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B7-H3 in acute myeloid leukemia: From prognostic biomarker to immunotherapeutic target

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中华医学杂志(英文版) 2024年第21期137卷 2540-2551页

作者： Tan Xiao zhao xiangyu Peking University People’s Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China

B7-H3 (CD276), an immune checkpoint protein of the B7 family, exhibits significant upregulation in solid tumors and hematologic malignancies, exerting a crucial role in their pathophysiology. The distinct differential expression of B7-H3 between tumors and normal tissues and its multifaceted involvement in tumor pathogenesis position it as a promising therapeutic target for tumors. In the context of acute myeloid leukemia (AML), B7-H3 is prominently overexpressed and closely associated with unfavorable prognoses, yet it has remained understudied. Despite various ongoing clinical trials demonstrating the potential efficacy of immunotherapies targeting B7-H3, the precise underlying mechanisms responsible for B7-H3-mediated proliferation and immune evasion in AML remain enigmatic. In view of this, we comprehensively outline the current research progress concerning B7-H3 in AML, encompassing in-depth discussions on its structural attributes, receptor interactions, expression profiles, and biological significance in normal tissues and AML. Moreover, we delve into the protumor effects of B7-H3 in AML, examine the intricate mechanisms that underlie its function, and discuss the emerging application of B7-H3-targeted therapy in AML treatment. By juxtaposing B7-H3 with other molecules within the B7 family, this review emphasizes the distinctive advantages of B7-H3, not only as a valuable prognostic biomarker but also as a highly promising immunotherapeutic target in AML.

关键词： B7-H3 (CD276) B7 family Acute myeloid leukemia Immune checkpoint Immunotherapy

Dual MOFs composites:MIL-53 coated with amorphous UiO-66 for enhanced photocatalytic oxidation of tetracycline and methylene blue

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Nano Research 2023年第5期16卷 6160-6166页

作者： Xuesheng Liu xiangyu zhao Hong Meng Junsu Jin Beijing Key Laboratory of Membrane Science and Technology Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China

In this work,we proposed a novel strategy for the photocatalytic degradation of the target pollutants tetracycline(TC)and methylene blue(MB)using core–shell dual metal-organic frameworks(MOFs)composites.A series of mesoporous composites MIL-53@UiO-66 were synthesized by solvent-thermal synthesis via coating UiO-66 on the surface of *** results show that under the same degradation conditions,only 30 and 15 min are needed to degrade 93%of TC and 96%of MB in the photo-Fenton reaction system,*** amorphous shell layer brings stronger adsorption to the ***-53@UiO-66 composites with equalizing Fermi level are formed to promote photon absorption and electron ***,the MIL-53@UiO-66 composites with excellent stability will be a promising catalyst for environmental remediation.

关键词： dual metal-organic frameworks(MOFs) core–shell structure tetracycline methylene blue photocatalysis

Leukocyte immunoglobulin-like receptor B4 (LILRB4) in acute myeloid leukemia: From prognostic biomarker to immunotherapeutic target

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中华医学杂志(英文版) 2024年第22期137卷 2697-2711页

作者： Li Muzi zhao xiangyu Peking University People’s Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation National Clinical Research Center for Hematologic Disease Beijing China

Leukocyte immunoglobulin-like receptor (LILR) B4 (also known as ILT3/CD85k) is an immune checkpoint protein that is highly expressed in solid tumors and hematological malignancies and plays a significant role in the pathophysiology of cancer. LILRB4 is highly expressed in acute myeloid leukemia (AML), and this phenotype is associated with adverse patient outcomes. Its differential expression in tumors compared to normal tissues, its presence in tumor stem cells, and its multifaceted roles in tumorigenesis position it as a promising therapeutic target in AML. Currently, several immunotherapies targeting LILRB4 are undergoing clinical trials. This review summarizes advancements made in the study of LILRB4 in AML, focusing on its structure, ligands, expression, and significance in normal tissues and AML; its protumorigenic effects and mechanisms in AML; and the application of LILRB4-targeted therapies in AML. These insights highlight the potential advantages of LILRB4 as an immunotherapeutic target in the context of AML.

