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Nogo-A and Nogo-A receptor expression in periventricular white matter of experimental autoimmune encephalomyelitis rats

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Neural Regeneration Research 2010年第8期5卷 579-584页

作者： Liming Tan Ying Chi Chunyu Wang1, Jun Wu1, Hainan Zhang1, xiangmin shen1, ShujuanDuan1, Bo JiangI Jun Wu Hainan Zhang xiangmin shen Shujuan Duan Bo Jiang Department of Neurology Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina The First College of Clinical Medical Science China Three Gorges UniversityYichang 443003Hubei ProvinceChina Department of Neurology Yichang Central People's HospitalYichang 443003Hubei ProvinceChina Department of Neurology Yichang Central People's HospitalYichang 443003Hubei ProvinceChina

BACKGROUND：Previous studies have focused on the correlation between Nogo-A expression and multiple sclerosis or between Nogo-A receptor （NgR） expression and multiple sclerosis in the central nervous system. Expression patterns of Nogo-A and NgR remain poorly understood in rat models of experimental autoimmune encephalomyelitis （EAE）.OBJECTIVE：To observe dynamic changes in Nogo-A and NgR protein expression, and to verify the correlation between Nogo-A and NgR protein, as well as expression patterns at various time points, in periventricular tissue of EAE ***, TIME AND SETrlNG：A neuroimmunological, randomized, controlled experiment was performed at the Clinical Institute of Hunan People＇s Hospital of China from September to November ***：Immunohistochemistry （streptavidin-biotin-peroxidase complex method） kit was purchased from Boster, ***：A total of 60 female, Wistar rats, aged 6-8 weeks, ware randomly assigned to EAE and control groups （n = 30, respectively）. Guinea pig spinal cord homogenate, self-made complete Freund＇s adjuvant （0.2 mL/100 g）, and pertussis vaccine （0.2 mL） were subcutaneously injected into the hindlimb foot pad of rats from the EAE group to create rat models of EAE. Complete Freund＇s adjuvant （0.2 mL） was infused into rats from the control *** OUTCOME MEASURES：Nogo-A and NgR protein expression was determined in periventricular white matter using immunohistochemical methods. Neurological scores ware determined in all ***：Rats from the EAE group developed acute-onset EAE following immunization. The pathogenetic symptoms reached a peak on day 15, and neurological scores ware also greatest at this time point. Neurological scores decreased with recovery of the illness. Nogo-A was shown to be expressed in neuronal cells and oligodendrocytes, and expression increased 11 days after immunization （P 〈 0.01）, decreased by day 13 （P 〈 0.01）, and then increased again by day 15. Nogo-A expression remained greater in

关键词： experimental autoimmune encephalomyelitis immunohistochemistry pathogenesis Nogo-A Nogo-A receptor

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Neuroprotective role of edaravone and the effects of endoplasmic reticulum stress in an adult rat model of focal cerebral ischemia/reperfusion

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Neural Regeneration Research 2010年第3期5卷 197-204页

作者： xiangmin shen Liming Tan Yunhai Liu Hainan Zhang Chunyu Wang Qidong Yang QingHuang Lin Zhou Zhenyu Tang Department of Neurology Xiangya Hospital Central South University Changsha 410008 Hunan Province China Department of Neurology Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

