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Bioactive Materials 2021年第11期6卷 3935-3946页

作者： Xiuxiu Jiang Xingmiao Li xiangwei fei Jiajie Shen Jianhua Chen Meijun Guo Yangyang Li Department of Gynecology Women’s HospitalZhejiang University School of MedicineHangzhou CityZhejiang Province310006China Key Laboratory of Women′s Reproductive Health Research of Zhejiang Province Women’s HospitalZhejiang University School of MedicineHangzhou CityZhejiang Province310006China Department of Pathology Women’s HospitalZhejiang University School of MedicineHangzhou CityZhejiang Province310006China

Asherman’s syndrome(AS),a leading cause of uterine infertility worldwide,is characterized by scarring of the uterine surfaces lacking endometrial epithelial cells,which prevents endometrial *** research on cell therapy for AS focuses on mesenchymal and adult stem cells from the ***,insufficient number,lack of purity,and rapid senescence of endometrial epithelial progenitor cells(EEPCs)during experimental processes restrict their use in cell *** this study,we induced human embryonic stem cells-9(H9-ESC)into EEPCs by optimizing the induction factors from the definitive ***,which act as endometrial epithelial cells,accompanied by human endometrial stromal cells provide a niche environment for the development of endometrial membrane organoids(EMOs)in an in vitro 3D culture *** investigate the function of EMOs,we transplanted tissue-engineered constructs with EMOs into an in vivo rat AS *** implantation of EMOs into the damaged endometrium facilitates endometrial regeneration and *** EMOs developed from human embryonic stem cells into the endometrium might prove useful for“endometrial re-engineering”in the treatment of Asherman’s syndrome.

关键词： Asherman’s syndrome H9-ESC Rat AS model Endometrial membrane organoids 3D culture

外源性细胞因子信号转导抑制因子3对异位子宫内膜间质细胞凋亡的影响

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中华医学杂志 2014年第1期94卷 55-58页

作者：李敏阮菲詹宏费向炜马俊彦林俊浙江大学医学院附属妇产科医院州310006

目的研究外源性细胞因子信号转导抑制因子3（SOCS3）对内异症患者异位子宫内膜间质细胞中Janus激酶／信号转导与转录活化因子3（JAK／STAT3）信号通路的调控及其对该细胞凋亡和增殖的影响。方法原代培养异位子宫内膜间质细胞；利用重组... 详细信息

目的研究外源性细胞因子信号转导抑制因子3（SOCS3）对内异症患者异位子宫内膜间质细胞中Janus激酶／信号转导与转录活化因子3（JAK／STAT3）信号通路的调控及其对该细胞凋亡和增殖的影响。方法原代培养异位子宫内膜间质细胞；利用重组构建的SOCS3和GFP融合表达的慢病毒载体（LV—SOCS3-GFP）感染异位子宫内膜间质细胞，使其高表达SOCS3，设为实验组，同时将LV—GFP慢病毒载体感染同源细胞，设为对照组；实时荧光定量PCR检测各组细胞的SOCS3、JAK2、STAT3mRNA表达水平；蛋白免疫印迹检测各组细胞中SOCS3、JAK2、STAT3的蛋白表达情况，以及JAK2、STAT3蛋白的磷酸化水平；流式细胞仪检测外源性SOCS3对异位子宫内膜间质细胞凋亡及细胞周期的影响。结果慢病毒载体感染异位子宫内膜间质细胞后，实验组SOCS3mRNA水平明显上调，与阴性对照组比较P〈0．01）；实验组SOCS3蛋白表达显著上升，同时p-STAT3蛋白表达下调，而STAT3、JAK2及p-JAK2蛋白水平与对照组差异无统计学意义；实验组细胞凋亡比例（22．0±1．3）％，对照组（4．4±1．3）％，实验组细胞周期中Go／G．期比例（87．04±3．7）％，对照组（76．04±3．7）％，两指标比较均P〈0．05。结论外源性SOCS3可促进异位子宫内膜间质细胞的凋亡并抑制细胞增殖。

关键词：子宫内膜异位症细胞因子信号转导抑制因子3 信号转导与转录活化因子3 细胞凋亡

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren fei Zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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共同富裕视角下乐清市渔业发展的现状与对策

中阿科技论坛（中英文） 2022年第8期 62-65页

作者：张利兵李欢费湘伟乐清市农业农村局浙江温州325000 平阳县市场监督管理局浙江温州325000

当前,浙江省渔业正处于转型升级的关键时期,共同富裕示范区的持续推进,对渔业的发展提出了新要求,指明了新方向。近年来,浙江省乐清市凭借自身渔业资源禀赋,坚持科学统筹,以省级渔业健康养殖示范县建设为主抓手,通过道路谋划、体系建立... 详细信息