关键词： LILRB4 Leukemia, myeloid, acute Immune checkpoint Tumor microenvironment Immunotherapy

Bismuth chloride@mesocellular carbon foam nanocomposite cathode materials for rechargeable chloride ion batteries

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Chinese Chemical Letters 2022年第4期33卷 2200-2204页

作者： Chang Zhang Shijiao Sun Meifen Wu xiangyu zhao College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211816China CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Jiangsu Collaborative Innovation Center for Advanced Inorganic Functional Composites Nanjing Tech UniversityNanjing 211816China

Chloride ion batteries(CIB) are considered to be one of the most promising energy storage devices. As cathode materials for CIBs, metal chlorides have many advantages, such as high theoretical energy density, abundant elemental resources and ideal discharge voltage plateau. However, the dissolution and huge volume change of metal chlorides during cycling lead to considerable short lifespan, which limits their potential application for CIBs. Herein, the bismuth chloride nanocrystal is confined in mesocellular carbon foam matrix by a new vacuum impregnation approach. The mesocellular carbon foam with large interconnected pores(15.7 or 23.2 nm) may buffer the large volume variation of bismuth chloride during charge and discharge, giving rise to significantly enhanced electrochemical performance. The as-prepared bismuth chloride@mesocellular carbon foam cathode delivered an initial discharge capacity of 298 m Ah/g and a reversible capacity of 91 m Ah/g after 60 cycles. In contrast, the pure bismuth chloride cathode almost cannot discharge after 30 cycles. This is the first report that the metal chloride cathode can achieve a prolonged cycling in CIBs.

关键词： Chloride ion batteries Cathode materials Bismuth chloride Mesocellular carbon foam Electrochemistry

Combined effects of high temperature and waterlogging on yield and stem development of summer maize

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The Crop Journal 2023年第2期11卷 651-660页

作者： Jingyi Shao Peng Liu Bin zhao Jiwang Zhang xiangyu zhao Baizhao Ren State Key Laboratory of Crop Biology and College of Agronomy Shandong Agricultural UniversityTai’an 271018ShandongChina

The purpose of this study was to identify the physiological mechanism underlying the effects of high temperature and waterlogging on summer *** stem development and yield of the maize hybrid Denghai 605 in response to high-temperature stress,waterlogging stress,and their combination applied for six days at the third-leaf,sixth-leaf,and tasseling stages were *** combined stresses reduced lignin biosynthetic enzyme activity and lignin accumulation,leading to abnormal stem *** of the area and number of vascular bundles in stems led to reduced dry matter accumulation and *** grain dry weight at all three stages reduced grain yield relative to a *** summary,high temperature,waterlogging,and their combined stress impaired stem development and grain yield of summer *** combined stresses were more damaging than either stress alone.

关键词： Summer maize Lignin Stem microstructure Dry matter accumulation and distribution Yield

Genome-Wide Analysis and Expression Patterns of the YUCCA Genes in Maize

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Journal of Genetics and Genomics 2015年第12期42卷 707-710页

作者： Wenlan Li xiangyu zhao Xiansheng Zhang State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology College of Life Sciences Shandong Agricultural University

Auxin plays important roles in various aspects of plant growth and development （zhao, 2010）. In Arabidopsis, a number of YUCCA （YUC） genes, which are involved in auxin biosyn- thesis, have been identified （zhao et al., 2001; Woodward et al., 2005; Cheng et al., 2006, 2007; Kim et al., 2007; Chen et al., 2014）. YUC genes encode flavin monooxygenases （FMOs） that convert indole-3-pyruvate （IPA） to indole-3-acetic acid （IAA）（zhao, 2012）. The Arabidopsis YUC family is comprised of 11 members （zhao et al., 2001;

关键词： Genome-Wide Analysis and Expression Patterns of the YUCCA Genes in Maize SPI

SlMYB1 regulates the accumulation of lycopene, fruit shape, and resistance to Botrytis cinerea in tomato

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Horticulture Research 2023年第2期10卷 286-297页

作者： Ziyi Yin Jiazong Liu Haipeng zhao Xiaomeng Chu Haoqi Liu xiangyu Ding Chongchong Lu Xinyu Wang xiangyu zhao Yang Li Xinhua Ding State Key Laboratory of Crop Biology Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect PestsCollege of plant protectionShandong Agricultural UniversityTaian 271018ShandongChina State Key Laboratory of Crop Biology College of Academy of Life ScienceShandong Agricultural UniversityTaian 271018ShandongChina