BACKGROUND： Endoplasmic reticulum （ER） stress impairs ER functions and leads to the accumulation of unfolded or misfolded proteins in the ER lumen. ER stress-induced cell death plays an important role in cerebral ischemia. Edaravon （3-methyl-1-phenyl-2-pyrazolin-5-one） is a potent and novel scavenger of free radicals that inhibit delayed neuronal death, as demonstrated by in vitro and animal studies. However, its effect on ER stress and induced neuronal apoptosis in a rat model of brief middle cerebral artery occlusion remains unclear. OBJECTIVE： To explore the effects of edaravone on the expression of ER stress-related factors and neuronal apoptosis, based on the hypothesis that edaravone influences ER stress in a rat model of cerebral ischemia/reperfusion. DESIGN, TIME AND SETTING： A randomized, controlled, animal study was performed at the Laboratory of Department of Neurology, Xiangya Hospital and the Department of Laboratory Animals, Xiangya Medical College, Central South University in China from June 2005 to May 2006. MATERIALS： Edaravone was purchased from Simcere Pharmaceutical Group, China. METHODS： A total of 216 adult, male, Sprague Dawley rats were randomly assigned to sham-surgery, model and edaravone groups, with 72 rats in each group, Brief middle cerebral artery occlusion was established in the model and edaravone groups. In addition, the edaravone group rats were injected with 3 mg/kg edaravone through the tail vein. MAIN OUTCOME MEASURES： RNA-dependent protein kinase-like endoplasmic reticulum eukaryotic translation initiation factor 2a kinase （PERK） and C/EBP homology protein （CHOP） mRNA expression in the ischemic parietal cortex was determined by reverse transcriptionpolymerase chain reaction; phosphorylated PERK and CHOP protein expression was detected by immunohistochemistry; neuronal apoptosis was detected by TdT-mediated-dUTP nick end labeling. RESULTS： Neurological deficit scores were significantly reduced in the edaravone group compared to

关键词： edaravone cerebral ischemia/reperfusion endoplasmic reticulum stress RNA-dependent protein kinase-like endoplasmic reticulum elF2a kinase C/EBP homology protein brain injury neural regeneration

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我国个人所得税改革历程和目标设想

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南京政治学院学报 2012年第2期28卷 36-40页

作者：沈向民东北财经大学财政税务学院辽宁大连116023

个人所得税作为现行税制中唯一能通过累进税制实现纵向公平的税种,在调节收入分配、缩小贫富差距的政策选择中被寄予厚望,成为当下中国社会普遍关注的焦点。我国的个人所得税制度自1980年随着第一部《个人所得税法》的颁布而正式确立以... 详细信息

个人所得税作为现行税制中唯一能通过累进税制实现纵向公平的税种,在调节收入分配、缩小贫富差距的政策选择中被寄予厚望,成为当下中国社会普遍关注的焦点。我国的个人所得税制度自1980年随着第一部《个人所得税法》的颁布而正式确立以来,经历了不断调整完善的改革过程。现行的个人所得税制度符合当前我国经济社会发展的实际,对调节收入分配、改善民众福利、促进经济发展有积极的作用。但与社会转型相适应,个人所得税依然面临着改革的压力。兼顾公平和效率、兼顾经济规律与社会文化、兼顾流量与存量的职能调节、兼顾短期与长期调节是改革的原则,为此,需要加强对高收入群体的管理,增加个人所得税管理的透明度,建立居民个人信息共享系统和个人所得税信息化管理平台,建立综合与分类相结合的制度体系直至建立完全意义上的综合个人所得税征收模式,配套完善自然人税收制度和管理,完善税制设计。

关键词：个人所得税制度改革目标公平

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The exploration and practice of low-altitude airspace flight service and traffic management in China

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Green Energy and Intelligent Transportation 2024年第2期3卷 1-8页

作者： xiangmin Guan Hongxia Shi Dongsong Xu Binhua Zhang Jian Wei Jun Chen CAAC Key Laboratory of General Aviation Operation Department of General AviationCivil Aviation Management Institute of ChinaBeijing 100102China Research Institute of Civil Aviation Regulations and Standardization China Academy of Civil Aviation Science and TechnologyBeijing 100028China Department of Technology Platform Phoenix Wings Technology(Shen zhen)Co.LtdShenZhen 518054China shenzhen Highgreat Innovation Technology Development Co. Ltd dShenzhen 518000China School of Engineering and Materials Science Queen Mary University of LondonLondonE14NSUK

Due to the inherent nature of being highly digitalized,networked and intelligent,Unmanned Aerial System(UAS)operations pose a huge challenge to traditional aviation regulation and technical *** to keep safe,efficient and integrated operation for different Airspace users has become a pressing issue faced by civil aviation around the *** paper focuses on the main operational scenarios and characteristics of unmanned aviation development in *** operational characteristics and associated challenges due to diverse low-altitude users are analyzed,including operation concepts,UAS traffic management,technological test and verification,and *** light on the practices in Europe and the United States,this paper summarizes China's practices and progress in low-altitude operations management,and analyzes future technological development needs and trends,as well as feasible implementation pathways and measures based on actual needs.

