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CPR5 positively regulates pattern-triggered immunity via a mediator protein

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Journal of Integrative Plant Biology 2023年第7期65卷 1613-1619页

作者： Miaomiao Ma Meng Li Rongfang Zhou Jian-Bin Yu Ying Wu Xiaojuan Zhang Jinlong Wang Jian-Min Zhou xiangxiu liang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Agronomy Sichuan Agricultural UniversityChengdu 611130China State Key Laboratory for Conservation and Utilization of Subtropical Agro‐bioresources College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Plant cells possess a two-layered immune system consisting of pattern-triggered immunity(PTI)and effector-triggered immunity(ETI), mediated by cell surface pattern-recognition receptors and intracellular nucleotide-binding leucine-rich repeat receptors(NLRs), respectively. The CONSTITUTIVE EXPRESSION OF PR GENES 5(CPR5) nuclear pore complex protein negatively regulates ETI, including ETI-associated hypersensitive response. Here, we show that CPR5 is essential for the activation of various PTI responses in Arabidopsis, such as resistance to the non-adapted bacterium Pseudomonas syringae pv. tomato DC3000 hrc C-. In a forward-genetic screen for suppressors of cpr5, we identified the mediator protein MED4. Mutation of MED4 in cpr5 greatly restored the defective PTI of cpr5. Our findings reveal that CPR5 plays opposite roles in regulating PTI and ETI, and genetically regulates PTI via MED4.

关键词： CPR5 MED4 plant immunity PTI

The secret of fertilization in flowering plants unveiled

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Science Bulletin 2018年第7期63卷 408-410页

作者： xiangxiu liang Jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences

As recapitulated in the famous Chinese fairy tale Journey to the West,the Buddhist monk Xuanzang of the Tang Dynasty(Tangseng)took a heroic journey in a quest for India Buddhist sacred scriptures.The long and dangerous journey was made possible only with the help of the powerful Monkey King,who had been pinned down under a mountain by the Buddha as a punishment for his prior misdemeanor.The Buddha had to secure the

关键词：授精植物旅行猴子佛家佛像封口

A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex

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Journal of Integrative Plant Biology 2023年第5期65卷 1312-1327页

作者： Yazhou Bao Yixin Li Qin Chang Rubin Chen Weijie Wang Qian Zhang Shuxian Chen Guangyuan Xu Xiaodan Wang Fuhao Cui Daolong Dou xiangxiu liang MOA Key Laboratory of Pest Monitoring and Green Management Department of Plant PathologyCollege of Plant ProtectionChina Agricultural UniversityBeijing100193China College of Plant Protection Nanjing Agricultural UniversityNanjing 210095China Collegeof LifeSciences SouthChinaAgricultural UniversityGuangzhou 510642China

Plant cells recognize microbial patterns with the plasma-membrane-localized pattern-recognition receptors consisting mainly of receptor kinases(RKs) and receptor-like proteins(RLPs). RKs, such as bacterial flagellin receptor FLS2, and their downstream signaling components have been studied extensively. However, newly discovered regulatory components of RLP-mediated immune signaling, such as the nlp20 receptor RLP23, await identification. Unlike RKs, RLPs lack a cytoplasmic kinase domain, instead recruiting the receptor-like kinases(RLKs) BAK1 and SOBIR1. SOBIR1 specifically works as an adapter for RLP-mediated immunity. To identify new regulators of RLP-mediated signaling, we looked for SOBIR1-binding proteins(SBPs) in Arabidopsis thaliana using protein immunoprecipitation and mass spectrometry,identifying two G-type lectin RLKs, SBP1 and SBP2, that physically interacted with SOBIR1.SBP1 and SBP2 showed high sequence similarity,were tandemly repeated on chromosome 4, and also interacted with both RLP23 and BAK1. sbp1 sbp2 double mutants obtained via CRISPR-Cas9 gene editing showed severely impaired nlp20-induced reactive oxygen species burst, mitogenactivated protein kinase(MAPK) activation, and defense gene expression, but normal flg22-induced immune responses. We showed that SBP1 regulated nlp20-induced immunity in a kinase activityindependent manner. Furthermore, the nlp20-induced the RLP23–BAK1 interaction, although not the flg22-induced FLS2–BAK1 interaction, was significantly reduced in sbp1 sbp2. This study identified SBPs as new regulatory components in RLP23 receptor complex that may specifically modulate RLP23-mediated immunity by positively regulating the interaction between the RLP23 receptor and the BAK1 co-receptor.

关键词： immune responses pattern-recognition receptors receptor-like proteins SBPs SOBIR1

Role of Heterotrimeric G protein in plant immunity

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Role of Heterotrimeric G protein in plant immunity

Pattern-recognition at the forefront of plant-pathogen interactions

2018全国植物生物学大会

作者： xiangxiu liang Miaomiao Ma Jian-Min Zhou Institue of Genetics and Developmental Biology Chinese Academy of Sciences

Heterotrimeric G proteins are universal signaling modules in eukaryotic organisms.They regulate transmembrane signaling by coupling to cell surface-localized receptors.In animals,heterotrimeric G proteins are activated by seven-transmembrane G proteincoupled receptors(GPCRs).GPCRs act as guanine nucleotide exchange factors(GEFs)to promote GDP-GTP exchange in Ga to activate the G proteins.Unlike animals,no functional GPCR proteins are identified in plants and plant heterotrimeric G proteins are reported to directly couple to single transmembrane receptor kinases(RKs) or receptor-like proteins(RLPs).Furthermore,plant Ga proteins are self-activating and can bind GTP in the absence of GPCRs.How plant receptor kinases regulate heterotrimeric G proteins remains unknown.Arabidopsis immune receptor kinase FLS2 perceives bacterial flagellin and triggers downstream immune signaling through the central kinase BIK1.We found that heterotrimeric G proteins directly coupled to the FLS2-BIK1 immune complex and positively regulate BIK1 stability in the resting state.This is distinct form animal G proteins,which regulate immune signaling only after ligand perception.Recently,we show that G protein activation is directly controlled by RGS1,a GTPase accelerating protein(GAP),which maintains Ga protein in a GDP-bound form by it GAP activity.Further study showed that RGS1 is directly coupled to FLS2 receptor and Ga proteins.After flg22 perception,BIK1 and its related PBL kinases directly phosphorylate RGS1,which triggers the dissociation of RGS1 from the FLS2-G protein complex.This relieves G proteins from the RGS 1-mediated repression and enables positive regulation of immune signaling.Our study revealed that ligand-induced derepression as a mechanism for G protein signaling that is distinct from animal heterotrimeric G proteins.

关键词： Heterotrimeric G proteins Arabidopsis Plant immunity FLS2 receptor RGS1

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Pattern-recognition at the forefront of plant-pathogen inter...

Linking receptor kinases to downstream immune signaling

2016年全国植物生物学大会

作者： xiangxiu liang Jinlong Wang Lei Li Shaofei Rao Jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Higher plants deploy a large repertoire of Pattern-Recognition Receptors(PRRs),composed of Receptor Kinases(RKs) or Receptor Proteins(RPs) to perceive in the apoplast molecular patterns of microbe or plant origin during infection,activating pattern-triggered immunity(PTI). Previous and ongoing studies in our and other labs show that a subfamily of cytoplasmic kinases including BIK1 and PBS1-Like(PBL) proteins play a central role in PTI by acting directly downstream of multiple PRRs. They regulate important downstream signaling events including production of ROS,calcium influx,and MAPK activation,and are subject to tight regulations by heterotrimeric G proteins and ubiquitination proteasome system. A growing number of bacterial pathogen effectors are found to target PRR complexes for pathogenesis. However,these effector proteins can be recognized by intracellular NOD-Like Receptors(NLRs),thereby ?betray? the pathogen and activate the second layer of immunity. For example,we have recently shown that the Xanthomonas campestris campestris effector Avr AC post-translationaly modifies BIK1 for enhanced virulence. A BIK1 homolog,PBL2,acts as a decoy to deceive Avr AC and activates the NLR protein ZAR1. In addition,the perturbation of BAK1,a co-receptor of multiple PRRs,is known to heighten host immune responses. Our recent work showed that another Pseudomonas syringae effector,Hop B1,is a novel protease that specifically cleaves BAK1. Surprisingly,the cleavage of BAK1 by Hop B1 enhances bacterial virulence but heightened immunity in plants. Hop B1 cleaves BAK1 only when the latter is stimulated by bacterial molecular patterns. This constrained action of Hop B1 probably has allowed the bacterium to achieve virulence at the same time minimize the likelihood of stimulating the second layer of immunity. Together the studies highlight pattern-recognition as a major battleground in plant-bacterial pathogen interactions.

