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《肉毒毒素注射在皮肤美容中应用的专家共识(2023版)》解读

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皮肤科学通报 2024年第4期41卷 391-396+402页

作者：王向熙吴艳国家皮肤与免疫疾病临床医学研究中心皮肤病分子诊断北京市重点实验室国家药品监督管理局化妆品质量控制与评价重点实验室北京大学第一医院皮肤性病科

《肉毒毒素注射在皮肤美容中应用的专家共识(2023版)》[《共识(2023版)》]是在2017版《肉毒毒素注射在皮肤美容中应用的专家共识》的基础上的更新，不仅增加了新产品、新剂量单位、新用途，还进一步完善了常用美容适应证的注射要点。本... 详细信息

《肉毒毒素注射在皮肤美容中应用的专家共识(2023版)》[《共识(2023版)》]是在2017版《肉毒毒素注射在皮肤美容中应用的专家共识》的基础上的更新，不仅增加了新产品、新剂量单位、新用途，还进一步完善了常用美容适应证的注射要点。本文针对《共识(2023版)》的制订流程、新产品和新剂量单位、在常用美容适应证及新用途的注射要点等方面进行深入解析，并针对暂时未纳入共识的部分在皮肤病治疗中的新应用进行总结，以更好地指导肉毒毒素在皮肤科的临床应用。

关键词：肉毒毒素美容应用专家共识解读

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肉毒毒素在中国临床医疗美容中的应用分析

皮肤科学通报 2024年第4期41卷 407-414页

目的观察我国已上市肉毒毒素在医疗美容中应用的有效性及安全性，总结目前在研的肉毒毒素在医疗美容中应用的临床研究，探究我国肉毒毒素市场的发展趋势。方法汇总我国已上市肉毒毒素在我国医疗美容临床研究中的安全性和有效性数据，... 详细信息

目的观察我国已上市肉毒毒素在医疗美容中应用的有效性及安全性，总结目前在研的肉毒毒素在医疗美容中应用的临床研究，探究我国肉毒毒素市场的发展趋势。方法汇总我国已上市肉毒毒素在我国医疗美容临床研究中的安全性和有效性数据，分析肉毒毒素针对不同适应症的疗效及安全性，并总结目前在研的肉毒毒素针对美容适应症的研究。结果肉毒毒素针对眉间纹、鱼尾纹和咬肌肥大治疗，在采用推荐剂量时的疗效均显著优于安慰剂，并且具有很高的安全性。目前有多个新产品及新适应症在进行临床研究，肉毒毒素的应用前景广阔。结论肉毒毒素针对眉间纹、鱼尾纹和咬肌肥大的疗效肯定，安全性好，并且具有广阔应用前景。

关键词：肉毒毒素临床研究眉间纹鱼尾纹咬肌肥大

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基于微信小程序的预约挂号系统的设计与实现

现代计算机 2024年第8期30卷 116-120页

作者：王相喜周晓波倪甜弟西京学院计算机学院西安710123

微信小程序具有方便、快捷、简单的特点,它不需要下载,也不占据太大的内存空间,操作简单,而且成本低廉。因此,使用微信小程序进行线上预约挂号已经成为一种趋势。项目采用eclipse微信开发者工具、JSP技术、Java技术和MySQL等,运用这些... 详细信息

微信小程序具有方便、快捷、简单的特点,它不需要下载,也不占据太大的内存空间,操作简单,而且成本低廉。因此,使用微信小程序进行线上预约挂号已经成为一种趋势。项目采用eclipse微信开发者工具、JSP技术、Java技术和MySQL等,运用这些工具和技术开发出基于微信小程序的预约挂号系统。该系统可以直接远程实现预约挂号功能,成为一种便捷的医疗服务工具。

关键词：微信小程序微信开发者工具 Java JSP MySQL

基于JSP图书馆自习室预约系统的设计与实现

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现代计算机 2024年第9期30卷 117-120页

作者：倪甜弟周晓波王相喜西京学院计算机学院西安710123

系统采用微软最新发行出版的Windows 11专业版本的操作系统,用MySQL去管理数据库,最主要的开发语言是Java、HTML、JavaScript。在安装数据库的时候就提前配置好数据库与本系统之间的连接,可以直接在浏览器端进行数据库的配置和修改。利... 详细信息

系统采用微软最新发行出版的Windows 11专业版本的操作系统,用MySQL去管理数据库,最主要的开发语言是Java、HTML、JavaScript。在安装数据库的时候就提前配置好数据库与本系统之间的连接,可以直接在浏览器端进行数据库的配置和修改。利用这些技术实现对图书馆自习室预约系统的设计和开发,解决图书馆自习室日益突出的管理问题。

