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How can we establish animal models of HIV-associated lymphoma?

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Animal Models and Experimental Medicine 2024年第4期7卷 484-496页

作者： Qing Xiao Liuyue Zhai Xiaomei Zhang Yi Liu Jun Li Xiaoqing Xie Guofa xu Sanxiu He Huihui Fu Yifeng Tang Fujie Zhang Yao Liu Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Department of Hematology-OncologyChongqing University Cancer HospitalChongqingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina

Human immunodeficiency virus(HIV)infection is strongly associated with a height-ened incidence of *** mirror the natural course of human HIV infection,animal models have been *** models serve as valuable tools to inves-tigate disease pathobiology,assess antiretroviral and immunomodulatory drugs,ex-plore viral reservoirs,and develop eradication ***,there are currently no validated in vivo models of HIV-associated lymphoma(HAL),hampering progress in this crucial domain,and scant attention has been given to developing animal models dedicated to studying HAL,despite their pivotal role in advancing *** re-view provides a comprehensive overview of the existing animal models of HAL,which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.

关键词： animal model HIV-associated lymphoma(HAL) human immunodeficiency virus(HIV) immunodeficient mice primate model

SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA Yun-ding ZOU Zhi-long LIU Gui-xian WU Yuan-ze ZHOU Cheng-xin LUO Xiang-tao HUANG Ming-ling XIE Shuang-nian xu Xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis

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World Journal of Orthopedics 2024年第4期15卷 363-378页

作者： xu-Chang Zhou Dong-xue Wang Chun-Yu Zhang Ya-Jing Yang Ruo-Bing Zhao Sheng-Yao Liu Guo-Xin Ni School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina Department of Spinal Surgery The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina Department of Rehabilitation Medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Regular physical activity during childhood and adolescence is beneficial to bone development,as evidenced by the ability to increase bone density and peak bone mass by promoting bone *** To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying *** 20 growing mice were randomly divided into two groups:Con group(control group,n=10)and Ex group(treadmill exercise group,n=10).Hematoxylin-eosin staining,immunohistochemistry,and micro-CT scanning were used to assess the bone formation-related indexes of the mouse *** analysis was used to find potential miRNAs targets of long non-coding RNA H19(lncRNA H19).RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic *** Compared with the Con group,the expression of bone morphogenetic protein 2 was also significantly *** micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density,bone volume fraction,and the number of trabeculae,and decreased trabecular segregation in the femur of *** of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic *** addition,knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers,which is consistent with the results of autophagy-related protein changes detected in mouse femurs by *** Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice,thus enhancing the peak bone mass of *** lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.

关键词： Exercise Osteogenic differentiation Bone formation Bone mesenchymal stem cells Autophagy

Groundwater contaminant source identification considering unknown boundary condition based on an automated machine learning surrogate

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Geoscience Frontiers 2024年第1期15卷 402-416页

作者： Yaning xu Wenxi Lu Zidong Pan Chengming Luo Yukun Bai Shuwei Qiu Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Water Resources and Environment Jilin UniversityChangchun 130021China College of New Energy and Environment Jilin UniversityChangchun 130021China School of Water Resources and Environment Hebei GEO UniversityShijiazhuang 050031China

Groundwater contamination source identification(GCSI)is a prerequisite for contamination risk evaluation and efficient groundwater contamination remediation *** boundary condition generally is set as known variables in previous GCSI ***,in many practical cases,the boundary condition is complicated and cannot be estimated accurately in *** the boundary condition as known variables may seriously deviate from the actual situation and lead to distorted identification *** the results of GCSI are affected by multiple factors,including contaminant source information,model parameters,boundary condition,***,if the boundary condition is not estimated accurately,other factors will also be estimated *** study focuses on the unknown boundary condition and proposed to identify three types of unknown variables(contaminant source information,model parameters and boundary condition)*** simulation-optimization(S-O)method is applied to GCSI,the huge computational load is usually reduced by building surrogate ***,when building surrogate models,the researchers need to select the models and optimize the hyperparameters to make the model powerful,which can be a lengthy *** automated machine learning(AutoML)method was used to build surrogate model,which automates the model selection and hyperparameter optimization in machine learning engineering,largely reducing human operations and saving *** accuracy of AutoML surrogate model is compared with the surrogate model used in eXtreme Gradient Boosting method(XGBoost),random forest method(RF),extra trees regressor method(ETR)and elasticnet method(EN)respectively,which are automatically selected in AutoML *** results show that the surrogate model constructed by AutoML method has the best accuracy compared with the other four *** study provides reliable and strong support for GCSI.

关键词： Groundwater contamination source Boundary condition Automated machine learning Surrogate model

Recycled polymer:Green roads for polyester plastics

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Green Carbon 2024年第1期2卷 1-11页

作者： Rulin Yang Guangqiang xu Wenjie Tao Qinggang Wang Yong Tang Key Laboratory of Biobased Materials Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China Qingdao New Energy Shandong Laboratory Qingdao 266101China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Plastics are integral to numerous significant social ***,their contribution to environmental pollution and climate crises cannot be disregarded,as their negative impact on the environment increases with incremental production capacity and *** global action is urgently required to promote the green recycle of plastics to prevent their accumulation in the environment and mitigate carbon *** review aims to reveal the paths of green development for polyester plastics,incorporating the trends of the green revolution in mature commercial polyester plastics,newly emerging biodegradable polyester plastics,and future polyester plastics.A critical discussion was conducted on the current and potential future research areas from multiple perspectives,including raw materials,processes,and recycling,to propel us into a future marked by sustainability.

关键词： Recycled polymer Polyester plastics Recycling Bio-based Plastic economy

综合学习理念下高中英语大单元教学目标的研制

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教学与管理 2024年第19期 40-44页

作者：许杰陕西师范大学教育学部西安710062

综合学习作为一种先进的教育理念,对高中英语大单元教学目标的研制提出了新的要求。首先,教学目标应依据课程标准与教材而研制,确保教学内容的完整性与系统性;其次,教学目标应具体而层次分明,体现综合学习的广度和深度,促进学生能力的... 详细信息

综合学习作为一种先进的教育理念,对高中英语大单元教学目标的研制提出了新的要求。首先,教学目标应依据课程标准与教材而研制,确保教学内容的完整性与系统性;其次,教学目标应具体而层次分明,体现综合学习的广度和深度,促进学生能力的分层发展;最后,教学目标研制路径应具体化、行为化和规范化,保障学习目标的细化框架、学习结果的具体界定、目标的精细叙写以及目标结构的设计。通过这些步骤,期望能够更好地整合和联结知识与生活,推动高中英语教学的创新发展,同时优化学习环境,更有效地培养学生面对21世纪挑战的关键能力。

关键词：大单元教学综合学习高中英语教学目标研制

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金融护航中原经济可持续发展

中国金融 2024年第2期 38-40页

作者：许小萍不详

党的十八大以来,以习近平同志为核心的党中央更加重视调查研究工作。习近平总书记强调,调查研究是谋事之基、成事之道,没有调查就没有发言权,没有调查就没有决策权。2023年3月底,党中央决定,在全党开展学习贯彻习近平新时代中国特色社... 详细信息

党的十八大以来,以习近平同志为核心的党中央更加重视调查研究工作。习近平总书记强调,调查研究是谋事之基、成事之道,没有调查就没有发言权,没有调查就没有决策权。2023年3月底,党中央决定,在全党开展学习贯彻习近平新时代中国特色社会主义思想主题教育,并以此为契机,在全党大兴调查研究,以强化理论学习指导发展实践,以深化调查研究推动解决发展难题,以推动高质量发展的新成效检验主题教育成果。近年来,人民银行、金融管理部门以及各金融机构全面贯彻新发展理念,持续深化金融改革,出台落地多项稳经济、稳就业、稳民生政策,有力推动了地方经济的高质量发展。为此,本刊特开设“金融服务高质量发展调研行”专栏,由记者深入基层开展调研,走访企业、市场与农户,推出系列报道,全面反映金融服务地方高质量发展的生动实践。

关键词：习近平新时代中国特色社会主义思想金融管理部门人民银行调查研究工作金融机构民生政策强化理论经济可持续发展

Research on Improving the Thermal Conductivity of Epoxy Resin with Flexible Assisted Rigid Groups

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Chinese Journal of Polymer Science 2024年第11期 1845-1854页

作者： Hong-Yu Zhu Yan-Ji Zhu Di Bao Lu-Chao Pei Fei xu Zhe Wang Huai-Yuan Wang School of Materials Science and Engineering Tianjin University Collaborative Innovation Centre of Chemical Science and Engineering (Tianjin) Tianjin University Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology Tianjin University School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin University

Epoxy resins are cross-linked polymeric materials with typically low thermal ***,the introduction of rigid groups into epoxy resins is the main method to improve their intrinsic thermal *** researchers explored the relationship between the flexible chains of epoxy monomers and the thermal conductivity of the modified epoxy resins （MEP）.The effect of flexible chain length on the introduction of rigid groups into the cross-linked structure of epoxy is worth investigating,which is of great significance for the improvement of thermal conductivity of polymers and related *** prepared a small molecule liquid crystal （SMLC） containing a long flexible chain via a simple synthesis reaction,and introduced rigid mesocrystalline units into the epoxy resin via a curing *** high-temperature curing,the introduced mesocrystalline units underwent orientational stacking and were immobilized within the *** and TGA tests showed that the ordering within the modified epoxy resin was increased,which improved the thermal conductivity of the epoxy ***,during the above process,the flexible chains of SMLC provide space for the biphenyl groups to align and therefore affect the thermal conductivity of the ***,the MEP-Ⅵ cured with SMLC-Ⅵ containing six carbon atoms in the flexible chain has the highest thermal conductivity of 0.40W·m-1·K-1,which is 125%of the thermal conductivity of SMLC-IV of 0.32 W·m-1·K-1,111%of the thermal conductivity of SMLC-Ⅷ of 0.36W·m-1·K-1,and 182%of the thermal conductivity of pure epoxy of 0.22 W·m-1·*** introduction of appropriate length flexible chains for SMLC promotes the stacking of rigid groups within the resin while reducing the occurrence of chain *** study will provide new ideas for the enhancement of thermal conductivity of cross-linked polymeric materials.

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes