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A telomere-to-telomere genome assembly of Zhonghuang 13,a widely-grown soybean variety from the original center of Glycine max

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The Crop Journal 2024年第1期12卷 142-153页

作者： Anqi Zhang Tangchao Kong Baiquan Sun Shizheng Qiu Jiahe Guo Shuyong Ruan Yu Guo Jirui Guo Zhishuai Zhang Yue Liu Zheng Hu Tao Jiang Yadong Liu Shuqi Cao Shi Sun Tingting Wu Huilong Hong Bingjun Jiang Maoxiang Yang xiangyu yao Yang Hu Bo Liu Tianfu Han Yadong Wang Center for Bioinformatics School of Computer Science and TechnologyHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Ministry of Agriculture Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Soybean(Glycine max)stands as a globally significant agricultural crop,and the comprehensive assembly of its genome is of paramount importance for unraveling its biological characteristics and evolutionary ***,previous soybean genome assemblies have harbored gaps and incompleteness,which have constrained in-depth investigations into ***,we present Telomere-to-Telomere(T2T)assembly of the Chinese soybean cultivar Zhonghuang 13(ZH13)genome,termed ZH13-T2T,utilizing PacBio Hifi and ONT ultralong *** employed a multi-assembler approach,integrating Hifiasm,NextDenovo,and Canu,to minimize biases and enhance assembly *** assembly spans 1,015,024,879 bp,effectively resolving all 393 gaps that previously plagued the reference *** annotation efforts identified 50,564 high-confidence protein-coding genes,707 of which are ***13-T2T revealed longer chromosomes,421 not-aligned regions(NARs),112 structure variations(SVs),and a substantial expansion of repetitive element compared to earlier ***,we identified 25.67 Mb of tandem repeats,an enrichment of 5S and 48S rDNAs,and characterized their genotypic *** summary,we deliver the first complete Chinese soybean cultivar T2T *** comprehensive annotation,along with precise centromere and telomere characterization,as well as insights into structural variations,further enhance our understanding of soybean genetics and evolution.

关键词： Soybean Telomere-to-Telomere assembly Zhonghuang 13 Structure variations

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5G无线网智能统一切片管理器的开发与应用

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通信与信息技术 2024年第2期 50-54页

作者：汪锋姚翔宇李君改中国联通河南省分公司云网运营中心河南郑州450000

切片是5G的特性功能之一,运营商通过切片改变过去“一刀切”和“尽力而为”的网络运行模式,可以为客户提供个性化且有保障的网络服务。针对现阶段5G基于切片业务的网络架构中存在的问题,提出了无线网智能统一切片管理器的概念,实现了对... 详细信息

切片是5G的特性功能之一,运营商通过切片改变过去“一刀切”和“尽力而为”的网络运行模式,可以为客户提供个性化且有保障的网络服务。针对现阶段5G基于切片业务的网络架构中存在的问题,提出了无线网智能统一切片管理器的概念,实现了对数量众多的AN-NSSMF(接入网络切片子网管理功能)的统一管理,同时向上级NSMF(网络切片管理功能)提供统一接口用于功能调用。

关键词： 5G 无线网切片管理器

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Dynamic synthetic analysis of circulation field of tropical cyclones affecting Shanghai

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Frontiers of Earth Science 2024年第2期18卷 347-363页

作者： Wen GU Caijun YUE Zhihui HAN Yanqing GAO Yuqi TANG xiangyu AO yao yao Shanghai Ecological Forecasting&Remote Sensing Center Shanghai 200030China Shanghai Marine Meteorological Centre Shanghai 200030China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclone(China Meteorological Administration) Shanghai 200030China