当前,浙江省渔业正处于转型升级的关键时期,共同富裕示范区的持续推进,对渔业的发展提出了新要求,指明了新方向。近年来,浙江省乐清市凭借自身渔业资源禀赋,坚持科学统筹,以省级渔业健康养殖示范县建设为主抓手,通过道路谋划、体系建立、渠道拓展等措施,全面提升渔业核心竞争力,助推渔民实现共同富裕。文章立足乐清市渔业现状,指出该市渔业发展中存在产业结构不平衡,渔业资金投入不足,科技兴渔、质量强渔后劲不足,渔业人口素质偏低等问题,并针对问题提出了相关对策建议,旨在为浙江省乃至全国的渔业发展提供借鉴。

关键词：乐清市渔业发展共同富裕现状与对策

Corrigendum to’Endometrial membrane organoids from human embryonic stem cell combined with the 3D Matrigel for endometrium regeneration in asherman syndrome’[Bioactive Mater.6(2021)3935-3946]

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Bioactive Materials 2021年第12期6卷 4591-4591页

作者： Xiuxiu Jiang Xingmiao Li xiangwei fei Jiajie Shen Jianhua Chen Meijun Guo Yangyang Li Department of Gynecology Women's Hospital Zhejiang University School of Medicine Hangzhou City Zhejiang Province 310006 China Key Laboratory of Women′s Reproductive Health Research of Zhejiang Province Women's Hospital Zhejiang University School of Medicine Hangzhou City Zhejiang Province 310006 China Department of Pathology Women's Hospital Zhejiang University School of Medicine Hangzhou City Zhejiang Province 310006 China

Xiuxiu Jiang a,Xingmiao Li a,xiangwei fei b,Jiajie Shen b,Jianhua Chen c,Meijun Guo a,Yangyang Li b,*a Department of Gynecology,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou City,Zhejiang Province,310006,China b Key Laboratory of Women′s Reproductive Health Research of Zhejiang Province,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou City,Zhejiang Province,310006,China c Department of Pathology,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou City,Zhejiang Province,310006,China The authors regret the incorrect publication of Fig.3A,which was not identified during the proofing *** corrected figure *** authors would like to apologise for any inconvenience ***.3.(A)Immunocharacterization of EEPC purity was analysed using flow cytometry by checking the expression of endoderm epithelial surface markers CXCR4(CD184)and E-cadherin(CD324)without sorting.

关键词： figure corrected Cor

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang fei Yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： fei Lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Application of Instantaneous Rotational Speed to Detect Gearbox Faults Based on Double Encoders

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Chinese Journal of Mechanical Engineering 2019年第1期32卷 54-64页

作者： Lin Liang fei Liu xiangwei Kong Maolin Li Guanghua Xu School of Mechanical Engineering Xi’an Jiaotong University Key Laboratory of Education Ministry for Modern Design and Rotor-bearing System Xi’an Jiaotong University Engineering Workshop Xi’an Jiaotong University State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong University

Considerable studies have been carried out on fault diagnosis of gears, with most of them concentrated on conventional vibration analysis. However, besides the complexity of gear dynamics, the diagnosis results in terms of vibration signal are easily misjudged owing to the interference of sensor position or other components. In this paper, an alternative gearbox fault detection method based on the instantaneous rotational speed is proposed because of its advantages over vibration analysis. Depending on the timer/counter-based method for the pulse signal of the optical encoder, the varying rotational speed can be obtained e ectively. Owing to the coupling and meshing of gears in transmission, the excitations are the same for the instantaneous rotational speed of the input and output shafts. Thus, the di erential signal of instantaneous rotational speeds can be adopted to eliminate the e ect of the interference excitations and extract the associated feature of the localized fault e ectively. With the experiments on multistage gearbox test system, the di erential signal of instantaneous speeds is compared with other signals. It is proved that localized faults in the gearbox generate small angular speed fluctuations, which are measurable with an optical encoder. Using the di erential signal of instantaneous speeds, the fault characteristics are extracted in the spectrum where the deterministic frequency component and its harmonics corresponding to crack fault characteristics are displayed clearly.

关键词： Instantaneous rotational speed Optical encoder Localized fault Multistage gearbox

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi Song Sujuan Qin Qiaoyan Wen fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing