检索结果-南通市图书馆

考虑碳税政策的组合型可复用容器押金策略研究

在线全文

学校读者我要写书评

暂无评论

运筹与管理 2024年第7期33卷 166-172页

作者：徐贤浩陈雪梅岳睿婷华中科技大学管理学院湖北武汉430074

近年来,全球经济迅速发展,产业发展与环境污染的矛盾也日渐突出,可复用容器的出现为解决此矛盾提供了可行方案。本文在外卖餐饮行业背景下,基于碳税政策,考虑供应商使用组合型可复用容器装运产品。通过建立收取容器押金和不收取容器押... 详细信息

近年来,全球经济迅速发展,产业发展与环境污染的矛盾也日渐突出,可复用容器的出现为解决此矛盾提供了可行方案。本文在外卖餐饮行业背景下,基于碳税政策,考虑供应商使用组合型可复用容器装运产品。通过建立收取容器押金和不收取容器押金下的两种优化模型,本文探究了押金策略对供应商容器运作、碳排放量的影响,最后以某外卖餐饮公司为例进行了数值分析。结果表明,首先,供应商应当保持较小的容器丢失率且不收取押金,或者保持较高的单位时间最大市场需求量且收取押金。此外,收取押金总能减少供应商的碳排放,因此供应商可以通过收取押金降低碳排放量。另外,收取押金可以降低供应商每周期投入使用的容器数量,不收取押金可以降低供应商每周期的容器采购次数。最后,碳排放系数和碳税对供应商碳排放量的作用是相反的,而采购、检查清洗维修环节碳排放系数与碳税对容器押金的作用是相同的。本文可为组合型可复用容器的运作管理提供一定的参考。

关键词：组合型可复用容器押金策略碳税政策碳排放量

维普期刊数据库博看期刊

点胶成型热硫化镍碳导电硅橡胶的制备及性能研究

在线全文

学校读者我要写书评

暂无评论

有机硅材料 2024年第1期38卷 17-21页

作者：刘诚徐贤浩江宇辉李斌斌深圳市欧普特工业材料有限公司广东深圳518000 深圳市中欧新材料有限公司广东深圳518000

以加成型硅橡胶为基胶、镍碳颗粒为导电填料,添加偶联剂、增粘剂、含氢硅油制得热硫化镍碳导电硅橡胶。探讨了硅橡胶的较佳配方并测试了产品性能,结果表明:较佳配方为加成型硅橡胶100份、镍碳颗粒A 150份、三异硬脂酰基钛酸异丙酯偶联剂... 详细信息

以加成型硅橡胶为基胶、镍碳颗粒为导电填料,添加偶联剂、增粘剂、含氢硅油制得热硫化镍碳导电硅橡胶。探讨了硅橡胶的较佳配方并测试了产品性能,结果表明:较佳配方为加成型硅橡胶100份、镍碳颗粒A 150份、三异硬脂酰基钛酸异丙酯偶联剂1.5份、增粘剂1份、含氢硅油3份。该配方制得的硅橡胶表面电阻为29.47 mΩ、附着力为23.66 N,密度为1.93 g/cm^(3)、邵氏A硬度为65、拉伸强度为1.21 MPa、断裂伸长率为119%,在双“85”老化1000 h后电阻基本保持稳定,可满足市场对点胶成型导电硅橡胶性能的基本需求。

关键词：加成型硅橡胶镍碳颗粒点胶成型导电硅橡胶

Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction

在线全文

学校读者我要写书评

暂无评论

Engineering 2023年第9期28卷 166-178页

作者： xianhao xu xueqin Lv Shixiu Cui Yanfeng Liu Hongzhi Xia Jianghua Li Guocheng Du Zhaofeng Li Rodrigo Ledesma-Amaro Jian Chen Long Liu Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationJiangnan UniversityWuxi 214122China Science Center for Future Foods Ministry of EducationJiangnan UniversityWuxi 214122China Richen Bioengineering Co. Ltd.Nantong 226000China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Department of Bioengineering and Centre for Synthetic Biology Imperial College LondonLondon SW72AZUK

Terpenoids are the largest family of natural *** are made from the building block isoprene pyrophosphate(IPP),and their bioproduction using engineered cell factories has received a great deal of *** date,the insufficient metabolic supply of IPP remains a great challenge for the efficient synthesis of *** this work,we discover that the imbalanced metabolic flux distribution between the central metabolism and the IPP supply hinders IPP accumulation in Bacillus subtilis(***).Therefore,we remodel the IPP metabolism using a series of genetically encoded two-input-multioutput(TIMO)circuits that are responsive to pyruvate or/and malonyl-CoA,resulting in an IPP pool that is significantly increased by up to *** a proof-of-concept validation,we design an IPP metabolism remodeling strategy to improve the production of three valuable terpenoids,including menaquinone-7(MK-7,4.1-fold),lycopene(9-fold),andβ-carotene(0.9-fold).In particular,the titer of MK-7 in a 50-L bioreactor reached 1549.6 mg·L^(-1),representing the highest titer reported so ***,we propose a TIMO genetic circuits-assisted IPP metabolism remodeling framework that can be generally used for the synergistic fine-tuning of complicated metabolic modules to achieve the efficient bioproduction of terpenoids.

关键词： Terpenoids Genetic circuits Bacillus subtilis Isoprene pyrophosphate

Comparison of diagnosis value for new onset myasthenia gravis by many clinical auxiliary examinations

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2007年第7期2卷 446-448页

作者： Jian Yin Shiguang Wen Yinhong Liu Cuidi Wang Hua Zhang Hong Guo xianhao xu Department of Neurology Beijing Hospital Ministry of Health Beijing 100730 China

BACKGROUND： The clinical values of neostigmine test, clinical electrophysiologic study and acetylcholine receptor antibody detection in diagnosing myasthenia gravis （MG） found newly are unclear in China.OBJECTIVE： To investigate the reference value of common clinical diagnosis parameters in correctly diagnosing untreated MG found newly.DESIGN： Retrospective case analysis.SETTING： Department of Neurology, Beijing Hospital, Ministry of Health.PARTICIPANTS： Totally 156 outpatients with MG admitted to Department of Neurology, Beijing Hospital,Ministry of Health between January 1999 and December 2002. The involved patients, 72 males and 84 females, were aged 2 - 79 years. They were classified according to Osserman＇s criteria： ⅡA 72, ⅡB 76, Ⅲ3 and Ⅳ 5. They were all subjected to being inquired of disease history, neostigmine test, and acetylcholine receptor antibody detection, met the diagnosis criteria of Neuroimmunology Committee of China, and confirmed by clinical electrophysiologic detections; Informed consents were obtained from all the involved subjects.METHODS： ①After admission, every patient was intramuscularly injected with 1.5 mg neostigmine; If the patient was a child, the injection dose was decreased according to his/her age. If his/her score of any observation index after injection was improved ≥ 50% as compared with before injection , his positive index was Set as positive. Positive neostigmine test was set if there was one positive index. ②Repetitive nerve stimulation and single fiber electromyography were performed with Dantec Keypoint electromyogram （EMG） apparatus. ③Acetylcholine receptor antibody was detected by ELISA method.MAIN OUTCOME MEASURES： Clinical absolute and relative scores of MG, acetylcholine receptor antibody level, and repetitive nerve stimulation and single fiber electromyography examination ***： The positive rates of neostigmine test, repetitive nerve stimulation and single fiber electromyography examination for

关键词： myasthenia gravis electromyography acetylcholine receptor antibody

多发性硬化患者的生活质量评估:Teri-PRO研究述评

在线全文

学校读者我要写书评

暂无评论

中华神经科杂志 2021年第2期54卷 81-84页

作者：许贤豪北京医院神经内科 100730

多发性硬化(MS)是一种慢性进展性疾病,可见躯体和心理功能障碍症状,对生活质量产生严重负面影响。生活质量是常用的患者报告结局(PRO)指标之一,可对疾病进行广泛和主观的评估,也可对治疗效果进行测评。Teri-PRO研究通过治疗满意度问卷... 详细信息