Eleven tropical cyclones(TCs)affected Shanghai and crossed the same latitude as Shanghai from 2007 to *** to similar tracks from best-track data,TCs that cause significant precipitation in Shanghai can be divided into three types:landfall TCs,nearshore northward TCs,and western *** on ERA5 reanalysis data,the dynamic synthesis method was used to synthesize TC circulation situations to compare thermal,dynamic,water vapor,and stability conditions within TC circulations during the period when they affected *** conclusions are as follows.1)When the three TC types are at the same latitude as Shanghai,they are all in the divergent field in the upper *** the landfall type,the subtropical high at 500 hPa is stronger and farther north than usual,and there is a high-pressure dam on the north side of the TCs.2)The warm advection of the three TC types at 925 hPa is located in the northern quadrant of the *** dynamic and water vapor conditions are good in the north-western quadrant of landfall and western TCs,and more favorable in the eastern quadrant of nearshore northward TCs.3)The favorable effects of all three types on precipitation in Shanghai come from the boundary *** vapor,upward motion,and instability conditions of landfall TCs are superior to the other two TC *** best water vapor,dynamic,and convective instability conditions are at the northern boundary in Shanghai during landfall TCs,and the main sources of water vapor in Shanghai come from the eastern and northern *** nearshore northward TCs,the main contribution to precipitation is from the eastern boundary,while better dynamic and water vapor conditions come from the western and northern boundaries during western *** above findings provide scientific and technical support for operational forecasting precipitation from TCs affecting mega-cities.

关键词： tropical cyclones dynamic synthetic analysis ERA5 reanalysis Shanghai similar track

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β-葡萄糖苷酶J384W位点突变的生物信息学及分子对接

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西安工程大学学报 2024年第3期38卷 61-67页

作者：潘虹姚向钰洪一楠王晓军樊雨柔西安工程大学环境与化学工程学院陕西西安710048

为提高β-葡萄糖苷酶对人参皂苷Rb1的转化效率,通过分子对接得到β-葡萄糖苷酶转化人参皂苷Rb1中参与底物识别及结合的关键区域和位点。将J384位点进行定点突变为W384,并通过生物信息学比较野生酶和突变酶的理化性质、亲/疏水性、跨膜... 详细信息

为提高β-葡萄糖苷酶对人参皂苷Rb1的转化效率,通过分子对接得到β-葡萄糖苷酶转化人参皂苷Rb1中参与底物识别及结合的关键区域和位点。将J384位点进行定点突变为W384,并通过生物信息学比较野生酶和突变酶的理化性质、亲/疏水性、跨膜区、二/三级结构。结果表明:改变酶的内部结构可使结合位点数增加,整体的稳定性更强;突变酶比野生酶与人参皂苷Rb1更容易自发进行结合,最低结合能为-9.02 kJ/mol。

关键词： β-葡萄糖苷酶定点突变生物信息学分子对接

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Exploring the Cation Regulation Mechanism for Interfacial Water Involved in the Hydrogen Evolution Reaction by In Situ Raman Spectroscopy

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Nano-Micro Letters 2024年第3期16卷 303-312页

作者： Xueqiu You Dongao Zhang Xia‑Guang Zhang xiangyu Li Jing‑Hua Tian yao‑Hui Wang Jian‑Feng Li School of Ocean Information Engineering Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent ProcessingJimei UniversityXiamen 361021People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005People’s Republic of China Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsCollege of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007People’s Republic of China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005People’s Republic of China

Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER ***,investigating interfacial water is extremely challenging owing to the interference caused by bulk water molecules and complexity of the interfacial ***,the behaviors of interfacial water in different cationic electrolytes on Pd surfaces were investigated by the electrochemistry,in situ core-shell nanostructure enhanced Raman spectroscopy and theoretical simulation *** spectral evidence reveals a red shift in the frequency and a decrease in the intensity of interfacial water as the potential is shifted in the positively *** comparing the different cation electrolyte systems at a given potential,the frequency of the interfacial water peak increases in the specified order:Li+

关键词： In situ Raman Interfacial water Hydrogen evolution reaction Cations

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Toward understanding the microstructure characteristics,phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

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International Journal of Extreme Manufacturing 2024年第1期6卷 277-294页

