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Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options

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Infectious Diseases of Poverty 2014年第1期3卷 18-25页

作者： Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li xiangman zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu Sichuan Provincial Center for Diseases Control and Prevention ChengduSichuanChina Ganzi Prefecture Center for Diseases Control and Prevention KangdingSichuanChina Institute of Parasitic Diseases China Center for Diseases Control and PreventionShanghaiChina WHO Collaborating Center for Prevention and Treatment of Human Echinococcosis University Hospital and University of Franche-Comté25030 BesançonFrance Department of Chrono-Environment UMR UFC/CNRS 6249 aff.INRAUniversity of Franche-ComtéBesançonFrance Cestode Zoonoses Research Group Bioscience Research Institute and School of Environment and Life SciencesUniversity of SalfordGreat Manchester M54WTUK

Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were

关键词： Control options Echinococcosis Qinghai-Tibet Plateau Risk factors

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TOPSIS法在临床专科医疗服务绩效评价的应用分析

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职业卫生与病伤 2024年第2期39卷 130-136页

作者：曾祥嫚宁波市第二医院浙江宁波315010

目的采用TOPSIS法对临床专科医疗服务绩效进行综合评价,为高质量发展下公立医院绩效管理研究与实践提供理论支撑。方法在宁波市某三甲医院“DRGs绩效考核系统”、“不良事件上报平台”、“门诊管理系统”和“医务系统”中,从医疗服务能... 详细信息

目的采用TOPSIS法对临床专科医疗服务绩效进行综合评价,为高质量发展下公立医院绩效管理研究与实践提供理论支撑。方法在宁波市某三甲医院“DRGs绩效考核系统”、“不良事件上报平台”、“门诊管理系统”和“医务系统”中,从医疗服务能力、效率、质量与安全3个维度,选取评价指标,根据专家咨询法确定的各指标权重系数,采用TOPSIS法对该院2022年各临床专科医疗服务绩效进行综合评价。结果2022年该院54个临床科室中,肛肠外科和疼痛科分别在医疗服务能力和医疗服务效率排名第1。在医疗服务质量与安全方面,疼痛科、重症肝病科、重症医学科、肝硬化科、肺二科、急诊创伤、孕妇肝病科、肺一科、免疫肝科、放疗二科、肿瘤内科、老年医学科、放疗一科和全科医学科14个科室表现较好,均无扣分。综合排名前3的科室依次为肛肠科、心血管内科和口腔科。结论应用TOPSIS法对公立医院高质量发展下临床专科医疗服务绩效进行综合评价具有很好的实用性。

关键词：临床专科医疗服务绩效 TOPSIS法综合评价

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基于信息技术的住院病案首页质量评估

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中国病案 2024年第5期25卷 15-17页

作者：曾祥嫚宁波市第二医院浙江省宁波市315010

目的采用信息技术对住院病案首页数据进行评估,为提高住院病案首页数据质量提供参考。方法2023年1月1日-2023年6月30日按照疾病和手术编码基本规则、主要诊断选择原则、公立医院绩效考核数据上报规范设置校验规则,系统对不规范的住院病... 详细信息

目的采用信息技术对住院病案首页数据进行评估,为提高住院病案首页数据质量提供参考。方法2023年1月1日-2023年6月30日按照疾病和手术编码基本规则、主要诊断选择原则、公立医院绩效考核数据上报规范设置校验规则,系统对不规范的住院病案首页信息自动提示详细的错误,再由质控医师和编码员逐一核对、整改。结果51185份病案中,有15369份病案存在缺陷,其中内科缺陷率为28.46%,外科缺陷率为31.30%,差异有统计学意义(χ^(2)=48.36,P<0.05);8696份病案存在1项缺陷,5963份病案存在2项缺陷,632份病案存在3项缺陷,69份病案存在4项缺陷,7份病案存在5项缺陷,2份病案存在6项缺陷,占比依次为56.58%、38.80%、4.11%、0.45%、0.05%和0.01%。结论基于信息技术能够快速高效对住院病案首页质量进行评估,住院病案首页缺陷主要涉及基本信息和诊疗信息两部分内容,但在诊疗信息内涵质量评估方面规则还待进一步挖掘。

关键词：住院病案首页质量信息技术

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应用累积比数logit模型和偏比例优势模型分析肺癌手术患者住院费用影响因素

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中国医院统计 2024年第1期31卷 47-49,55页

作者：曾祥嫚宁波市第二医院浙江宁波315010

目的阐明累积比数logit模型和偏比例优势模型在有序分类资料中的应用。方法以肺癌手术住院费用的相关因素分析为例,采用累积比数logit模型和偏比例优势模型对肺癌手术住院费用与各相关因素关系进行拟合,通过模型的对数似然值(-2ln L)判... 详细信息

目的阐明累积比数logit模型和偏比例优势模型在有序分类资料中的应用。方法以肺癌手术住院费用的相关因素分析为例,采用累积比数logit模型和偏比例优势模型对肺癌手术住院费用与各相关因素关系进行拟合,通过模型的对数似然值(-2ln L)判断2种模型拟合的优度。结果在自变量不全满足比例优势假定条件时(性别χ^(2)=15.888,P<0.001;手术术式χ^(2)=35.874,P<0.001),2种分析方法拟合结果不同。在不同分割点,住院费用与手术术式关系的差别较大。偏比例优势模型(-2ln L=5797.112)优于累积比数logit模型(-2ln L=5852.420),差异具有统计学意义(P<0.05)。结论有序分类资料的分析,首先应进行比例优势假定条件验证,如果自变量均满足该条件,选择累积比数logit模型,否则采用偏比例优势模型拟合。

关键词：有序分类资料累积比数logit模型偏比例优势模型比例优势假定条件

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基于DRG组的年龄和术式对肺癌手术患者住院费用的影响

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中国医院统计 2024年第4期31卷 253-257页

作者：曾祥嫚宁波市第二医院浙江宁波315010

目的分析年龄和术式对肺癌手术患者住院费用的影响。方法以宁波市某三甲医院2022年1月1日至2022年12月31日主要诊断为肺癌(C34.-)的手术患者为研究对象,对其诊断相关分组(DRG)入组情况进行分析。采用t检验和方差分析从年龄和术式对DRG... 详细信息

目的分析年龄和术式对肺癌手术患者住院费用的影响。方法以宁波市某三甲医院2022年1月1日至2022年12月31日主要诊断为肺癌(C34.-)的手术患者为研究对象,对其诊断相关分组(DRG)入组情况进行分析。采用t检验和方差分析从年龄和术式对DRG组中患者费用进行差异性分析。结果2489例肺癌手术患者均被分到了EB1胸部大手术组。EB11胸部大手术,伴严重并发症与合并症组年龄和术式对患者费用的影响无统计学差异(P>0.05)。EB13胸部大手术、伴一般并发症与合并症组,EB15胸部大手术、不伴并发症与合并症组60岁以上患者住院费用显著高于60岁以下患者(P<0.05)。随着年龄的增加,住院费用增加,医院医保亏损金额越大,差异具有统计学意义(P<0.05)。EB13组除肺叶切除与全肺切除住院费用无统计学差异外,其余术式间患者住院费用差异均有统计学意义(P<0.05);EB15组除肺叶部分切除、肺叶切除均与全肺切除住院费用无差异外,其余术式间差异均有统计学意义(P<0.05)。随着手术切除范围增大,住院费用增高,医院医保亏损越多,差异具有统计学意义(P<0.05)。结论肺癌手术患者住院费用受年龄和手术术式的影响较大,在DRG分组方案优化时,应提高与临床的契合度,在充分考虑临床实际情况下进一步细化。

关键词：诊断相关分组肺癌手术年龄术式住院费用

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Advances in genotypic antimicrobialresistance testing: a comprehensive review

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Science China Life Sciences 2025年第01期 130-143页

作者： Boheng Duan Xianjun zeng Junping Peng Huan Kui College of Nanchang University Department of Imaging The Second Affiliated Hospital of Nanchang University NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences & Peking Union Medical College Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences & Peking Union Medical College Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education) State Key Laboratory of Respiratory Health and MultimorbidityNational Institute of Pathogen BiologyChinese Academy of Medical Sciences & Peking Union Medical College

Antimicrobial resistance(AMR) represents a substantial threat to global public health, complicating the treatment of common infections and leading to prolonged illness and escalated healthcare expenses. To effectively combat AMR, timely and accurate detection is crucial for AMR surveillance and individual-based therapy. Phenotypic antibiotic resistance testing(AST) has long been considered the gold standard in clinical applications, serving as the foundation for clinical AMR diagnosis and optimized therapy. It has significantly contributed to ensuring patients′ health and the development of novel antimicrobials. Despite advancements in automated culture-based AST technologies,inherent limitations impede the widespread use of phenotypic AST in AMR surveillance. Genotypic AST technologies offer a promising alternative option, exhibiting advantages of rapidity, high sensitivity, and specificity. With the continuous advancement and expanding applications of genotypic AST technologies, such as microfluidics, mass spectrometry, and high-resolution melting curve analysis, new vigor has been injected into the development and clinical implementation of genotypic AST technologies. In this narrative review, we discuss the principles, applications, and advancements of emerging genotypic AST methods in clinical settings. The comprehensive review aims to highlight the significant scientific potential of emerging genotypic AST technologies in clinical AMR diagnosis, providing insights to enhance existing methods and explore novel approaches.

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： Wen Huang zeng Lian Kening Lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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新疆内脏利什曼病流行区人群免疫状况调查

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中华地方病学杂志 2014年第1期33卷 90-92页

作者：王立英伍卫平官亚宜付青曾祥嫚童苏祥伊斯拉音·乌斯曼凯赛尔中国疾病预防控制中心寄生虫病预防控制所上海200025 新疆维吾尔自治区疾病预防控制中心新疆维吾尔自治区喀什地区疾病预防控制中心

目的了解新疆喀什人源型利什曼病流行区人群的免疫状况，为当地开展内脏利什曼病的防治工作提供参考信息。方法选择喀什市利什曼病发病率较高的3个大队为调查点，入户调查时，除老人与〈2岁婴幼JL#b，户内成员均开展利什曼素皮内试验（... 详细信息

目的了解新疆喀什人源型利什曼病流行区人群的免疫状况，为当地开展内脏利什曼病的防治工作提供参考信息。方法选择喀什市利什曼病发病率较高的3个大队为调查点，入户调查时，除老人与〈2岁婴幼JL#b，户内成员均开展利什曼素皮内试验（LDT）。要求人户皮试数不得低于该小队总户数的50％。记录皮试者的年龄、性别、文化程度及患病情况。运用SPSS13．0软件对调查结果进行统计分析。结果LDT总计人数1126人，阳性人数435人，阳性率为38．63％（435／1126）。皮试阳性率与年龄有密切关系（X2=34．29，P〈0．05），皮试阳性率随年龄的增加有逐渐增高的趋势。结论随着年龄的增加，人群的免疫水平增加。低年龄组人群的免疫人口所占比例较低，应重点加强低年龄组人群的监测和防治力度。

关键词：利什曼病免疫状况利什曼素皮内试验(LDT)

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