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Stem cell niche-inspired microcarriers with ADSCs encapsulation for diabetic wound treatment

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Bioactive Materials 2023年第8期26卷 159-168页

作者： xiangyi wu Haofang Zhu Junyi Che Ye Xu Qian Tan Yuanjin Zhao Department of Burns and Plastic Surgery Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210002China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325000China

Stem cell therapies have made great progress in the treatment of diabetic wounds during recent decades,while their short in vivo residence,alloimmune reactions,undesired behaviors,and dramatic losses of cell functions still hinder the translation of them into ***,inspired by the natural components of stem cell niches,we presented novel microfluidic hydrogel microcarriers with extracellular matrix(ECM)-like composition and adipose-derived stem cells(ADSCs)encapsulation for diabetic wound *** the hydrogel was synthesized by conjugating hyaluronic acid methacryloyl(HAMA)onto the Fibronectin(FN)molecule chain(FN-HAMA),the laden ADSCs in the microcarriers showed improved bioactivities and pro-regenerative *** on these features,we have demonstrated that these ADSCs microcarriers exhibited significant promotion of neovascularization,follicular rejuvenation,and collagen deposition in a mouse diabetic wound *** results indicated that the stem cell niche-inspired FN-HAMA microcarriers with ADSCs encapsulation have great clinical potential for diabetic wound treatment.

关键词： Stem cell Bio-inspired Microfluidics Microcarrier Wound healing Hydrogel

Emerging biomedical technologies for scarless wound healing

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Bioactive Materials 2024年第12期42卷 449-477页

作者： Xinyue Cao xiangyi wu Yuanyuan Zhang Xiaoyun Qian Weijian Sun Yuanjin Zhao Department of Otolaryngology Head and Neck Surgery Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Department of Gastrointestinal Surgery The First Affiliated HospitalWenzhou Medical UniversityWenzhou325035China Shenzhen Research Institute Southeast UniversityShenzhen518071China

Complete wound healing without scar formation has attracted increasing attention,prompting the development of various strategies to address this *** clinical settings,there is a growing preference for emerging biomedical technologies that effectively manage fibrosis following skin injury,as they provide high efficacy,cost-effectiveness,and minimal side effects compared to invasive and costly surgical *** review gives an overview of the latest developments in advanced biomedical technologies for scarless wound *** first introduce the wound healing process and key mechanisms involved in scar ***,we explore common strategies for wound treatment,including their fabrication methods,superior performance and the latest research developments in this *** then shift our focus to emerging biomedical technologies for scarless wound healing,detailing the mechanism of action,unique properties,and advanced practical applications of various biomedical technology-based therapies,such as cell therapy,drug therapy,biomaterial therapy,and synergistic ***,we critically assess the shortcomings and potential applications of these biomedical technologies and therapeutic methods in the realm of scar treatment.

关键词： Biomedical technologies Scarless wound healing Nonsurgical therapies Biomaterial Drug delivery

Cartilage-on-a-chip with magneto-mechanical transformation for osteoarthritis recruitment

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Bioactive Materials 2024年第3期33卷 61-68页

作者： Hao Liu xiangyi wu Rui Liu Weijun Wang Dagan Zhang Qing Jiang State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School321 Zhongshan RoadNanjing210008JiangsuChina Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210008China

Osteoarthritis (OA) is a prevalent joint disease primarily induced by overstrain, leading to disability and significantly impacting patients’ quality of life. However, current OA studies lack an ideal in vitro model, which can recapitulate the high peripheral strain of the joint and precisely model the disease onset process. In this paper, we propose a novel cartilage-on-a-chip platform that incorporates a biohybrid hydrogel comprising Neodymium (NdFeB)/Poly-GelMA-HAMA remote magneto-control hydrogel film. This platform facilitates chondrocyte culture and stress loading, enabling the investigation of chondrocytes under various stress stimuli. The Neodymium (NdFeB)/Poly-GelMA-HAMA hydrogel film exhibits magneto-responsive shape-transition behavior, further dragging the chondrocytes cultured in hydrogels under magnetic stimulation. It was investigated that inflammation-related genes and proteins in chondrocytes are changed with mechanical stress stimulation in the cartilage-on-a-chip. Especially, MMP-13 and the proportion of collagen secretion are upregulated, showing a phenotype similar to that of real human osteoarthritis. Therefore, we believed that this cartilage-on-a-chip platform provides a desired in vitro model for osteoarthritis, which is of great significance in disease research and drug development.

关键词： Cartilage-on-a-chip Neodymium magnet GelMA-HAMA Mechanical loading

Chronic wounds:pathological characteristics and their stem cell-based therapies

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Engineered Regeneration 2023年第1期4卷 81-94页

作者： xiangyi wu Haofang Zhu Ye Xu Bin Kong Qian Tan Department of Burns and Plastic Surgery Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhen 518060China

Chronic wounds are characterized by prolonged healing processes and poor prognoses,which have substantially impacted human health and daily *** treatment strategies have various limitations and ***,fully effective therapeutic approaches remain urgently *** cell(SC)-based therapies have drawn significant attention for their abilities of immunomodulation and *** has been demon-strated that stem cells(SCs)can improve angiogenesis,collagen deposition,and hair rejuvenation,thus facilitating wound *** addition,attempts were performed to facilitate the cell survival,function,retention,and en-graftment of the delivered *** this review,we first introduce the pathological process involved in chronic wound *** that,the mechanism of SCs in promoting chronic wound repair is discussed in ***,we highlight recent SC-based therapies for chronic wound repair ***,we present our views on the remaining challenges and future trends of SC-based therapies for chronic wound treatment.

