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Vav1 promotes inflammation and neuronal apoptosis in cerebral ischemia/reperfusion injury by upregulating microglial and NLRP3 inflammasome activation

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Neural Regeneration Research 2023年第11期18卷 2436-2442页

作者： Jing Qiu Jun Guo Liang Liu Xin Liu xianhui sun Huisheng Chen Department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Department of Neurology Tangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina

Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral *** guanine nucleotide exchange factor 1(Vav1) is a guanine nucleotide exchange factor that is related to microglial ***,how Vav1 participates in the inflammato ry response after cerebral ischemia/reperfusion inj ury remains unclea *** this study,we subjected rats to occlusion and repe rfusion of the middle cerebral artery and subjected the BV-2 mic roglia cell line to oxygen-glucose deprivatio n/reoxygenation to mimic cerebral ischemia/repe rfusion in vivo and in vitro,*** found that Vav1 levels were increased in the brain tissue of rats subjected to occlusion and reperfusion of the middle cerebral arte ry and in BV-2 cells subjected to oxygen-glucose deprivation/*** Vav1 reduced the cerebral infarct volume and brain water content,inhibited neuronal loss and apoptosis in the ischemic penumbra,and im p roved neurological function in rats subjected to occlusion and repe rfusion of the middle cerebral *** analysis showed that Vav1 was almost exclusively localized to microglia and that Vav1 downregulation inhibited microglial activation and the NOD-like receptor pyrin 3(NLRP3) inflammasome in the ischemic penumbra,as well as the expression of inflammato ry facto *** addition,Vov1 knoc kdown decreased the inflammatory response exhibited by BV-2 cells after oxygen-glucose deprivation/reoxyge *** together,these findings show that silencing Vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/repe rfusion through inhibiting the activation of mic roglia and NLRP3 inflammasome.

关键词： apoptosis cerebral ischemia/reperfusion inflammatory cytokines microglia microglial activation middle cerebral artery occlusion neuroprotection NLRP3 inflammasome oxygen-glucose deprivation/reoxygenation Vav1

Knee osteoarthritis:A review of animal models and intervention of traditional Chinese medicine

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Animal Models and Experimental Medicine 2024年第2期7卷 114-126页

作者： Xuyu Song Ying Liu Siyi Chen Lei Zhang Huijie Zhang xianhui Shen Hang Du Rong sun Orthopaedic trauma surgery The Second Hospital of Shandong UniversityJinanShandongChina Academy of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Department of Traditional Chinese Medicine The Second Hospital of Shandong UniversityJinanShandongChina College of pharmacy Shandong University of Traditional Chinese MedicineJinanShandongChina The Second Clinical College of Shandong University Shandong UniversityJinanShandongChina Advanced Medical Research Institute Shandong UniversityJinanShandongChina The Second Hospital of Shandong University JinanShandongChina

Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging *** pathophysiology of KOA remains poorly understood,as it involves complex mechanisms that result in the same ***,researchers are interested in studying KOA and require appropriate animal models for basic *** herbal compounds,which consist of multiple herbs with diverse pharmacological properties,possess characteristics such as multicomponent,multipathway,and multitarget *** potential benefits in the treatment of KOA continue to attract ***:This study aims to provide a comprehensive overview of the advantages,limitations,and specific considerations in selecting different species and methods for KOA animal *** will help researchers make informed decisions when choosing an animal ***:Online academic databases(e.g.,PubMed,Google Scholar,Web of Science,and CNKI)were searched using the search terms“knee osteoarthritis,”“animal models,”“traditional Chinese medicine,”and their combinations,primarily including KOA studies published from 2010 to ***:Based on literature retrieval,this review provides a comprehensive overview of the methods of establishing KOA animal models;introduces the current status of advantages and disadvantages of various animal models,including mice,rats,rabbits,dogs,and sheep/goats;and presents the current status of methods used to establish KOA animal ***:This study provides a review of the animal models used in recent KOA research,discusses the common modeling methods,and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

关键词： animal models knee osteoarthritis system review traditional Chinese medicine

Effect　of　Al　in　Ti－microalloyed　Mn－Ni－Mo　welding　wire　on　microstructure　and　toughness　of　deposited　metal

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China Welding 1995年第1期4卷 28-36页

作者： Tan Changying Zhang xianhui and sun Weifeng(Harbin Research Institute of Welding)

The effect of Al in Ti-microalloyed welding wire on microstructure and toughness of deposited metals is *** results show that the deposited metal toughness worsens with increasing Al in wire' The mechanism of Al is as follows:(1) Al makes oxygen content in deposited metal increase.(2)Al restrains the formation of Ti-rich oxide inclusion, which causes granular bainite microstructure in deposited metal.(3)The content of solute Ti in deposited metal increases with Al content in welding wire,as a result,a part of carbonrich constitution in deposited metal is in the form of twin martensite.

