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Chinese Journal of Chemistry 2022年第21期40卷 2502-2506页

作者： xiangxiang chen Bo Li Huarong Tong Liping Qi Gang He Gong chen State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

A new method for post-assembly modification of peptides via the Pd-catalyzed endogenous group-directed sp^(3) C—H arylation with aryl iodides is *** sulfide side chain of methionine(Met)residue can facilitate the arylation of bothβandγmethyl C—H bonds of N-terminal aliphatic amino acids of peptides via formation of 5 or 6-membered palladacycle *** reactions can proceed in moderate to good yield and with excellent diastereoselectivity.

关键词： Methionine Endogenous directing group C(sp^(3))-H arylation Palladium Peptides

Evaluation of the Rural Human Settlement in Shandong Province

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Chinese Journal of Population,Resources and Environment 2012年第4期10卷 95-100页

作者： Xu Hong Shen Meiyu chen xiangxiang Business School Shandong Normal University College of Population Resource and EnvironmentShandong Normal University

Taking Shandong Province as the research object,this paper uses the principal component analysis method to evaluate the status of the rural human settlement in Shandong *** establishes the evaluation index system of the rural residential environment in Shandong Province,including living environment,economy,infrastructure,public service facilities,and ecological environment,in total five comprehensive index,and 20 secondary *** measurement and sorting of rural human environment development level of Shandong Province in 2010,the 17 cities are divided into-excellent,good,ordinary,poor-four development areas and are analyzed based on the restriction factor in the development of the region.

关键词： rural human settlements comprehensive evaluation Shandong Province

Crown evolution kinematics of a camellia oil droplet impacting on a liquid layer

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Chinese Physics B 2022年第5期31卷 448-458页

作者： Zhongyu Shi Guanqing Wang xiangxiang chen Lu Wang Ning Ding Jiangrong Xu Energy Institute Hangzhou Dianzi UniversityHangzhou 310018China

The phenomenon of droplet impact on an immiscible liquid is encountered in a variety of scenarios in nature and industrial production. Despite exhaustive research, it is not fully clear how the immiscibility of the liquid on which a droplet impacts affects the crown evolution. The present work experimentally investigates the evolution kinematics of a crown formed by the normal impact of a camellia oil droplet on an immiscible water layer. Based on discussion of dynamic impact behaviors for three critical Weber numbers(We), the radius of the crown and its average spreading velocity are compared with those of previous theoretical models to discuss their applicability to the immiscible liquid. The evolution kinematics(morphology and velocity) are analyzed by considering the effects of the We and layer thickness. Furthermore,the ability of crown expansion in radial and vertical directions is characterized by a velocity ratio. The results show that our experimental crown radius still follows a square-root function of evolution time, which agrees with the theoretical predictions. The dimensionless average spreading velocity decreases with We and follows a multivariate power law, while the dimensionless average rising velocity remains constant. The velocity ratio is shown to linearly increase with We,demonstrating that the rising movement in crown evolution gradually enhances with We. These results are helpful for further investigation on the droplet impact on an immiscible liquid layer.

关键词： biomass oil droplet impact crown kinematics

A universal hydrochloric acid-assistant powder-to-powder strategy for quick and mass preparation of lead-free perovskite microcrystals

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Light(Science & Applications) 2023年第4期12卷 613-624页

作者： Huanxin Yang xiangxiang chen Yiyue Chu Changjiu Sun Haolin Lu Mingjian Yuan Yuhai Zhang Guankui Long Libing Zhang Xiyan Li Institute of Photoelectronic Thin Film Devices and Technology Solar Energy Conversion CenterNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Nankai UniversityTianjin 300350China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Nankai UniversityTianjin 300350China Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong Institute for Advanced Interdisciplinary Research(IAIR)University of JinanJinan 250022 ShandongChina Tianjin Key Laboratory of Molecular Optoelectronic Department of ChemistryTianjin UniversityTianjin 300354China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China Schoolof Materials Science and Engineering Nankai UniversityTianjin 300350China

Lead-free halide perovskite materials possess low toxicity,broadband luminescence and robust stability compared with conventional lead-based perovskites,thus holding great promise for eyes-friendly white light ***,the traditionally used preparation methods with a long period and limited product yield have curtailed the commercialization of these *** we introduce a universal hydrochloric acid-assistant powder-to-powder strategy which can accomplish the goals of thermal-,pressure-free,eco-friendliness,short time,low cost and high product yield,*** obtained Cs_(2)Na_(0.9)Ag_(0.1)In_(0.95)Bi_(0.05)Cl_(6)microcrystals exhibit bright self-trapped excitons emission with quantum yield of(98.3±3.8)%,which could retain(90.5±1.3)%and(96.8±0.8)%after continuous heating or ultraviolet-irradiation for 1000 h,*** phosphor converted-LED exhibited near-unity conversion efficiency from ultraviolet chip to self-trapped excitons emission at~200 *** ions doping(such as Cs_(2)Na_(0.9)Ag_(0.1)InCl_(6):Ln^(3+))and other derived lead-free perovskite materials(such as Cs_(2)ZrCl_(6)and Cs_(4)MnBi_(2)Cl_(12))with high luminous performance are all realized by our proposed strategy,which has shown excellent availability towards commercialization.

关键词： perovskite preparation hydrochloric

Microtubes with gradient decellularized porcine sciatic nerve matrix from microfluidics for sciatic nerve regeneration

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Bioactive Materials 2023年第3期21卷 511-519页

作者： Binghui Jin Yunru Yu xiangxiang chen Yanhong Yang Yushan Xiong Young Jun Im Yuanjin Zhao Jian Xiao Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouZhejiang Province325035China Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China College of Pharmacy Chonnam National UniversityGwangju61186Republic of Korea Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang325001China

Long-range peripheral nerve defect is a severe and worldwide *** the increasing development of tissue engineering,the excellent ability of nerve extracellular matrix(ECM)in peripheral nerve injury(PNI)has been widely studied and ***,we present a novel microtube that contains gradient decellularized porcine sciatic nerve ECM hydrogel(pDScNM-gel)from microfluidics for sciatic nerve *** pDScNM is confirmed to enhance cell proliferation and migration,and improve the axon growth of primary dorsal root ganglions(DRGs)in a concentration-related *** behaviors were also achieved when cells were co-cultured in a gradient pDScNM *** in vivo sciatic nerve regeneration and functional recovery were also demonstrated by assembling the gradient pDScNM microtubes with a medical silicon *** results indicated that the microtubes with gradient pDScNM could act as a promising alternative for repairing peripheral nerve defects and showed great potential in clinical use.

关键词： Microfiber Peripheral nerve injury Extracellular matrix Microfluidics Nerve regeneration

Application of the Probability Matching Correction Method in Precipitation Forecast

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Meteorological and Environmental Research 2018年第3期9卷 64-71,74页

作者： Guo Dafeng chen xiangxiang Jiangxi Meteorological Observatory Nanchang 330096China

Based on the observation data of 24-hour cumulative precipitation from 92 ground meteorological observation stations in Jiangxi province from March to July during 2015-2016 and the high-resolution numerical forecast data of precipitation predicted within 24-72 h by the European Centre for Medium-Range Weather Forecasts（ ECMWF）,the Gamma function was used as the fitting function of probability distribution of cumulative precipitation to match the probability of predicted and observed precipitation. Moreover,the change of forecast score before and after the correction was tested. The results showed that the predicted values of heavy precipitation based on ECMWF model were smaller than the observed values,while the predicted values of light precipitation were larger than the observed values. The probability matching correction method could be used to effectively correct systematic errors of model forecast,and the correction effect of all grades of precipitation（ especially for rainstorm） was *** shorter the period of validity was,the better the correction effect was. The correction method has a good application effect in the interpretation of model precipitation products,and can provide better security services for agricultural production.

关键词： Probability matching Precipitation forecast Correction Application

A mobile application framework of the BIM-based facility management system under the cross-platform structure

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Computer Aided Drafting,Design and Manufacturing 2016年第1期26卷 58-65页

作者： Xiao Yaqi Hu Zhenzhong Wang Wei chen xiangxiang Department of Civil Engineering Tsinghua UniversityBeijing100084China Guangzhou Metro Corporation Guangzhou510000China Shenzhen BStar Technology Co. LtdShenzhen518055China.

The building information model/modeling （BIM） technology is currently applied in a broad range of applications and research for facility management, while the BIM-based mobile FM is difficult owing to various factors and environments. For example, the mobile applications usually require frequent cross-equipment compatibility. This paper proposes a reasonable BIM-based FM cross-platform framework and develops a mobile application on the basis of an existing BIM-based FM system. The developed mobile application is applied in a case study of a metro station project in Guangzhou to verify its effectiveness in FM practice. It helps maintenance staff in viewing BIMs, accessing related information, and updating maintenance records in a unique platform. The test results demonstrate that the proposed BIM-based cross-platform framework meet the FM application requirements and supports the extension of FM functions.

