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Journal of Genetics and Genomics 2024年第9期51卷 900-910页

作者： Shuang Zhao Chen wanga Haiping Luo Feifei Li Qiang Wang Jin Xu Zhibin Huang Wei Liu Wenqing Zhang The Innovation Centre of Ministry of Education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518055China

The hindbrain,which develops from the anterior end of the neural tube expansion,can differentiate into the metencephalon and myelencephalon,with varying sizes and *** midbrain–hindbrain boundary(MHB)and hindbrain myelencephalon/ventral midline(HMVM)are known to be the source of the progenitors for the anterior hindbrain and myelencephalon,***,the molecular networks regulating hindbrain morphogenesis in these structures remain *** this study,we show that retinoblastoma 1(rb1)is highly expressed at the MHB and HMVM in *** out rb1 in mice and zebrafish results in an enlarged hindbrain due to hindbrain neuronal *** study reveals that Rb1 controls the hindbrain morphogenesis by suppressing the expression of Gbx1/Gbx2,essential transcription factors for hindbrain development,through its binding to E2f3/Hdac1,***,we find that Gbx1 and Gbx2 are expressed in different types of hindbrain neurons,suggesting distinct roles in hindbrain *** summary,our study clarifies the specific role of RB1 in hindbrain neural cell proliferation and morphogenesis by regulating the E2f3–Gbx1 axis and the Hdac1–Gbx2 *** findings provide a research paradigm for exploring the differential proliferation of neurons in various brain regions.

关键词： Zebrafish Hindbrain Rb1 Gbx1/Gbx2 Proliferation

Chemical composition and pharmacological activities of Atractylodes lancea:A review

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Asian Journal of Traditional Medicines 2024年第3期19卷 159-171页

作者： Shuo wanga Yunpeng Yang Yibo Wang Wenhan Wang Meng Zhang Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Jiangxi Alpha Hi-Tech Pharmaceutical Co. LtdWuxi 214422China

Atractylodes lancea(called Cangzhu in China)is a medicinal plant that has long been used as tonic agent in various ethno-medical systems in East Asia,especially in China,for the treatment of gastrointestinal dysfunction,cancer,osteoporosis,obesity and fetal *** used the TCMSP database to search for the main active ingredients and traditional Chinese medicine targets of Atractylodes *** are a total of 38 related articles,of which 27 are closely related to chemical composition and *** study reviews the chemical components and pharmacological effects of ***,aiming to provide reference for its further research and development.

关键词： Atractylodes lancea chemical composition pharmacological activities

A novel method for measuring the coma aberration of lithographic projection optics by relative image displacements at multiple illumination settings

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A novel method for measuring the coma aberration of lithogra...

Projected impacts of climate change on the habitat of Xerophyta species in Africa

2007亚洲光电子会议量子光学在计算与通信中的应用分会场

作者： Qiongyan Yuana,b, xiangzhao wanga,b, Zicheng Qiua,b, Fan Wangc, Mingying Mac a Information Optics Laboratory, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China b Graduate School of the Chinese Academy of Sciences, Beijing 100039, China c National Engineering Research Center for Lithographic Equipment, Shanghai 201203, China

As the critical dimension shrinks, deterioration of image quality caused by coma aberrations of the lithographic projection optics has become a serious problem in optical lithography. Fast and accurate in-situ measurement techniques for measuring the coma aberration are necessary. In the present paper, we propose a novel method for measuring the coma aberrations of lithographic projection optics by use of a novel mark, which is composed of two fine-segmented phase-shifting gratings and two sufficiently large binary gratings. The coma aberration is extracted from the relative displacements between the phase-shifting gratings and the binary gratings at multiple illumination settings. The PROLITH simulation results show that compared with the TAMIS technique, the measurement accuracy of coma aberration increases by more than 34% under conventional illumination, and the measurement accuracy of low-order coma aberration increases by more than 28% under annular illumination.

关键词： Lithographic tools, Projection optics, Coma aberration, Zernike coefficients, Relative displacements

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Plant Diversity 2024年第1期46卷 91-100页

作者： Vincent Okelo wanga Boniface KNgarega Millicent Akinyi Oulo Elijah Mbandi Mkala Veronicah Mutele Ngumbau Guy Eric Onjalalaina Wyclif Ochieng Odago Consolata Nanjala Clintone Onyango Ochieng Moses Kirega Gichua Robert Wahiti Gituru Guang-Wan Hu CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074China Centre for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglun 666303China Botany Department Jomo Kenyatta University of Agriculture and TechnologyNairobiKenya East African Herbarium National Museums of KenyaP.O.Box 451660-0100NairobiKenya

