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Risk prediction of advanced colorectal neoplasia varies by race and neighbourhood socioeconomic status

Family Medicine and Community Health 2024年第S2期12卷 26-33页

作者： xiangqing sun Zhengyi Chen Gregory S Cooper Nathan A Berger Claudia Coulton Li Li Department of Family Medicine University of VirginiaCharlottesvilleVirginiaUSA Department of Population and Quantitative Health Sciences Case Western Reserve UniversityClevelandOhioUSA University Hospitals Cleveland Medical Center ClevelandOhioUSA Case Comprehensive Cancer Center ClevelandOhioUSA Jack Joseph and Morton Mandel School of Applied Social SciencesCase Western Reserve UniversityClevelandOhioUSA

Objective Neighbourhood deprivation increases the risk of colorectal neoplasia and contributes to racial disparities observed in this *** race-specific advanced colorectal neoplasia(ACN)prediction models that include neighbourhood socioeconomic status has the potential to improve the accuracy of *** The study includes 1457 European Americans(EAs)and 936 African Americans(AAs)aged 50–80 years undergoing screening ***-specific ACN risk prediction models were developed for EAs and AAs,*** Deprivation Index(ADI),derived from 17 variables of neighbourhood socioeconomic status,was evaluated by adding it to the ACN risk prediction *** accuracy was evaluated by concordance statistic(C-statistic)for discrimination and Hosmer-Lemeshow goodness-of-fit test for *** With fewer predictors,the EA-specific and AA-specific prediction models had better prediction accuracy in the corresponding race/ethnic subpopulation than the overall *** with the overall model which had poor calibration(P_(Calibration)=0.053 in the whole population and P_(Calibration)=0.011 in AAs),the EA model had C-statistic of 0.655(95%CI 0.594 to 0.717)and P_(Calibration)=0.663;and the AA model had C-statistic of 0.637((95%CI 0.572 to 0.702)and P_(Calibration)=*** was a significant predictor of ACN in EAs(OR=1.24((95%CI 1.03 to 1.50),P=0.029),but not in AAs(OR=1.07((95%CI 0.89 to 1.28),P=0.487).Adding ADI to the EA-specific ACN prediction model substantially improved ACN calibration accuracy of the prediction across area deprivation groups(P_(Calibration)=0.924 with ADI vs P_(Calibration)=0.140 without ADI)in *** Neighbourhood socioeconomic status is an important factor to consider in ACN risk prediction ***,non-race-specific prediction models have poor ***-specific prediction models incorporating neighbourhood socioeconomic factors are needed to improve ACN predicti

关键词： colorectal neoplasia prediction

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Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method

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Science China(Life Sciences) 2005年第3期48卷 263-269页

作者： sun xiangqing JIA Yanbin ZHANG Xuegong XU Qi SHEN Yan LI Yanda Ministry of Education(MOE)Key Laboratory of Bioinformatics at Tsinghua University Department of AutomationTsinghua UniversityBeijing 100084China National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Schizophrenia is a serious neuropsychiatric illness affecting about 1% of the world’s population. It is considered a complex inheritance disorder. A number of genes are involved in combination in the etiology of the disorder. Evidence implicates the altered dopaminergic trans- mission in schizophrenia. In the present study, in order to identify susceptibility genes for schizophrenia in dopaminergic metabolism, we analyzed 59 single nucleotide polymorphisms (SNPs) in 24 genes of the dopaminergic pathway among 82 unrelated patients with schizophre- nia and 108 matched normal controls. Considering that traditional single-locus association stud- ies ignore the multigenic nature of complex diseases and do not take into account possible in- teractions between susceptibility genes, we proposed a multi-locus analysis method, using the posterior probability of morbidity as a measure of absolute disease risk for a multi-locus genotype combination, and developed an algorithm based on perturbation and average to detect the sus- ceptibility multi-locus genotype combinations, as well as to repress noise and avoid false positive results at our best. A three-locus SNP genotype combination involved in the interactions of COMT and ALDH3B1 genes was detected to be significantly susceptible to schizophrenia.