关键词： pattern recognition immunity effectors receptor kinases ubiquitination

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Linking receptor kinases to downstream immune signaling

Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis

2018全国植物生物学大会

作者： xiangxiu liang Miaomiao Ma jinlong wang guozhi bi zhaoyang zhou meijuan hu chulei gao weibing wang xiuming li wei wang jiayu wang Jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Receptor kinases(RKs) govern transmembrane signaling that regulates plant reproduction,growth and development,and interactions with diverse microbes.Receptorlike cytoplasmic kinases(RLCKs),which lack extracellular ligand-binding domains,have emerged as a major class of signaling proteins acting directly downstream of various RKs.We have been using immune RKs as a model to understand role of RLCKs in transmembrane signaling and underlying mechanisms.We have shown that several

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1426-1428页

作者： Tiantian Wang Lin Yang Zejun liang Lin Wang Feijing Su xiangxiu Wang Xuanhe You Chengqi He Department of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuanChina Department of MR Research Center Nuclear MedicineFrontiers Science Center for Disease-related Molecular NetworkNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuanChina Department of Orthopedic Surgery and drthopedic Research Institute West China Hospital Sichuan UniversityChengduChina

Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear.

关键词： SASP drugs glucocorticoid

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福建苦苣苔科植物一新种--邵武报春苣苔

西北植物学报 2022年第7期42卷 1248-1255页

作者：连辉马良陈新艳苏享修陈世品福建农林大学林学院福州350002 福建农林大学园林学院福州350002 三明市园林中心福建三明365000

该研究描述了产于福建省邵武市的苦苣苔科(Gesneriaceae)报春苣苔属(Primulina)一新种——邵武报春苣苔(P.shaowuensis X.X.Su,liang Ma&S.P.Chen)。形态学观察结果表明,邵武报春苣苔与休宁报春苣苔(P.xiuningensis)最相近,二者的主要... 详细信息

该研究描述了产于福建省邵武市的苦苣苔科(Gesneriaceae)报春苣苔属(Primulina)一新种——邵武报春苣苔(P.shaowuensis X.X.Su,liang Ma&S.P.Chen)。形态学观察结果表明,邵武报春苣苔与休宁报春苣苔(P.xiuningensis)最相近,二者的主要区别为:邵武报春苣苔的花筒近钟形,在中部膨大;花冠乳白色;退化雄蕊3,顶端稍显头状。经核糖体ITS和两个质体标记(atpB-rbcL和rpL32-trnL)进行系统发育分析结果表明,邵武报春苣苔在系统发育树上具有独立的位置,支持邵武报春苣苔为苦苣苔科植物一新种,且休宁报春苣苔和大齿报春苣苔(P.juliae)为其姐妹类群。

关键词：报春苣苔属新种系统发育分析分类学福建

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福建省蕨类植物分布新记录(Ⅱ)

植物资源与环境学报 2022年第6期31卷 93-95页

作者：付厚华马良韦宏金苏享修陈炳华陈彬福建农林大学林学院福建福州350002 上海辰山植物园华东野生濒危资源植物保育中心上海201602 福建师范大学生命科学学院福建福州350117

通过野外调查和标本查阅,共发现福建省蕨类植物分布新记录7种1变种,隶属于6科7属,分别为阔片里白〔Diplopterygium blotianum(C.Christensen)Nakai〕、华南芒萁(Dicranopteris austrosinensis Y.H.Yan et Z.Y.Wei)、深绿双盖蕨(Diplazium viridissimum Christ)、顶羽裂双盖蕨(Diplazium donianum var.lobatum Tagawa)、假毛蕨〔Pseudocyclosorus tylodes(Kunze)Ching〕、日本香鳞始蕨〔Osmolindsaea japonica(Baker)Lehtonen et Christenhusz〕、黑边铁角蕨(Asplenium speluncae Christ)和鳞果星蕨〔Lepisorus buergerianus(Miq.)C.F.Zhao,R.Wei et X.C.Zhang〕。

关键词：福建省蕨类植物新记录