关键词： Chronic wounds Stem cell Cell scaffold Cell-free therapy Gene modification

Engineered artificial skins:Current construction strategies and applications

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Engineered Regeneration 2023年第4期4卷 438-450页

作者： Ye Xu xiangyi wu Yuanyuan Zhang Yunru Yu Jingjing Gan Qian Tan Department of Burn and Plastic Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina Pharmaceutical Sciences Laboratory Åbo Akademi UniversityTurku 20520Finland

Skin damage resulting from burns,injuries,or diseases can lead to significant functional and esthetic ***,traditional treatments,such as skin grafting,have limitations including limited donor skin availability,poor aesthetics,and functional *** tissue engineering provides a promising alternative,with engineered artificial skins offering a highly viable *** artificial skin is designed to mimic or replace the functions of natural human skin and find applications in various medical treatments,particularly for severe burns,chronic wounds,and other skin injuries or *** artificial skins aim to promote wound healing,provide temporary coverage,permanent skin replacement,and restore the skin’s barrier *** skins have diverse applications in medicine and wound care,addressing burns,chronic wounds,and traumatic *** also serve as valuable tools for research in tissue engineering,offering experimental models for studying wound healing mechanisms,testing new biomaterials,and exploring innovative approaches to skin *** review provides an overview of current construction strategies for engineered artificial skin,including cell sources,biomaterials,and construction *** further explores the primary application areas and future prospects of artificial skin,highlighting their potential to revolutionize skin reconstruction and advance the field of regenerative medicine.

关键词： Artificial skin Skin tissue engineering Biomaterial Cell scaffold Wound healing

A Preliminary Study of Embedded Supervision Thoughts:Based on a Distributed Financial System

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Contemporary Social Sciences 2022年第2期7卷 25-44页

作者： wu xiangyi Du Kunlun Tang Zhou Li Xianbin Institute of Finance and Trade Sichuan Academy of Social Sciences

Regulation of technology has been a hot issue in the financial field in recent *** financial regulation is constructed by a centralized account system,which relies on ex-ante *** supervision,which relies on regulation during and after the matter,operates in a decentralized and trusted environment and has the characteristics of high efficiency,transparency,and *** provides a breakthrough to solve the lag of traditional financial *** paper clarifies the concepts and theoretical basis of embedded supervision,constructs the embedded supervision model with a lag,and analyzes the feasibility of embedded supervision with a *** research can promote scientific exploration and method innovations in the domestic finance field,enrich China’s financial discipline system,and provide decision-making references for practical financial supervision innovation.

关键词： blockchain embedded supervision distributed financial system

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan Ye xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

线性高振荡常微分方程的Neumann展开方法

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北京交通大学学报 2008年第3期32卷 107-109页

作者：吴相逸赵平福北京交通大学理学院北京100044

考虑了线性高振荡方程y″+g(t)y=0数值解法的构造问题.以两个格式为例,研究了Neumann展开方法.数值实验显示,两个格式产生的截断误差较小.

关键词：计算数学线性高振荡方程 Neumann展开

氯胺酮对新生大鼠海马乙酰胆碱酯酶和乙酰胆碱转移酶的影响

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安徽医科大学学报 2012年第1期47卷 12-15页

作者：喻红彪伍湘伊安徽医科大学新疆临床学院新疆维吾尔自治区人民医院麻醉科乌鲁木齐830001

目的探讨氯胺酮对新生大鼠学习记忆和海马乙酰胆碱酯酶(AchE)、乙酰胆碱转移酶(ChAT)的影响。方法 80只7 d龄大鼠随机分为C、K1、K2、K3组,每组20只。C组给予生理盐水2 ml;K1组单次腹腔注射氯胺酮80 mg/kg,K2、K3组分别按同等剂量注射2... 详细信息

目的探讨氯胺酮对新生大鼠学习记忆和海马乙酰胆碱酯酶(AchE)、乙酰胆碱转移酶(ChAT)的影响。方法 80只7 d龄大鼠随机分为C、K1、K2、K3组,每组20只。C组给予生理盐水2 ml;K1组单次腹腔注射氯胺酮80 mg/kg,K2、K3组分别按同等剂量注射2、3 d。末次给药后1 d各组处死10只、余大鼠至21 d龄行Morris水迷宫实验。迷宫实验后检测海马AchE和ChAT水平。结果水迷宫结果:C组与K1组比较、K2组与K3组比较差异均无统计学意义;K2、K3组较C、K1组潜伏期延长且穿越平台次数减少(P<0.05)。酶测定:8 d龄,各组间差异有统计学意义(P<0.05)。27 d龄,C组与K1组比较、K2组与K3组比较差异均无统计学意义,K2、K3组较C、K1组差异有统计学意义(P<0.05)。结论氯胺酮引起新生大鼠空间辨别记忆能力下降,可能与海马胆碱能系统有关;单次给药能引起短期内海马胆碱能系统变化,而重复给药则会导致较长时间的影响。

关键词：氯胺酮海马乙酰胆碱酯酶乙酰胆碱转移酶 Morris水迷宫