多发性硬化(MS)是一种慢性进展性疾病,可见躯体和心理功能障碍症状,对生活质量产生严重负面影响。生活质量是常用的患者报告结局(PRO)指标之一,可对疾病进行广泛和主观的评估,也可对治疗效果进行测评。Teri-PRO研究通过治疗满意度问卷调查了MS患者经特立氟胺治疗的整体满意度,结果显示MS患者在将注射用疾病修正治疗(DMT)药物转换为口服特立氟胺治疗后生活质量得到改善,满意度更高。将生活质量测评引入中国MS研究,或可让神经科医师更为全面地了解DMT的临床疗效及患者对其的主观评价,也为监管机构评估MS药物疗效提供了颇具价值的视角。

关键词：多发性硬化生活质量疾病修正治疗

奖励型众筹模式下考虑银行融资的企业最优运作策略研究

在线全文

学校读者我要写书评

暂无评论

管理工程学报 2022年第1期36卷 205-216页

作者：曾款徐贤浩武汉纺织大学管理学院湖北武汉430200 华中科技大学管理学院湖北武汉430074

本文研究了企业在奖励型众筹模式下的最优运作策略,同时考虑了众筹融资不足时,企业继续向银行贷款的情况。通过分析众筹项目的运作机制,我们构建了企业在奖励型众筹模式下的决策模型,并研究得到了关于企业研发投入成本,产品生产量及众... 详细信息

本文研究了企业在奖励型众筹模式下的最优运作策略,同时考虑了众筹融资不足时,企业继续向银行贷款的情况。通过分析众筹项目的运作机制,我们构建了企业在奖励型众筹模式下的决策模型,并研究得到了关于企业研发投入成本,产品生产量及众筹融资目标的最优策略及相关性质。最后,利用Kickstarter众筹平台上的实际数据进行数值实验,本文验证了相关的研究结论。研究表明:1)只有在众筹融资额达到一定阈值的前提下,企业才愿意投入研发成本,此时企业的研发投入成本及产品生产量都将随众筹投资者的需求增大;2)为保证投资者和银行对众筹项目具有投资意愿,同时也为确保众筹成功的项目具有盈利性,存在关于融资目标的可行域,使企业在启动众筹项目时需要将融资目标设置在该可行域内;3)企业通过众筹平台获得的期望融资额不会随融资目标增加,且企业的最优融资目标为融资目标在其可行域中的下界;4)此外,我们通过数值实验还发现最优众筹目标不会随企业的研发效率而增加。

关键词：奖励型众筹银行融资资金约束预售运作金融交叉

THE　T　CELL　REPERTOIRE　TO　ACETYLCHOLINE　RECEPTOR　SUBUNITS　IN　MYASTHENIA　GRAVIS　AND　CONTROLS

在线全文

学校读者我要写书评

暂无评论

中国神经免疫学和神经病学杂志 1996年第1期 8-14页

作者： Jiabin Sun Zengyu Wang Jian Qiao Sten Fredrikson xianhao xu Hans Link

（１）目的：多数重症肌无力（ＭＧ）患者可见作为烟碱样乙酰胆碱受体（ｎＡＣｈＲ）抗体（Ａｂ）升高基础的抗原特异性辅助性Ｔ细胞（Ｔｈ）增多，本研究目的在于探讨此类细胞的可能作用。（２）方法：设重症肌无力、其它神经科患者和... 详细信息

（１）目的：多数重症肌无力（ＭＧ）患者可见作为烟碱样乙酰胆碱受体（ｎＡＣｈＲ）抗体（Ａｂ）升高基础的抗原特异性辅助性Ｔ细胞（Ｔｈ）增多，本研究目的在于探讨此类细胞的可能作用。（２）方法：设重症肌无力、其它神经科患者和正常对照三组。用体外测试的免疫酶点法，即以电鳗的ＡＣｈＲα－，β－，γ－，和δ－亚单位作为特异性抗原以及ＰＰＤ和与多发性硬化相关的髓鞘碱性蛋白作为非特异性抗原，于抗原刺激后计数分泌γ干扰素（ＩＦＮ－γ）的Ｔｈ１细胞数。测定周围血中针对这些抗原的Ｔ细胞亚群计数。（３）结果：ＭＧ患者识别ＡＣｈＲ四种亚单位的Ｔ细胞数均增高，依次为：１／２５０００，１／５９０００，１／８３０００和１／２５０００个细胞。６５％ＭＧ患者的Ｔ细胞主要识别α－亚单位，有些则主要识别γ－和δ－亚单位。少数ＭＧ患者测不到对任何亚单位起反应的Ｔ细胞。（４）结论：ＭＧ患者中，ＡＣｈＲ的四种亚单位均为通过分泌ＩＦＮγ的Ｔｈ１样细胞自身免疫攻击的靶。

