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青少年非自杀性自伤与自杀未遂的关联:焦虑、抑郁的调节作用

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中国临床心理学杂志 2024年第3期32卷 536-541页

作者：张溪罗均潘辰王欣琪聂飞李龙春唐秋萍中南大学湘雅三医院临床心理科长沙410013 郴州市第一人民医院心身医学科郴州423000

目的:探讨非自杀性自伤与自杀未遂的关联,并考察焦虑和抑郁在其中的调节作用。方法:采用非自杀性自伤、焦虑、抑郁自评量表及相关临床访谈工具对就诊于综合医院心理门诊的青少年患者进行评估与诊断。共收集到非自杀性自伤青少年患者277... 详细信息

目的:探讨非自杀性自伤与自杀未遂的关联,并考察焦虑和抑郁在其中的调节作用。方法:采用非自杀性自伤、焦虑、抑郁自评量表及相关临床访谈工具对就诊于综合医院心理门诊的青少年患者进行评估与诊断。共收集到非自杀性自伤青少年患者277名,其中有自杀未遂经历者110例,无自杀未遂经历者167例。结果:非自杀性自伤青少年患者的自伤方式数量(OR=0.627,P=0.037)、击打自己(OR=4.017,P=0.010)和在皮肤或指甲下插入物体(OR=4.892,P=0.008)的自伤行为与自杀未遂存在显著关联;非自杀性自伤的频率和焦虑的交互作用对自杀未遂的预测作用显著(B=0.081,P=0.011);“击打自己”自伤方式与焦虑(B=0.085,P=0.030)和抑郁(B=0.090,P=0.009)之间的交互作用显著。结论:特定的自伤方式如击打自己、皮肤下插入物体对自杀未遂有直接影响;焦虑、抑郁对非自杀性自伤频率、击打自己自伤方式与自杀未遂的关系有一定的调节作用。

关键词：非自杀性自伤自杀未遂青少年

Predicting Metabolic Syndrome Using Anthropometric Indices among Chinese Adolescents with Different Nutritional Status:A Multicenter Cross-sectional Study

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Biomedical and Environmental Sciences 2021年第9期34卷 673-682页

作者： LI Ya Mei ZOU Zhi Yong MA Ying Hua luo Jia You JING Jin ZHANG Xin luo Chun Yan WANG Hong ZHAO Hai Ping PAN De Hong luo Mi Yang xiangya School of Public Health Central South UniversityChangsha 410008HunanChina Institute of Child and Adolescent Health Peking University School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthBeijing 100191China Department of Maternal and Child Health School of Public HealthSun Yat-sen UniversityGuangzhou 510080GuangdongChina School of Public Health Tianjin Medical UniversityTianjin 300070China Department of School Health Shanghai Municipal Center for Disease Control and Prevention&Shanghai Institutes of Preventive MedicineShanghai 200336China School of Public Health and Management Chongqing Medical UniversityChongqing 400016China School of Public Health and Management Ningxia Medical UniversityYinchuan 750004NingxiaChina Liaoning Health Supervision Bureau Shenyang 110000LiaoningChina

Objective To evaluate the predictive performance of anthropometric indices for metabolic syndrome(Met S)among Chinese adolescents with different nutritional *** We recruited 9,513 adolescents aged 10–18 years from seven provinces in China during September *** indices and blood pressure were measured at recruitment,and blood samples were collected for determining fasting plasma glucose and lipid *** operating characteristic(ROC)analyses were used to assess the predictive performance of anthropometric indices,including body mass index(BMI)percentile,waist circumference percentile,waist-height ratio,and waist-hip *** Overall,the four anthropometric indices showed good accuracy for predicting Met S with areas under ROC curves(AUCs)ranging from 0.86 to 0.94;similar AUCs ranging from 0.73 to 0.99 were observed for participants with normal *** performance of all four indices was poor in overweight and obese participants,with AUCs ranging from 0.66 to 0.77 and from 0.60 to 0.67,*** circumference showed relatively better performance in all the subgroup *** We suggest using anthropometric indices with the cutoff values presented here for predicting Met S in the overall and normal-weight adolescent population,but not in the overweight and obese adolescent population where more specific screening tests are required.

关键词： Metabolic syndrome Anthropometry Body mass index Waist circumference Waist-height ratio Waist-hip ratio Adolescents

Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 482-487页

作者： Yong-Heng luo Xuan-Chu Duan Bai-Hua Chen luo-Sheng Tang and Xiao-Jian Guo Department of Ophthalmology the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

AIM: To compare the efficacy of prophylactic vitrectomy for acute retinal necrosis syndrome(ARN) with routine treatment in Chinese patients, thereby investigate the necessity of prophylactic vitrectomy for ARN. METHODS: Thirty patients (37 eyes) were retrospectively included in this study. The eyes were divided into 2 groups by treatment, including routine treatment, which consisted of antiviral medication and vitrectomy after retinal detachment (RD) (n=21), and prophylactic vitrectomy, which consisted of antiviral medication and vitrectomy for the prevention of RD performed during the active inflammatory phase (n=16). The extent of necrosis was determined by fundus photographs at the time of presentation (for eyes with mild vitreous opacity) or the drawings in the operation records. Necrosis of the 37 eyes was divided into 3 grades, including peripheral, middle-peripheral and extensive. The follow-up period ranged from 8 to 57 months. Differences in visual acuity and necrosis between groups were identified using independent samples t-test. RESULTS: Necrosis was more extensive in the routine treatment group than in the prophylactic vitrectomy group (P<0.05). In the routine treatment group, conservative treatment improved necrosis and prevented RD in 6 eyes (29%). Seven eyes (33%) obtained anatomical success, but retinal redetachment occurred in 8 eyes (57%). There were also 5 eyes (24%) developed ocular hypotony or atrophy. Ten eyes (48%) achieved equal or increased visual acuity. In the prophylactic vitrectomy group, RD occurred in 2 eyes (13%). Twelve eyes (75%) were completely anatomically successful, and 10 eyes underwent silicone oil removal. Only one eye (6%) became ocular hypotony. Fourteen eyes (88%) achieved equal or increased visual acuity. The prophylactic vitrectomy group achieved better vision trends than the routine treatment group (P<0.05). Eyes with peripheral necrosis had better visual outcomes than those with mid-peripheral (P<0.05) or extensive (P

关键词： acute retinal necrosis prophylactic vitrectomy retinal detachment visual acuity

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中国主动脉疾病治疗现状

中华普通外科杂志 2024年第9期39卷 657-661页

作者：舒畅范博文卓樾罗明尧方坤国家心血管病中心、中国医学科学院北京协和医学院阜外医院血管外科中心北京100037 中南大学湘雅二医院血管外科长沙410011 云南省阜外心血管病医院血管外科昆明650102

在人口老龄化加剧的背景下,我国心血管疾病患病率持续攀升,其中,主动脉疾病死亡率高,救治难度大,风险高。近年来,我国主动脉疾病的外科治疗发展迅猛,整体规模不断增长。本文介绍了中国主动脉疾病的治疗现状,具体分析了主动脉腔内手术和... 详细信息

在人口老龄化加剧的背景下,我国心血管疾病患病率持续攀升,其中,主动脉疾病死亡率高,救治难度大,风险高。近年来,我国主动脉疾病的外科治疗发展迅猛,整体规模不断增长。本文介绍了中国主动脉疾病的治疗现状,具体分析了主动脉腔内手术和开放手术的医疗质量,包括手术数量、患者特征、死亡率、再入院率等指标,并比较了各地区之间的差异。此外,本文还讨论了主动脉疾病的治疗进展,包括手术方法、效果评估和新技术的应用。整体来看,中国在主动脉疾病治疗领域取得了一定的进展,但仍面临着医疗资源分配不均衡和医疗质量提升的挑战。

关键词：主动脉疾病腔内修复术开放手术

GCG干预LMP1激活的NF-κB信号转导通路中的靶分子

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生物化学与生物物理进展 2003年第1期30卷 122-128页

作者：赵燕罗非君唐发清唐敏曹亚中南大学湘雅医学院肿瘤研究所长沙410078

为阐明在鼻咽癌 (nasopharyngealcarcinoma,NPC)细胞中茶多酚干预EB病毒潜伏膜蛋白 1(latentmembraneprotein 1,LMP1)激活的NF κB信号转导通路中的靶分子 ,采用EBV阴性及阳性的鼻咽癌细胞系CNE1和CNE1 LMP1细胞 ,利用噻唑蓝 (MTT)法 ,... 详细信息

为阐明在鼻咽癌 (nasopharyngealcarcinoma,NPC)细胞中茶多酚干预EB病毒潜伏膜蛋白 1(latentmembraneprotein 1,LMP1)激活的NF κB信号转导通路中的靶分子 ,采用EBV阴性及阳性的鼻咽癌细胞系CNE1和CNE1 LMP1细胞 ,利用噻唑蓝 (MTT)法 ,观察表没食子儿茶素没食子酸酯 (EGCG)对CNE1和CNE1 LMP1细胞生存率的影响 .采用瞬间转染及报道基因法观察EGCG对NF κB活性的作用 .利用间接免疫荧光法 ,观察EGCG对NF κB (p6 5 )核移位的影响 ,再分别提取CNE1和CNE1 LMP1的胞浆及胞核蛋白 ,通过蛋白质印迹分析EGCG抑制NF κB (p6 5 )的核移位后胞浆及胞核蛋白中NF κB (p6 5 )的变化 .采用蛋白质印迹分析EGCG对IκBα的磷酸化水平的影响 .采用瞬间转染及报道基因法观察EGCG对EGFR启动子活性的影响 ,并用蛋白质印迹分析EGCG对EGFR自身磷酸化的作用 .结果表明EGCG对鼻咽癌细胞的抑制作用有剂量依赖性 ,并可抑制NF κB的活性 .EGCG能抑制NF κB (p6 5 )的核移位 ,并抑制IκBα的磷酸化 .EGCG对NF κB信号通路下游的靶基因EGFR的启动子活性及自身磷酸化都有抑制作用 .由上述结果可以推断 ,EGCG对信号转导通路上的NF κB、NF κB (p6 5 )、IκBα、EGFR多个靶点分子具有干预作用 .LMP1是EB病毒编码的蛋白质 ,因此。

关键词：茶多酚 EGCG EB病毒 LMP) 激活 NF-κB信号转导通路靶分子潜伏膜蛋白1 鼻咽癌干预

Adiponectin:friend or foe in obesity and inflammation

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Medical Review 2022年第4期2卷 349-362页

作者： Liping luo Meilian Liu Department of Biochemistry and Molecular Biology University of New Mexico Health Sciences CenterAlbuquerqueNM 87131USA Department of Endocrinology Endocrinology Research CenterXiangya HospitalCentral South UniversityChangshaHunan Province 410008China

Adiponectin is an adipokine predominantly produced by fat cells,circulates and exerts insulin-sensitizing,cardioprotective and anti-inflammatory *** of adiponectin and/or adiponectin signaling is implicated in a number of metabolic diseases such as obesity,insulin resistance,diabetes,and cardiovascular ***,while the insulin-sensitizing and cardioprotective effects of adiponectin have been widely appreciated in the field,the obesogenic and anti-inflammatory effects of adiponectin are still of much *** the physiological function of adi-ponectin is critical for adiponectin-based therapeutics for the treatment of metabolic diseases.

关键词： adipogenesis adiponectin inflammation in-sulin sensitivity obesity

appps1双转基因阿尔茨海默病模型小鼠脑内胶质细胞的激活及iNOS的表达

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解剖学报 2004年第5期35卷 497-501页

作者：雷德亮罗学港中南大学湘雅医学院解剖学与神经生物学系长沙410013

目的　研究 10～ 12月龄雌性app ps1双转基因阿尔茨海默病 (AD)模型小鼠 (app ps1,dtg)脑内小胶质细胞和星形胶质细胞的激活 ,以及诱导型一氧化氮合酶 (induciblenitricoxide,iNOS)的表达。　方法　免疫组织化学结合刚果红组织学染色 ,... 详细信息

目的　研究 10～ 12月龄雌性app ps1双转基因阿尔茨海默病 (AD)模型小鼠 (app ps1,dtg)脑内小胶质细胞和星形胶质细胞的激活 ,以及诱导型一氧化氮合酶 (induciblenitricoxide,iNOS)的表达。　方法　免疫组织化学结合刚果红组织学染色 ,普通光学显微镜观察。　结果　在app ps1dtg小鼠皮质和海马内有广泛的神经炎斑形成 ,围绕在神经炎斑周围的小胶质细胞和星形胶质细胞处于活化状态 ,且活化的星形胶质细胞表达iNOS。　结论　app ps1dtg小鼠能够模拟AD病人脑内的主要病理过程。神经胶质细胞的激活及iNOS的表达在app ps1dtg小鼠和AD脑内病理过程中具有重要的作用。

关键词：神经胶质细胞诱导型一氧化氮合酶阿尔茨海默病转基因小鼠

Survivin and p53 expression in primary and recurrent pterygium in Chinese patients

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 388-392页

作者： Li-Wei Zhang, luo-Sheng Tang Department of Ophthalmology the Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China Department of Ophthalmology Shenzhen People's Hospital Shenzhen 518033 Guangdong Province China

AIM: To assess the expression of anti-apoptotic protein survivin and tumor suppressor p53 protein in primary and recurrent pterygium and to investigate the relationship between them. METHODS: Survivin was assessed immunohistochemically using rabbit polyclonal antibody and p53 using mouse monoclonal antibody in a study sample of 20 cases of primary pterygium, 10 cases of recurrent pterygium and 10 cases of normal conjunctiva. RESULTS: In our study, 35% of primary (7 of 20) and 40% of recurrent (4 of 10) pterygium specimens were positive for survivin staining; 45% of primary (9 of 20) and 50% of recurrent (5 of 10) pterygium specimens were positive for p53 expression; and all normal conjunctiva showed no staining of either survivin or p53. The p53 and survivin immunoreactivity in primary and recurrent pterygium groups was greater than those in normal conjunctiva group (P0.05). The expression of survivin clearly segregated with p53-positive pterygium as compared with p53-negative cases [8 of 14 cases (57.1%) vs ersus 3 of 16 cases (15.2%)]. The Fisher's exact test analysis confirmed a highly statistically significant correlation between survivin and p53 expression (P <0.05). CONCLUSION: The survivin and p53 are overerpressed with correlation between them in primary and recurrent pterygium.

关键词： pterygium survivin p53

基于PI3K/Akt/mTOR 通路探究七氟醚麻醉对大鼠神经细胞凋亡的影响

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西北药学杂志 2024年第2期39卷 47-52页

作者：程亮亮田毅谭义文王伟明罗琳侯春燕罗珏中南大学湘雅医学院附属海口医院麻醉与疼痛医学科海口570208

目的探讨七氟醚麻醉对大鼠认知功能及神经细胞凋亡的影响。方法取96只大鼠,随机分为对照组(吸入2 L·min^(−1)氧气)、七氟醚低浓度组(吸入体积分数为1%的七氟醚+2 L·min^(−1)氧气)、七氟醚中浓度组(吸入体积分数为2%的七氟醚+2 L·min^... 详细信息

目的探讨七氟醚麻醉对大鼠认知功能及神经细胞凋亡的影响。方法取96只大鼠,随机分为对照组(吸入2 L·min^(−1)氧气)、七氟醚低浓度组(吸入体积分数为1%的七氟醚+2 L·min^(−1)氧气)、七氟醚中浓度组(吸入体积分数为2%的七氟醚+2 L·min^(−1)氧气)、七氟醚高浓度组(吸入体积分数为4%的七氟醚+2 L·min^(−1)氧气),持续吸入6 h。用Morris水迷宫实验观察各组大鼠认知能力,用HE染色观察海马组织学形态,用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)测定海马组织中枢神经特异性蛋白(soluble protein 100β,S-100β)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、白细胞介素-1β(interleukin-1β,IL-1β)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平,流式细胞术测定神经细胞凋亡情况,蛋白印迹法(Western blotting)测定海马组织B淋巴细胞瘤-2(B-cell lymphoma-2,Bcl-2)、Bcl-2相关X蛋白(Bcl2-associated X protein,Bax)、磷酸化磷脂酰肌醇3-激酶(phosphorylated phosphatidylinositol 3-kinase,p-PI3K)、磷酸化丝氨酸/苏氨酸激酶(phosphorylated serine/threonine kinase,p-Akt)和磷酸化哺乳动物雷帕霉素靶蛋白(phosphorylated mammalian target of rapamycin,p-mTOR)的水平。结果HE染色结果表明,对照组海马组织神经细胞结构正常,排列紧密,七氟醚各浓度组大鼠海马组织神经细胞减少,排列紊乱,分布不均匀。与对照组比较,七氟醚各浓度组大鼠逃避潜伏期时间,S100-β、NSE、IL-1β、TNF-α水平,Bax蛋白水平和神经细胞凋亡率均升高,穿越平台次数,平台停留时间,Bcl-2、p-PI3K、p-Akt和p-mTOR蛋白水平均降低(P<0.05);七氟醚各浓度组诸项指数水平变化规律相同,并呈剂量依赖性(P<0.05)。结论七氟醚麻醉可诱导大鼠神经细胞凋亡,使大鼠认知能力衰退,其可能与调控PI3K/Akt/mTOR信号通路有关。

关键词：七氟醚神经细胞凋亡磷脂酰肌醇3-激酶丝氨酸/苏氨酸激酶哺乳动物雷帕霉素靶蛋白