关键词：图书馆 JSP MySQL

Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3069-3079页

作者： Qianqian Li Li Zhang Ziteng Liang Nan wang Shuo Liu Tao Li Yuanling Yu Qianqian Cui Xi Wu Jianhui Nie Jiajing Wu Zhimin Cui Qiong Lu xiangxi wang Weijin Huang Youchun wang Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)WHO Collaborating Center for Standardization and Evaluation of BiologicalsNHC Key Laboratory of Research on Quality and Standardization of Biotech Products and NMPA Key Laboratory for Quality Research and Evaluation of Biological Products102629 BeijingChina Jiangsu Recbio Technology Co. Ltd.215300 TaizhouChina Graduate School of Chinese Academy of Medical Sciences&Peking Union Medical College No.9 Dongdan SantiaoDongcheng District100730 BeijingChina CAS Key Laboratory of Infection and Immunity CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences100101 BeijingChina

A steep rise in Omicron reinfection cases suggests that this variant has increased immune evasion *** evaluate its antigenicity relationship with other variants,antisera from guinea pigs immunized with spike protein of SARS-CoV-2 variants of concern(VOCs)and variants of interest(VOIs)were cross-tested against pseudotyped *** neutralization activity against Omicron was markedly reduced when other VOCs or VOIs were used as immunogens,and Omicron(BA.1)-elicited sera did not efficiently neutralize the other ***,a Beta or Omicron booster,when administered as the 4th dose 3-months after the 3rd dose of any of the variants,could elicit broad neutralizing antibodies against all of the current variants including Omicron *** analysis with 280 available antigen–antibody structures and quantification of immune escape from 715 reported neutralizing antibodies provide explanations for the observed differential *** distinct clades predicted using an in silico algorithm for clustering of sarbecoviruses based on immune escape provide key information for rational design of vaccines.

关键词： rational escape neutral

Comparing T-and B-cell responses to COVID-19 vaccines across varied immune backgrounds

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3029-3038页

作者： Zhen Cui Wenxin Luo Ruihong Chen Yalun Li Zhoufeng wang Yong Liu Shuo Liu LeiLei Feng Zijing Jia Ruixin Cheng Jun Tang Weijin Huang Yanjun Zhang Huawen Liu xiangxi wang Weimin Li CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China Department of Respiratory and Critical Care Medicine Institute of Respiratory HealthPrecision Medicine CenterPrecision Medicine Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu610041China Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu610041China Department of Neurology Chongqing University Three Gorges HospitalChongqing UniversityChongqingChina Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)No.31 Huatuo StreetDaxing DistrictBeijing102629China Department of Microbiology Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Department of Oncology Chongqing University Three Gorges HospitalChongqing UniversityChongqingChina

The emergence of adapted variants of the SARS-CoV-2 virus has led to a surge in breakthrough infections worldwide.A recent analysis of immune responses in people who received inactivated vaccines has revealed that individuals with no prior infection have limited resistance to Omicron and its sub-lineages,while those with previous infections exhibit a significant amount of neutralizing antibodies and memory B ***,specific T-cell responses remain largely unaffected by the mutations,indicating that T-cell-mediated cellular immunity can still provide ***,the administration of a third dose of vaccine has resulted in a marked increase in the spectrum and duration of neutralizing antibodies and memory B cells in vivo,which has enhanced resistance to emerging variants such as BA.2.75 and *** results highlight the need to consider booster immunization for previously infected individuals and the development of novel vaccination *** rapid spread of adapted variants of the SARS-CoV-2 virus presents a significant challenge to global *** findings from this study underscore the importance of tailoring vaccination strategies based on individual immune backgrounds and the potential need for booster shots to combat emerging *** research and development are crucial to discovering new immunization strategies that will effectively protect public health against the evolving virus.

关键词： vaccines immunity adapted

Effect of semi-continuous water washing on the combustion behaviors of agricultural organic solid waste

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Carbon Resources Conversion 2023年第1期6卷 58-64页

作者： xiangxi wang Zhenzhong Hu Jinrong Ma Linlin Yi Jian Li Yanfeng Cheng Jianfei Ma Na An Feng wang Xian Li Junjun Yan Bo Wei Yue Li Guangqian Luo Hong Yao State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Coal Clean Conversion and Chemical Process Autonomous Region School of Chemical Engineering and TechnologyXinjiang UniversityUrumqi 830000China Xinjiang Xinye Energy Chemical Engineering Co.Ltd Urumqi 830000China

Combustion of agricultural organic solid waste(AOSW)was an ideal solution for their resource utilization in view of their massive annual production and great potential for reduction of fossil fuel ***,high alkali and alkaline earth metals(AAEMs)content in the feedstock can arose severe fouling and slagging issues and thus prohibiting its vast *** this study,a semi-continuous water washing method was proposed to preliminarily remove AAEMs from agricultural organic solid waste and its effects on the combustion behaviors of washed solid product were *** showed that the combustion index S were improved to 2.63×10-6,over 68%of the total ashes were removed from the cotton stalk,and 96.3%,89.0%and 74.7%of K,Na and Mg were effectively removed,***,the softening temperature of low temperature ash from the washed sample was as high as 1450◦C,538◦C higher than the low temperature ash from the original sample;the base acid ratio and fouling index were improved from high slagging and fouling risk(1.7 and 90.8)of the original organic solid waste to low and medium risk(0.4 and 3.5),*** these results signified the contributing effect of proposed semi-continuous water washing method on the combustion of agricultural organic solid *** a word,this study provided a promising method for fouling and slagging inhibition during the agricultural organic solid waste combustion.

关键词： Agricultural organic solid waste Semi-continue water washing Alkali and alkaline earth metals Fouling and slagging Combustion characteristics

高碱煤热烟气强化水洗脱碱及其燃烧结渣沾污研究

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工程热物理学报 2024年第8期45卷 2509-2516页

作者：程小爱王祥曦马金荣程延峰胡振中马剑飞魏博李建钟梅刘景梅马凤云罗光前姚洪新疆大学化工学院煤炭清洁转化与化工过程自治区重点实验室乌鲁木齐830000 华中科技大学能源与动力工程学院煤燃烧国家重点实验室武汉430074 新疆新业能源化工有限责任公司五家渠831300

新疆高碱煤强结渣沾污特性是影响其大规模燃烧发电的瓶颈问题。本研究基于CO_(2)溶于水形成的碳酸可有效脱除煤中水不溶碱金属碱土金属的原理,提出以热烟气为CO_(2)来源的高碱煤热烟气强化水洗脱碱方法。通过对多种典型新疆高碱煤的实... 详细信息

新疆高碱煤强结渣沾污特性是影响其大规模燃烧发电的瓶颈问题。本研究基于CO_(2)溶于水形成的碳酸可有效脱除煤中水不溶碱金属碱土金属的原理,提出以热烟气为CO_(2)来源的高碱煤热烟气强化水洗脱碱方法。通过对多种典型新疆高碱煤的实验研究发现,Na的脱除率达到90%以上,Ca的脱除率达到45%,显著优于普通水洗对Na和Ca的脱除效果。洗后煤灰的碱酸比显著降低,灰熔点提高了150℃左右,大部分煤的结渣沾污倾向从严重结渣变为了中等结渣,或从中等结渣变为了不结渣。所以,热烟气强化水洗对高碱煤脱碱及抑制其燃烧过程的结渣沾污具有明显效果。另外,本方法简单可行,而且为电厂烟气(CO_(2))提供了一条新的资源化利用途径,具有明显的经济价值和社会意义。

关键词：高碱煤热烟气洗煤结渣沾污

Architecture of the herpesvirus genomepackaging complex and implications for DNA translocation

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Protein & Cell 2020年第5期11卷 339-351页

作者： Yunxiang Yang Pan Yang Nan wang Zhonghao Chen Dan Su ZHong Zhou Zihe Rao xiangxi wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Biotherapy West China HospitalCollaborative Innovation Center for BiotherapySichuan UniversityChengdu 610041China Department of Microbiology Immunologyand Molecular GeneticsUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Laboratory of Structural Biology School of MedicineTsinghua UniversityBeijing 100084China State Key Laboratory of Medicinal Chemical Biology and College of Life Science Nankai UniversityTianjin 300353China

Genome packaging is a fundamental process in a viral life cycle and a prime target of antiviral *** use an ATP-driven packaging motor/terminase complex to translocate and cleave concatemeric dsDNA into procapsids but its molecular architecture and mechanism are *** report atomic structures of a herpesvirus hexameric terminase complex in both the apo and ADP·BeF3-bound *** subunit of the hexameric ring comprises three components-the ATPase/terminase pUL15 and two regulator/fixer proteins,pUL28 and pUL33-unlike bacteriophage *** to the nuclease domains,six ATPase domains form a central channel with conserved basicpatches conducive to DNA binding and trans-acting arginine fingers are essential to ATP hydrolysis and sequential DNA *** of the nuclease domains mediated by regulatory domains converts DNA translocation mode to cleavage *** structures favor a sequential revolution model for DNA translocation and suggest mechanisms for concerted domain rearrangements leading to DNA cleavage.

关键词： dsDNA virus genome packaging viral maturation terminase complex drug target