关键词： UAS Low-altitude airspace UAS traffic management Exploration and practice

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国际税收竞争效应分析:一个理论分析框架

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国际税收 2017年第10期 77-81页

作者：蔡建勋沈向民吴健江苏省南京市地方税务局江苏南京210000 东南大学经济管理学院江苏南京210000

国际税收竞争是经济全球化的产物,具有正面效应和负面效应。一般对国际税收竞争效应的分析主要是建立在政府是"自利"或是"善良"的假定基础上。多数学者认为适度的国际税收竞争是有利的。本文通过一个理论分析模型说明在不同情况下的国... 详细信息

国际税收竞争是经济全球化的产物,具有正面效应和负面效应。一般对国际税收竞争效应的分析主要是建立在政府是"自利"或是"善良"的假定基础上。多数学者认为适度的国际税收竞争是有利的。本文通过一个理论分析模型说明在不同情况下的国际竞争对于国民福利水平的影响,从福利效应的角度分析了公共选择过程中,中间投票人的经济地位与国际税收竞争福利效应之间的关系。

关键词：福利效应中间投票人拉姆齐法则边际超额负担

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基于改进混合樽海鞘群算法的航空发动机模型求解方法

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应用科技 2024年第2期51卷 31-39页

作者：沈昂徐含灵胡春艳谭湘敏江苏大学流体机械工程技术研究中心江苏镇江212013 中国科学院工程热物理研究所/轻型动力重点实验室北京100190 中国科学院轻型动力创新研究院北京100190 中国科学院大学航空宇航学院北京100049

针对传统智能优化算法在求解航空发动机模型非线性方程组时收敛速度慢、精度低的问题,提出采用樽海鞘群优化算法(salps swarm algorithm,SSA)。为了提升标准SSA求解复杂发动机模型的随机搜索能力,采用了混沌映射、正余弦算法、自适应权... 详细信息

针对传统智能优化算法在求解航空发动机模型非线性方程组时收敛速度慢、精度低的问题,提出采用樽海鞘群优化算法(salps swarm algorithm,SSA)。为了提升标准SSA求解复杂发动机模型的随机搜索能力,采用了混沌映射、正余弦算法、自适应权重、逐维变异策略对SSA进行改进,并且更进一步调整了算法流程(Process improved SSA),提高算法收敛概率,最终将Process improved SSA与Newton-Raphson算法结合为混合算法,并以适应度值作为算法切换的判断条件以提升混合算法的计算效率。仿真实验验证了Process improved SSA求解航空发动机模型的有效性。仿真结果表明混合算法能够实现全局收敛并提升收敛速度,且能够在模型输入强瞬变仿真时实现快速收敛。

关键词：非线性模型航空发动机智能优化算法樽海鞘群算法混沌映射正余弦算法 Newton-Raphson算法混合算法

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0.5%阿维菌素液体药肥抗番茄根结线虫病及促生的效果

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浙江农业科学 2024年第5期65卷 1194-1197页

作者：神兴明王娜任士伟喻大昭刘村平郑磊陈宏坤张献民金正大生态工程集团股份有限公司农业农村部植物营养与新型肥料创制重点实验室山东临沂276700 菏泽金正大生态工程有限公司山东菏泽274000 菏泽市牡丹区南城办事处社区服务中心山东菏泽274000

阿维菌素是一种具有杀虫、杀螨、杀线虫活性的十六元大环内酯化合物,具有结构新颖、农畜两用、抗性产生缓慢、触杀、胃毒、渗透力强,无致畸、致癌、致突变作用等的特点,是当前生物农药市场中最受欢迎产品之一。为了探索0.5%阿维菌素液... 详细信息

