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Core–Shell Microfiber Encapsulation Enables Glycerol‑Free Cryopreservation of RBCs with High Hematocrit

Nano-Micro Letters 2024年第1期16卷 35-54页

作者： xianhui qin Zhongrong Chen Lingxiao Shen Huilan Liu Xilin Ouyang Gang Zhao Department of Electronic Engineering and Information Science University of Science and Technology of ChinaHefei 230027People’s Republic of China School of Biomedical Engineering Anhui Medical UniversityHefei 230022People’s Republic of China Department of Blood Transfusion The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001People’s Republic of China The Fourth Medical Center Chinese PLA General HospitalBeijing 100089People’s Republic of China

Cryopreservation of red blood cells(RBCs)provides great potential benefits for providing transfusion timely in emergencies.High concentrations of glycerol(20%or 40%)are used for RBC cryopreservation in current clinical practice,which results in cytotoxicity and osmotic injuries that must be carefully controlled.However,existing studies on the low-glycerol cryopreservation of RBCs still suffer from the bottleneck of low hematocrit levels,which require relatively large storage space and an extra concentration process before transfusion,making it inconvenient(time-consuming,and also may cause injury and sample lose)for clinical applications.To this end,we develop a novel method for the glycerol-free cryopreservation of human RBCs with a high final hematocrit by using trehalose as the sole cryoprotectant to dehydrate RBCs and using core–shell alginate hydrogel microfibers to enhance heat transfer during cryopreservation.Different from previous studies,we achieve the cryopreservation of human RBCs at high hematocrit(>40%)with high recovery(up to 95%).Additionally,the washed RBCs post-cryopreserved are proved to maintain their morphology,mechanics,and functional properties.This may provide a nontoxic,high-efficiency,and glycerol-free approach for RBC cryopreservation,along with potential clinical transfusion benefits.

关键词： Cryopreservation Human red blood cells Core-shell microfibers Trehalose Hematocrit

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J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals

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General Psychiatry 2024年第1期37卷 44-52页

作者： Chengzhang Liu Qiguo Meng Yuanxiu Wei Xinyue Su Yuanyuan Zhang Panpan He Chun Zhou Mengyi Liu Ziliang Ye xianhui qin Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhuiChina institute of Biomedicine Anhui Medical UniversityHefeiAnhuiChina Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhouGuangdongChina

Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains uncertain.Aims To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals.Methods The study included a total of 3106 participants capable of completing repeated cognitive function tests.Dietary nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment consumption.Cognitive decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive Status-modified.Results The median follow-up duration was 5.9 years.There was a J-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.Before the inflection point,thiamine intake was not significantly associated with cognitive decline.Beyond the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all p<0.05).Conclusions This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

关键词： intake shaped cognitive

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Functional gastrointestinal disorders, mental health, genetic susceptibility, and incident chronic kidney disease

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中华医学杂志(英文版) 2024年第9期137卷 2023 Sep 5页

作者： Liu Mengyi He Panpan Ye Ziliang Yang Sisi Zhang Yanjun Wu Qimeng Zhou Chun Zhang Yuanyuan Hou Fan Fan qin xianhui Division of Nephrology Nanfang Hospital Southern Medical University National Clinical Research Center for Kidney Disease State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of Nephrology Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Guangdong China

Background: Whether functional gastrointestinal disorders (FGIDs) are associated with the long-term risk of chronic kidney disease (CKD) remains unclear. We aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the association.Methods: About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were included. Participants with FGIDs (including irritable bowel syndrome [IBS], dyspepsia, and other functional intestinal disorders [FIDs; mainly composed of constipation]) were the exposure group, and non-FGID participants were the non-exposure group. The primary outcome was incident CKD, ascertained from hospital admission and death registry records. A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD, and the mediation analysis was performed to investigate the mediation proportions of mental health.Results: At baseline, 33,156 (8.0%) participants were diagnosed with FGIDs, including 21,060 (5.1%), 8262 (2.0%), and 6437 (1.6%) cases of IBS, dyspepsia, and other FIDs, respectively. During a mean follow-up period of 12.1 years, 11,001 (2.6%) participants developed CKD. FGIDs were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.28–1.44). Similar results were observed for IBS (HR, 1.27; 95% CI, 1.17–1.38), dyspepsia (HR, 1.30; 95% CI, 1.17–1.44), and other FIDs (HR, 1.60; 95% CI, 1.43–1.79). Mediation analyses suggested that the mental health score significantly mediated 9.05% of the association of FGIDs with incident CKD and 5.63–13.97% of the associations of FGID subtypes with CKD. Specifically, the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of CKD.Conclusion: Participants with FGIDs had a higher risk of incident CKD, which was partly explained by mental health scores and was more pronounced

关键词： Functional gastrointestinal disorders Chronic kidney diseases Genetic susceptibility Mental health

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J-shaped association between dietary zinc intake and new-onset hypertension:a nationwide cohort study in China

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Frontiers of Medicine 2023年第1期17卷 156-164页

作者： Panpan He Huan Li Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Chun Zhou Ziliang Ye Qimeng Wu Min Liang Jianping Jiang Guobao Wang Jing Nie Fan Fan Hou Chengzhang Liu xianhui qin Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangdong Provincial Clinical Research Center for Kidney DiseaseGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510515China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China Institute of Biomedicine Anhui Medical UniversityHefei 230032China

We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults.A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included.Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory.Participants with systolic blood pressure≥140 mmHg or diastolic blood pressure≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension.During a median follow-up duration of 6.1 years,4269 participants developed new-onset hypertension.Overall,the association between dietary zinc intake and new-onset hypertension followed a J-shape(P for non-linearity<0.001).The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake(per mg/day:hazard ratio(HR)0.93;95%confidence interval(CI)0.88–0.98)in participants with zinc intake<10.9 mg/day,and increased with the increment of zinc intake(per mg/day:HR 1.14;95%CI 1.11–1.16)in participants with zinc intake≥10.9 mg/day.In conclusion,there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults,with an inflection point at about 10.9 mg/day.

关键词： dietary zinc intake new-onset hypertension general population CHNS

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适用于双级矩阵变换器整流级功率开关故障的容错策略研究

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中国电机工程学报 2018年第10期38卷 3049-3058页

作者：韩娜周波秦显慧雷家兴石宝平江苏省新能源发电与电能变换重点实验室(南京航空航天大学)

将传统矩阵变换器逆变级的单向开关更换为双向开关，可构成全双向开关型双级矩阵变换器。该拓扑通过增加6个开关管以具备母线电压可反向、拓扑结构高度对称等特征。上述特征结合使得该拓扑在整流级功率开关发生故障时，可仅通过修正调... 详细信息

将传统矩阵变换器逆变级的单向开关更换为双向开关，可构成全双向开关型双级矩阵变换器。该拓扑通过增加6个开关管以具备母线电压可反向、拓扑结构高度对称等特征。上述特征结合使得该拓扑在整流级功率开关发生故障时，可仅通过修正调制算法保证变换器正常运行，实现容错。该文针对整流级一个双向开关单元开路、两个不同侧双向开关单元开路两个故障，提出相应的容错策略。为保证容错策略安全有效的实施，随后提出相应的模态切换策略，并分析模态切换对电压调制比的影响。所提整流级容错策略的有效性最终通过实验得到验证。

关键词：全双向开关型双级矩阵变换器空间矢量调制容错整流级

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拓宽双级式矩阵变换器反向发电功率范围的控制策略

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电工技术学报 2016年第5期31卷 9-16页

作者：卞金梁周波雷家兴秦显慧梁莹南京航空航天大学江苏省新能源发电与电能变换重点实验室南京210016

基于一种双级式矩阵变换器反向发电系统结构,研究其实现升压发电的控制方法,提出一种能够拓宽反向发电功率范围的控制策略,对变换器调制比进行闭环控制,使得轻载时发电机能自动减小励磁电流,从而使系统能够正常工作。这种励磁调节的方... 详细信息

基于一种双级式矩阵变换器反向发电系统结构,研究其实现升压发电的控制方法,提出一种能够拓宽反向发电功率范围的控制策略,对变换器调制比进行闭环控制,使得轻载时发电机能自动减小励磁电流,从而使系统能够正常工作。这种励磁调节的方法与常规的恒压励磁控制不同,它是将励磁控制与变换器调制比控制相结合,拓宽了反向发电功率范围,提高了系统性能。实验结果验证了该新型控制策略的有效性。

关键词：双级式矩阵变换器升压发电励磁控制拓宽反向发电功率范围

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全双向开关型双级矩阵变换器逆变级容错策略

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中国电机工程学报 2017年第15期37卷 4454-4462页

作者：韩娜周波秦显慧雷家兴石宝平江苏省新能源发电与电能变换重点实验室(南京航空航天大学) 江苏省南京市210016

整流级逆变级均由双向开关构成的全双向开关型双级矩阵变换器比传统双级矩阵变换器多了6个开关管。新增的6个开关管可作为逆变级冗余器件,且其双向开关结构也为直流母线电压反向提供了可能,两者结合使得全双向开关型双级矩阵变换器能够... 详细信息

整流级逆变级均由双向开关构成的全双向开关型双级矩阵变换器比传统双级矩阵变换器多了6个开关管。新增的6个开关管可作为逆变级冗余器件,且其双向开关结构也为直流母线电压反向提供了可能,两者结合使得全双向开关型双级矩阵变换器能够实现多种故障的容错。该文从调制角度出发,提出了适用于逆变级双向开关单元开路、单管开路、双向开关单元短路以及单管短路等四种故障的容错策略。所提容错策略利用开关管的故障特性,通过增加非故障开关管切换次数以模拟故障开关管的切换,从而实现容错。实验结果验证了文中所提逆变级容错策略的有效性和可靠性。

关键词：全双向开关型双级矩阵变换器逆变级容错双空间矢量调制

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基于双级矩阵变换器的变速恒频电源系统的稳定性分析及其改善措施

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电工技术学报 2016年第13期31卷 18-25页

作者：秦显慧周波刘晓宇雷家兴韩娜江苏省新能源发电与电能变换重点实验室(南京航空航天大学)南京210016

基于双级矩阵变换器(TSMC)的变速恒频电源系统具有效率高、功率密度高、可靠性高和使用寿命长等诸多优点,在航空电源系统中具有广阔的应用前景。但受输入滤波器欠阻尼振荡的影响,基于TSMC的电源系统存在稳定性差的问题。本文讨论了输出... 详细信息

基于双级矩阵变换器(TSMC)的变速恒频电源系统具有效率高、功率密度高、可靠性高和使用寿命长等诸多优点,在航空电源系统中具有广阔的应用前景。但受输入滤波器欠阻尼振荡的影响,基于TSMC的电源系统存在稳定性差的问题。本文讨论了输出侧LC滤波器和输出电压闭环对系统稳定性的影响,在输出电压双闭环的基础上,提出一种基于输入侧电容电压微分前馈的新型有源阻尼算法,改善了系统的稳定性。在定频和变频输入的条件下,实验结果均验证了该算法的有效性和可行性。

关键词：双级矩阵变换器变速恒频稳定性有源阻尼算法

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热重和差示扫描量热分析技术在药物分析中的应用进展

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中国药物警戒 2024年第3期21卷 283-289页

作者：刘毅覃玲郭贤辉陈华裴宇盛中国食品药品检定研究院化学药品检定所化学药品质量研究与评价重点实验室北京102629

目的探讨热重分析(TGA)和差示扫描量热分析(DSC)在药物分析中的应用,为药品质量控制奠定基础。方法通过文献综述着重报道了这2种技术方法在水分含量分析、热稳定性研究、熔点测量、纯度分析、晶型分析等药物研究中的多方面应用研究情... 详细信息

目的探讨热重分析(TGA)和差示扫描量热分析(DSC)在药物分析中的应用,为药品质量控制奠定基础。方法通过文献综述着重报道了这2种技术方法在水分含量分析、热稳定性研究、熔点测量、纯度分析、晶型分析等药物研究中的多方面应用研究情况。结果与结论热重和差示扫描量热分析技术在药物的水分、熔点、纯度、晶型以及稳定性等相关分析中发挥重要作用,满足药品检验检测工作的更高分析需求。

关键词：热重分析差示扫描量热分析水分含量热稳定性熔点纯度晶型安全性

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不对称调制下双级矩阵变换器的谐波分析

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电工技术学报 2016年第2期31卷 102-111页

作者：秦显慧周波黄海涛刘晓宇雷家兴南京航空航天大学江苏省新能源发电与电能变换重点实验室南京210016

将双级矩阵变换器应用于360～800Hz航空变速恒频发电系统中，较高的输入频率是对变换器控制性能的重大挑战。仿真和实验表明，采用传统的不对称双空间矢量调制方法虽然具有控制简单、开关损耗低等优点，但在高频输入时，输出电压和输入... 详细信息

将双级矩阵变换器应用于360～800Hz航空变速恒频发电系统中，较高的输入频率是对变换器控制性能的重大挑战。仿真和实验表明，采用传统的不对称双空间矢量调制方法虽然具有控制简单、开关损耗低等优点，但在高频输入时，输出电压和输入电流将出现低频谐波和畸变。通过简化的Buck电路模型，引入脉冲重心的概念，推导了脉冲重心偏移对实际输出电压的影响规律。基于此，分析了双级矩阵变换器的谐波分布规律，发现不对称调制在输出电压中引起频率为3nωin±（3m±1）ω0的低频谐波，而在输入电流中引起3n±1次谐波。仿真和实验验证了结论的正确性，为进一步提高双级矩阵变换器性能提供了理论依据。

关键词：双级矩阵变换器变速恒频发电系统双空间矢量调制脉冲重心谐波分析

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