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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan Ye xiangyi Liu Yingsheng Xu Dongsheng fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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Gold nanoclusters conjugated berberine reduce inflammation and alleviate neuronal apoptosis by mediating M2 polarization for spinal cord injury repair

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Regenerative Biomaterials 2022年第1期9卷 247-259页

作者： Zipeng Zhou Dan Li xiangyi fan Yajiang Yuan Hongyu Wang Dahao Wang Xifan Mei Department of The First Clinical College Liaoning University of Traditional Chinese MedicineNo.79Chongshan East RoadHuanggu DistrictShenyang CityLiaoning Province 110847P.R.China Department of Orthopedics First Affiliated Hospital of Jinzhou Medical UniversityJinzhouChina Department of Basic Science Jinzhou Medical UniversityJinzhouChina Department of Otolaryngology-Head and Neck Surgery First Affiliated Hospital of Jinzhou Medical UniversityJinzhouChina Jinzhou Medical University No.40Section 3Songpo RoadLinghe District Jinzhou CityLiaoning Province 121001P.R.China

Spinal cord injury(SCI)leads to nerve cell apoptosis and loss of motor ***,excessive activation of the M1 phenotype macrophages/microglia is found to be the main reason for the poor prognosis of SCI,but the selective activation phenotype(M2)macrophages/microglia facilitates the recovery of ***,we used gold nanoclusters loaded berberine(BRB-AuNCs)to reduce inflammation by inhibiting the activation of M1 phenotype macrophages/microglia,which simultaneously inhibited neuronal apoptosis after *** vitro and in vivo experiments showed that BRB-AuNCs reduced M1 protein marker CD86,increased M2 protein marker CD206,reduced inflammation and apoptotic cytokines(IL-1β,IL-6,TNF-α,Cleaved Caspase-3 and Bax).These results indicate that BRB-AuNCs have excellent anti-inflammatory and anti-apoptotic effects by inducing the polarization of macrophages/microglia from M1 phenotype to M2 ***,the motor functions of SCI rats were significantly improved after treatment with *** work not only provides a new way for the treatment of SCI but also broadens BRB utilization strategies.

关键词： gold nanoclusters berberine macrophages/microglia spinal cord injury

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Complete Universal Scaling in First-Order Phase Transitions

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Chinese Physics Letters 2024年第10期41卷 8-13页

作者： fan Zhong School of Physics and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Phase transitions and critical phenomena are among the most intriguing phenomena in nature and *** are classified into first-order phase transitions(FOPTs)and continuous *** the latter shows marvelous phenomena of scaling and universality,whether the former behaves similarly is a long-standing controversial *** we definitely demonstrate complete universal scaling in field driven FOPTs for Langevin equations in both zero and two spatial dimensions by rescaling all parameters and subtracting nonuniversal contributions with singular dimensions from an effective temperature and a special field according to an effective *** offers a perspective different from the usual nucleation and growth but conforming to continuous phase transitions to study FOPTs.

关键词： theory. transitions scaling

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吉林省泥炭沼泽现状分析与评价

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林业勘查设计 2017年第1期46卷 26-27页

作者：樊祥义吉林省林业调查规划院

通过对泥炭沼泽调查得到的结果数据进行分析,对全省泥炭沼泽的数量、质量、分布、理化特征进行评价。为泥炭沼泽资源保护及合理利用提供借鉴。

关键词：泥炭沼泽生物量含碳量容量

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吉林省泥炭沼泽现状分析与评价

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林业勘查设计 2016年第4期45卷 10-11页

作者：樊祥义吉林省林业调查规划院

通过对吉林省泥炭沼泽调查数据进行分析,继而对该省泥炭沼泽的数量、质量、分布、理化特征进行评价。旨为泥炭沼泽资源的保护及合理利用提供借鉴。

关键词：泥炭沼泽生物量含碳量容重

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Semi-analytical Solutions for Wellbores with Graded Skin Zones in Poroelastic Media

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Acta Mechanica Solida Sinica 2024年第3期37卷 385-395页

作者： Zhiqiang fan Zhihe Jin School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China Department of Mechanical Engineering University of MaineOronoME04469USA

In analyzing the complex interaction between the wellbore and the reservoir formation,the hydromechanical properties of the region proximal to the wellbore,referred to as the“wellbore skin zone”,play a pivotal role in determining flow dynamics and the resulting formation *** models of the wellbore skin zone generally assume a constant permeability throughout,resulting in a sharp permeability discontinuity at the skin-reservoir *** paper introduces a model for a wellbore with a continuously graded skin zone of finite thickness within a poroelastic *** solutions are derived using the Laplace transform method,addressing both positive and negative skin *** results are presented to illustrate the effects of graded permeability/skin zone thickness on pore pressures and stresses around a *** results highlight a distinct divergence in stress and pore pressure fields when comparing wellbores with negative skin zones to those with positive skin zones or no skin at all.

关键词： Poroelastic Graded permeability Analytical solution Wellbore Skin zone

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A progressive framework for rotary motion deblurring

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Defence Technology（防务技术） 2024年第2期32卷 159-172页

作者： Jinhui Qin Yong Ma Jun Huang fan fan You Du School of Electronic Information Wuhan UniversityWuhan430072China

The rotary motion deblurring is an inevitable procedure when the imaging seeker is mounted in the rotating *** rotary motion deblurring methods suffer from ringing artifacts and noise,especially for large blur *** solve the above problems,we propose a progressive rotary motion deblurring framework consisting of a coarse deblurring stage and a refinement *** the first stage,we design an adaptive blur extents factor(BE factor)to balance noise suppression and details *** a novel deconvolution model is proposed based on BE *** the second stage,a triplescale deformable module CNN(TDM-CNN)is designed to reduce the ringing artifacts,which can exploit the 2D information of an image and adaptively adjust spatial sampling *** establish a standard evaluation benchmark,a real-world rotary motion blur dataset is proposed and released,which includes rotary blurred images and corresponding ground truth images with different blur *** results demonstrate that the proposed method outperforms the state-of-the-art models on synthetic and real-world rotary motion blur *** code and dataset are available at https://***/JinhuiQin/RotaryDeblurring.