Fruit lycopene,shape,and resistance are essential traits in vegetables whose final product is fruit,and they are also closely related to and strictly regulated by multiple transcription ***,which cannot be synthesized by the human body and can only be ingested from the outside,was important in maintaining human *** fruit ripening and post-harvest,tomato plants face a variety of biotic or abiotic stresses,which might inf lict great damage to fruit quality due to its f lat shape and pointed tip during storage and ***,there is an urgent need for key molecular switches to simultaneously improve fruit lycopene and resistance to biotic stress during ***,we identified the MYB transcription factor SlMYB1 in tomato plants which could bind to the promoters of lycopene synthesis-related genes,SlLCY1,SlPSY2,and the pathogen-related gene SlPR5 directly,to regulate the fruit lycopene and resistance to Botrytis cinerea in *** addition to regulating lycopene synthesis,SlMYB1 also regulates the content of soluble sugar,soluble protein and f lavonoid in ***’s more,SlMYB1 could regulate the tomato fruit shape,making it smoother or f latter to prevent skin damage caused by vibration on *** sequencing(RNA-seq)further showed that SlMYB1 fruit-specific expression lines had multiple differentially expressed genes compared with those from wild-type plants,suggesting that SlMYB1 might have multiple roles in fruit nutritional quality control and resistance to stresses,which is a rare occurrence in previous *** summary,our results revealed that SlMYB1 was an essential multi-functional transcription factor that could regulate the lycopene and resistance to Botrytis cinerea,and change the shape of fruit in tomato plants.

关键词： resistance shape MYB1

Electrochemical properties of Co-S/x wt.% AB_5 composite materials

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Science China(Technological Sciences) 2015年第8期58卷 1355-1359页

作者： LI JiaJia zhao xiangyu HU LiNa MA LiQun SHEN XiaoDong College of Materials Science and Engineering Nanjing Tech University

The Co-S/x wt.% AB5 （x=0, 10, 20, 30） composite materials were prepared by simply mixing Co-S material fabricated by hy- drothermal method and AB5 alloy. The structure and morphology of the composite materials were characterized by XRD and SEM, respectively. The electrochemical properties of the composite electrodes were studied by the galvanostatic charge, dis- charge test and electrochemical impedance spectroscopy. The results showed that the Co-S/20 wt.% AB5 composite electrode showed the highest discharge capacity and the best cycling stability. The existence of the AB5 alloy improved the electro- chemical activity of composite electrodes, reduced the electrochemical polarization resistances and promoted the electrochem- ical conversion reaction between Co and Co（OH）2. In order to improve the utilization rate of active materials, 0.0! mol/L Na2S203 was added into the electrolyte. The electrochemical properties of the composite electrode were significantly enhanced. After fifty cycles, the discharge capacity of the composite electrode increased from 407 to 481.7 mAh/g and the capacity reten- tion increased from 79.7% to 91.2%.

关键词： Co-S AB5 hydrogen storage alloy composite materials electrochemical properties

Rapid reconstitution of NK1 cells after allogeneic transplantation is associated with a reduced incidence of graft-versus-host disease

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Science China(Life Sciences) 2018年第8期61卷 902-911页

作者： Xingxing Yu Lingling Xu Yingjun Chang Xiaojun Huang xiangyu zhao Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044 China Peking-Tsinghua Center for Life Sciences Beijing 100871 China Yantai Yu Huang Ding Hospital Yantai 264000 China

The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Thl, Th2, Th3 and Trl cells. Here, we investigate levels of type 1 （IFN-gamma; NK1）, type 2 （IL-13; NK2）, type 3 （TGF-beta; NK3） and regulatory （IL-10; NKr） cytokines in peripheral blood to assess the cytokine profiles of natural killer （NK） cells following human allogeneic hematopoietic stem cell transplantation （allo-HSCT）. NK2 and NK3 cell expansion was observed after aUo-HSCT; levels of NKr ceils reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease （GVHD）（HR 0.157, P=-0.010） as well as II-IV acute GVHD （HR 0.260, P=-0.059）. Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus （CMV） reactivation （HR 0.040, 0.005-0.348,/9=-0.003）. These results indicate that rapid reconstitution of NK cells, especially NK1 cells, can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation.

关键词： NK1 NK2 NK3 NKr GVHD CMV