关键词： posterior probability of morbidity schizophrenia association study multi-locus genotype combination.

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轮式联合收割机智能辅助操控系统设计

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机械制造与自动化 2018年第3期47卷 220-224页

作者：孙祥青南京理工大学机械工程学院江苏南京210094

为克服轮式联合收割机在作业自动化、智能化方面的不足,提出了一种轮式联合收割机智能辅助操控系统设计方案,介绍了系统的软硬件设计。系统通过对收割机作业关键运行状态的采集与处理,实现对收割机作业过程的实时监测和执行机构的智能... 详细信息

为克服轮式联合收割机在作业自动化、智能化方面的不足,提出了一种轮式联合收割机智能辅助操控系统设计方案,介绍了系统的软硬件设计。系统通过对收割机作业关键运行状态的采集与处理,实现对收割机作业过程的实时监测和执行机构的智能调节。该系统具有较高的实时性与精确性,工作稳定,人机交互友好,实现了智能辅助操控的设计目标。

关键词：收割机智能化辅助操控实时监测

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长新冠综合征对心血管系统的影响:临床表现、机制与诊治原则

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中国全科医学 2024年第27期27卷 3325-3330页

作者：钟旻珊孙伟孔祥清南京医科大学第一附属医院心血管内科江苏省南京市210029

新型冠状病毒感染传播在全球造成了巨大的影响。在急性期感染结束后,有相当一部分感染者受到了后遗症的影响,目前暂将这一组涉及症状广泛、异质性强的临床症候群称为长新冠综合征。新型冠状病毒感染急性期相关的心血管并发症因其严重性... 详细信息

新型冠状病毒感染传播在全球造成了巨大的影响。在急性期感染结束后,有相当一部分感染者受到了后遗症的影响,目前暂将这一组涉及症状广泛、异质性强的临床症候群称为长新冠综合征。新型冠状病毒感染急性期相关的心血管并发症因其严重性已受到学界广泛的关注,但急性期感染结束后的心血管受累情况亟需被重视。本文就长新冠综合征心血管系统的常见临床表现、发生机制和诊治原则进行综述,意在提高人们对于长新冠综合征心血管系统并发症的认识,从而更加科学合理地应对和降低疾病带来的危害。

关键词：新型冠状病毒感染长新冠综合征心血管疾病综述

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汕头内港泥沙运移规律及其开发整治问题

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热带地理 1988年第1期8卷 1-12页

作者：孙献清南京水利科学研究院

■港区能否发展成为深水作业区,是交通部和有关部门极为关心的问题。为此应对整个内港海域进行全面的研究,以便合理规划深水码头的位置。本文首先从汕头湾的来水来沙和边界条件,对内港淤积原因进行了探讨,并根据实测水文全潮(站位见图1)... 详细信息

■港区能否发展成为深水作业区,是交通部和有关部门极为关心的问题。为此应对整个内港海域进行全面的研究,以便合理规划深水码头的位置。本文首先从汕头湾的来水来沙和边界条件,对内港淤积原因进行了探讨,并根据实测水文全潮(站位见图1),历史水深地形演变,结合模型试验资料,对拟建的珠池肚、牛田洋深水港区内的回淤进行了估算和分析,探讨了汕头内港海域开发深水泊位的可行性和整治问题。

关键词：内港开发整治水深珠池纳潮量水文要素老港区广东汕头

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带式输送机参数化设计系统的设计与实现

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无线互联科技 2023年第20期20卷 71-75页

作者：孙向青龚军解玲中国石油运输有限公司新疆乌鲁木齐830012 新疆大学新疆乌鲁木齐830046

带式输送机是一种以连续方式输送物料的机械设备,能够部署在各种复杂的环境场所,现已成为散装物料的主要输送设备,具有安装方便、使用寿命长、工作效率高等诸多优点。文章提出了一种在.NET框架下,采用C#.NET为编程语言实现的带式输送机... 详细信息

带式输送机是一种以连续方式输送物料的机械设备,能够部署在各种复杂的环境场所,现已成为散装物料的主要输送设备,具有安装方便、使用寿命长、工作效率高等诸多优点。文章提出了一种在.NET框架下,采用C#.NET为编程语言实现的带式输送机参数化设计系统。实践证明,参数化设计系统,能够使得带式输送机设计过程变得更加高效、准确和灵活,大大提高了设计者的工作水平和工作效率。

关键词： NET框架带式输送机参数化设计

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杉木大径材培育研究进展

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世界林业研究 2024年第1期37卷 54-58页

作者：周柏屹孙麟均吴鹏飞李明马祥庆福建农林大学林学院福州350002 国家林业和草原局杉木工程技术研究中心福州350002

杉木是我国人工林面积最大的造林树种,在我国林业产业中占有重要地位。随着市场对杉木大径材需求不断增加,有关杉木大径材高效培育的研究成为热点,取得了较多研究成果。文中分别从遗传控制、立地控制、密度控制等方面综述杉木大径材培... 详细信息

杉木是我国人工林面积最大的造林树种,在我国林业产业中占有重要地位。随着市场对杉木大径材需求不断增加,有关杉木大径材高效培育的研究成为热点,取得了较多研究成果。文中分别从遗传控制、立地控制、密度控制等方面综述杉木大径材培育的研究进展,探讨杉木大径材培育的技术体系,指出目前大径材培育研究中存在的问题,并提出加强杉木大径材培育品种筛选、进行高世代良种杉木大径材成材机理长期定位观测、加强杉木大径材定向培育技术的组装配套研究及编制适合大径材培育使用的长轮伐期杉木地位指数表等建议,以为杉木大径材培育提供科学依据。

关键词：杉木大径材遗传控制立地控制密度调控

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增温对杉木凋落叶和宿存叶分解过程养分释放的影响——基于移位试验模拟

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生态学报 2024年第17期44卷 7713-7724页

作者：吴小健李江飞江宇孙麟钧吴鹏飞马祥庆福建农林大学林学院福州350002 国家林业和草原局杉木工程技术研究中心福州350002

凋落物分解是森林生态系统养分循环的重要组成部分,为探究气温变化对杉木枯死叶片分解的影响,以杉木人工林的凋落叶和宿存叶为研究对象,采用分解网袋法,利用武夷山气温垂直分布特征,选择了620 m、1003 m、1410 m和1948 m四个海拔气温梯... 详细信息

凋落物分解是森林生态系统养分循环的重要组成部分,为探究气温变化对杉木枯死叶片分解的影响,以杉木人工林的凋落叶和宿存叶为研究对象,采用分解网袋法,利用武夷山气温垂直分布特征,选择了620 m、1003 m、1410 m和1948 m四个海拔气温梯度,采用异地移位试验模拟增温对杉木凋落叶和宿存叶分解速率及分解过程中N、P、Mg、Ca元素释放的影响。结果表明:(1)凋落叶和宿存叶的干重残留率随分解时间的延长呈下降趋势,且在不同海拔气温下存在显著差异(PK_(1003 m)>K_(1410 m)>K_(1948 m),宿存叶则表现为K_(1003 m)>K_(620 m)>K_(1410 m)>K_(1948 m)。增温缩短了凋落叶和宿存叶的半衰期和周转期。(2)增温显著影响凋落叶和宿存叶的N、P、Mg、Ca残留率(P<0.05),二者整体均表现为在T620 m下具有较低的养分残留率,而在300—360 d分解时段,宿存叶在T620 m下具有较高的P残留率。增温并未改变凋落叶和宿存叶P、Mg、Ca素的释放模式,但改变了宿存叶N素的释放模式。(3)凋落叶和宿存叶的干重残留率与N残留率呈极显著正相关(P<0.001),与P残留率呈显著负相关(P<0.05)。相较于N、P而言,Mg、Ca残留率与干重残留率间的相关性较弱。气温升高显著加快了凋落叶和宿存叶的质量损失速率及养分释放速率,促进杉木人工林生态系统的养分物质循环。研究结果为全面了解杉木枯死叶片分解过程中养分释放对气候变暖的响应机制提供科学依据。

关键词：增温杉木凋落叶宿存叶干重残留养分释放

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Experimental and Theoretical Study on the Flexural Behavior of Recycled Concrete Beams Reinforced with GFRP Bars

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Journal of Renewable Materials 2021年第6期9卷 1169-1188页

作者： Xinzhan Chen xiangqing Kong Ying Fu Wanting sun Renguo Guan School of Civil Engineering Liaoning University of TechnologyJinzhou121001China Engineering Research Center of Continuous Extrusion Dalian Jiaotong UniversityDalian116028China

This paper experimentally investigated the flexural behavior of reinforced recycled aggregate concrete(RAC)beams reinforced with glass fiber-reinforced polymer(GFRP)bars.A total of twelve beams were built and tested up to failure under four-point *** main parameters were reinforcement ratio(0.38%,0.60%,and 1.17%),recycled aggregate replacement ratio(R=0,50%,and 100%)and longitudinal reinforcement types(GFRP and steel).The flexural capacity,failure modes,flexibility deformation,reinforcement strains and crack distribution of the tested beams were investigated and compared with the calculation models of American code ACI 440.1-R-15,Canadian code CSA S806-12 and *** tested results indicated that the reinforcement ratio has great influence on the ultimate load,crack width and deflection of GFRP-RAC beams,the recycled aggregate replacement ratio has little influence on ***,it was found that the reinforcement ratio has no obvious influence on the cracking load which was only related to the recycled aggregate replacement *** average cracking load decreased by 5%and 15%as the recycled aggregate replacement ratio increased from 0 to 50%and 100%.For the steel-RAC beams,the ultimate load was found to be about 1/2 of the ultimate load of GFRP-RAC beam under the same condition and the trend of strain,deflection and crack width were different from GFRP-RAC *** is due to the different material properties of GFRP bars and steel *** the other hand,the calculation results showed that ACI 440.1-R-15 and CSA S806-12 underestimated the ultimate load of GFRP-RAC ***,the deflection prediction of GFRP-RAC beams by CSA S806-12 is relatively accurate compared with ACI 440.1-R-15 and *** for the prediction of crack width,the results of ACI 440.1-R-15 prediction were in good agreement with the experimental results at the ultimate load,with the average value of 1.09±0.28.

关键词： GFRP bars recycled aggregate concrete replacing ratio flexural capacity reinforcement ratio

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Gamma generalized linear model to investigate the effects of climate variables on the area burned by forest fire in northeast China

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Journal of Forestry Research 2015年第3期26卷 545-555页

作者： Futao Guo Guangyu Wang John L. Innes xiangqing Ma Long sun Haiqing Hu Fujian Agriculture and Forestry University Sustainable Forest Management Laboratory Faculty of Forestry University of British Columbia VancouverBC V6T 1Z4 Canada Faculty of Forestry Northeast Forestry University

The purpose of this study was to determine a suitable model for investigating the effects of climate factors on the area burned by forest fire in the Tahe forest region, Daxing＇an Mountains, in northeast China. The response variables were the area burned by lightning- caused fire, human-caused fire, and total burned area. The predictor variables were nine climate variables collected from the local weather station. Three regression models were utilized, including multiple linear regression, log- linear model （log-transformation on both response and predictor variables）, and gamma-generalized linear model. The goodness-of-fit of the models were compared based on model fitting statistics such as R2, AIC, and RMSE. The results revealed that the gamma-generalized linear model was generally superior to both multiple linear regressionmodel and log-linear model for fitting the fire data. Further, the best models were selected based on the criteria that the climate variables were statistically significant at at = 0.05. The gamma best models indicated that maximum wind speed, precipitation, and days that rainfall greater than 0.1 mm had significant impacts on the area burned by the lightning-caused fire, while the mean temperature and minimum relative humidity were the .main drivers of the burned area caused by human activities. Overall, the total burned area by forest fire was significantly influenced by days that rainfall greater than 0.1 mm and minimum rela- tive humidity, indicating that the moisture condition of forest stands determine the burned area by forest fire.

关键词： Lightning-caused fire Human-caused fire Multiple linear regression Log-linear model Daxing'anmountains

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