Climate change poses a serious long-term threat to *** effectively reduce biodiversity loss,conservationists need to have a thorough understanding of the preferred habitats of species and the variables that affect their ***,predicting the impact of climate change on speciesappropriate habitats may help mitigate the potential threats to biodiversity ***,a monocotyledonous genus of the family Velloziaceae is native to mainland Africa,Madagascar,and the Arabian *** key drivers of Xerophyta habitat distribution and preference are *** 308 species occurrence data and eight environmental variables,the MaxEnt model was used to determine the potential distribution of six Xerophyta species in Africa under past,current and future climate change *** results showed that the models had a good predictive ability(Area Under the Curve and True Skill Statistics values for all SDMs were more than 0.902),indicating high accuracy in forecasting the potential geographic distribution of Xerophyta *** main bioclimatic variables that impacted potential distributions of most Xerophyta species were mean temperature of the driest quarter(Bio9)and precipitation of the warmest quarter(Bio18).According to our models,tropical Africa has zones of moderate and high suitability for Xerophyta taxa,which is consistent with the majority of documented species *** habitat suitability of the existing range of the Xerophyta species varied based on the climate scenario,with most species experiencing a range loss greater than the range gain regardless of the climate *** projected spatiotemporal patterns of Xerophyta species help guide recommendations for conservation efforts.

关键词： Africa Climate change MaxEnt model Potential suitable distribution Velloziaceae Xerophyta

Recent advances in the electrocatalytic oxidative upgrading of lignocellulosic biomass

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ChemPhysMater

ChemPhysMater 2024年第2期3卷 157-186页

作者： Yufeng Qi Hairui Guo Junting Li Li Ma Yang Xu Huiling Liu Cheng wanga Zhicheng Zhang Institute for New Energy Materials and Low-Carbon Technologies School of Materials Science and EngineeringTianjin Key Laboratory of Advanced Functional Porous MaterialsTianjinUniversityof TechnologyTianjin 300384China Key Laboratory of Organic Integrated Circuit Minitry of Education&Tianjin Key Laboratoryof Molecular Optoelectronic Sciencespartment of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Lignocellulosic biomass is a critical renewable carbon resource,but most of its utilization is inefficient,and elec-trocatalytic oxidation is a promising method of upgrading lignocellulose into value-added fuels and chemicals under mild operating ***,efforts to enable conversion with a high efficiency and low energy con-sumption have been reported,but understanding the reaction mechanisms and realizing scaled-up applications of the electrooxidation of lignocellulosic biomass are still in their early stages.A timely overview of recently reported general reaction mechanisms,particularly the strategies developed for use in improving the reaction efficiencies,is necessary to inspire research regarding the highly efficient utilization of ***,we summa-rize the strategies developed to improve electrocatalytic performance in oxidative lignocellulose *** organized summary includes strategies ranging from designing efficient electrocatalysts and adding functional co-catalysts or electrolytes to employing advanced electrolyzers.A comprehensive overview of representative examples should provide universal principles to yield insight into the reaction processes and guide the design of efficient electrocatalytic ***,the challenges and opportunities in developing the electrocatalytic oxidative upgrading of lignocellulosic biomass in the near future are proposed.

关键词： Biomass conversion Lignocellulose Electrocatalysis Oxidative upgrading Electrocatalyst

Phase I clinical trial of intracerebral injection of lentiviral-ABCD1 for the treatment of cerebral adrenoleukodystrophy

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Science Bulletin 2024年第16期69卷 2596-2603页

作者： Qiu-Hong Wang Jing wanga Zhi-Pei Ling Zhi-Qiang Cui Jie Gong Rui Zhang Shi-Jun Li Yang-Yang Wang Rui Yang De-Hui Huang Wen He Jing Gao Chen Feng Pei-Li Hu Li-Ying Liu Lung-Ji Chang Li-Ping Zou Senior Department of Pediatrics Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Department of Neurosurgery Hainan Hospital of PLA General HospitalSanya 572013China Department of Neurosurgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054China Beijing Meikang Biotechnology Co. LTD.Beijing 100085China Department of Radiology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pediatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Shenzhen Geno-Immune Medical Institute Shenzhen 518057China Beijing Institute for Brain Disorders Center for Brain Disorders Research Capital Medical UniversityBeijing 100069China