关键词：重症肌无力,自身反应性T细胞,乙酰胆碱受体亚单位,γ-干扰素,自身免疫

Flexible 2 × 2 multiple access visible light communication system based on an integrated parallel GaN/InGaN micro-photodetector array module

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第4期12卷 793-803页

作者： ZENGYI xu xianhao LIN ZHITENG LUO QIANYING LIN JIANLI ZHANG GUANGxu WANG XIAOLAN WANG FENGYI JIANG ZIWEI LI JIANYANG SHI JUNWEN ZHANG CHAO SHEN NAN CHI Key Laboratory for Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringFudan UniversityShanghai 200433China National Institute of LED on Silicon Substrate Nanchang UniversityNanchang 330096China

In recent studies, visible light communication(VLC) has been predicted to be a prospective technique in the future 6G communication systems. To suit the trend of exponentially growing connectivity, researchers have intensively studied techniques that enable multiple access(MA) in VLC systems, such as the MIMO system based on LED devices to support potential applications in the Internet of Things(IoT) or edge computing in the nextgeneration access network. However, their transmission rate is limited due to the intrinsic bandwidth of ***, the majority of visible light laser communication (VLLC) research with beyond 10 Gb/s data rates concentrates on point-to-point links, or using discrete photodetector(PD) devices instead of an integrated array PD. In this paper, we demonstrated an integrated PD array device fabricated with a Si-substrated GaN/InGaN multiple-quantum-well(MQW) structure, which has a 4 × 4 array of 50 μm × 50 μm micro-PD units with a common cathode and anode. This single-integrated array successfully provides access for two different transmitters simultaneously in the experiment, implementing a 2 × 2 MIMO-VLLC link at 405 nm. The highest data rate achieved is 13.2 Gb/s, and the corresponding net data rate(NDR) achieved is 12.27 Gb/s after deducing the FEC overhead, using 2.2 GHz bandwidth and superposed PAM signals. Furthermore, we assess the Huffman-coded coding scheme, which brings a fine-grain adjustment in access capacity and enhances the overall data throughput when the user signal power varies drastically due to distance, weather, or other challenges in the channel condition. As far as we know, this is the first demonstration of multiple visible light laser source access based on a single integrated GaN/InGaN receiver module.

关键词： communication visible light

特立氟胺用于复发型多发性硬化患者的长期安全性和有效性:Ⅲ期TOWER延长试验解读

在线全文

学校读者我要写书评

暂无评论

中国神经免疫学和神经病学杂志 2021年第4期28卷 280-282,306页

作者：胡学强许贤豪中山大学附属第三医院神经内科 510630 北京医院神经内科国家老年医学中心 100730

多发性硬化(multiple sclerosis,MS)是好发于年轻人的最常见的神经系统疾病之一,疾病修正疗法(DMT)是MS患者缓解期的标准治疗。由于MS是终生性神经退行性疾病,患者需要长期有效且耐受性良好的治疗,因此DMT药物的长期安全性问题值得关注... 详细信息

多发性硬化(multiple sclerosis,MS)是好发于年轻人的最常见的神经系统疾病之一,疾病修正疗法(DMT)是MS患者缓解期的标准治疗。由于MS是终生性神经退行性疾病,患者需要长期有效且耐受性良好的治疗,因此DMT药物的长期安全性问题值得关注。Ⅲ期TOWER核心+延长试验显示,在特立氟胺14 mg/d最长应用达7.22年期间,治疗有效且安全性和耐受性良好,无新发病变或非预期安全性问题,与Ⅲ期TOWER核心研究结果一致,提示特立氟胺长期治疗的安全性和有效性。

关键词：特立氟胺复发型多发性硬化安全性