关键词： facility management building information model/modeling mobile application cross-platform hybrid application

钯催化阻转选择性C—H键活化和瞬时手性转移构筑季碳立体中心

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有机化学 2022年第12期42卷 4358-4359页

作者：陈祥祥何刚南开大学化学学院元素有机化学国家重点实验室天津300071

含有季碳中心的茚是一类重要的分子骨架,被广泛应用于生物活性分子和有机材料研发领域[1].由于茚环骨架的高张力和季碳手性中心较大的空间位阻,发展茚骨架的不对称合成方法极具挑战性.已经报道的方法中,芳烃与炔烃经历钯催化的Heck型不... 详细信息

含有季碳中心的茚是一类重要的分子骨架,被广泛应用于生物活性分子和有机材料研发领域[1].由于茚环骨架的高张力和季碳手性中心较大的空间位阻,发展茚骨架的不对称合成方法极具挑战性.已经报道的方法中,芳烃与炔烃经历钯催化的Heck型不对称[3+2]环加成反应,是最为直接高效构筑茚骨架季碳立体中心的方法.但这些方法仅限于使用预官能团化的底物,如芳基溴化物与内炔烃的不对称环加成反应(Scheme 1a)[2-5].相比之下,从芳烃底物出发经过C—H键活化的途径无疑是构建茚骨架更为实用的策略.最近,杭州师范大学材料与化学化工学院徐利文团队[6]利用肟醚导向阻转选择性C—H键活化和瞬态轴手性到中心手性转移的策略,发展了茚骨架季碳手性中心的高对映选择性合成方法(Scheme 1b).

关键词：化学化工学院手性中心环加成反应钯催化季碳生物活性分子轴手性炔烃

Delivery of pOXR1 through an injectable liposomal nanoparticle enhances spinal cord injury regeneration by alleviating oxidative stress

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Bioactive Materials 2021年第10期6卷 3177-3191页

作者： Jing Zhang Yao Li Jun Xiong Helin Xu Guanghen Xiang Mingqiao Fan Kailiang Zhou Yutian Lin xiangxiang chen Lin Xie Hongyu Zhang Jian Wang Jian Xiao Department of Hand Surgery and Peripheral Neurosurgery The First Affiliated Hospital and School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou325025China Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325000China

Oxidation resistance 1(OXR1)is regarded as a critical regulator of cellular homeostasis in response to oxidative ***,the role of OXR1 in the neuronal response to spinal cord injury(SCI)remains *** the other hand,gene therapy for SCI has shown limited success to date due in part to the poor utility of conventional gene *** this study,we evaluated the function of OXR1 in SCI and developed an available carrier for delivering the OXR1 plasmid(pOXR1).We found that OXR1 expression is remarkably increased after SCI and that this regulation is protective after ***,we assembled cationic nanoparticles with vitamin E succinate-graftedε-polylysine(VES-g-PLL)(Nps).The pOXR1 was precompressed with Nps and then encapsulated into cationic *** particle size of pOXR1 was compressed to 58 nm,which suggests that pOXR1 can be encapsulated inside liposomes with high encapsulation efficiency and stability to enhance the transfection *** agarose gel results indicated that Nps-pOXR1-Lip eliminated the degradation of DNA by DNase I and maintained its activity,and the cytotoxicity results indicated that pOXR1 was successfully transported into cells and exhibited lower ***,Nps-pOXR1-Lip promoted functional recovery by alleviating neuronal apoptosis,attenuating oxidative stress and inhibiting ***,our study provides considerable evidence that OXR1 is a beneficial factor in resistance to SCI and that Nps-Lip-pOXR1 exerts therapeutic effects in acute traumatic SCI.

关键词： Gene therapy OXR1 DNA condensed agent Spinal cord injury Oxidative stress

Study on the Relationship between Characteristics of Haze Days and Lung Cancer in Nanchang City

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Meteorological and Environmental Research 2018年第5期9卷 7-10页

作者： Hu Lei Zhong Sirong chen xiangxiang Zhong Landi Jiangxi Agro-meteorological Test Station Nanchang 330200China Jiangxi Agricultural University Nanchang 330045China Jiangxi Meteorological Observatory Nanchang 330096China Nanchang Meteorological Bureau Nanchang 330038China

Based on the conventional meteorological observation data during 1959-2014 and data of lung cancer cases of a third-grade classA tumor hospital in Nanchang City during 1997-2013,the annual variation of haze days in Nanchang City during 1959-2014 and its correlation with the related meteorological factors,as well as the characteristics of different types of lung cancer patients in Nanchang during 1997-2013 were analyzed. A correlation analysis method was used to study the correlation between the number of urban lung cancer patients and the number of haze days and fog days in each month in Nanchang. The lagging period of lung cancer was also discussed. The results show that the number of haze days in Nanchang rose since 1959,which is mainly related to the increase in the emissions of urban pollutants and the decrease of surface wind speed. The average age of female lung cancer was earlier than that of men. The number of men lung cancer patients was significantly larger than that of women. The number of urban lung cancer patients was obviously larger than that in rural areas. Haze had a great impact on the occurrence of lung cancer,with the lagging period of three years. Haze had a greater impact on urban women than urban men. The impact of haze on old people was greater than that of young and middle-aged people.

关键词： Lung cancer Haze days Correlation analysis Nanchang