作者： Bo yao Nan Kang xiangyu Li Dou Li Mohamed EL Mansori Jing Chen Haiou Yang Hua Tan Xin Lin State Key Laboratory of Solidiffcation Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Technology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic *** essential magnetic properties of Nd-Fe-B magnets,particularly coercivity and remanent magnetization,are significantly infuenced by the phase characteristics and *** this work,Nd-Fe-B magnets were manufactured using vacuum induction melting(VIM),laser directed energy deposition(LDED)and laser powder bed fusion(LPBF)*** evolution and phase selection of Nd-Fe-B magnets were then clarified in *** results indicated that the solidification velocity(V)and cooling rate(R)are key factors in the phase *** terms of the VIM-casting Nd-Fe-B magnet,a large volume fraction of theα-Fe soft magnetic phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?C s-1),whereas only a minor fraction of the Nd2Fe14B hard magnetic phase(5.15 vol.%)is *** the LDED-processed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic phase also had a low value(3.4 vol.%)as the values of V(10-2m s-1)and R(1.45×106?C s-1)in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase(55.8 vol.%)directly from the liquid,while theα-Fe soft magnetic phase and Nd2Fe17Bxmetastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B ***,crystallographic texture analysis reveals that the LPBF-processedNd-Fe-B magnets exhibit isotropic magnetic ***,the LPBF-processed Nd-Fe-B deposit,exhibiting a coercivity of 656 k A m-1,remanence of 0.79 T and maximum energy product of 71.5 k J m-3,achieved an acceptable magnetic perfor

关键词： laser additive manufacturing(LAM) Nd-Fe-B permanent magnets numerical simulation microstructure magnetic properties

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Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1a

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Genes & Diseases 2024年第5期11卷 13-16页

作者： xiangyu Sun Qiang Zhang Mozhi Wang Litong yao Xiang Li Hongyi Cao Yingying Xu Department of Breast Surgery Liaoning Cancer Hospital&InstituteShenyangLiaoning 110000China Department of Breast Surgery The First Hospital of China Medical UniversityShenyangLiaoning 110000China Department of Ultrasound The First Hospital of China Medical UniversityShenyangLiaoning 110000China Department of Pathology The First Hospital of China Medical University and College of Basic Medical SciencesShenyangLiaoning 110000China

Metabolic reprogramming is a key feature of tumor cells and plays a key role in the adaptation of tumor cells to increased demands of biosynthesis and rapid proliferation.1 Numerous studies have shown that some key metabolic enzymes are essential for the initiation and progression of breast cancer(BC).These metabolic enzymes are involved in the regulation of many biological processes such as gene transcription,post-translational modification,and antioxidant capacity of cells,which endow tumor cells with the ability to adapt to divergent environmental stimuli.2 Therefore,it is of great significance to identify the role of important metabolic enzymes in the occurrence and development of BC to determine promising therapeutic targets.

关键词： breast cancer oxidative

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Core-shell nanoparticle enhanced Raman spectroscopy in situ probing the composition and evolution of interfacial species on PtCo surfaces

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Nano Research 2024年第6期17卷 4687-4692页

作者： Jing Liu Han-Liang Zhong xiangyu Li Mu-Fei Yue Wei-Min Yang Xueqiu You Jing-Hua Tian yao-Hui Wang Jian-Feng Li Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing School of Ocean Information EngineeringJimei UniversityXiamen 361021China College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China

The composition and evolution of interfacial species play a key role during electrocatalytic *** the structural evolution and intermediate during catalytic process by in situ characterization can shed new light on the electrocatalytic reaction mechanism and develop highly efficient ***,directly probing the interfacial species is extremely difficult for most spectroscopic techniques due to complicated interfacial environment and ultra-low surface ***,electrochemical core-shell nanoparticle enhanced Raman spectroscopy is utilized to probe the composition and evolution processes of interfacial species on Au@Pt,Au@Co,and Au@PtCo core-shell nanoparticle *** spectral evidences of interfacial intermediates including hydroxide radical(OH*),superoxide ion(O_(2)^(−)),as well as metal oxide species are directly captured by in situ Raman spectroscopy,which are further confirmed by the both isotopic experiment and density functional theory *** results provide a mechanistic guideline for the rational design of highly efficient electrocatalysts.

