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Particuology 2024年第7期90卷 128-139页

作者： Haiting Liu Yong yang xiangliang Wang Jiewen Deng Bingbing Wang School of Energy and Power Engineering Northeast Electric Power UniversityJilin132012China CNBM Hefei Mechanical&Electrical Engineering technology Co.Ltd Hefei230051China

The Coriolis force method is a recently developed and highly regarded direct measurement technique that enables high-precision measurement of bulk *** operational parameters and variations thereof directly influence the measurement accuracy of the *** this study,a measurement correction coefficient is introduced to improve the calculation method for mass flow rate of the *** DEM is employed to simulate the motion of particle groups within the Coriolis force scale under different parameters,and the effects of various structural and operational parameters on the measurement results are *** research findings indicate that a lower rotational speed leads to more stable instantaneous measurement results,although the measurement error is relatively *** the rotational speed exceeds 300 rpm,the measurement error remains within 15%.For materials with a radius of 1–2 mm,the variation range of precision error is approximately 0.4%.Among the structural parameters,the radius of the measurement wheel has the most significant impact on the measurement results,wherein a larger measurement wheel radius corresponds to a smaller measurement *** horizontal angle of the blades follows as the next influential parameter,with a clockwise rotation and a horizontal angle of 30°resulting in a measurement error below 2%.

关键词： Parameter optimization Discrete element method Coriolis force scale Measurement error Numerical simulation

Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang Wang Tian yang Shiyou Li Chen Xu Chong Wang Yuxuan Xiong Xing Wang Jiangling Wan xiangliang yang Zifu Li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

Design and Manufacture of Dual-gate DDSCR with High Failure Current and Holding Voltage

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Chinese Journal of Electrical Engineering 2024年第2期10卷 116-125页

作者： Xingtao Bao yang Wang Yujie Liu xiangliang Jin School of Physics and Electronics Hunan Normal UniversityChangsha 410081China Key Laboratory of Physics and Devices in the Post-Moore Era Hunan Normal UniversityChangsha 410081China School of Integrated Circuits Peking UniversityBeijing 100871China

High-voltage controller area network(CAN)buses have a harsh working environment and require a robust electrostatic discharge(ESD)design ***,ordinary silicon-controlled rectifier(SCR)devices do not satisfy these design *** streamline the design and manufacturing of SCRs,this study proposes a novel dual-gate dual-direction SCR(DG-DDSCR)with a high failure current and holding ***,four polysilicon gates,GateA1,GateA2,GateC1,and GateC2,were introduced to the N+and P+middle regions of the anode and *** the voltage acts on the anode,the electric field generated by the polysilicon gate strengthens the SCR current path while promoting the release of ESD current in the substrate ***,the holding voltage of the DG-DDSCR and failure current derived from the test results of a transmission line pulse(TLP)are 29.4 V and 16.7 A,*** the clamping voltage was 40 V,the transient current release of the structure can reach 11.61 A,which met the specifications of the CAN bus ESD window and was suitable for the ESD protection of the target application.

关键词： High failure current high holding voltage CMOS technology dual-direction SCR gate controlled device

Simultaneous determination of five plant hormones in cotton leaves using QuEChERS combined with HPLC‒MS/MS

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Journal of Cotton Research 2024年第2期7卷 163-176页

作者： WANG Wenhao SONG Xianpeng WANG Dan MA Yajie SHAN Yongpan REN xiangliang HU Hongyan WU Changcai yang Jun MA Yan National Key Laboratory of Cotton Biobreeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China college of Agriculture Hebei Agricultural UniversityBaodingHebei 071000China Zhengzhou Research Base National Key Laboratory of Cotton Biobreeding and Integrated UtilizationZhengzhou UniversityZhengzhouHenan 450001China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangjiXinjiang 831100China

Background Plant hormones profoundly influence cotton growth,development,and responses to various ***,there is a pressing need for an efficient assay to quantify these hormones in *** this groundbreaking study,we have established QuEChERS-HPLC‒MS/MS method,for the simultaneous detection of multiple plant hormones in cotton leaves,allowing the analysis and quantification of five key plant *** Sample extraction and purification employed 0.1%acetic acid in methanol and C18 for optimal recovery of plant *** method applied to cotton demonstrated excellent linearity across a concentration range of 0.05–1 mg・L−1,with linear regression coefficients exceeding *** limits of quantification(LOQs)were 20μg・kg−1 for GA3 and 5μg・kg−1 for the other four plant *** rates for the five plant hormones matrix spiked at levels of 5,10,100,and 1000μg・kg−1 were in the range of 79.07%to 98.97%,with intraday relative standard deviations(RSDs)ranging from 2.11%to 8.47%.The method was successfully employed to analyze and quantify the five analytes in cotton leaves treated with plant growth *** The study demonstrates that the method is well-suited for the determination of five plant hormones in *** exhibits excellent selectivity and sensitivity in detecting field samples,thus serving as a robust tool for indepth research into cotton physiology.

关键词： Cotton Plant hormones QuEChERS HPLC‒MS/MS

A physics-informed deep learning framework for spacecraft pursuit-evasion task assessment

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Chinese Journal of Aeronautics 2024年第5期37卷 363-376页

作者： Fuyunxiang yang Leping yang Yanwei ZHU college of Aerospace science and Engineering National University of Defense TechnologyChangsha 410073China

Qualitative spacecraft pursuit-evasion problem which focuses on feasibility is rarely studied because of high-dimensional dynamics,intractable terminal constraints and heavy computational *** this paper,A physics-informed framework is proposed for the problem,providing an intuitive method for spacecraft threat relationship determination,situation assessment,mission feasibility analysis and orbital game rules *** the first time,situation adjustment suggestions can be provided for the weak player in orbital ***,a dimension-reduction dynamics is derived in the line-of-sight rotation coordinate system and the qualitative model is determined,reducing complexity and avoiding the difficulty of target set presentation caused by individual ***,the Backwards Reachable Set(BRS)of the target set is used for state space partition and capture zone ***-time analysis can eliminate the influence of changeable initial state and enable the proposed framework to analyze plural situations ***,a time-dependent Hamilton-Jacobi-Isaacs(HJI)Partial Differential Equation(PDE)is established to describe BRS evolution driven by dimension-reduction dynamics,based on level set ***,Physics-Informed Neural Networks(PINNs)are extended to HJI PDE final value problem,supporting orbital game rules summarization through capture zone evolution ***,numerical results demonstrate the feasibility and efficiency of the proposed framework.

关键词： Spacecraft pursuit-evasion Qualitative differential game Physics-Informed Neural Networks(PINNs) Reachability analysis Hamilton-Jacobi-Isaacs(HJI) Partial Differential Equations(PDEs)

Recent progress on copper catalysts with different surface states for CO_(2)electroreduction

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Journal of Energy Chemistry 2024年第1期88卷 10-27,I0001页

作者： Wenjun Zhang yang yang Donggang Guo Lu Liu Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Shanxi Laboratory for Yellow River College of Environment and ResourceShanxi UniversityTaiyuan 030006ShanxiChina

The electrochemical carbon dioxide reduction reaction(eCO_(2)RR),which converts CO_(2)into various hydrocarbons or alcohols,has been extensively researched because it promises a sustainable energy ***,only copper(Cu)can currently achieve stable and efficient hydrocarbon conversion in the eCO_(2)***,understanding the catalytic mechanisms and summarizing the research progress on synthesis strategies of Cu catalysts are essential for the eCO_(2)*** paper reviews Cu catalysts with different surface states of Cu catalysts:oxide-derived Cu,Cu nanoparticles,Cu single atoms,and Cu *** then reviews the development and progress of different Cu-catalyst preparation methods in recent years,focusing on the activity and selectivity of *** revealing the tendencies of catalytic selection and deep reactive mechanisms of Cu catalysts with four different surface states,this review can guide the subsequent construction of catalysts and provides an understanding of catalytic mechanisms.

关键词： eCO_(2)RR Oxide-derived Cu Cu nanoparticles Cu single atoms Cu nanoclusters

Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

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Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu yang Shuming Dong Shili Gai Dan yang He Ding Lili Feng Guixin yang Ziaur Rehman Piaoping yang Key Laboratory of Superlight Materials and Surface technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical Engineering and technology of Heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale ***,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side ***,various nanozymes have been developed and used for tumor *** this review,more than 270 research articles are discussed systematically to present progress in the past five ***,the discovery and development of nanozymes are ***,classification and catalytic mechanism of nanozymes are ***,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical ***,synergistic theranostic strategy of nanozymes are ***,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

PEGylated PLGA Nanoparticles as Tumor Ecrosis Factor-α Receptor Blocking Peptide Carriers:Preparation,Characterization and Release in vitro

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Journal of Wuhan University of technology(Materials science) 2007年第1期22卷 112-116页

作者：刘卫杨祥良 college of life science and technology Huazhong University of Science and Technology

To assess the merits of PEGylated poly （lactic-co-glycolic acid）（PEG-PLGA） nanoparticles as drug carriers for tumor necrosis factor-α receptor blocking peptide （TNFR-BP）, PEG-PLGA copolymer, which could be used to prepare the stealth nanoparticles, was synthesized with methoxypolyethyleneglycol, DL-lactide and glycolide. The structure of PEG-PLGA was confirmed with ^1H-NMR and FT-IR spectroscopy, and the molecular weight （MW） was determined by gel permeation chromatography. Fluorescent FITC-TNFR- BP was chosen as model protein and encapsulated within PEG-PLGA nanoparticles using the double emulsion method. Atomic force microscopy and photon correlation spectroscopy were employed to characterize the stealth nanoparticles fabricated for morphology, size with polydispersity index and zeta potential. Encapsulation efficiency （EE） and the release of FITC-TNFR-BP in nanopartieles in vitro were measured by the fluorescence measurement. The stealth nanoparticles were found to have the mean diameter less than 270 nm and zeta potential less than -20 mV. In all nanoparticle formulations, more than 45% of EE were obtained. FITC-TNFR-BP release from the PEG-PLGA nanoparticles exhibited a biphasic pattern, initial burst release and consequently sustained release. The experimental results show that PEG-PLGA nanoparticles possess the potential to develop as drug carriers for controlled release applications of TNFR-BP.

关键词： tumor necrosis factor-α receptor blocking peptide PEG-PLGA stealth nanoparticles ring-opening polymerization controlled and sustained drug release

The δ^(15)N values of foxtail millet(Setaria italica)and common millet(Panicum miliaceum)are reliable indicators of manuring practices

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science China Earth sciences 2024年第9期67卷 2910-2923页

作者： Jishuai yang Xiaoyan yang Ting YOU Fahu CHEN Key Scientific Research Base of Bioarchaeology in Cold and Arid Regions(National Cultural Heritage Administration) Key Laboratory of Western China’s Environmental Systems(Ministry of Education)College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Group of Alpine Paleoecology and Human Adaptation(ALPHA) State Key Laboratory of Tibetan Plateau Earth SystemResources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730000China

Millet agriculture,which originated in northern China,alongside rice agriculture,have nurtured the Chinese *** manuring practices likely promoted and maintained sustainable millet agricultural production in the loess area of northern ***,ongoing controversy exists regarding the indicators of prehistoric manuring intensity of foxtail millet(Setaria italica)and common millet(Panicum miliaceum).Here,we present the results of pot and field fertilization experiments on two millet *** findings suggest that manuring can significantly increase the δ^(15)N values of foxtail millet,and its δ^(15)N values increase with increasing manuring *** δ^(15)N values of foxtail millet leaves are systematically greater than those of grains by approximately 1.6‰.Manuring could have a long-term residual impact on increasing the δ^(15)N values of soil and millet *** with previous crop fertilization experiment results,we propose that the impact of manuring on the δ^(15)N values of non-nitrogen-fixing crops is roughly *** δ^(15)N value and amount of manure are key factors determining the extent of change in plant δ^(15)N *** millet grain δ^(15)N values can serve as reliable indicators of manuring ***,we provide an interpretive framework for assessing the correlation between manuring levels and the δ^(15)N values of archaeological millet *** δ^(15)N values of ancient millet grains suggest widespread and intensive manuring practices in prehistoric millet agriculture in northern China,spanning from the early yangshao period to the Longshan period.

关键词： Millet farming Manuring experiment Farming system Archaeobotany North China