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Core–Shell Microfiber Encapsulation Enables Glycerol‑Free Cryopreservation of RBCs with High Hematocrit

Nano-Micro Letters 2024年第1期16卷 35-54页

作者： xianhui Qin Zhongrong Chen Lingxiao shen Huilan Liu Xilin Ouyang Gang Zhao Department of Electronic Engineering and Information Science University of Science and Technology of ChinaHefei 230027People’s Republic of China School of Biomedical Engineering Anhui Medical UniversityHefei 230022People’s Republic of China Department of Blood Transfusion The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001People’s Republic of China The Fourth Medical Center Chinese PLA General HospitalBeijing 100089People’s Republic of China

Cryopreservation of red blood cells(RBCs)provides great potential benefits for providing transfusion timely in *** concentrations of glycerol(20%or 40%)are used for RBC cryopreservation in current clinical practice,which results in cytotoxicity and osmotic injuries that must be carefully ***,existing studies on the low-glycerol cryopreservation of RBCs still suffer from the bottleneck of low hematocrit levels,which require relatively large storage space and an extra concentration process before transfusion,making it inconvenient(time-consuming,and also may cause injury and sample lose)for clinical *** this end,we develop a novel method for the glycerol-free cryopreservation of human RBCs with a high final hematocrit by using trehalose as the sole cryoprotectant to dehydrate RBCs and using core–shell alginate hydrogel microfibers to enhance heat transfer during *** from previous studies,we achieve the cryopreservation of human RBCs at high hematocrit(>40%)with high recovery(up to 95%).Additionally,the washed RBCs post-cryopreserved are proved to maintain their morphology,mechanics,and functional *** may provide a nontoxic,high-efficiency,and glycerol-free approach for RBC cryopreservation,along with potential clinical transfusion benefits.

关键词： Cryopreservation Human red blood cells Core-shell microfibers Trehalose Hematocrit

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Coaxing Polysaccharide Granules into Supramolecular Biocolloidal Additives for Papermaking

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Paper And Biomaterials 2020年第2期5卷 1-19页

作者： Yongsheng Wang Wenyuan Zhu Xueren Qian Meiyun Zhang Shunxi Song Chuyan Jing Zhengren Meng Shiyu Xu xianhui An Xiujie Huang Jing shen Key Laboratory of Bio-based Material Science and Technology of Ministry of Education Northeast Forestry UniversityHarbinHeilongjiang Province150040China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjingJiangsu Province210037China College of Bioresources Chemical and Materials Engineering National Demonstration Center for Experimental Light Chemistry Engineering EducationShaanxi Province Key Laboratory of Papermaking Technology and Specialty Paper DevelopmentShaanxi University of Science&TechnologyXi'anShaanxi Province710021China

In light of developments in polysaccharide-based sustainable processes involving supramolecular interactions,we herein present our findings pertaining to coaxing polysaccharide granules into functional supramolecular *** biocolloidal dispersions containing various forms of starch are facilely designable,essentially built upon complexation between disassembled native cornstarch granules and amphiphilic *** moieties of guest molecules are dynamically attractable into cavities of helical structures,with cationic groups pointing toward the bulk *** noncovalent attraction can generate core-shell biocolloidal *** significantly higher gelatinizability of freeze-dried biocolloids in contrast to native cornstarch granules is attributable to complex formation,and a homogenous dispersion is readily formable at room *** results also show biocolloids'ligand-related antibacterial *** use of biocolloids as wet-end additives for biofiber assemblies(cellulosic paper)can enhance mechanical strength,fines retention,and filler *** biocolloids with positively charged,translucent,easily gelatinizable,antibacterial,and polysaccharide-bondable functionalities would find tailorable use in the paper industry.

关键词： polysaccharide granules inclusion complex supramolecular biocolloids functionalities papermaking wet-end chemistry

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蒸汽发生器传热管在泵致脉动压力载荷下的动力学响应研究

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原子能科学技术 2018年第2期52卷 269-275页

作者：蔡逢春黄旋沈平川叶献辉中国核动力研究设计院核反应堆系统设计技术重点实验室四川成都610213

泵致脉动压力是核电站中引起主设备部件疲劳失效的主要原因之一。本文建立了蒸汽发生器传热管的泵致脉动压力载荷表达式,并建立不同弯曲半径的传热管有限元模型,对蒸汽发生器传热管在泵致脉动压力载荷下的动力学响应进行了研究。结果表... 详细信息

泵致脉动压力是核电站中引起主设备部件疲劳失效的主要原因之一。本文建立了蒸汽发生器传热管的泵致脉动压力载荷表达式,并建立不同弯曲半径的传热管有限元模型,对蒸汽发生器传热管在泵致脉动压力载荷下的动力学响应进行了研究。结果表明:34、64、94、114、124、144排传热管附近的频率、振型对泵致脉动压力最为敏感;包络泵致脉动压力作用下,最大应力出现在32排传热管上;传热管在泵致脉动压力载荷作用下,泵致脉动压力载荷的轴频频率对结构响应的贡献最大。本文分析结果为蒸汽发生器传热管在泵致脉动压力载荷下的磨损分析提供了参考。

关键词：传热管脉动压力谐响应流致振动

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Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

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National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu Dong-Lai Feng xianhui Chen Sung-Kwan Mo Minjae Kim Young-Woo Son Dawei shen Wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

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Clinical efficacy of umbilical therapy with herbal cakes of different dosages for damp-heat diarrhea in young children

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Journal of Acupuncture and Tuina Science 2022年第1期20卷 72-78页

作者： XU Yinyin ZHENG xianhui ZHANG Xiaowen LAN Yu WANG Jiali shen Jian HONG Jue Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 201203China 不详

Objective:To observe the clinical efficacy of umbilical therapy with herbal cakes made of Ge Gen Qin Lian Tang prescription of different dosages in treating damp-heat diarrhea in young ***:Seventy-two kids with diarrhea of damp-heat pattern were recruited and divided into a high-dosage group and a low-dosage group using the random number table method,with 36 cases in each *** all received conventional antidiarrheal treatment and umbilical application with herbal ***,the herbal cakes for the high-dosage group were made of the mixture of Ge Gen Qin Lian Tang powder and water,and those for the low-dosage group consisted of 10%Ge Gen Qin Lian Tang powder and 90%auxiliary materials(corn starch)plus *** treatment duration was 3 *** clinical efficacy,antidiarrheal rate,effective rate for symptoms and signs of traditional Chinese medicine(TCM),TCM symptoms score,and safety indicators were compared between the two ***:After the treatment,the TCM symptoms scores dropped significantly in both groups(P<0.01)and were lower in the high-dosage group than in the low-dosage group(P<0.05).The clinical efficacy was more significant in the high-dosage group than in the low-dosage group after the treatment,and the between-group difference was statistically significant(P<0.05);the antidiarrheal rate was markedly higher in the high-dosage group than in the low-dosage group(P<0.05).Regarding the TCM symptoms and signs,the high-dosage group showed better results in improving the greasy and yellowish tongue coating,bowel movement frequency,watery excrement,short and dark urine,red tongue body,red anus,vomiting,bowel sounds,and abdominal bloating compared with the low-dosage group,and the between-group differences were statistically significant(P<0.01).Conclusion:Umbilical therapy with herbal cakes made of Ge Gen Qin Lian Tang is safe,reliable,and effective in treating damp-heat diarrhea in young children;the high-dosage herbal cakes produce mo

关键词： Point shenque(CV8) Administration on Umbilicus Acupoint Sticking Therapy External Therapies Ge Gen Qin Lian Tang Dampness-heat Diarrhea Child

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稳压器非线性支撑的HCLPF值计算方法研究

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核动力工程 2015年第S2期36卷 135-137页

作者：叶献辉蔡逢春黄茜沈平川张毅雄中国核动力研究设计院核反应堆系统设计技术重点实验室成都610041

核电厂地震裕度评价(SMA)的关键之一是分析结构和部件的高置信度、低失效概率(HCLPF)值。本文先对概率易损性法、保守的确定性失效裕度法(CDFM)、试验法以及非线性瞬态分析法等几种HCLPF值计算方法进行介绍,然后以稳压器支撑模型为研究... 详细信息

核电厂地震裕度评价(SMA)的关键之一是分析结构和部件的高置信度、低失效概率(HCLPF)值。本文先对概率易损性法、保守的确定性失效裕度法(CDFM)、试验法以及非线性瞬态分析法等几种HCLPF值计算方法进行介绍,然后以稳压器支撑模型为研究对象,通过非线性瞬态分析法和CDFM分析计算HCLPF值。结果表明2种结果有所差别,CDFM法较为保守,非线性瞬态分析方法更加准确,建议对稳压器等含非线性的结构与部件,应通过非线性瞬态分析法分析HCLPF值。

关键词：抗震能力地震裕度评价稳压器非线性

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微球制备的研究概况及发展

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力学与实践 2005年第2期27卷 7-13,6页

作者：傅宪辉沈志刚北京航空航天大学航空科学与工程学院北京100083

粉体加工生产中制备的颗粒有多种形态,其中微球具有很多不规则颗粒所没有的优异性能,如高的流动性、高的堆积密度、不易团聚、填充到复合材料中不易引起应力集中等,在生产和生活中受到越来越多的重视.就目前国内外微球制备的研究状况... 详细信息

粉体加工生产中制备的颗粒有多种形态,其中微球具有很多不规则颗粒所没有的优异性能,如高的流动性、高的堆积密度、不易团聚、填充到复合材料中不易引起应力集中等,在生产和生活中受到越来越多的重视.就目前国内外微球制备的研究状况,综述了近年来实心微球、空心微球、多孔微球这3种微球的制备原理、方法及应用,并对微球制备技术的发展作了介绍.

关键词：研究概况不规则颗粒加工生产堆积密度复合材料研究状况空心微球制备原理多孔微球制备技术流动性应力集国内外

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协商式转移定价与成本转移

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管理世界 2008年第2期24卷 110-116页

作者：吴联生申慧慧薄仙慧北京大学光华管理学院

企业制定转移定价的目的之一是对管理者的业绩进行评价,而转移定价采用协商方式进行,其目的则在于制定一个转移双方都满意的转移价格,从而有利于企业经营业绩的提高。那么,协商方式是否会影响转移定价的业绩评价功能呢?本文运用实验研... 详细信息

企业制定转移定价的目的之一是对管理者的业绩进行评价,而转移定价采用协商方式进行,其目的则在于制定一个转移双方都满意的转移价格,从而有利于企业经营业绩的提高。那么,协商方式是否会影响转移定价的业绩评价功能呢?本文运用实验研究方法就此展开研究。研究结果表明,当卖方成本上升时,协商式转移定价也会随之上升,它表明协商式转移定价导致了成本转移,从而对转移定价的业绩评价功能产生负面影响。本文首次研究了协商式转移定价对转移定价业绩评价功能的负面影响,为实施协商式转移定价的企业提出需要关注的重要问题。

关键词：转移定价同情理论前景理论公司业绩

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华龙一号反应堆冷却剂系统抗震设计关键技术

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原子能科学技术 2022年第S01期56卷 83-91页

作者：熊夫睿沈平川王新军叶献辉张毅雄中国核动力研究设计院核反应堆系统设计技术重点实验室四川成都610213

华龙一号是满足三代核电技术指标要求的自主化百万千瓦压水堆核电机组,其抗震能力达到0.3g。为达到该抗震指标,对反应堆冷却剂系统在关键设备结构加强及优化、管道破前漏技术应用、抗震载荷分配精细化计算、抗震设计标准化、抗震裕度评... 详细信息

华龙一号是满足三代核电技术指标要求的自主化百万千瓦压水堆核电机组,其抗震能力达到0.3g。为达到该抗震指标,对反应堆冷却剂系统在关键设备结构加强及优化、管道破前漏技术应用、抗震载荷分配精细化计算、抗震设计标准化、抗震裕度评价等方面开展了关键技术研究,建立了一套抗震能力提升的策略,完成了华龙一号反应堆冷却剂系统抗震优化和评估工作。相关技术已在华龙批量生产堆型中得以应用。

关键词：华龙一号反应堆冷却剂系统抗震分析载荷环境

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纤维环切口方式对椎间盘生物力学强度影响的动物实验研究

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中国修复重建外科杂志 2016年第2期30卷 202-207页

作者：李鹏飞贾楠沈亚欣靳宪辉申勇丁文元张为河北医科大学附属哈励逊国际和平医院骨科河北衡水053000 河北医科大学外科学教研室河北医科大学第三医院脊柱外科

目的探讨不同切口方式处理椎间盘纤维环对髓核摘除术后山羊椎间盘生物力学强度的影响。方法取30只成年健康山羊,雌雄各半,随机分为A、B、C 3组(n=10)。3组行L_(3、4)及L_(4、5)椎间盘髓核摘除术中,切开纤维环时,分别采用工作套筒刺入(A... 详细信息

目的探讨不同切口方式处理椎间盘纤维环对髓核摘除术后山羊椎间盘生物力学强度的影响。方法取30只成年健康山羊,雌雄各半,随机分为A、B、C 3组(n=10)。3组行L_(3、4)及L_(4、5)椎间盘髓核摘除术中,切开纤维环时,分别采用工作套筒刺入(A组)、圆形切口切开(B组)、方形切口切开(C组)。记录并比较3组山羊体质量、雌雄比例、年龄、术中出血量及切口愈合时间;术后观察各组山羊存活及切口愈合情况。术后24周时处死山羊,MRI检查髓核信号强度;游标卡尺测量L_(3、4)及L_(4、5)椎间盘高度,取均值,并计算手术前后高度丢失程度;生物力学测定L_(3、4)诱发椎间盘突出的压力值及椎间盘承受的最大压力值;大体、组织学染色观察L_(4、5)椎间盘纤维环的修复效果。结果 3组山羊体质量、雌雄比例、年龄、术中出血量、切口愈合时间比较差异均无统计学意义(P>0.05),具有可比性。3组山羊均存活至实验完成。MRI检查3组椎间盘均可见退变现象,信号均降低;根据改良Thompson分级法,A组椎间盘退变程度高于B、C组(P0.05)。3组术前椎间隙高度比较差异无统计学意义(P>0.05);但术后24周A组椎间隙高度高于B、C组,其丢失程度低于B、C组差异均有统计学意义(P0.05)。HE及Masson染色示:A组纤维环连续性良好层次较清淅;B、C组切开处可见纤维环连续性破坏,瘢痕组织填充明显。结论椎间盘髓核摘除术中,采用工作套筒切开纤维环对纤维环结构破坏小,对维持椎间盘生物力学强度及术后纤维环修复起到积极作用。

关键词：椎间盘髓核摘除术切口方式生物力学纤维环山羊

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