关键词： Mn-Ni-Mo Al microstructure toughness deposited metal

Performance and mechanism of CO_(2) absorption during the simultaneous removal of SO_(2) and NO_(x) by wet scrubbing process

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Journal of Environmental Sciences 2024年第1期135卷 534-545页

作者： Peng Lu xianhui Yan Lyumeng Ye Dingsheng Chen Dongyao Chen Jianhang Huang Chaoping Cen Guangdong Province Engineering Laboratory for Air Pollution Control South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655China Guangdong Provincial Key Laboratory of Water and Air Pollution Control Guangzhou 510655China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

The co-removal of CO_(2)while removing SO_(2)and NOxfrom industrial flue gas has great potential of carbon emission reduction but related research is *** this study,a wet scrubbing process with various urea solutions for desulfurization and denitrification was explored for the possibility of CO_(2)*** results showed that the urea-additive solutions were efficient for NOxand SO_(2)abatement,but delivered<10%CO_(2)absorption *** addition of Ca(OH)_(2)dramatically enhanced the CO_(2)absorption,remained the desulfurization efficiency,unfortunately restricted the denitrification *** various operating parameters,pH of solution played a determining role during the *** contradictory pH demands of CO_(2)absorption and denitrification were observed and discussed in detail.A higher pH of solution than 10 was favorable for CO_(2)absorption,while the oxidizing of NO to NO_(2),NO_(2)^(-)or NO_(3)^(-)by NaClO_(2)was inhibited in this ***7

关键词： CO_(2)absorption Synergistic desulfurization and denitrification Wet scrubbing process Urea-NaClO_(2)-Ca(OH)_(2)absorbent Carbonation reaction

Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development

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Chinese Herbal Medicines 2024年第2期16卷 239-247页

作者： Liping Gong Hang Du Xin Guo Jianchao Li Xiaomin Zhu xianhui Shen Zhiyan Huang Kaiyi Wu Guimin Zhang Rong sun The Second Hospital of Shandong University Jinan 250033China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276006China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Shandong University of Traditional Chinese Medicine Jinan 250355China Advanced Medical Research Institute Shandong UniversityJinan 250012China

Constipation is common in the diseases of the digestive system in *** the change in diet structure and the increase in life pressure,the prevalence rate increases year by *** traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other *** pathogenesis is conductive dysfunction of large *** on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the *** study has been carried out to review the latest advances of SHTB in the treatment of *** results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation associated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac ***,obvious adverse reactions were not *** could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation。

关键词： constipation gastrointestinal hormones interstitial cells of cajal intestinal fluid secretion intestinal motility Shouhui Tongbian Capsule

前置上向流臭氧生物活性炭深度处理水厂浮游动物监测与控制

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给水排水 2022年第6期48卷 20-25页

作者：黄慧宋欣马越孙显慧深圳市深水龙华水务有限公司深圳518100

对水厂全流程出水中浮游动物进行分类监测,浮游动物平均检出值从高到低依次为原水、沉后水、炭后水、滤后水、出厂水。原水浮游动物总量202~4456个/100 L,活体占比1%~4%。混凝沉淀为浮游动物去除的主要工艺段,沉后水浮游动物总量1.2~15.... 详细信息

对水厂全流程出水中浮游动物进行分类监测,浮游动物平均检出值从高到低依次为原水、沉后水、炭后水、滤后水、出厂水。原水浮游动物总量202~4456个/100 L,活体占比1%~4%。混凝沉淀为浮游动物去除的主要工艺段,沉后水浮游动物总量1.2~15.9个/100 L,去除率92.1%~99.9%。上向流活性炭滤池出水浮游动物0.15~3.87个/100 L,检测值和检出率均低于沉淀池出水。南方地区选用的上向流臭氧生物活性炭滤池,在微型动物孳生控制方面较下向流生物活性炭滤池更具优势。滤池过滤可进一步降低出水中浮游动物数量,但仍存在浮游动物穿透滤池的风险。可通过提前预警,采取强化混凝沉淀、滤前加氯及滤后加拦截网的方式进行防控。

关键词：上向流臭氧生物活性炭浮游动物监测控制

Imaging momentum-space Cooper pair formation and its competition with the charge density wave gap in a kagome superconductor