关键词： in situ Raman core-shell nanoparticle PtCo interfacial species composition and evolution

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数字环境下面状要素分级设色的适宜方案分析

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测绘学报 2022年第2期51卷 290-300页

作者：姚翔宇黄丽娜于洋武汉大学资源与环境科学学院湖北武汉430079 武汉大学地理信息系统教育部重点实验室湖北武汉430079 苏州工业园区测绘地理信息有限公司江苏苏州215000

为探究明度与色相同步变化时不同分级设色方案在数字环境下的适宜性,基于Munsell色彩调和秩序与CIEDE2000色差公式设计了7种分级设色方案,并开展了视觉认知试验。试验结果表明:①增加各级间色差会导致颜色辨识的准确性增强;②与各级间... 详细信息

为探究明度与色相同步变化时不同分级设色方案在数字环境下的适宜性,基于Munsell色彩调和秩序与CIEDE2000色差公式设计了7种分级设色方案,并开展了视觉认知试验。试验结果表明:①增加各级间色差会导致颜色辨识的准确性增强;②与各级间色差相等的色阶相比,色差先增大后减小的色阶有利于读图判别;③图斑面积分布均匀程度对颜色辨识的影响并不显著;④色阶的总色差增大,会导致颜色过渡的协调性降低。色差先增大后减小的色阶能产生较好的辨识效果,同时保持较好的色彩协调性,且相关规律可以推广到图斑面积分布均匀程度不同的地图中,在分级设色中运用具有优势。

关键词：分级设色色差色彩方案地图图斑视觉认知实验

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ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis

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Cancer Biology & Medicine 2024年第7期21卷 606-635页

作者： Shirong Tan xiangyu Sun Haoran Dong Mozhi Wang Litong yao Mengshen Wang Ling Xu Yingying Xu Department of Breast Surgery The First Affiliated Hospital of China Medical University Department of Thyroid and Breast Surgery Affiliated Hospital of Xuzhou Medical University Department of Medical Oncology The First Hospital of China Medical University

Objective: Mitochondrial fatty acid oxidation is a metabolic pathway whose dysregulation is recognized as a critical factor in various cancers, because it sustains cancer cell survival, proliferation, and metastasis. The acyl-Co A synthetase long-chain(ACSL) family is known to activate long-chain fatty acids, yet the specific role of ACSL3 in breast cancer has not been ***: We assessed the prognostic value of ACSL3 in breast cancer by using data from tumor samples. Gain-of-function and lossof-function assays were also conducted to determine the roles and downstream regulatory mechanisms of ACSL3 in vitro and in ***: ACSL3 expression was notably downregulated in breast cancer tissues compared with normal tissues, and this phenotype correlated with improved survival outcomes. Functional experiments revealed that ACSL3 knockdown in breast cancer cells promoted cell proliferation, migration, and epithelial±mesenchymal transition. Mechanistically, ACSL3 was found to inhibit β-oxidation and the formation of associated byproducts, thereby suppressing malignant behavior in breast cancer. Importantly, ACSL3 was found to interact with YES proto-oncogene 1, a member of the Src family of tyrosine kinases, and to suppress its activation through phosphorylation at Tyr419. The decrease in activated YES1 consequently inhibited YAP1 nuclear colocalization and transcriptional complex formation, and the expression of its downstream genes in breast cancer cell ***: ACSL3 suppresses breast cancer progression by impeding lipid metabolism reprogramming, and inhibiting malignant behaviors through phospho-YES1 mediated inhibition of YAP1 and its downstream pathways. These findings suggest that ACSL3 may serve as a potential biomarker and target for comprehensive therapeutic strategies for breast cancer.

关键词： ACSL3 Breast cancer YAP lipid metabolism metastasis

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