阿维菌素是一种具有杀虫、杀螨、杀线虫活性的十六元大环内酯化合物,具有结构新颖、农畜两用、抗性产生缓慢、触杀、胃毒、渗透力强,无致畸、致癌、致突变作用等的特点,是当前生物农药市场中最受欢迎产品之一。为了探索0.5%阿维菌素液体药肥对番茄抗根结线虫病及其促生应用技术,将0.5%阿维菌素液体药肥配制成不同浓度溶液,在室内进行了抑制线虫活性测定;并对盆栽番茄进行冲施,观察并记录番茄根结线虫病发生情况及农艺性状指标变化。研究表明,0.5%阿维菌素液体药肥对根结线虫有击倒能力和致死能力。稀释800倍时,番茄农艺性状各指标达到最高。因此,推荐0.5%阿维菌素液体药肥使用浓度为稀释800倍,此时番茄抗根结线虫病和促生效果最优。

关键词：阿维菌素液体药肥番茄根结线虫

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A 5V 8b 40MSample/s Pipelined Analog-to-Digital Converter

A 5V 8b 40MSample/s Pipelined Analog-to-Digital Converter

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2004 7th International Conference on Solid-State and Integrated Circuits Technology（ICSICT 2004）

作者： Xue Liang shen Yanzhao Zhang xiangmin Institute of Microelectronics Tsinghua University Beijing 100084 China

＜正＞In this paper,a 5V 8b 40Msamp les/s pipelined A/D converter is *** A/D converter contains seven stages and each stage realizes a resolution of *** reduce both linear and nonlinear errors,bottom-plate sampling,bootstrap and digital correction techniques are applied in ADC *** clocks are necessary for those *** results are obtained,with 1MHz input signal,the ADC acquired SNDR of 48.2dB,SFDR of 58.2dB and 7.8 *** chip is fabricated in 0.35 m N-well CMOS technology and occupies an area of 4 mm2.

关键词： A/D Pipelined Bootstrap Bottom-Plate Sampling

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Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis

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International Journal of Oral Science 2022年第2期14卷 140-144页

作者： Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management West China Hospital of StomatologySichuan UniversityChengduChina College of Stomatology Chongqing Medical UniversityChongqingChina Department of Oral Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Stomatology Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Oral Medicine Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjingChina Department of Oral Medicine The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingChina The Third Affiliated Hospital of Air Force Medical University Xi’anChina School and Hospital of Stomatology Cheeloo College of MedicineShandong UniversityJinanChina Beijing Stomatological Hospital Capital Medical UniversityBeijingChina Department of Oral Medicine Peking University School and Hospital of StomatologyBeijingChina Department of Oral Mucosal Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Centre of Stomatology Xiangya HospitalCental South UniversityChangshaChina Stomatology Hospital Zhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesCancer Center of Zhejiang UniversityHangzhouChina Guanghua School of Stomatology Guangdong Provincial Key Laboratory of StomatologyStomatological HospitalSun Yat-Sen UniversityGuangzhouChina Shanghai Engineering Research Center of Tooth Restoration and Regeneration Department of Oral MedicineSchool of StomatologyTongji UniversityShanghaiChina Department of Oral Medicine Hospital of StomatologyZunyi Medical UniversityZunyiChina Department of Oral Medicine School of StomatologyCapital Medical UniversityBeijingChina Department of Emergency and Oral Medicine School and Hospital of Stomatology

The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral *** expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases *** only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis.

关键词： ulceration diagnosis diseases

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The UAV dynamic path planning algorithm research based on Voronoi diagram

The UAV dynamic path planning algorithm research based on Vo...

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第26届中国控制与决策会议

作者： Xia Chen xiangmin Chen shen yang Aerospace University

According to the flight path planning problem in dynamic environment, this paper gives a method of analysis. First, the radar threat field based on Voronoi diagram is created, and the track performance indicators established based on radar threat cost and fuel cost. Then the dijkstra algorithm was improved, and the algorithm is used for path planning in dynamic environment..Finally, the simulation experiment is made, the result of simulation shows that the improved algorithm can achieve real-time tracking of moving targets, so the effectiveness of the algorithm is be verified.

关键词： UAV Voronoi diagram dijkstra algorithm Moving target Dynamic path planning

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