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中国新药与临床杂志 2010年第8期29卷 571-575页

作者：常麦会李乐华中南大学湘雅二医院精神卫生研究所湖南长沙410011

布南色林是一种新型非典型抗精神病药物,为高度选择性的5-HT2受体和多巴胺D2受体拮抗药,对多巴胺D1受体、α1肾上腺素受体、组胺H1受体和M1胆碱受体亲和力较小。该药对精神分裂症疗效明显,不良反应小,能有效改善精神分裂症患者的阴性症... 详细信息

布南色林是一种新型非典型抗精神病药物,为高度选择性的5-HT2受体和多巴胺D2受体拮抗药,对多巴胺D1受体、α1肾上腺素受体、组胺H1受体和M1胆碱受体亲和力较小。该药对精神分裂症疗效明显,不良反应小,能有效改善精神分裂症患者的阴性症状、阳性症状和认知功能。本文对该药的研究进展作一综述。

关键词：精神分裂症抗精神病药布南色林多巴胺拮抗药

A Small Interfering CD147-Targeting RNA Inhibits the Proliferation,Invasiveness,and VEGF Production of Human Malignant Melanoma Cells by Down-Regulating Glycolysis

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A Small Interfering CD147-Targeting RNA Inhibits the Prolife...

扎来普隆与唑吡坦治疗失眠症的多中心随机双盲对照比较

The 10th China-Japan Joint Meeting of Dermatology 20th Anniversary

作者： Juan Su~1 Xiang Chen~1 Tuo Lang Jin Zang~2 1.Department of Dermatology xiangya hospital of centre-south university Shangsha 410008 China 2.Department of Dermatology Field of Sensory Organology Graduate School of Medical and Denta Sciences Kagoshima university Kagoshima Japan

＜正＞Objective:Cancer cells require glycolysis for cellular energy;this results in excessive lactate production and ***,the end product of glycolysis,reduces the extracellular pH and contributes to the proliferation,...

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中国新药与临床杂志 2003年第11期22卷 667-670页

作者：李乐华陈晋东赵靖平张鸿燕舒良顾牛范李华芳黄明生李静马崔李婷陈远光中南大学湘雅二医院精神卫生研究所湖南长沙410011 北京大学精神卫生研究所北京100083 上海精神卫生中心上海200030 四川大学华西医院心理卫生中心四川成都610041 广州市精神病医院广东广州510370

目的 :评价国产Ⅱ类新药扎来普隆治疗失眠症的有效性和安全性。方法 :采用多中心随机双盲双模拟、阳性药平行对照研究。唑吡坦组 12 0例 ,扎来普隆组 118例分别口服扎来普隆片 10mg·d- 1或唑吡坦片 10mg·d- 1。 14d为一个疗程。结果 ... 详细信息

目的 :评价国产Ⅱ类新药扎来普隆治疗失眠症的有效性和安全性。方法 :采用多中心随机双盲双模拟、阳性药平行对照研究。唑吡坦组 12 0例 ,扎来普隆组 118例分别口服扎来普隆片 10mg·d- 1或唑吡坦片 10mg·d- 1。 14d为一个疗程。结果 :意向性 (ITT)分析样本病人有 2 38例。疗效评价的睡眠障碍量表 (SDRS)评分在治疗结束时较基线显著减少 (F检验 ,P 0 .0 5 )。不良反应分析显示 2组较常见的不良反应为思睡、口干、便秘、头晕和头痛。结论 :国产扎来普隆与唑吡坦具有类似的疗效 ,不良反应相当。为治疗睡眠障碍的安全而有效的新药。

关键词：安定药失眠症随机对照试验双盲法扎来普隆唑吡坦

Vitrectomy for vitreous amyloidosis

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 307-310页

作者： Jiang You Department of Ophthalmology,the Second xiangya hospital of Central south university,Changsha 410011,Hunan Province,China Department of Ophthalmology the Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China.

AIM: To study the clinical features of vitreous amyloidosis and the effect of vitrectomy for it. METHODS: We treated 6 eyes (4 Patients) with vitreous amyloidosis from 2008 to 2009, and followed up for 18-30 months after vitrectomy. RESULTS: The visual acuity ranged from counting fingers to 3/50 before surgery and 15/50-40/50 after vitrectomy. No severe complication was observed. CONCLUSION: Vitrectomy is an effective and safe treatment for eyes with vitreous amyloidosis. A long period of follow-up after surgery should be performed.

关键词： vitreous amyloidosis surgical treatment

Surgical Treatment for Complications of Congenital Retinoschisis

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2011年第3期31卷 404-408页

作者：游江 Department of Ophthalmology Xiangya HospitalCentral South University

This study examined the clinical features of complications of congenital retinoschisis and the clinical efficacy of vitreoretinal surgery in the treatment of these *** clinical efficacy of surgical treatments was retrospectively analyzed in 10 patients with congenital retinoschisis（10 eyes） complicated with rhegmatogenous retinal detachment（n=5）,vitreous hemorrhage（n=2） and macula-involving schisis（n=1）.All the patients suffered foveal and peripheral *** were treated with scleral buckling（n=1） or vitrectomy（n=9）.After the surgical treatment,the retina was reattached in patients with rhegmatogenous retinal detachment;the refractive media became transparent in those with vitreous hemorrhage;the visual acuity in 80% of patients was improved;no remarkable progression of schisis was found;no severe operative complications *** was concluded that vitreoretinal surgery in the treatment of complications of congenital retinoschisis is safe and effective,and helps improve and maintain the visual function.

关键词： congenital retinoschisis complication vitreoretinal surgery

Sequencing of phosphopeptides sulfonated by 4-sulfophenyl isothiocyanate using post-source decay matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

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Progress in Natural Science:Materials International 2006年第9期16卷 930-935页

作者： TANG Jianguang , WANG Yongjun , ZHANG Hainan, WANG Chunyu, HU Zhiping, XUE Zhigang, XIA Kun3 and SHI Xiaoliu ( Department of Neurology, the Second xiangya hospital, Central south university, Changsha 410011, China Department of Digestion, the Second xiangya hospital, Central south university, Changsha 410011, China National Key Laboratory of Chinese Genetics, Changsha 410078, China) Department of Neurology The Second Xiangya Hospital Central South University Changsha 410011 China Department of Digestion The Second Xiangya Hospital Central South University Changsha 410011 China National Key Laboratory of Chinese Genetics Changsha 410078 China

Phosphorylation/dephosphorylation is probably the most common and important reversible post-translational modification of proteins. Analyzing the functional effects of phosphorylation is helpful for understanding the biological functions of proteins. Identification of the phosphorylation sites of phosphorylated protein is a prerequisite for research on phosphorylation. In this work, an effective and simple method of identification of protein phosphorylation sites has been developed. Phosphopeptides were selectively enriched with immobilized metal affinity chromatography (IMAC) and subsequently chemically modified by 4-sulfophenyI isothiocyanate, and then the chemically modified phosphopeptides were sequenced with post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry for detecting phosphorylation sites. The charge of derivatization by 4-sulfophenyl isothiocyanate introduces a negative sulfonic acid group at the N-terminus of a peptide, and enables the selective detection of only a single series of C-terminal y-type ions. This chemically assisted method greatly simplifies the extremely complex pattern of PSD fragment ions and makes the PSD spectra more easier to be interpreted. The phosphorylation sites of a synthesized model phosphopeptide and human c-myc protein have been successfully identified by this method.

关键词： phosphopeptides sequencing 4-sulfophenyl isothiocyanate post-source decay matrix-assisted laser desorption/ion-ization time-of-flight mass spectrometry.

Metallothionein expression in hepatocellular carcinoma

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World Journal of Gastroenterology 2002年第4期8卷 650-653页

作者： Geng-Wen Huang Lian-Yue Yang Department of General Surgery,xiangya hospital,Central south university,Changsha 410008,Hunan Province,China Department of General Surgery Xiangya Hospital Central South University Changsha 410008 Hunan Province China. hgw21@***

AIM: To investigate the expression of metallothioneins(MTs), which were recently thought to have closerelationship with tumors, in human ***: Histological specimens of 35 cases of primaryhuman hepatocellular carcinoma with para-neoplasticliver tissue and 5 cases of normal liver were stainedfor MTs with monoclonal mouse anti-MTs serum (Eg)by the immunohistochemical ABC technique. RESULTS: MTs were stained in the 35 cases of HCC,including 6 cases negative (17.1 %), 23 weaklypositive (65.7 %), and 6 strongly positive(17.1%).But MTs were stained strongly positive in all the fivecases of normal liver and 35 cases of para-neoplasticliver tissue. The differences of MTs expression betweenHCC and normal liver tissue or para-neoplastic livertissue were highly significant (P＜0.01). The rate ofMTs expression in HCC grade I was 100 percent,higher than that in grade Ⅱ(81%) and grade Ⅲand Ⅳ (78 %). But the differences were notsignificant (P＞0.05). No obvious correlationsbetween MTs expression in HCC and tumor size,clinical stage or serum alpha fetoproteinconcentration were found (P＞0.05).CONCLUSION: Decrease of MTs expression in HCC mayplay a role in carcinogenesis of HCC. MTs are stainedheterogenously in HCC. We can choose the anticanceragents according to the MTs concentraiton in HCC, whichmay improve the results of chemotherapy for HCC.

关键词：肝癌金属硫蛋白蛋白表达临床意义免疫组织化学ABC法

Potential role of retina as a biomarker for progression of Parkinson's disease

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 433-438页

作者： Tian Tian 1, Xiao-Hua Zhu 2, Yun-Hai Liu 1 1Department of Neurology, xiangya hospital, Central-south university, 87 xiangya Road, Changsha 410008, Hunan Province, China 2Department of Ophthalmology, the Second xiangya hospital, Central-south university, 139 Renmin Middle Road, Changsha 410011, Hunan Province, China Department of Neurology Xiangya Hospital Central-South University 87 Xiangya Road Changsha 410008 Hunan Province China.

Optical coherence tomography (OCT) noninvasively quantifies the thickness of the retinal nerve fiber layer (RNFL). OCT has been studied in several neuro-ophthalmic conditions, including Parkinson’s disease (PD). Recent studies suggest that the quantitative analysis of RNFL can be precisely and noninvasively done by OCT scans and the results suggest that the thickness of RNFL is significantly decreased in patients with PD compared with age-matched controls and the foveal retinal thickness correlates with disease severity in PD. In this article, the application of OCT imaging of the retina in PD was reviewed. Literature survey of PubMed was carried out using the search terms of "Optical Coherence Tomography" combined with "Parkinson’s Disease" and "retinal nerve fiber layer" (without restriction to the year of publication). Some related articles were also included. The search was completed in Jul. 2011 and revised and updated as necessary. The aim of this article is to review the current literatures on the use of optical coherence tomography in patients affected by PD and to enhance its use in clinical practice in neuro-ophthalmology.

关键词： Parkinson disease optical coherence tomography retinal nerve fiber layer thickness

Hepatitis B virus X protein promotes proliferation and upregulates TGF-β1 and CTGF in human hepatic stellate cell line,LX-2

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 59-64页

作者： Guang-Hui Guo,De-Ming Tan,Ping-An Zhu and Fei Liu Department of Infectious Diseases,xiangya hospital,Central south university,Changsha 410008,China Department of Infectious Diseases Xiangya Hospital Central South University Changsha 410008 China. guanghuiguo2008@***

BACKGROUND:Chronic hepatitis B virus(HBV)infection is a major cause of liver fibrosis,but the mechanisms underlying HBV-related fibrogenesis are still unknown. Although the roles of HBV X protein(HBx)remain poorly understood,it is thought to play an important role in the regulation of cellular growth and hepatocarcinogenesis. The aim of this study was to determine the role of HBx in liver fibrogenesis by studying the effect of HBx on the proliferation and expression of fibrosis-related molecules in the human hepatic stellate cell line,LX-2. METHODS:We established an in vitro co-culture system with LX-2 cells and a stable QSG7701-HBx cell line which had been transfected with the HBx gene. 3 H-TdR incorporation and flow cytometry were used to determine the effects of HBx on the proliferation of LX-2 cells. α-smooth muscle actin(α-SMA),transforming growth factor-β1(TGF-β1),transforming growth factor-βreceptor Ⅱ(TGF-βRⅡ),and connective tissue growth factor (CTGF)in LX-2 cells were analyzed by Western *** addition,the expression levels of collagen typeⅠ(ColⅠ) from the co-cultured media were measured by ELISA. RESULTS: 3 H-TdR incorporation increased significantly in LX-2 cells co-cultured with QSG7701-HBx cells compared to those cultured with QSG7701-pcDNA3 and QSG7701 (non-tumorigenic human liver cell line).Cell cycle results revealed that HBx accelerated the progression of G1 to S in LX-2 *** expressions ofα-SMA,TGF-β1,TGF-βR Ⅱ,CTGF and ColⅠwere significantly increased in the co- cultures of LX-2 cells with stable QSG7701-HBx cells. CONCLUSION:These results suggest that HBx may facilitate liver fibrosis by promoting hepatic stellate cell proliferation and upregulating the expression of fibrosis- related molecules.

关键词： hepatitis B virus HBx liver cirrhosis hepatic stellate cell proliferation