therapy cellular metabolism ferroptosis inducer ferroptosis

Pinning energies of organic semiconductors in high-efficiency organic solar cells

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Journal of Semiconductors 2023年第3期44卷 52-61页

作者： Xian’e Li Qilun Zhang xianjie liu Mats Fahlman Laboratory of Organic Electronics Department of Science and Technology(ITN)Linköping UniversitySE-60174NorrköpingSweden Wallenberg Wood Science Center Department of Science and Technology(ITN)Linköping UniversitySE-60174NorrköpingSweden

With the emergence of new materials for high-efficiency organic solar cells(OSCs),understanding and finetuning the interface energetics become increasingly important.Precise determination of the so-called pinning energies,one of the critical characteristics of the material to predict the energy level alignment(ELA)at either electrode/organic or organic/organic interfaces,are urgently needed for the new materials.Here,pinning energies of a wide variety of newly developed donors and nonfullerene acceptors(NFAs)are measured through ultraviolet photoelectron spectroscopy.The positive pinning energies of the studied donors and the negative pinning energies of NFAs are in the same energy range of 4.3−4.6 eV,which follows the design rules developed for fullerene-based OSCs.The ELA for metal/organic and inorganic/organic interfaces follows the predicted behavior for all of the materials studied.For organic-organic heterojunctions where both the donor and the NFA feature strong intramolecular charge transfer,the pinning energies often underestimate the experimentally obtained interface vacuum level shift,which has consequences for OSC device performance.

关键词： organic semiconductors organic solar cells pinning energies integer charge transfer interface dipoles

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基于语境与语义模态的多任务情感原因对抽取

北京邮电大学学报 2024年第2期47卷 18-23,89页

作者：刘宇鹏冯贤杰姚登举哈尔滨理工大学计算机科学与技术学院哈尔滨150006

为了综合考虑更多模态信息,对语境和语义特征进行了建模,并将它们融合在一起以提取情感原因对。针对语境模态,采用了子句嵌入方法来获取情绪和原因的表示,并通过双因素注意力机制得到全局语境矩阵。同时,通过构建子句间语义的图神经网络... 详细信息

为了综合考虑更多模态信息,对语境和语义特征进行了建模,并将它们融合在一起以提取情感原因对。针对语境模态,采用了子句嵌入方法来获取情绪和原因的表示,并通过双因素注意力机制得到全局语境矩阵。同时,通过构建子句间语义的图神经网络,得到了局部语义特征。最后,通过主模态和辅助模态的匹配,得到了融合特征,以进行多任务预测,包括情感句、原因句和情感-原因对的抽取。实验结果表明,在抽取经典中文情感原因对数据时,相较于最佳基线系统,所提模型的F测度提高了2.2%。

关键词：情感原因对全局语境局部语义模态匹配

Effect of Loss-of-function of the Herpes Simplex Virus-1 microRNA H6-5p on Virus Replication

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Virologica Sinica 2019年第4期34卷 386-396页

作者： Rongquan Huang Xusha Zhou Shuqi Ren xianjie liu Zhiyuan Han Grace Guoying Zhou School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China Shenzhen International Institute for Biomedical Research Shenzhen 518116China

To date, 29 distinct microRNAs(miRNAs) have been reported to be expressed during herpes simplex virus infections.Sequence analysis of mature herpes simplex virus-1(HSV-1) miRNAs revealed five sets of miRNAs that are complementary to each other: miR-H6-5p/H1-3p, miR-H6-3p/H1-5p, H2-5p/H14-3p, miR-H2-3p/H14-5p, and miR-H7/H27.However, the roles of individual miRNAs and consequences of this complementarity remain unclear. Here, we focus on two of these complementary miRNAs, miR-H6-5p and miR-H1-3p, using loss-of-function experiments in vitro and in a mouse model of infection using an miRNA sponge approach, including tandem multiplex artificial miRNA-binding sequences that do not match perfectly to the target miRNA inserted downstream of a green fluorescent protein reporter gene. Infection with recombinant virus expressing the miR-H6-5p sponge reduced viral protein levels and virus yield.Decreased accumulation of viral proteins was also observed at early stages of infection in the presence of both an miR-H6-5p inhibitor and plasmid-expressed miR-H1-3p. Moreover, establishment of latency and reactivation did not differ between the recombinant virus expressing the miR-H6-5p sponge and wild-type HSV-1. Taken together, these data suggest that miR-H6-5p has an as-yet-unidentified role in the early stages of viral infection, and its complement miR-H1-3p suppresses this role in later stages of infection. This report extends understanding of the roles of miRNAs in infection by herpes simplex viruses, supporting a model of infection in which the production of virus and its virulent effects are tightly controlled to maximize persistence in the host and population.

关键词： miR-H6-5p miR-H1-3p Sponge Replication Herpes simplex virus-1(HSV-1)

基于反射系数与核函数构建的新型电缆缺陷诊断方法

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电工技术学报 2024年第7期39卷 2184-2192,2213页

作者：饶显杰徐忠林刘翔宇关惠方周凯国网四川省电力公司成都供电公司成都610041 四川大学电气工程学院成都610065

为解决现有的电缆局部缺陷检测方法中缺陷定位效果差、缺陷类型判断困难等问题,提出一种基于反射系数谱(RCS)的新型电缆缺陷诊断方法。首先,利用电缆线路的分布参数模型,建立了含局部缺陷电缆线路的RCS数学模型,根据RCS数学模型,确定合... 详细信息

为解决现有的电缆局部缺陷检测方法中缺陷定位效果差、缺陷类型判断困难等问题,提出一种基于反射系数谱(RCS)的新型电缆缺陷诊断方法。首先,利用电缆线路的分布参数模型,建立了含局部缺陷电缆线路的RCS数学模型,根据RCS数学模型,确定合理的核函数,设计出基于RCS的新型缺陷诊断函数,该缺陷诊断函数的极值峰可用于定位电缆线路中的缺陷,并确定缺陷的类型、严重程度等特征;然后,对不同类型与严重程度的电缆线路缺陷进行建模仿真诊断,测试该方法的可行性与准确性;最后,在同轴电缆与10 kV电力电缆上设计了局部缺陷,并用该方法对真实电缆缺陷进行诊断分析。仿真与实测结果表明,该方法能精准地定位电缆线路中的缺陷,并且可以准确地判断出缺陷的类型与严重程度,说明了该方法的实用性,且具有较高的实际工程价值。

关键词：电缆线路局部缺陷反射系数谱缺陷定位缺陷分析

Termination of Transcription of LAT Increases the Amounts of ICP0 mRNA but Does Not Alter the Course of HSV-1 Infection in Latently Infected Murine Ganglia

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Virologica Sinica 2021年第2期36卷 264-272页

作者： Haifang Jiang Jiaming Wu xianjie liu Ruitao Lu Manling Zhou Meiling Chen Yonghong liu Grace Guoying Zhou Wenmin Fu School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China Shenzhen International Institute for Biomedical Research Shenzhen 518116China

On entering sensory ganglia,herpes simplex viruses 1(HSV-1)establishes a latent infection with the synthesis of a latency associated transcript(LAT)or initiates productive infection with expression of a set of immediate early viral proteins.The precise mechanisms how expression of a genes is suppressed during the latency are unknown.One mechanism that has been proposed is illustrated in the case of ICP0,a key immediate early viral regulatory protein.Specifically,the 2 kb LAT intron is complementary to the 30 terminal portion of ICP0 m RNA.To test the hypothesis that accumulation of LAT negatively affects the accumulation of ICP0 m RNA,we inserted a DNA fragment encoding two poly(A)sequences into LAT to early terminate LAT transcript without interrupting the complementary sequence of ICP0 transcript(named as SR1603).Comparisons of the parent(SR1601)and mutant(SR1603)HSV-1 viruses showed the following:Neurons harboring latent SR1603 virus accumulated equivalent amounts of viral DNA but higher amounts of ICP0 m RNA and lower amounts of LAT,when compared to neurons harboring the SR1601 virus.One notable difference between the two viruses is that viral RNA accumulation in explanted ganglia harboring SR1603 virus initiated significantly sooner than that in neurons harboring SR1601 virus,suggesting that ICP0 may act as an activator of viral gene expression in permissive cells.Collectively,these data suggest that increased ICP0 m RNA by suppressed LAT did not affect the establishment of latency in latently infected murine ganglia.

关键词： Herpes simplex viruses 1(HSV-1) Latency associated transcript(LAT) ICP0 Latency

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光电效应与光电子能谱分析技术

物理教学 2023年第5期45卷 2-7页

作者：王伟杨金彭 xianjie liu 保秦烨扬州大学物理科学与技术学院江苏225009 瑞典林雪平大学有机电子实验室北雪平60174 华东师范大学物理与电子科学学院上海200241

本文介绍光电效应现象及其实验验证的重要性,从光电效应的原理出发介绍光电子能谱分析仪的构建、发展及其应用,如何利用光电子能谱分析技术手段来开展对各种材料表面进行物理特性的研究,最后对光电子能谱的运用发展进行展望。

关键词：光电效应电子结构光电子能谱能带色散

固体NaOH/Na_(2)SiO_(3)激发矿粉/粉煤灰-炉渣基注浆材料性能研究

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中南大学学报（自然科学版） 2024年第2期55卷 628-637页

作者：徐先杰朱志敬王孟白继文陈孟军刘人太山东大学岩土与结构工程研究中心山东济南250061

以矿粉和粉煤灰-炉渣作为前驱体,其中粉煤灰、炉渣以质量比4:1共同粉磨制备前驱体之一,以NaOH和Na_(2)SiO_(3)配制模数为1.2的固体激发剂,制备碱激发注浆材料。研究粉煤灰-炉渣的掺量、激发剂的掺量(以Na_(2)O计)对注浆材料工作性能和... 详细信息

以矿粉和粉煤灰-炉渣作为前驱体,其中粉煤灰、炉渣以质量比4:1共同粉磨制备前驱体之一,以NaOH和Na_(2)SiO_(3)配制模数为1.2的固体激发剂,制备碱激发注浆材料。研究粉煤灰-炉渣的掺量、激发剂的掺量(以Na_(2)O计)对注浆材料工作性能和力学性能的影响,并通过扫描电镜(SEM)和能谱分析(EDS)对水化产物进行物理化学表征,使用核磁共振分析注浆材料孔结构特征。研究结果表明:粉煤灰-炉渣掺量为50%的注浆材料的28 d最大抗压强度达31.25 MPa。水化产物主要为C-A-S-H凝胶,浆液结石体内部孔隙主要为胶凝孔(孔径<10 nm)和过渡孔(孔径为[10~100) nm),占比超过90%。

关键词：炉渣粉煤灰固体激发剂碱激发注浆材料力学性能微观结构

Defect passivation by nontoxic biomaterial yields 21% efficiency perovskite solar cells

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Journal of Energy Chemistry 2021年第4期30卷 265-271页

作者： Shaobing Xiong Tianyu Hao Yuyun Sun Jianming Yang Ruru Ma Jiulong Wang Shijing Gong xianjie liu Liming Ding Mats Fahlman Qinye Bao Key Laboratory of Polar Materials and Devices Department of Electronic ScienceSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200025China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006ShanxiChina Laboratory of Organic Electronics ITNLinköping UniversitySE-60174 NorrköpingSweden Wallenberg Wood Science Center Linköping UniversitySE-60174 NorrköpingSweden Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Defect passivation is one of the most important strategies to boost both the efficiency and stability of perovskite solar cells(PSCs).Here,nontoxic and sustainable forest-based biomaterial,betulin,is first introduced into perovskites.The experiments and calculations reveal that betulin can effectively passivate the uncoordinated lead ions in perovskites via sharing the lone pair electrons of hydroxyl group,promoting charge transport.As a result,the power conversion efficiencies of the p-i-n planar PSCs remarkably increase from 19.14%to 21.15%,with the improvement of other parameters.The hydrogen bonds of betulin lock methylamine and halogen ions along the grain boundaries and on the film surface and thus suppress ion migration,further stabilizing perovskite crystal structures.These positive effects enable the PSCs to maintain 90%of the initial efficiency after 30 days in ambient air with 60%±5%relative humidity,75%after 300 h aging at 85℃,and 55%after 250 h light soaking,respectively.This work opens a new pathway for using nontoxic and low-cost biomaterials from forest to make highly efficient and stable PSCs.

关键词： Perovskite solar cells Defect passivation Nontoxic biomaterial Efficiency