关键词： Rotary motion deblurring Progressive framework Blur extents factor TDM-CNN

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Seismic response of pile-supported structures considering the coupling of inertial and kinematic interactions in different soil sites

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1350-1361页

作者： Huiling ZHAO fan ZHANG Department of Civil Engineering Shanghai UniversityShanghai 200444China

Dynamic soil−pile−superstructure interaction is crucial for understanding pile behavior in earthquake-prone *** the safety of piles requires determining the seismic bending moment caused by combined inertial and kinematic interactions,which is *** paper addresses this problem through numerical simulations of piles in different soil sites,considering soil *** reveal that the period of the soil site significantly affects the interaction among soil,piles,and *** moments in soft and hard soil sites exceed those in medium soil sites by more than *** modes of piles exhibit distinct characteristics between hard and soft soil *** soil sites exhibit a singular inflection point,while hard soil sites show two inflection *** soft soil sites,pile-soil kinematic interaction gradually increases bending moment from tip to head,with minor influence from superstructure’s inertial *** hard soil sites,significant inertial effects from soil,even surpassing pile-soil kinematic effects near the tip,lead to reversed superposition bending ***’s inertial interaction notably impacts pile head in hard soil sites.A simplified coupling method is proposed using correlation coefficient to represent inertial and kinematic *** findings provide insights into complex seismic interactions among soil,piles,and structures.

关键词： pile seismic response soft soil inertial interaction kinematic interaction

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Impact of non-ideal UE hardware on cell-free massive MIMO network with centralized operation

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Science China(Information Sciences) 2024年第4期67卷 255-271页

作者： Ning LI Pingzhi fan Institute of Mobile Communications Southwest Jiaotong University

This paper investigates the impact of non-ideal user equipment(UE) hardware on a cell-free(CF) massive MIMO(mMIMO) network with centralized operation under spatially correlated channels. The minimum mean-squared error(MMSE) estimator can be derived with the help of the generic non-ideal UE hardware model. It is demonstrated that even if the effective signal-to-noise ratio approaches infinity, pilot contamination and imperfect hardware can cause a non-zero estimation error floor. After that, a lower bound is determined for the ergodic uplink capacity of the centralized CF mMIMO network under non-ideal UE hardware. Moreover, the optimal receive combining vector is obtained to maximize the uplink spectral efficiency(SE). The maximum ratio(MR) and regularized zero-forcing(RZF) combining schemes are offered as alternatives in light of the computational complexity of the MMSE receiver. Comparing the RZF to the MMSE scheme under different levels of hardware impairments, our findings indicate that the RZF receiver suffers a negligible loss in total SE. For MR combining, a novel closed-form uplink achievable SE expression is obtained based on the MMSE estimator and the use-and-then-forget bounding technique. This expression gives vital insights into the achievable uplink performance with UE hardware impairments. Besides, for various hardware impairment factors, the impact of pilot sequence length on average sum SE is disclosed for different receive combining schemes. To increase the overall SE of the max-min fairness scheme, a heuristic fractional power control scheme with UE hardware impairments is developed, which can essentially avoid sacrificing the SE of other UEs while maximizing the SE of the unluckiest UE in the whole network. Finally,our theoretical performance analysis and power control algorithm are validated by simulation results, and fundamental design guidelines are provided for selecting hardware satisfying the practical UE requirements.

关键词： cell-free massive MIMO centralized operation spatially correlated channels hardware impairments channel estimation uplink spectral efficiency optimal receive combining pilot length design fractional power control

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Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction:Efficient photodegradation of organic pollutant and toxicity evaluation

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Journal of Materials Science & Technology 2024年第3期170卷 200-211页

作者： Yanyan Zhao Xu fan Hongxing Zheng Enzhou Liu Jun fan Xuejun Wang College of Biology Pharmacy and Food Engineering Shangluo UniversityShangluo 726000China QinLing-Bashan Mountains Bioresources Comprehensive Development C.I.C. Shaanxi University of TechnologyHanzhong 723001China School of Chemical Engineering Northwest UniversityXi’an 710069China

Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of *** this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for organic pollutants *** Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction exhibited much higher pho-tocatalytic activity towards Rhodamine B(92.24%,expose to visible light for 60 min),norfloxacin(81.73%,expose to visible light for 90 min)and levofloxacin(87.46%,expose to visible light for 90 min)than pure Bi_(2)WO_(6)and pure AgInS_(2).Toxicity analysis indicated the low environmental toxicity of Rhodamine B degradation intermediates for Rye seeds and Sudangrass seeds germination and *** study displayed that AgInS_(2)and Bi_(2)WO_(6)work as the primary photocatalyst to form·O_(2)−and ·OH,*** improved photocatalytic activity of the Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was due to the im-proved light response range and intensified carrier separation ***,a S-scheme charge transfer mechanism including multiple charge transfer channels was *** work could provide an effective strategy for organic pollutants degradation in wastewater.

关键词： Photocatalysis S-scheme heterojunction AgInS_(2) Bi_(2)WO_(6) Toxicity experiments

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