This was a single-arm,multicenter,open-label phase I *** vectors(LV)carrying the ABCD1 gene(LV-ABCD1)was directly injected into the brain of patients with childhood cerebral adrenoleukodystrophy(CCALD),and multi-site injection was *** injection dose increased from 200 to 1600 lL(vector titer:1×10^(9) transduction units per mL(TU/mL)),and the average dose per kilogram body weight ranges from 8 to 63.6 lL/*** primary endpoint was safety,dose-exploration and immunogenicity and the secondary endpoint was initial evaluation of efficacy and the expression of ABCD1 protein.A total of 7 patients participated in this phase I study and were followed for 1 *** injectionrelated serious adverse event or death *** adverse events associated with the injection were irritability(71%,5/7)and fever(37.2-38.5℃,57%,4/7).Adverse events were mild and selflimited,or resolved within 3 d of symptomatic *** maximal tolerable dose is 1600 *** 5 cases(83.3%,5/6),no lentivirus associated antibodies were *** overall survival at 1-year was 100%.The ABCD1 protein expression was detected in neutrophils,monocytes and *** study suggests that the intracerebral injection of LV-ABCD1 for CCALD is safe and can achieve successful LV transduction in vivo;even the maximal dose did not increase the risk of adverse ***,the direct LV-ABCD1 injection displayed low *** addition,the effectiveness of intracerebral LV-ABCD1 injection has been preliminarily demonstrated while further investigation is *** study has been registered in the Chinese Clinical Trial Registry(https://***/,registration number:ChiCTR1900026649).

关键词： Adrenoleukodystrophy Lentiviral vectors ABCD1 Intracerebral injection

Al Preparation from Solid Al_2O_3 by Direct Electrochemical Deoxidation in Molten CaCl_2-NaCl at 550℃

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Journal of Materials Science & Technology 2009年第4期25卷 459-461页

作者： Hongwei Xie He Zhang Yuchun Zhai Jinxia wanga Chengde Li School of Materials and Metallurgy Northeastern University Shenyang 110004 China School of Science Northeastern University Shenyang 110004 China

Al was prepared by a new method in molten salt at low temperature. Sintered alumina pellets were used as cathode; graphite rod was employed as anode; and the molten CaCl2-NaCl was the electrolyte. A constant 3.2 V voltage was applied in this experiment, and oxygen in solid alumina cathode was reduced by direct electrochemical deoxidation at 550℃. In this process, the current gradually decreased with increasing time and the alumina pellets became grey and porous. The metallic particles were obtained and characterized by XRD （X-ray diffraction） and SEM （scanning electron microscopy）.

关键词： Aluminium Alumina Electrochemical deoxidation Low temperature

Electrical contacts to two-dimensional transition-metal dichalcogenides

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Journal of Semiconductors 2018年第12期39卷 60-67页

作者： Shuxian wanga Zhihao Yu Xinran Wang Kansas Academy of Mathematics and Science Fort Hays State University600ark StreetHaysKansas 67601-4099USA National Laboratory of Solid State Microstructures School of Electronic Science and Engineeringand Collaborate Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Two-dimensional(2D) transition-metal dichalcogenides(TMDCs) have attracted enormous interests as the novel channel materials for atomically thin transistors. Despite considerable progress in recent years, the transistor performance is largely limited by the excessive contact resistance at the source/drain interface. In this review, a summary of recent progress on improving electrical contact to TMDC transistors is presented. Several important strategies including topology of contacts, choice of metals and interface engineering are discussed.

关键词： two-dimension channel materials Fin-FET

Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 400-406页

作者： Zhaomin Tang Qian He Jianren Zhou Shuang Yan Li Jiang Yudong Wang Chenxing Yao Huangzhao Wei Keda Yang Jiajia Wang School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China Department of Laboratory Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor microenvironment(TME)for chemodynamic therapy(CDT)with high ***,the low pH environment and insufficient endogenous hydrogen peroxide(H_(2)O_(2))of the highly efficient Fenton reaction limits its practical application in ***,a Cu(Ⅱ)-doped mesoporous silica nanoagent(Cu-MSN)with excellent dispersity was successfully *** loaded with doxorubicin(DOX)and ascorbate(AA),Cu-MSN@DA was coated with active targeting ligand folic acid(FA),dimethyl maleic an-hydride(DMMA)and carboxymethyl chitosan(CMC)to obtain an active transporting nanoagent(FCDC@Cu-MSN@DA)with tunable charge-reversal property,which is more adaptable to the pH value of TME than Fe-based Fenton agents,and can self-supply exogenous H_(2)O_(2)by ascorbate to produce more toxic·OH to trigger the apoptosis of cancer ***,the high level of glutathione(GSH)in TME can reduce Cu(Ⅱ)to Cu(I)by Fenton-like reaction,increasing the generation rate of·OH and relieving tumor antioxidant *** supply of exogenous H_(2)O_(2)significantly enhanced the synergistic effect of CDT by oxidative *** with DOX-induced cell apoptosis,this novel nanoagent FCDC@Cu-MSN@DA can achieve maximum therapeutic efficacy,creating a new model of safe and effective tumor treatment with high specificity.

关键词： Cu(Ⅱ)-doped Ascorbate Hydrogen peroxide Charge-reversal Oxidative damage

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