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 142-150页

作者： Yiming sun Yubing Tu Yang Luo Shuikang Yu Hongyu Li Yunmei Zhang Ping Wu Zhuying Wang Fan Zhang Wanru Ma Zuowei Liang Jianjun Ying Tao Wu Ziji Xiang Junfeng He Lei Shan Zhenyu Wang xianhui Chen Department of Physics CAS Key Laboratory of Strongly Coupled Quantum Matter Physicsand Hefei National LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Information Materials and Intelligent Sensing Laboratory of Anhui Province Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

The superconducting ground state of kagome metals AV_(3)Sb_(5)(where A stands for K,Rb,or Cs)emerges from an exotic charge density wave(CDW)state that potentially breaks both rotational and time reversal ***,the specifics of the Cooper pairing mechanism,and the nature of the interplay between these two states remain elusive,largely due to the lack of momentum-space(k-space)superconducting energy gap *** implementing Bogoliubov quasiparticle interference(B QPI)imaging,we obtain k-space information on the multiband superconducting gap structureΔ_(SC)^(i)(k)in pristine CsV_(3)Sb_(5).We show that the estimated energy gap on the vanadium d_(xy/x^(2)-y^(2))orbital is anisotropic but nodeless,with a minimal value located near the M ***,a comparison ofΔ_(SC)^(i)(k)with the CDW gapΔ_(CDW)^(i)(k)obtained by angle-re solved photoemission spectro scopy(ARPES)reveals direct k-space competition between the se two order parameters,i.e.,the opening of a large(small)CDW gap at a given momentum corresponds to a small(large)superconducting *** the long-range CDW order is suppressed by replacing vanadium with titanium,we find a nearly isotropic energy gap on both the V and Sb *** information will be critical for identifying the microscopic pairing mechanism and its interplay with intertwined electro nic orders in this kagome superconductor family.

关键词： kagome lattice charge density wave superconducting energy gap scanning tunneling microscopy

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Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

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National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping sun Zhongkai Liu Dong-Lai Feng xianhui Chen sung-Kwan Mo Minjae Kim Young-Woo Son Dawei Shen Wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

Biochar-compost-based controlled-release nitrogen fertilizer intended for an active microbial community

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 326-343页

作者： Robiul Islam RUBEL Lin WEI Salman ALANAZI Abdulkarim ALDEKHAIL Anne CMCIDREIRA Xufei YANG Sanjita WASTI Samarthya BHAGIA xianhui ZHAO Department of Agricultural and Biosystem Engineering South Dakota State UniversityBrookingsSD 57007USA Tickle College of Engineering University of Tennessee KnoxvilleKnoxvilleTN 37996USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

Nitrogen(N) fertilizers in agriculture suffer losses by volatilization of N to the air, surface runoff and leaching into the soil, resulting in low N use efficiency(NUE)( 50%) and raising severe environmental pollutions. Controlledrelease nitrogen fertilizers(CRNFs) can control the release of N nutrients to NUE in crop production. Different methods were used to develop new ***, different CRNF technologies are still underdeveloped due to inadequate controlling on N releasing time and/or unsustainable diffusion. The study on the influences of CRNF processing parameters on microbial conditions are lacking when the CRNFs composed of various bio-ingredients such as biochar, composts, and biowaste. The complexity of processing methods, material biodegradability, and other physical properties make current CRNFs of questionable value in agricultural production. This research aims to develop a novel biochar-compost-based controlled-release urea fertilizer(BCRUF) to preserve microbial properties carried by the compost. The BCRUF was synthesized by pelletizing the 50:50(dry, wt/wt) mixture of biochar and compost. BCRUF was loaded with urea and then spray-coated with polylactic acid(PLA). The releasing time of two types of BCRUFs, coated and uncoated with PLA, for 80% of N release in water was up to 6 h at three different temperatures(4, 23, and 40 °C), compared to conventional urea fertilizer and commercial environmentally smart N(ESN) fertilizer. The releasing time of coated BCRUF for 80% N release in soil was up to 192 h(8 days). Fourier-transform infrared spectroscopy(FTIR) analysis revealed that no new functional groups were found in the release solution, indicating no new chemical hazards generated. The differential scanning calorimetry(DSC)tests also verified that its thermal stability could be up to 160 °C. The microbe populations in the BCRUF pellets were reduced after the pelleting and drying processes in BCRUF fabrication, but a few bacteria can endure in t

关键词： Soil microbial community biochar compost controlled-release nitrogen fertilizer polylactic acid spray coating